Cellular iron depletion stimulates the JNK and p38 MAPK signaling transduction pathways, dissociation of ASK1-thioredoxin, and activation of ASK1

Journal of Biological Chemistry

Volumn 286, Issue 17, 2011, Pages 15413-15427

  Yu, Yu ^a   Richardson, Des R ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; CANCER THERAPY; CELL-CYCLE ARREST; COMPLEX FORMATIONS; DESFERRIOXAMINE; EXTRACELLULAR SIGNAL-REGULATED KINASE; IN-CELL; IRON CHELATION; IRON CHELATORS; IRON COMPLEX; IRON DEPLETION; IRON METABOLISM; MITOGEN ACTIVATED PROTEIN KINASE; N-ACETYLCYSTEINE; P38 MAPK; REDOX-ACTIVE; SIGNALING PATHWAYS; STRESS-ACTIVATED PROTEINS; THIOREDOXINS; THIOSEMICARBAZONES; UP-REGULATION;

CELL DEATH; CHELATION; DISSOCIATION; ENZYME ACTIVITY; ENZYMES; IRON; PHOSPHORYLATION; SIGNALING;

IRON COMPOUNDS;

APOPTOSIS SIGNAL REGULATING KINASE 1; DEFEROXAMINE; IRON; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; THIOREDOXIN;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; COMPLEX FORMATION; CONTROLLED STUDY; DISSOCIATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IRON CHELATION; IRON DEPLETION; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

CELL LINE, TUMOR; HUMANS; IRON; IRON CHELATING AGENTS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE KINASE 5; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; SIGNAL TRANSDUCTION; THIOREDOXINS;

EID: 79955462543     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.225946     Document Type: Article

References (64)

