Simvastatin treatment highlights a new role for the isoprenoid/cholesterol biosynthetic pathway in the modulation of emotional reactivity and cognitive performance in rats

Neuropsychopharmacology

Volumn 39, Issue 4, 2014, Pages 841-854

  Segatto, Marco ^a   Manduca, Antonia ^a   Lecis, Claudio ^a   Rosso, Pamela ^a   Jozwiak, Adam ^b   Swiezewska, Ewa ^b   Moreno, Sandra ^a   Trezza, Viviana ^a   Pallottini, Valentina ^a  

^a ROMA TRE UNIVERSITY   (Italy)

^b INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS   (Poland)

Author keywords

anxiety; CREB; memory; Rab3; RhoA; simvastatin

Indexed keywords

ANIMALS; ANTICHOLESTEREMIC AGENTS; AVOIDANCE LEARNING; BRAIN; CELLS, CULTURED; CHOLESTEROL; COGNITION; CREB-BINDING PROTEIN; EMOTIONS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MAZE LEARNING; MEMBRANE PROTEINS; NEURONS; RATS; RATS, WISTAR; SIMVASTATIN; SYNAPTIC VESICLES; TERPENES; TRIGLYCERIDES;

EID: 84894086258     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2013.284     Document Type: Article

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