-
1
-
-
84872967522
-
Cancer statistics, 2013
-
Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin 2013;63(1):11-30
-
(2013)
CA Cancer J Clin
, vol.63
, Issue.1
, pp. 11-30
-
-
Siegel, R.1
Naishadham, D.2
Jemal, A.3
-
2
-
-
78149347499
-
Seer cancer statistics review
-
Editors Bethesda, MD. Available from Accessed 4 October 2013]
-
Altekruse SF, Kosary CL, Krapcho M, et al. editors. SEER cancer statistics review, 1975-2007. National Cancer Institute, Bethesda, MD. Available from: Http://seer.cancer.gov/csr/19752007/ [Accessed 4 October 2013]
-
National Cancer Institute
, pp. 1975-2007
-
-
Altekruse, S.F.1
Kosary, C.L.2
Krapcho, M.3
-
3
-
-
34247385434
-
Evolving principles of surgical management and prognostic factors for outcome in renal cell carcinoma
-
Lam JS, Breda A, Belldegrun AS, Figlin RA. Evolving principles of surgical management and prognostic factors for outcome in renal cell carcinoma. J Clin Oncol 2006;24(35):5565-75
-
(2006)
J Clin Oncol
, vol.24
, Issue.35
, pp. 5565-5575
-
-
Lam, J.S.1
Breda, A.2
Belldegrun, A.S.3
Figlin, R.A.4
-
4
-
-
0027954044
-
Mutations of the VHL tumour suppressor gene in renal carcinoma
-
Gnarra JR, Tory K, Weng Y, et al. Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat Genet 1994;7(1):85-90
-
(1994)
Nat Genet
, vol.7
, Issue.1
, pp. 85-90
-
-
Gnarra, J.R.1
Tory, K.2
Weng, Y.3
-
5
-
-
0028235907
-
Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas
-
Shuin T, Kondo K, Torigoe S, et al. Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas. Cancer Res 1994;54(11):2852-5
-
(1994)
Cancer Res
, vol.54
, Issue.11
, pp. 2852-2855
-
-
Shuin, T.1
Kondo, K.2
Torigoe, S.3
-
6
-
-
0035394516
-
Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas
-
Wiesener MS, Munchenhagen PM, Berger I, et al. Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas. Cancer Res 2001;61(13):5215-22
-
(2001)
Cancer Res
, vol.61
, Issue.13
, pp. 5215-5222
-
-
Wiesener, M.S.1
Munchenhagen, P.M.2
Berger, I.3
-
7
-
-
0028072991
-
Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma
-
Herman JG, Latif F, Weng Y, et al. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci USA 1994;91(21):9700-4
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, Issue.21
, pp. 9700-9704
-
-
Herman, J.G.1
Latif, F.2
Weng, Y.3
-
9
-
-
28844484134
-
Renal-cell carcinoma
-
Cohen HT, McGovern FJ. Renal-cell carcinoma. N Engl J Med 2005;353(23):2477-90
-
(2005)
N Engl J Med
, vol.353
, Issue.23
, pp. 2477-2490
-
-
Cohen, H.T.1
McGovern, F.J.2
-
10
-
-
75149188170
-
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
-
Dalgliesh GL, Furge K, Greenman C, et al. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature 2010;463(7279):360-3
-
(2010)
Nature
, vol.463
, Issue.7279
, pp. 360-363
-
-
Dalgliesh, G.L.1
Furge, K.2
Greenman, C.3
-
11
-
-
79251635938
-
Exome sequencing identifies frequent mutation of the swisnf complex gene pbrm1 in renal carcinoma
-
Varela I, Tarpey P, Raine K, et al. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature 2011;469(7331):539-42
-
(2011)
Nature
, vol.469
, Issue.7331
, pp. 539-542
-
-
Varela, I.1
Tarpey, P.2
Raine, K.3
-
12
-
-
84873081430
-
