Age-related HMG-CoA reductase deregulation depends on ROS-induced p38 activation

Mechanisms of Ageing and Development

Volumn 128, Issue 11-12, 2007, Pages 688-695

  Pallottini, Valentina ^a   Martini, Chiara ^a   Cavallini, Gabriella ^b   Bergamini, Ettore ^b   Mustard, Kirsty J ^c   Hardie, D Grahame ^c   Trentalance, Anna ^a  

^a ROMA TRE UNIVERSITY   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c Sir James Black Centre   (United Kingdom)

Author keywords

Ageing; AMPK ; Cholesterol; HepG2 cell line; HMG CoAR; Liver; p38; PP2A; ROS

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; AZELASTINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; PHOSPHOPROTEIN PHOSPHATASE 2A; REACTIVE OXYGEN METABOLITE;

AGING; ANIMAL EXPERIMENT; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG INHIBITION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; HUMAN CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

AGE FACTORS; AGING; ANIMALS; CELL LINE, TUMOR; ENZYME ACTIVATION; HUMANS; HYDROGEN PEROXIDE; HYDROXYMETHYLGLUTARYL COA REDUCTASES; LIVER; MALE; MULTIENZYME COMPLEXES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TIME FACTORS;

RATTUS;

EID: 37349057499     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2007.10.001     Document Type: Article

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