1. Antosiewicz, J., Ziolkowski, W., Kaczor, J. J., and Herman-Antosiewicz, A. (2007) Free Radic. Biol. Med. 43, 265-270
2. Deb, S., Johnson, E. E., Robalinho-Teixeira, R. L., and Wessling-Resnick, M. (2009) Biometals 22, 855-862
3. Babitt, J. L., Huang, F. W., Xia, Y., Sidis, Y., Andrews, N. C., and Lin, H. Y. (2007) J. Clin. Invest. 117, 1933-1939
4. Le, N. T., and Richardson, D. R. (2002) Biochim. Biophys. Acta 1603, 31-46
5. Brodie, C., Siriwardana, G., Lucas, J., Schleicher, R., Terada, N., Szepesi, A., Gelfand, E., and Seligman, P. (1993) Cancer Res. 53, 3968-3975
6. Hileti, D., Panayiotidis, P., and Hoffbrand, A. V. (1995) Br. J. Haematol. 89, 181-187
7. Buss, J. L., Torti, F. M., and Torti, S. V. (2003) Curr. Med. Chem. 10, 1021-1034
8. Kalinowski, D. S., and Richardson, D. R. (2005) Pharmacol. Rev. 57, 547-583
9. Donfrancesco, A., Deb, G., Dominici, C., Pileggi, D., Castello, M. A., and Helson, L. (1990) Cancer Res. 50, 4929-4930
10. Blatt, J., and Stitely, S. (1987) Cancer Res. 47, 1749-1750
11. Estrov, Z., Tawa, A., Wang, X. H., Dubé, I. D., Sulh, H., Cohen, A., Gelfand, E. W., and Freedman, M. H. (1987) Blood 69, 757-761
12. Selig, R. A., Madafiglio, J., Haber, M., Norris, M. D., White, L., and Stewart, B. W. (1993) Anticancer Res. 13, 721-725
13. Yuan, J., Lovejoy, D. B., and Richardson, D. R. (2004) Blood 104, 1450-1458
14. Whitnall, M., Howard, J., Ponka, P., and Richardson, D. R. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 14901-14906
15. Kulp, K. S., Green, S. L., and Vulliet, P. R. (1996) Exp. Cell Res. 229, 60-68
16. Simonart, T., Degraef, C., Andrei, G., Mosselmans, R., Hermans, P., Van Vooren, J. P., Noel, J. C., Boelaert, J. R., Snoeck, R., and Heenen, M. (2000) J. Invest. Dermatol. 115, 893-900
17. Lucas, J. J., Szepesi, A., Domenico, J., Takase, K., Tordai, A., Terada, N., and Gelfand, E. W. (1995) Blood 86, 2268-2280
18. Fukuchi, K., Tomoyasu, S., Tsuruoka, N., and Gomi, K. (1994) FEBS Lett. 350, 139-142
19. Gao, J., and Richardson, D. R. (2001) Blood 98, 842-850
20. Nurtjahja-Tjendraputra, E., Fu, D., Phang, J. M., and Richardson, D. R. (2007) Blood 109, 4045-4054
21. Saletta, F., Rahmanto, Y. S., Noulsri, E., and Richardson, D. R. (2010) Mol. Pharmacol. 77, 443-458
22. Noulsri, E., Richardson, D. R., Lerdwana, S., Fucharoen, S., Yamagishi, T., Kalinowski, D. S., and Pattanapanyasat, K. (2009) Am. J. Hematol. 84, 170-176
23. Rao, V. A., Klein, S. R., Agama, K. K., Toyoda, E., Adachi, N., Pommier, Y., and Shacter, E. B. (2009) Cancer Res. 69, 948-957
24. Dhillon, A. S., Hagan, S., Rath, O., and Kolch, W. (2007) Oncogene 26, 3279-3290
25. Raman, M., Chen, W., and Cobb, M. H. (2007) Oncogene 26, 3100-3112
26. Lewis, T. S., Shapiro, P. S., and Ahn, N. G. (1998) Adv. Cancer Res. 74, 49-139
27. Richardson, D. R., Sharpe, P. C., Lovejoy, D. B., Senaratne, D., Kalinowski, D. S., Islam, M., and Bernhardt, P. V. (2006) J. Med. Chem. 49, 6510-6521
28. Kalinowski, D. S., Yu, Y., Sharpe, P. C., Islam, M., Liao, Y. T., Lovejoy, D. B., Kumar, N., Bernhardt, P. V., and Richardson, D. R. (2007) J. Med. Chem. 50, 3716-3729
29. Richardson, D. R., and Baker, E. (1990) Biochim. Biophys. Acta 1053, 1-12
30. Le, N. T., and Richardson, D. R. (2004) Blood 104, 2967-2975
31. Suryo Rahmanto, Y., Dunn, L. L., and Richardson, D. R. (2007) Carcinogenesis 28, 2172-2183