Effects on survival of bap1 and pbrm1 mutations in sporadic clear-cell renal-cell carcinoma: A retrospective analysis with independent validation
-
Kapur P, Pena-Llopis S, Christie A, et al. Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: A retrospective analysis with independent validation. Lancet Oncol 2013;14(2):159-67
-
(2013)
Lancet Oncol
, vol.14
, Issue.2
, pp. 159-167
-
-
Kapur, P.1
Pena-Llopis, S.2
Christie, A.3
-
13
-
-
84655176646
-
Frequent mutations of genes encoding ubiquitinmediated proteolysis pathway components in clear cell renal cell carcinoma
-
Guo G, Gui Y, Gao S, et al. Frequent mutations of genes encoding ubiquitinmediated proteolysis pathway components in clear cell renal cell carcinoma. Nat Genet 2011;44(1):17-19
-
(2011)
Nat Genet
, vol.44
, Issue.1
, pp. 17-19
-
-
Guo, G.1
Gui, Y.2
Gao, S.3
-
14
-
-
49249087039
-
Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma
-
Rini BI, Michaelson MD, Rosenberg JE, et al. Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma. J Clin Oncol 2008;26(22):3743-8
-
(2008)
J Clin Oncol
, vol.26
, Issue.22
, pp. 3743-3748
-
-
Rini, B.I.1
Michaelson, M.D.2
Rosenberg, J.E.3
-
15
-
-
37349080670
-
Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase III trial
-
Escudier B, Pluzanska A, Koralewski P, et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase III trial. Lancet 2007;370(9605):2103-11
-
(2007)
Lancet
, vol.370
, Issue.9605
, pp. 2103-2111
-
-
Escudier, B.1
Pluzanska, A.2
Koralewski, P.3
-
16
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
Motzer RJ, Hutson TE, Tomczak P, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007;356(2):115-24
-
(2007)
N Engl J Med
, vol.356
, Issue.2
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
-
18
-
-
7144227930
-
Recombinant human interleukin-2, recombinant human interferon alfa-2a, or both in metastatic renal-cell carcinoma Groupe Français d'Immunotherapie
-
Negrier S, Escudier B, Lasset C, et al. Recombinant human interleukin-2, recombinant human interferon alfa-2a, or both in metastatic renal-cell carcinoma. Groupe Français d'Immunotherapie. N Engl J Med 1998;338(18):1272-8
-
(1998)
N Engl J Med
, vol.338
, Issue.18
, pp. 1272-1278
-
-
Negrier, S.1
Escudier, B.2
Lasset, C.3
-
19
-
-
84894062473
-
Words of wisdom Re: Radical nephrectomy with and without lymph-node dissection: Final results of European Organization for Research and Treatment of Cancer (EORTC) randomized phase 3 trial 30881
-
Ljungberg B. Words of wisdom. Re: Radical nephrectomy with and without lymph-node dissection: Final results of European Organization for Research and Treatment of Cancer (EORTC) randomized phase 3 trial 30881. Eur Urol 2009;55(6):1486-7
-
(2009)
Eur Urol
, vol.55
, Issue.6
, pp. 1486-1487
-
-
Ljungberg, B.1
-
20
-
-
56749161699
-
Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206
-
Rini BI, Halabi S, Rosenberg JE, et al. Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206. J Clin Oncol 2008;26(33):5422-8
-
(2008)
J Clin Oncol
, vol.26
, Issue.33
, pp. 5422-5428
-
-
Rini, B.I.1
Halabi, S.2
Rosenberg, J.E.3
-
21
-
-
77949890945
-
Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial
-
Sternberg CN, Davis ID, Mardiak J, et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial. J Clin Oncol 2010;28(6):1061-8
