Reduction of GRP78 expression with siRNA activates unfolded protein response leading to apoptosis in HeLa cells

Archives of Biochemistry and Biophysics

Volumn 468, Issue 1, 2007, Pages 1-14

  Suzuki, Toshikazu ^a   Lu, Jun ^a   Zahed, Muhammed ^a   Kita, Kazuko ^a   Suzuki, Nobuo ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

Apoptosis; ER chaperone; GRP78; GRP78 siRNA; HeLa cells; UPR activation

Indexed keywords

CHAPERONE; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MESSENGER RNA; PROTEIN ERDJ4; PROTEIN P5; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CALCIUM BINDING; CELL STRESS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HELA CELL; HOMEOSTASIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN PROCESSING; SENSOR; UNFOLDED PROTEIN RESPONSE; UPREGULATION;

APOPTOSIS; DOWN-REGULATION; GENE SILENCING; HEAT-SHOCK PROTEINS; HELA CELLS; HUMANS; MOLECULAR CHAPERONES; PROTEIN DENATURATION; PROTEIN FOLDING; RNA, SMALL INTERFERING;

EID: 36049042707     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2007.09.004     Document Type: Article

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