Mechanisms underlying reductant-induced reactive oxygen species formation by anticancer copper(II) compounds

Journal of Biological Inorganic Chemistry

Volumn 17, Issue 3, 2012, Pages 409-423

  Kowol, Christian R ^a,b   Heffeter, Petra ^b,c   Miklos, Walter ^c   Gille, Lars ^d   Trondl, Robert ^a   Cappellacci, Loredana ^e   Berger, Walter ^b,c   Keppler, Bernhard K ^a,b  

^a UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^e UNIVERSITY OF CAMERINO   (Italy)

Author keywords

Anticancer; Copper; Glutathione; Reactive oxygen species; Thiosemicarbazone

Indexed keywords

2,2' BIPYRIDYL 6 CARBOTHIOAMIDE; 2,2' BIPYRIDYL 6 CARBOTHIOAMIDE N,N,S DICHLORIDOCOPPER; 3 AMINOPICOLINALDEHYDE THIOSEMICARBAZONE; 3 AMINOPYRIDINE 2 CARBOXALDEHYDE 4N,4N DIMETHYLTHIOSEMICARBAZONE; 3 AMINOPYRIDINE 2 CARBOXALDEHYDE N,N DIMETHYLTHIOSEMICARBAZONATO N,N,S DICHLORIDOCOPPER; 3 AMINOPYRIDINE 2 CARBOXALDEHYDE THIOSEMICARBAZONATO N,N,S DICHLORIDOCOPPER MONOHYDRATE; ACETATO(3 AMINOPYRIDINE 2 CARBOXALDEHYDE THIOSEMICARBAZONATO N,N,S)COPPER; ANTINEOPLASTIC AGENT; ASCORBIC ACID; COPPER COMPLEX; CUPRIC ION; CUPROUS ION; GLUTATHIONE; HYDROGEN PEROXIDE; PICOLINALDEHYDE THIOSEMICARBAZONE; PYRIDINE 2 CARBOXALDEHYDETHIOSEMICARBAZONATO N,N,S DICHLORIDOCOPPER; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; THIOL; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL STRESS; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; HUMAN; HUMAN CELL; IC 50; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; ELECTROCHEMISTRY; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; THIOSEMICARBAZONES;

EID: 84862523043     PISSN: 09498257     EISSN: 14321327     Source Type: Journal    
DOI: 10.1007/s00775-011-0864-x     Document Type: Article

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