-
(2010)
J Clin Oncol
, vol.28
, Issue.6
, pp. 1061-1068
-
-
Sternberg, C.N.1
Davis, I.D.2
Mardiak, J.3
-
22
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007;356(2):125-34
-
(2007)
N Engl J Med
, vol.356
, Issue.2
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
-
23
-
-
84856211584
-
Everolimus in metastatic renal cell carcinoma: Subgroup analysis of patients with 1 or 2 previous vascular endothelial growth factor receptor-tyrosine kinase inhibitor therapies enrolled in the phase III RECORD-1 study
-
Calvo E, Escudier B, Motzer RJ, et al. Everolimus in metastatic renal cell carcinoma: Subgroup analysis of patients with 1 or 2 previous vascular endothelial growth factor receptor-tyrosine kinase inhibitor therapies enrolled in the phase III RECORD-1 study. Eur J Cancer 2012;48(3):333-9
-
(2012)
Eur J Cancer
, vol.48
, Issue.3
, pp. 333-339
-
-
Calvo, E.1
Escudier, B.2
Motzer, R.J.3
-
24
-
-
77951729433
-
Fda approval summary: Temsirolimus as treatment for advanced renal cell carcinoma
-
Kwitkowski VE, Prowell TM, Ibrahim A, et al. FDA approval summary: Temsirolimus as treatment for advanced renal cell carcinoma. Oncologist 2010;15(4):428-35
-
(2010)
Oncologist
, vol.15
, Issue.4
, pp. 428-435
-
-
Kwitkowski, V.E.1
Prowell, T.M.2
Ibrahim, A.3
-
25
-
-
70349385645
-
Resistance to targeted therapy in renal-cell carcinoma
-
Rini BI, Atkins MB. Resistance to targeted therapy in renal-cell carcinoma. Lancet Oncol 2009;10(10):992-1000
-
(2009)
Lancet Oncol
, vol.10
, Issue.10
, pp. 992-1000
-
-
Rini, B.I.1
Atkins, M.B.2
-
26
-
-
60649106195
-
Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
-
Paez-Ribes M, Allen E, Hudock J, et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009;15(3):220-31
-
(2009)
Cancer Cell
, vol.15
, Issue.3
, pp. 220-231
-
-
Paez-Ribes, M.1
Allen, E.2
Hudock, J.3
-
27
-
-
76249133170
-
Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma
-
Huang D, Ding Y, Zhou M, et al. Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma. Cancer Res 2010;70(3):1063-71
-
(2010)
Cancer Res
, vol.70
, Issue.3
, pp. 1063-1071
-
-
Huang, D.1
Ding, Y.2
Zhou, M.3
-
28
-
-
26644471951
-
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
-
Casanovas O, Hicklin DJ, Bergers G, Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 2005;8(4):299-309
-
(2005)
Cancer Cell
, vol.8
, Issue.4
, pp. 299-309
-
-
Casanovas, O.1
Hicklin, D.J.2
Bergers, G.3
Hanahan, D.4
-
29
-
-
84860878985
-
Fgf receptor inhibitors: Role in cancer therapy
-
Daniele G, Corral J, Molife LR, de Bono JS. FGF receptor inhibitors: Role in cancer therapy. Curr Oncol Rep 2012;14(2):111-19
-
(2012)
Curr Oncol Rep
, vol.14
, Issue.2
, pp. 111-119
-
-
Daniele, G.1
Corral, J.2
Molife, L.R.3
De Bono, J.S.4
-
30
-
-
69249216604
-
The role of fibroblast growth factors in tumor growth
-
Korc M, Friesel RE. The role of fibroblast growth factors in tumor growth. Curr Cancer Drug Targets 2009;9(5):639-51
-
(2009)
Curr Cancer Drug Targets
, vol.9
, Issue.5
, pp. 639-651
-
-
Korc, M.1
Friesel, R.E.2
-
31
-
-
61649100307
-
The FGF family: Biology, pathophysiology and therapy
-
Beenken A, Mohammadi M. The FGF family: Biology, pathophysiology and therapy. Nat Rev Drug Discov 2009;8(3):235-53
