Wingless (Wnt)-3A induces trophoblast migration and matrix metalloproteinase-2 secretion through canonical Wnt signaling and protein kinase B/AKT activation

Endocrinology

Volumn 151, Issue 1, 2010, Pages 211-220

  Sonderegger, Stefan ^a   Haslinger, Peter ^a   Sabri, Alia ^a   Leisser, Christina ^a   Otten, Jan V ^a   Fiala, Christian ^b   Knöfler, Martin ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Gynmed Clinic   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; DICKKOPF 1 PROTEIN; GELATINASE A; GLYCOGEN SYNTHASE KINASE; LUCIFERASE; PROTEIN KINASE; PROTEIN KINASE B; RECOMBINANT ENZYME; TRANSCRIPTION FACTOR 7; WNT PROTEIN;

ARTICLE; CELL CULTURE; CELL MIGRATION; CONTROLLED STUDY; CYTOTROPHOBLAST; ENZYME RELEASE; FEMALE; FIRST TRIMESTER PREGNANCY; GENE TARGETING; HUMAN; HUMAN TISSUE; MOTOR DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TROPHOBLAST; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELL MOVEMENT; CELLS, CULTURED; ENZYME ACTIVATION; FEMALE; HUMANS; MATRIX METALLOPROTEINASE 2; MODELS, BIOLOGICAL; PREGNANCY; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TROPHOBLASTS; WNT PROTEINS;

EID: 73649096235     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2009-0557     Document Type: Article

References (44)

