Cholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cells

Journal of Biological Chemistry

Volumn 281, Issue 26, 2006, Pages 17890-17899

  Ganley, Ian G ^a   Pfeffer, Suzanne R ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS; CHOLESTEROL; CYTOLOGY; ENZYME INHIBITION; LIPIDS; PHOSPHATES; PROTEINS;

CHOLESTEROL ACCUMULATION; ENDOSOME FUNCTION; GFP-TAGGED RAB9; INHIBITOR-MEDIATED EXTRACTION;

DISEASES;

CHOLESTEROL; GREEN FLUORESCENT PROTEIN; GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR; LIPOSOME; PROTEIN RAB9; RAB PROTEIN; SOMATOMEDIN B RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL ISOLATION; CELL MEMBRANE; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; ENDOSOME; FAT CONTENT; FIBROBLAST; HALF LIFE TIME; HUMAN; HUMAN CELL; LIPID STORAGE; MEMBRANE STABILIZATION; NIEMANN PICK DISEASE; PHENOTYPE; PRENYLATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA INTERFERENCE; WILD TYPE;

ANIMALS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CHOLESTEROL; ENDOSOMES; FIBROBLASTS; GLYCOSPHINGOLIPIDS; HELA CELLS; HUMANS; INSECTS; INTRACELLULAR MEMBRANES; MEMBRANE GLYCOPROTEINS; NIEMANN-PICK DISEASES; PHENOTYPE; PROTEIN ISOPRENYLATION; PROTEIN TRANSPORT; RAB GTP-BINDING PROTEINS; RECEPTOR, IGF TYPE 2;

EID: 33745846377     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M601679200     Document Type: Article

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