메뉴 건너뛰기




Volumn 214, Issue 4, 2008, Pages 341-349

Simvastatin impairs spatial memory in rats at a specific dose level

Author keywords

Barnes maze; Behavior; Brain; Locomotor; Statins

Indexed keywords

SIMVASTATIN; HYPOCHOLESTEROLEMIC AGENT;

EID: 44449120224     PISSN: 00408727     EISSN: 13493329     Source Type: Journal    
DOI: 10.1620/tjem.214.341     Document Type: Article
Times cited : (26)

References (45)
  • 2
    • 0018344553 scopus 로고
    • Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat
    • Barnes, C.A. (1979) Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. J. Comp. Physiol. Psychol., 93, 74-104.
    • (1979) J. Comp. Physiol. Psychol , vol.93 , pp. 74-104
    • Barnes, C.A.1
  • 3
    • 33746632472 scopus 로고    scopus 로고
    • Fluvastatin alters psychomotor performance and daily activity but not the spatial memory in rats
    • Baytan, S.H., Alkanat, M., Ozeren, M., Ekinci, M. & Akgun, A. (2006) Fluvastatin alters psychomotor performance and daily activity but not the spatial memory in rats, Tohoku. J. Exp. Med., 209, 311-320.
    • (2006) Tohoku. J. Exp. Med , vol.209 , pp. 311-320
    • Baytan, S.H.1    Alkanat, M.2    Ozeren, M.3    Ekinci, M.4    Akgun, A.5
  • 4
    • 0017328634 scopus 로고
    • Exercise-induced growth in golden hamsters: Effects of age, weight and activity levels
    • Borer, K. & Kaplan, L. (1977) Exercise-induced growth in golden hamsters: effects of age, weight and activity levels. Physiol. Behav., 18, 23-34.
    • (1977) Physiol. Behav , vol.18 , pp. 23-34
    • Borer, K.1    Kaplan, L.2
  • 6
    • 44449143255 scopus 로고    scopus 로고
    • Differential effects of statins and alendronate on cholinesterases in serum and brain of rats
    • Nov. 6, Epub ahead of print
    • Cibickova, L., Palicka, V, Cibicek, N., Cermakova, E., Micuda, S., Bartosova, L. & Daniel, J. (2006) Differential effects of statins and alendronate on cholinesterases in serum and brain of rats. Physiol. Res., Nov. 6. [Epub ahead of print]
    • (2006) Physiol. Res
    • Cibickova, L.1    Palicka, V.2    Cibicek, N.3    Cermakova, E.4    Micuda, S.5    Bartosova, L.6    Daniel, J.7
  • 7
    • 0020507677 scopus 로고
    • Acetylcholine mediates a slow synaptic potential in hippocampal pyramidal cells
    • Cole, A.E. & Nicoll, R.A. (1983) Acetylcholine mediates a slow synaptic potential in hippocampal pyramidal cells. Science, 221, 1299-1301.
    • (1983) Science , vol.221 , pp. 1299-1301
    • Cole, A.E.1    Nicoll, R.A.2
  • 8
    • 0347481473 scopus 로고    scopus 로고
    • A Differential effects of lipid-lowering agents on human cholinesterases
    • Darvesh, S., Martin, E., Walsh, R. & Rockwood, K. (2004) A Differential effects of lipid-lowering agents on human cholinesterases. Clin. Biochem., 37, 42-49.
    • (2004) Clin. Biochem , vol.37 , pp. 42-49
    • Darvesh, S.1    Martin, E.2    Walsh, R.3    Rockwood, K.4
  • 9
    • 0038284773 scopus 로고    scopus 로고
    • Mechanisms of actions of statins and fibrates
    • Duriez, P. (2003) Mechanisms of actions of statins and fibrates. Therapie, 58, 5-14.