1. Pijnenborg R, Bland JM, Robertson WB, Brosens I 1983 Uteroplacental arterial changes related to interstitial trophoblast migration in early human pregnancy. Placenta 4:397-413
2. Pijnenborg R, Anthony J, Davey DA, Rees A, Tiltman A, Vercruysse L, van Assche A 1991 Placental bed spiral arteries in the hypertensive disorders of pregnancy. Br J Obstet Gynaecol 98:648-655
3. Norwitz ER 2006 Defective implantation and placentation: laying the blueprint for pregnancy complications. Reprod Biomed Online 13:591-599
4. Bischof P, Meisser A, Campana A 2000 Paracrine and autocrine regulators of trophoblast invasion: a review. Placenta 21(Suppl A): S55-S60
5. Lala PK, Hamilton GS 1996 Growth factors, proteases and protease inhibitors in the maternal-fetal dialogue. Placenta 17:545-555
6. Pollheimer J, Knöfler M 2005 Signalling pathways regulating the invasive differentiation of human trophoblasts: a review. Placenta 26(Suppl A):S21-S30
7. Lash GE, Quenby S, Burton GJ, Nakashima A, Kamat BR, Ray J, Bulmer JN 2008 Gestational diseases: a workshop report. Placenta 29S:92-94
8. Balaram P, John M, Enose S, Symaladevi PK 2001 Demonstration of TGF-α-EGFR and EGF-EGFR autocrine loops and their relation to proliferation in complete hydatidiform moles (CHM). Int J Gynecol Cancer 11:397-402
9. Tseng JJ, Chou MM 2006 Differential expression of growth-, angiogenesis-and invasion-related factors in the development of placenta accreta. Taiwan J Obstet Gynecol 45:100-106
10. Pollheimer J, Loregger T, Sonderegger S, Saleh L, Bauer S, Bilban M, Czerwenka K, Husslein P, Knöfler M 2006 Activation of the canonical wingless/T-cell factor signaling pathway promotes invasive differentiation of human trophoblast. Am J Pathol 168:1134-1147
11. Gordon MD, Nusse R 2006 Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem 281:22429-22433
12. -/- mice. Genes Dev 13:709-717
13. Monkley SJ, Delaney SJ, Pennisi DJ, Christiansen JH, Wainwright BJ 1996 Targeted disruption of the Wnt2 gene results in placentation defects. Development 122:3343-3353
14. Parr BA, Cornish VA, Cybulsky MI, McMahon AP 2001 Wnt7b regulates placental development in mice. Dev Biol 237:324-332
15. Mohamed OA, Jonnaert M, Labelle-Dumais C, Kuroda K, Clarke HJ, Dufort D 2005 Uterine Wnt/β-catenin signaling is required for implantation. Proc Natl Acad Sci USA 102:8579-8584
16. Paria BC, Ma W, Tan J, Raja S, Das SK, Dey SK, Hogan BL 2001 Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors. Proc Natl Acad Sci USA 98:1047-1052
17. Tulac S, Nayak NR, Kao LC, Van Waes M, Huang J, Lobo S, Germeyer A, Lessey BA, Taylor RN, Suchanek E, Giudice LC 2003 Identification, characterization, and regulation of the canonical Wnt signaling pathway in human endometrium. J Clin Endocrinol Metab 88:3860-3866
18. Tulac S, Overgaard MT, Hamilton AE, Jumbe NL, Suchanek E, Giudice LC 2006 Dickkopf-1, an inhibitor of Wnt signaling, is regulated by progesterone in human endometrial stromal cells. J Clin Endocrinol Metab 91:1453-1461
19. Sonderegger S, Husslein H, Leisser C, Knöfler M 2007 Complex expression pattern of Wnt ligands and frizzled receptors in human placenta and its trophoblast subtypes. Placenta 28(Suppl A):S97-S102
20. Peng S, Li J, Miao C, Jia L, Hu Z, Zhao P, Li J, Zhang Y, Chen Q, Duan E 2008 Dickkopf-1 secreted by decidual cells promotes trophoblast cell invasion during murine placentation. Reproduction 135:367-375
21. Kühl M 2004 The WNT/calcium pathway: biochemical mediators, tools and future requirements. Front Biosci 9:967-974
22. Kim SE, Lee WJ, Choi KY 2007 The PI3 kinase-Akt pathway mediates Wnt3a-induced proliferation. Cell Signal 19:511-518
23. Yun MS, Kim SE, Jeon SH, Lee JS, Choi KY 2005 Both ERK and Wnt/β-catenin pathways are involved in Wnt3a-induced proliferation. J Cell Sci 118:313-322
24. He S, Pant D, Schiffmacher A, Meece A, Keefer CL 2008 Lymphoid enhancer factor 1-mediated Wnt signaling promotes the initiation of trophoblast lineage differentiation in mouse embryonic stem cells. Stem Cells 26:842-849
25. Naito AT, Akazawa H, Takano H, Minamino T, Nagai T, Aburatani H, Komuro I 2005 Phosphatidylinositol 3-kinase-Akt pathway plays a critical role in early cardiomyogenesis by regulating canonical Wnt signaling. Circ Res 97:144-151
26. Staun-Ram E, Goldman S, Gabarin D, Shalev E 2004 Expression and importance of matrix metalloproteinase 2 and 9 (MMP-2 and -9) in human trophoblast invasion. Reprod Biol Endocrinol 2:59
27. Tarrade A, Lai Kuen R, Malassiné A, Tricottet V, Blain P, Vidaud M, Evain-Brion D 2001 Characterization of human villous and extravillous trophoblasts isolated from first trimester placenta. Lab Invest 81:1199-1211
28. Choy MY, St Whitley G, Manyonda IT 2000 Efficient, rapid and reliable establishment of human trophoblast cell lines using poly-L-ornithine. Early Pregnancy 4:124-143
29. Huber AV, Saleh L, Prast J, Haslinger P, Knöfler M 2007 Human chorionic gonadotrophin attenuates NF-κB activation and cytokine expression of endometriotic stromal cells. Mol Hum Reprod 13: 595-604
30. Knöfler M, Saleh L, Bauer S, Galos B, Rotheneder H, Husslein P, Helmer H 2004 Transcriptional regulation of the human chorionic gonadotropin β gene during villous trophoblast differentiation. Endocrinology 145:1685-1694
31. Wu B, Crampton SP, Hughes CC 2007 Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration. Immunity 26:227-239
32. Qiu Q, Yang M, Tsang BK, Gruslin A 2004 Both mitogen-activated protein kinase and phosphatidylinositol 3-kinase signalling are required in epidermal growth factor-induced human trophoblast migration. Mol Hum Reprod 10:677-684
33. Qiu Q, Basak A, Mbikay M, Tsang BK, Gruslin A 2005 Role of pro-IGF-II processing by proprotein convertase 4 in human placental development. Proc Natl Acad Sci USA 102:11047-11052
34. Cartwright JE, Tse WK, Whitley GS 2002 Hepatocyte growth factor induced human trophoblast motility involves phosphatidylinositol-3-kinase, mitogen-activated protein kinase, and inducible nitric oxide synthase. Exp Cell Res 279:219-226
35. Prast J, Saleh L, Husslein H, Sonderegger S, Helmer H, Knöfler M 2008 Human chorionic gonadotropin stimulates trophoblast invasion through extracellularly regulated kinase and AKT signaling. Endocrinology 149:979-987
36. Jones SE, Jomary C 2002 Secreted Frizzled-related proteins: searching for relationships and patterns. Bioessays 24:811-820
37. Hendrickx M, Leyns L 2008 Non-conventional Frizzled ligands and Wnt receptors. Dev Growth Differ 50:229-243
38. Fukumoto S, Hsieh CM, Maemura K, Layne MD, Yet SF, Lee KH, Matsui T, Rosenzweig A, Taylor WG, Rubin JS, Perrella MA, Lee ME 2001 Akt participation in the Wnt signaling pathway through Dishevelled. J Biol Chem 276:17479-17483
39. Ding VW, Chen RH, McCormick F 2000 Differential regulation of glycogen synthase kinase 3β by insulin and Wnt signaling. J Biol Chem 275:32475-32481
40. Yuan H, Mao J, Li L, Wu D 1999 Suppression of glycogen synthase kinase activity is not sufficient for leukemia enhancer factor-1 activation. J Biol Chem 274:30419-30423
41. Gardner S, Maudsley S, Millar RP, Pawson AJ 2007 Nuclear stabilization of β-catenin and inactivation of glycogen synthase kinase-3β by gonadotropin-releasing hormone: targeting Wnt signaling in the pituitary gonadotrope. Mol Endocrinol 21:3028-3038
42. O'Connell MP, French AD, Leotlela PD, Weeraratna AT 2008 Assaying Wnt5A-mediated invasion in melanoma cells. Methods Mol Biol 468:243-253
43. Qiu Q, Yang M, Tsang BK, Gruslin A 2004 EGF-induced trophoblast secretion of MMP-9 and TIMP-1 involves activation of both PI3K and MAPK signalling pathways. Reproduction 128:355-363
44. Park BK, Zeng X, Glazer RI 2001 Akt1 induces extracellular matrix invasion and matrix metalloproteinase-2 activity in mouse mammary epithelial cells. Cancer Res 61:7647-7653