-
(2009)
Nat Rev Drug Discov
, vol.8
, Issue.3
, pp. 235-253
-
-
Beenken, A.1
Mohammadi, M.2
-
33
-
-
39549084750
-
Novel therapeutic targets in bladder cancer: Mutation and expression of FGF receptors
-
Knowles MA. Novel therapeutic targets in bladder cancer: Mutation and expression of FGF receptors. Future Oncol 2008;4(1):71-83
-
(2008)
Future Oncol
, vol.4
, Issue.1
, pp. 71-83
-
-
Knowles, M.A.1
-
34
-
-
47249122523
-
Drug-sensitive FGFR2 mutations in endometrial carcinoma
-
Dutt A, Salvesen HB, Chen TH, et al. Drug-sensitive FGFR2 mutations in endometrial carcinoma. Proc Natl Acad Sci USA 2008;105(25):8713-17
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.25
, pp. 8713-8717
-
-
Dutt, A.1
Salvesen, H.B.2
Chen, T.H.3
-
35
-
-
34250829395
-
Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes
-
Pollock PM, Gartside MG, Dejeza LC, et al. Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes. Oncogene 2007;26(50):7158-62
-
(2007)
Oncogene
, vol.26
, Issue.50
, pp. 7158-7162
-
-
Pollock, P.M.1
Gartside, M.G.2
Dejeza, L.C.3
-
36
-
-
42049120475
-
FGFR2-Amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival
-
Kunii K, Davis L, Gorenstein J, et al. FGFR2-Amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival. Cancer Res 2008;68(7):2340-8
-
(2008)
Cancer Res
, vol.68
, Issue.7
, pp. 2340-2348
-
-
Kunii, K.1
Davis, L.2
Gorenstein, J.3
-
37
-
-
77950278598
-
FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer
-
Turner N, Pearson A, Sharpe R, et al. FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer. Cancer Res 2010;70(5):2085-94
-
(2010)
Cancer Res
, vol.70
, Issue.5
, pp. 2085-2094
-
-
Turner, N.1
Pearson, A.2
Sharpe, R.3
-
38
-
-
59449094654
-
Molecular characterization of breast cancer with high-resolution oligonucleotide comparative genomic hybridization array
-
Andre F, Job B, Dessen P, et al. Molecular characterization of breast cancer with high-resolution oligonucleotide comparative genomic hybridization array. Clin Cancer Res 2009;15(2):441-51
-
(2009)
Clin Cancer Res
, vol.15
, Issue.2
, pp. 441-451
-
-
Andre, F.1
Job, B.2
Dessen, P.3
-
39
-
-
79952116987
-
Amplification of fibroblast growth factor receptor-1 in breast cancer and the effects of brivanib alaninate
-
Shiang CY, Qi Y, Wang B, et al. Amplification of fibroblast growth factor receptor-1 in breast cancer and the effects of brivanib alaninate. Breast Cancer Res Treat 2010;123(3):747-55
-
(2010)
Breast Cancer Res Treat
, vol.123
, Issue.3
, pp. 747-755
-
-
Shiang, C.Y.1
Qi, Y.2
Wang, B.3
-
40
-
-
0343355828
-
High incidence of translocations t(11;14) (q13;q32) and t(4;14)(p16;q32) in patients with plasma cell malignancies
-
Avet-Loiseau H, Li JY, Facon T, et al. High incidence of translocations t(11;14) (q13;q32) and t(4;14)(p16;q32) in patients with plasma cell malignancies. Cancer Res 1998;58(24):5640-5
-
(1998)
Cancer Res
, vol.58
, Issue.24
, pp. 5640-5645
-
-
Avet-Loiseau, H.1
Li, J.Y.2
Facon, T.3
-
41
-
-
0030922231
-
Frequent translocation t (4; 14)(p16. 3; q32. 3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3
-
Chesi M, Nardini E, Brents LA, et al. Frequent translocation t (4; 14)(p16. 3; q32. 3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3. Nat Genet 1997;16(3):260-4