32. Zhong, D., Liu, X., Khuri, F. R., Sun, S. Y., Vertino, P. M., and Zhou, W. (2008) Cancer Res. 68, 7270-7277
33. Richardson, D., Ponka, P., and Baker, E. (1994) Cancer Res. 54, 685-689
34. Darnell, G., and Richardson, D. R. (1999) Blood 94, 781-792
35. Beerepoot, L. V., Shima, D. T., Kuroki, M., Yeo, K. T., and Voest, E. E. (1996) Cancer Res. 56, 3747-3751
36. Richardson, D. R. (2005) Curr. Med. Chem. 12, 2711-2729
37. Takekawa, M., and Saito, H. (1998) Cell 95, 521-530
38. Wang, X. Z., and Ron, D. (1996) Science 272, 1347-1349
39. Jeffrey, K. L., Camps, M., Rommel, C., and Mackay, C. R. (2007) Nat. Rev. Drug Discov. 6, 391-403
40. Gomez, M. A., Alisaraie, L., Shio, M. T., Berghuis, A. M., Lebrun, C., Gautier-Luneau, I., and Olivier, M. (2010) J. Biol. Chem. 285, 24620-24628
41. Bardwell, L., and Shah, K. (2006) Methods 40, 213-223
42. Abe, J., Kusuhara, M., Ulevitch, R. J., Berk, B. C., and Lee, J. D. (1996) J. Biol. Chem. 271, 16586-16590
43. Park, Y. C., Ye, H., Hsia, C., Segal, D., Rich, R. L., Liou, H. C., Myszka, D. G., and Wu, H. (2000) Cell 101, 777-787
44. Cano, E., Hazzalin, C. A., and Mahadevan, L. C. (1994) Mol. Cell. Biol. 14, 7352-7362
45. Cuevas, B. D., Abell, A. N., and Johnson, G. L. (2007) Oncogene 26, 3159-3171
46. Ashcroft, M., Taya, Y., and Vousden, K. H. (2000) Mol. Cell. Biol. 20, 3224-3233
47. Clerk, A., and Sugden, P. H. (1997) Biochem. J. 325, 801-810
48. Wu, G. S. (2004) Cancer Biol. Ther. 3, 156-161
49. Jansson, P. J., Hawkins, C. L., Lovejoy, D. B., and Richardson, D. R. (2010) J. Inorg. Biochem. 104, 1224-1228
50. Matsuzawa, A., and Ichijo, H. (2008) Biochim. Biophys. Acta 1780, 1325-1336
51. Fu, D., and Richardson, D. R. (2007) Blood 110, 752-761
52. Schafer, F. Q., and Buettner, G. R. (2001) Free Radic. Biol. Med. 30, 1191-1212
53. Saitoh, M., Nishitoh, H., Fujii, M., Takeda, K., Tobiume, K., Sawada, Y., Kawabata, M., Miyazono, K., and Ichijo, H. (1998) EMBO J. 17, 2596-2606
54. Gupta, S., Campbell, D., Dérijard, B., and Davis, R. J. (1995) Science 267, 389-393
55. Zhu, T., and Lobie, P. E. (2000) J. Biol. Chem. 275, 2103-2114
56. Wilkinson, M. G., and Millar, J. B. (2000) FASEB J. 14, 2147-2157
57. Choi, S. C., Kim, B. S., Song, M. Y., Choi, E. Y., Oh, H. M., Lyou, J. H., Han, W. C., Moon, H. B., Kim, T. H., Oh, J. M., Chung, H. T., and Jun, C. D. (2003) Free Radic. Biol. Med. 35, 1171-1184
58. Kim, B. S., Yoon, K. H., Oh, H. M., Choi, E. Y., Kim, S. W., Han, W. C., Kim, E. A., Choi, S. C., Kim, T. H., Yun, K. J., Kim, E. C., Lyou, J. H., Nah, Y. H., Chung, H. T., Cha, Y. N., and Jun, C. D. (2002) Cell. Immunol. 220, 96-106
59. Wenger, R. H., Camenisch, G., Desbaillets, I., Chilov, D., and Gassmann, M. (1998) Cancer Res. 58, 5678-5680
60. Matsuzawa, A., and Ichijo, H. (2001) J. Biochem. 130, 1-8
61. Kim, B. M., and Chung, H. W. (2008) Toxicol. Appl. Pharmacol. 228, 24-31
62. Seo, G. S., Lee, S. H., Choi, S. C., Choi, E. Y., Oh, H. M., Choi, E. J., Park, D. S., Kim, S. W., Kim, T. H., Nah, Y. H., Kim, S., Kim, S. H., You, S. H., and Jun, C. D. (2006) Free Radic. Biol. Med. 40, 1502-1512
63. Mardini, L., Gasiorek, J., Derjuga, A., Carrière, L., Schranzhofer, M., Paw, B. H., Ponka, P., and Blank, V. (2010) Biochem. J. 432, 145-151
64. Yu, Y., Suryo Rahmanto, Y., Hawkins, C. L., and Richardson, D. R. (2011) Mol. Pharmacol., in press