    • (2003) Therapie , vol.58 , pp. 5-14
    • Duriez, P.1
  • 10
    • 26844523264 scopus 로고    scopus 로고
    • Dopamine D2 receptor plays a role in memory function: Implications of dopamine-acetylcholine interaction in the ventral hippocampus
    • Fujishiro, H., Umegaki, H., Suzuki, Y., Oohara-Kurotani, S., Yamaguchi, Y. & Iguchi, A. (2005) Dopamine D2 receptor plays a role in memory function: implications of dopamine-acetylcholine interaction in the ventral hippocampus. Psychopharmacology (Berl)., 182, 253-261.
    • (2005) Psychopharmacology (Berl) , vol.182 , pp. 253-261
    • Fujishiro, H.1    Umegaki, H.2    Suzuki, Y.3    Oohara-Kurotani, S.4    Yamaguchi, Y.5    Iguchi, A.6
  • 11
    • 1842844488 scopus 로고    scopus 로고
    • Severe irritability associated with statin cholesterol-lowering drugs
    • Golomb, B.A., Kane, T & Dimsdale, J.E. (2004) Severe irritability associated with statin cholesterol-lowering drugs, Q.J.M., 97, 229-235.
    • (2004) Q.J.M , vol.97 , pp. 229-235
    • Golomb, B.A.1    Kane, T.2    Dimsdale, J.E.3
  • 12
    • 0001440931 scopus 로고
    • Neural systems, emotion, and personality
    • edited by J. Madden, Raven Press, New York, pp
    • Gray, J.A. (1991) Neural systems, emotion, and personality, In: Neurobiology of Learning, Emotion, and Affect, edited by J. Madden, Raven Press, New York, pp. 273-306.
    • (1991) Neurobiology of Learning, Emotion, and Affect , pp. 273-306
    • Gray, J.A.1
  • 14
    • 0027464373 scopus 로고
    • Comparison of fluvastatin and lovastatin blood-brain barrier transfer using in vitro and in vivo methods
    • Guillot, F., Misslin, P. & Lemaire, M. (1993) Comparison of fluvastatin and lovastatin blood-brain barrier transfer using in vitro and in vivo methods. J. Cardiovasc. Pharmacol., 21, 339-346.
    • (1993) J. Cardiovasc. Pharmacol , vol.21 , pp. 339-346
    • Guillot, F.1    Misslin, P.2    Lemaire, M.3
  • 15
    • 36549044319 scopus 로고    scopus 로고
    • Accumbens dopamine-acetylcholine balance in approach and avoidance
    • Hoebel, B.G., Avena, N.M. & Rada, P. (2007) Accumbens dopamine-acetylcholine balance in approach and avoidance. Curr. Opin. Pharmacol., 6, 617-627.
    • (2007) Curr. Opin. Pharmacol , vol.6 , pp. 617-627
    • Hoebel, B.G.1    Avena, N.M.2    Rada, P.3
  • 17
    • 0037333737 scopus 로고    scopus 로고
    • Statin effects on cholesterol micro-domains in brain plasma membranes
    • Kirsch, C., Eckert, G.P. & Mueller, W.E. (2003) Statin effects on cholesterol micro-domains in brain plasma membranes. Biochem. Pharmacol., 65, 843-856.
    • (2003) Biochem. Pharmacol , vol.65 , pp. 843-856
    • Kirsch, C.1    Eckert, G.P.2    Mueller, W.E.3
  • 18
    • 0032551594 scopus 로고    scopus 로고
    • Electrophysiological responses of nucleus accumbens neurons to novelty stimuli and exploratory behavior in the awake, unrestrained rat
    • Lee, R.S., Koob, G.F. & Henriksen, S.J. (1998) Electrophysiological responses of nucleus accumbens neurons to novelty stimuli and exploratory behavior in the awake, unrestrained rat. Brain Res., 20, 317-322.
    • (1998) Brain Res , vol.20 , pp. 317-322
    • Lee, R.S.1    Koob, G.F.2    Henriksen, S.J.3
  • 19
    • 27644517404 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1
    • Li, W., Cui, Y., Kushner, S.A., Brown, R.A., Jentsch, J.D., Frankland, P.W., Cannon, T.D. & Silva, A.J. (2005) The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1. Curr. Biol., 15, 1961-1967.