-
(1997)
Nat Genet
, vol.16
, Issue.3
, pp. 260-264
-
-
Chesi, M.1
Nardini, E.2
Brents, L.A.3
-
42
-
-
39049092267
-
Fibroblast growth factors, fibroblast growth factor receptors, diseases, and drugs
-
Chen GJ, Forough R. Fibroblast growth factors, fibroblast growth factor receptors, diseases, and drugs. Recent Patent Cardiovasc Drug Discov 2006;1(2):211-24
-
(2006)
Recent Patent Cardiovasc Drug Discov
, vol.1
, Issue.2
, pp. 211-224
-
-
Chen, G.J.1
Forough, R.2
-
43
-
-
18144364350
-
Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis
-
Presta M, Dell'Era P, Mitola S, et al. Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis. Cytokine Growth Factor Rev 2005;16(2):159-78
-
(2005)
Cytokine Growth Factor Rev
, vol.16
, Issue.2
, pp. 159-178
-
-
Presta, M.1
Dell'Era, P.2
Mitola, S.3
-
44
-
-
0026608650
-
Correlation of basic fibroblast growth factor expression levels with the degree of malignancy and vascularity in human gliomas
-
Takahashi JA, Fukumoto M, Igarashi K, et al. Correlation of basic fibroblast growth factor expression levels with the degree of malignancy and vascularity in human gliomas. J Neurosurg 1992;76(5):792-8
-
(1992)
J Neurosurg
, vol.76
, Issue.5
, pp. 792-798
-
-
Takahashi, J.A.1
Fukumoto, M.2
Igarashi, K.3
-
45
-
-
11244283209
-
The role of fibroblast growth factors and their receptors in prostate cancer
-
Kwabi-Addo B, Ozen M, Ittmann M. The role of fibroblast growth factors and their receptors in prostate cancer. Endocr Relat Cancer 2004;11(4):709-24
-
(2004)
Endocr Relat Cancer
, vol.11
, Issue.4
, pp. 709-724
-
-
Kwabi-Addo, B.1
Ozen, M.2
Ittmann, M.3
-
46
-
-
0034055006
-
Differential response to transforming growth factor (TGF)-Alpha and fibroblast growth factor (FGF) in human renal cell carcinomas of the clear cell and papillary types
-
Ramp U, Reinecke P, Gabbert HE, Gerharz CD. Differential response to transforming growth factor (TGF)-Alpha and fibroblast growth factor (FGF) in human renal cell carcinomas of the clear cell and papillary types. Eur J Cancer 2000;36(7):932-41
-
(2000)
Eur J Cancer
, vol.36
, Issue.7
, pp. 932-941
-
-
Ramp, U.1
Reinecke, P.2
Gabbert, H.E.3
Gerharz, C.D.4
-
47
-
-
0031012779
-
Induction of tubulogenesis of microvascular endothelial cells by basic fibroblast growth factor from human SN12C renal cancer cells
-
Emoto A, Nakagawa M, Wakabayashi Y, et al. Induction of tubulogenesis of microvascular endothelial cells by basic fibroblast growth factor from human SN12C renal cancer cells. J Urol 1997;157(2):699-703
-
(1997)
J Urol
, vol.157
, Issue.2
, pp. 699-703
-
-
Emoto, A.1
Nakagawa, M.2
Wakabayashi, Y.3
-
48
-
-
0036558290
-
Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1alpha-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2-binding sites
-
Li J, Shworak NW, Simons M. Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1alpha-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2-binding sites. J Cell Sci 2002;115(Pt 9):1951-9
-
(2002)
J Cell Sci
, vol.115
, Issue.PART 9
, pp. 1951-1959
-
-
Li, J.1
Shworak, N.W.2
Simons, M.3
-
49
-
-
0027482301
-
Expression of basic fibroblast growth factor in primary human renal tumors: Correlation with poor survival
