Structure and function of the radical enzyme ribonucleotide reductase

Progress in Biophysics and Molecular Biology

Volumn 77, Issue 3, 2001, Pages 177-268

  Eklund, Hans ^a   Uhlin, Ulla ^a   Färnegårdh, Mathias ^a   Logan, Derek T ^b   Nordlund, Pär ^b  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; AZIDE; CARBOXYL GROUP; IRON; RIBONUCLEOTIDE REDUCTASE;

ALLOSTERISM; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL; BINDING SITE; CANCER; CATALYSIS; CHEMISTRY; CLASSIFICATION; CRYSTAL STRUCTURE; DNA SYNTHESIS; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBUNIT; ENZYME SYNTHESIS; EUKARYOTE; HUMAN; METABOLISM; MOLECULAR GENETICS; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATION REDUCTION STATE; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; REVIEW; SPECIES DIFFERENTIATION; DRUG ANTAGONISM;

EUKARYOTA;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATALYSIS; DRUG DESIGN; HUMANS; IRON; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; PROTEIN CONFORMATION; RIBONUCLEOTIDE REDUCTASES;

EID: 0035544604     PISSN: 00796107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0079-6107(01)00014-1     Document Type: Review

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198. Concurrent chemoradiation in carcinoma of the uterine cervix
199. Preclinical, pharmacologic, and phase I studies of gemcitabine
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222. Characterization of Y122F R2 of Escherichia coli ribonucleotide reductase by time-resolved physical biochemical methods and X-ray crystallography
223. The anaerobic (class III) ribonucleotide reductase from Lactococcus lactis. Catalytic properties and allosteric regulation of the pure enzyme system
224. The anaerobic ribonucleotide reductase from Lactococcus lactis. Interactions between the two proteins NRDD and NRDG
225. Structure of ribonucleotide reductase protein R1
226. The ten-stranded beta/alpha barrel in ribonucleotide reductase protein R1
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231. Structural basis for stabilization of a m-(1,2) peroxodiiron (III) intermediate in the D84E mutant of ribonucleotide reductase R2
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233. The free radical in pyruvate formate-lyase is located on glycine-734
234. Crystal structure of Escherichia coli thioredoxin reductase refined at 2 Å resolution
235. Rnr4p, a novel ribonucleotide reductase small-subunit protein
236. Structural conservation in parallel beta/alpha-barrel enzymes that catalyze three sequential reactions in the pathway of tryptophan biosynthesis
237. Synthesis and biological activity of a bivalent nucleotide inhibitor of ribonucleotide reductase
238. NMR structure of oxidized Escherichia coli glutaredoxin: Comparison with reduced Escherichia coli glutaredoxin and functionally related proteins
239. Isolation of ribonucleotide reductase from Mycobacterium tuberculosis and cloning, expression, and purification of the large subunit
240. Deoxyribonucleoside-triphosphate imbalance death: Deoxyadenosine-induced dNTP imbalance and DNA double strand breaks in mouse FM3A cells and the mechanism of cell death
241. Bacteriophage T4 anaerobic ribonucleotide reductase contains a stable glycyl radical at position 580