    • (2005) Curr. Biol , vol.15 , pp. 1961-1967
    • Li, W.1    Cui, Y.2    Kushner, S.A.3    Brown, R.A.4    Jentsch, J.D.5    Frankland, P.W.6    Cannon, T.D.7    Silva, A.J.8
  • 22
    • 33751584846 scopus 로고    scopus 로고
    • Statins induce differentiation and cell death in neurons and astroglia
    • Marz, P, Otten, U. & Miserez, A.R. (2007) Statins induce differentiation and cell death in neurons and astroglia. Glia, 55, 142.
    • (2007) Glia , vol.55 , pp. 142
    • Marz, P.1    Otten, U.2    Miserez, A.R.3
  • 23
    • 13844296729 scopus 로고    scopus 로고
    • Forebrain acetylcholine regulates adult hippocampal neurogenesis and learning
    • Mohapel, P., Leanza, G., Kokaia, M. & Lindvall, O. (2005) Forebrain acetylcholine regulates adult hippocampal neurogenesis and learning. Neurobiol. Aging, 26, 939-946.
    • (2005) Neurobiol. Aging , vol.26 , pp. 939-946
    • Mohapel, P.1    Leanza, G.2    Kokaia, M.3    Lindvall, O.4
  • 25
    • 3843148550 scopus 로고    scopus 로고
    • Randomized trial of the effects of simvastatin on cognitive functioning in hypercholesterolemic adults
    • Muldoon, M.F., Ryan, C.M., Sereika, S.M., Flory, J.D. & Manuck, S.B. (2004) Randomized trial of the effects of simvastatin on cognitive functioning in hypercholesterolemic adults. Am. J. Med., 117, 823-829.
    • (2004) Am. J. Med , vol.117 , pp. 823-829
    • Muldoon, M.F.1    Ryan, C.M.2    Sereika, S.M.3    Flory, J.D.4    Manuck, S.B.5
  • 26
    • 33745312505 scopus 로고    scopus 로고
    • Lipid-lowering drugs
    • Pahan, K. (2006) Lipid-lowering drugs. Cell Mol. Life Sci., 63, 1165-1178.
    • (2006) Cell Mol. Life Sci , vol.63 , pp. 1165-1178
    • Pahan, K.1
  • 27
    • 34447132931 scopus 로고    scopus 로고
    • Reversal of memory deficits by Atorvastatin and Simvastatin in rats
    • Parle, M. & Singh, N. (2007) Reversal of memory deficits by Atorvastatin and Simvastatin in rats. Yakugaku Zasshi, 127, 1125-1137.
    • (2007) Yakugaku Zasshi , vol.127 , pp. 1125-1137
    • Parle, M.1    Singh, N.2
  • 28
    • 33645854917 scopus 로고    scopus 로고
    • The 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitor pravastatin enhances neurite outgrowth in hippocampal neurons
    • Pooler, A.M., Xi, S.C. & Wurtman, R.J. (2006) The 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitor pravastatin enhances neurite outgrowth in hippocampal neurons. J. Neurochem., 97, 716-723.
    • (2006) J. Neurochem , vol.97 , pp. 716-723
    • Pooler, A.M.1    Xi, S.C.2    Wurtman, R.J.3
  • 29
    • 32044440770 scopus 로고    scopus 로고
    • Effect of atorvastatin on spatial memory, neuronal survival, and vascular density in female rats after traumatic brain injury
    • Qu, C., Lu, D., Goussev, A., Schallert, T., Mahmood, A. & Chopp, M. (2005) Effect of atorvastatin on spatial memory, neuronal survival, and vascular density in female rats after traumatic brain injury. J. Neurosurg., 103, 695-701.
    • (2005) J. Neurosurg , vol.103 , pp. 695-701
    • Qu, C.1    Lu, D.2    Goussev, A.3    Schallert, T.4    Mahmood, A.5    Chopp, M.6
  • 30
    • 0028281788 scopus 로고
    • In vivo and in vitro blood-brain barrier transport of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors
    • Saheki, A., Terasaki, T., Tamai, I. & Tsuji, A. (1994) In vivo and in vitro blood-brain barrier transport of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. Pharm. Res., 11, 305-311.
