Triapine and a more potent dimethyl derivative induce endoplasmic reticulum stress in cancer cells

Molecular Pharmacology

Volumn 85, Issue 3, 2014, Pages 451-459

  Trondl, Robert ^a,b   Flocke, Lea S ^a   Kowol, Christian R ^a,b   Heffeter, Petra ^b,c,d   Jungwirth, Ute ^b,c,d   Mair, Georg E ^e   Steinborn, Ralf ^e   Enyedy, Éva A ^f,g   Jakupec, Michael A ^a,b   Berger, Walter ^b,c,d   Keppler, Bernhard K ^a,b  

^a UNIVERSITY OF VIENNA   (Austria)

^b Research Platform Translational Cancer Therapy Research   (Austria)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^d MEDICAL UNIVERSITY OF VIENNA   (Austria)

^e University of Veterinary Medicine   (Australia)

^f UNIVERSITY OF SZEGED   (Hungary)

^g Hungarian Academy of Science USZ Bioinorganic Chemistry Research Group   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINOPICOLINALDEHYDE THIOSEMICARBAZONE; ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; BIM PROTEIN; CARRIER PROTEIN; CARRIER PROTEIN PERK; CYCLOHEXIMIDE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; N 4, N 4 DIMETHYLTRIAPINE; NITROGEN; PROTEIN IRE1; STRESS ACTIVATED PROTEIN KINASE; THIOSEMICARBAZONE DERIVATIVE; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELLULAR DISTRIBUTION; COLON CANCER; CONTROLLED STUDY; CYTOTOXICITY; DIMETHYLATION; DRUG STRUCTURE; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; HUMAN; HUMAN CELL; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; PROTEIN METHYLATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; UNFOLDED PROTEIN RESPONSE; UPREGULATION; WESTERN BLOTTING;

ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; APOPTOSIS; CELL LINE, TUMOR; COLONIC NEOPLASMS; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; EUKARYOTIC INITIATION FACTOR-2; HCT116 CELLS; HL-60 CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOCHONDRIAL MEMBRANES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PYRIDINES; THIOSEMICARBAZONES; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION FACTORS; UNFOLDED PROTEIN RESPONSE; UP-REGULATION;

EID: 84894092121     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.113.090605     Document Type: Article

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