    • (1994) Pharm. Res , vol.11 , pp. 305-311
    • Saheki, A.1    Terasaki, T.2    Tamai, I.3    Tsuji, A.4
  • 31
    • 1842510494 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis
    • Schulz, J.G., Bosel, J., Stoeckel, M., Megow, D., Dirnagl, U. & Endres, M. (2004) HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis. J. Neurochem., 89, 24-32.
    • (2004) J. Neurochem , vol.89 , pp. 24-32
    • Schulz, J.G.1    Bosel, J.2    Stoeckel, M.3    Megow, D.4    Dirnagl, U.5    Endres, M.6
  • 32
    • 0030628019 scopus 로고    scopus 로고
    • Cholesterol and Myelin
    • edited by R. Bittman, Plenum Press, New York, pp
    • Snipes, G.J. & Suter, U. (1997) Cholesterol and Myelin. In: Subcellular Biochemistry, edited by R. Bittman, Vol. 28, Plenum Press, New York, pp. 173-204.
    • (1997) Subcellular Biochemistry , vol.28 , pp. 173-204
    • Snipes, G.J.1    Suter, U.2
  • 33
    • 0037022581 scopus 로고    scopus 로고
    • Impaired retention of spatial memory after transection of longitudinally oriented axons of hippocampal CA3 pyramidal cells
    • Steffenach, H.A., Sloviter, R.S., Moser, E.I. & Moser, M.B. (2002) Impaired retention of spatial memory after transection of longitudinally oriented axons of hippocampal CA3 pyramidal cells. Proc. Natl. Acad. Sci. USA, 99, 3194-3198.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 3194-3198
    • Steffenach, H.A.1    Sloviter, R.S.2    Moser, E.I.3    Moser, M.B.4
  • 34
    • 33846846591 scopus 로고    scopus 로고
    • Effect of atorvastatin on cognitive function in patients from the Lipid Lowering and Onset of Renal Disease (LORD) trial
    • Summers, M.J., Oliver, K.R., Coombes, J.S. & Fassett, R.G. (2007) Effect of atorvastatin on cognitive function in patients from the Lipid Lowering and Onset of Renal Disease (LORD) trial. Pharmacotherapy, 27, 183-190.
    • (2007) Pharmacotherapy , vol.27 , pp. 183-190
    • Summers, M.J.1    Oliver, K.R.2    Coombes, J.S.3    Fassett, R.G.4
  • 36
    • 0032144469 scopus 로고    scopus 로고
    • Hippocampal acetylcholine and habituation learning
    • Thiel, C.M., Huston, J.P. & Schwarting, R.K. (1998) Hippocampal acetylcholine and habituation learning. Neuroscience, 85, 1253-1262.
    • (1998) Neuroscience , vol.85 , pp. 1253-1262
    • Thiel, C.M.1    Huston, J.P.2    Schwarting, R.K.3
  • 37
    • 0027723663 scopus 로고
    • Transport mechanism of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors at the blood-brain barrier
    • Tsuji, A., Saheki, A., Tamai, I. & Terasaki, T. (1993) Transport mechanism of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors at the blood-brain barrier. J. Pharmacol. Exp. Ther., 267, 1085-1090.
    • (1993) J. Pharmacol. Exp. Ther , vol.267 , pp. 1085-1090
    • Tsuji, A.1    Saheki, A.2    Tamai, I.3    Terasaki, T.4
  • 38
    • 16644390188 scopus 로고    scopus 로고
    • Amiloride increases neuronal damage after traumatic brain injury in rats
    • Turner, R.J., Van den Heuvel, C. & Vink, R. (2004) Amiloride increases neuronal damage after traumatic brain injury in rats. J. Am. Coll. Nutr., 23, 534S-537S.
    • (2004) J. Am. Coll. Nutr , vol.23
    • Turner, R.J.1    Van den Heuvel, C.2    Vink, R.3
  • 40
    • 0038381775 scopus 로고    scopus 로고
    • Statin-associated memory loss: Analysis of 60 case reports and review of the literature
    • Wagstaff, L.R., Mitton, M.W., Arvik, B.M. & Doraiswamy, P.M. (2003) Statin-associated memory loss: analysis of 60 case reports and review of the literature. Pharmacotherapy, 23, 871-880.
    • (2003) Pharmacotherapy , vol.23 , pp. 871-880
    • Wagstaff, L.R.1    Mitton, M.W.2    Arvik, B.M.3    Doraiswamy, P.M.4
  • 41
    • 17844411468 scopus 로고    scopus 로고
    • High doses of simvastatin upregulate dopamine D1 and D2 receptor expression in the rat prefrontal cortex: Possible involvement of endothelial nitric oxide synthase
    • Wang, Q., Ting, W.L., Yang, H. & Wong, P.T. (2005a) High doses of simvastatin upregulate dopamine D1 and D2 receptor expression in the rat prefrontal cortex: possible involvement of endothelial nitric oxide synthase. Br. J. Pharmacol., 144, 933-939.
    • (2005) Br. J. Pharmacol , vol.144 , pp. 933-939
    • Wang, Q.1    Ting, W.L.2    Yang, H.3    Wong, P.T.4
  • 42
    • 19444382315 scopus 로고    scopus 로고
    • Simvastatin reverses the downregulation of dopamine D1 and D2 receptor expression in the prefrontal cortex of 6-hydroxydopamine-induced Parkinsonian rats
    • Wang, Q., Wang, P.H., McLachlan, C. & Wong, P.T. (2005b) Simvastatin reverses the downregulation of dopamine D1 and D2 receptor expression in the prefrontal cortex of 6-hydroxydopamine-induced Parkinsonian rats. Brain Res., 1045, 229-233.
    • (2005) Brain Res , vol.1045 , pp. 229-233
    • Wang, Q.1    Wang, P.H.2    McLachlan, C.3    Wong, P.T.4
  • 43
    • 33749526659 scopus 로고    scopus 로고
    • Effects of high dose of simvastatin on levels of dopamine and its reuptake in prefrontal cortex and striatum among SD rats
    • Wang, Q,. Tang, X.N., Wang, L., Yenari, M.A., Ying, W., Goh, B.C., Lee, H.S., Wilder-Smith, E.P. & Wong, P.T. (2006) Effects of high dose of simvastatin on levels of dopamine and its reuptake in prefrontal cortex and striatum among SD rats. Neurosci. Lett., 408, 189-193.
    • (2006) Neurosci. Lett , vol.408 , pp. 189-193
    • Wang, Q.1    Tang, X.N.2    Wang, L.3    Yenari, M.A.4    Ying, W.5    Goh, B.C.6    Lee, H.S.7    Wilder-Smith, E.P.8    Wong, P.T.9
  • 44
    • 34250630954 scopus 로고    scopus 로고
    • Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury
    • Wang, H., Lynch, J.R., Song, P., Yang, H.J., Yates, R.B., Mace, B., Warner, D.S., Guyton, J.R. & Laskowitz, D.T. (2007) Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury. Exp. Neurol., 206, 59-69.
    • (2007) Exp. Neurol , vol.206 , pp. 59-69
    • Wang, H.1    Lynch, J.R.2    Song, P.3    Yang, H.J.4    Yates, R.B.5    Mace, B.6    Warner, D.S.7    Guyton, J.R.8    Laskowitz, D.T.9
  • 45
    • 0032934526 scopus 로고    scopus 로고
    • Ventral hippocampal dopamine D1 and D2 systems and spatial working memory in rats
    • Wilkerson, A. & Levin, E.D. (1999) Ventral hippocampal dopamine D1 and D2 systems and spatial working memory in rats. NeuroScience, 89, 743-749.
    • (1999) NeuroScience , vol.89 , pp. 743-749
    • Wilkerson, A.1    Levin, E.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.