-
Nanus DM, Schmitz-Drager BJ, Motzer RJ, et al. Expression of basic fibroblast growth factor in primary human renal tumors: Correlation with poor survival. J Natl Cancer Inst 1993;85(19):1597-9
-
(1993)
J Natl Cancer Inst
, vol.85
, Issue.19
, pp. 1597-1599
-
-
Nanus, D.M.1
Schmitz-Drager, B.J.2
Motzer, R.J.3
-
50
-
-
78650508926
-
Fibroblast growth factor pathway in renal cell carcinoma
-
Suppl
-
Tsimafeyeu I, Demidov H, Ta H, et al. Fibroblast growth factor pathway in renal cell carcinoma. J Clin Oncol (Meeting Abstracts) 2010;28(15s Suppl):4621
-
(2010)
J Clin Oncol (Meeting Abstracts
, vol.28
, Issue.15
, pp. 4621
-
-
Tsimafeyeu, I.1
Demidov, H.2
Ta, H.3
-
51
-
-
84868712956
-
Changes in circulating pro-Angiogenic cytokines other than vegf before progression to sunitinib therapy in advanced renal cell carcinoma patients
-
Porta C, Paglino C, Imarisio I, et al. Changes in circulating pro-Angiogenic cytokines, other than VEGF, before progression to sunitinib therapy in advanced renal cell carcinoma patients. Oncology 2013;84(2):115-22
-
(2013)
Oncology
, vol.84
, Issue.2
, pp. 115-122
-
-
Porta, C.1
Paglino, C.2
Imarisio, I.3
-
52
-
-
84874851836
-
Phase i study of dovitinib (tki258) an oral fgfr vegfr and pdgfr inhibitor in advanced or metastatic renal cell carcinoma
-
Angevin E, Lopez-Martin J, Lin CC, et al. Phase I study of dovitinib (TKI258), an oral FGFR, VEGFR, and PDGFR inhibitor, in advanced or metastatic renal cell carcinoma. Clin Cancer Res 2013;19(5):1257-68
-
(2013)
Clin Cancer Res
, vol.19
, Issue.5
, pp. 1257-1268
-
-
Angevin, E.1
Lopez-Martin, J.2
Lin, C.C.3
-
53
-
-
79954499886
-
Regorafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
-
Wilhelm SM, Dumas J, Adnane L, et al. Regorafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer 2011;129(1):245-55
-
(2011)
Int J Cancer
, vol.129
, Issue.1
, pp. 245-255
-
-
Wilhelm, S.M.1
Dumas, J.2
Adnane, L.3
-
54
-
-
15944378835
-
CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma
-
Trudel S, Li ZH, Wei E, et al. CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma. Blood 2005;105(7):2941-8
-
(2005)
Blood
, vol.105
, Issue.7
, pp. 2941-2948
-
-
Trudel, S.1
Li, Z.H.2
Wei, E.3
-
55
-
-
21044443128
-
In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models
-
Lee SH, Lopes de Menezes D, Vora J, et al. In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models. Clin Cancer Res 2005;11(10):3633-41
-
(2005)
Clin Cancer Res
, vol.11
, Issue.10
, pp. 3633-3641
-
-
Lee, S.H.1
Lopes De Menezes, D.2
Vora, J.3
-
56
-
-
84862145477
-
A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma
-
Sivanand S, Pena-Llopis S, Zhao H, et al. A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma. Sci Transl Med 2012;4(137):137ra75
-
(2012)
Sci Transl Med
, vol.4
, Issue.137
, pp. 137-175
-
-
Sivanand, S.1
Pena-Llopis, S.2
Zhao, H.3
-
57
-
-
84866888498
-
Regorafenib for patients with previously untreated metastatic or unresectable renal-cell carcinoma: A single-group phase 2 trial
-
Eisen T, Joensuu H, Nathan PD, et al. Regorafenib for patients with previously untreated metastatic or unresectable renal-cell carcinoma: A single-group phase 2 trial. Lancet Oncol 2012;13(10):1055-62
-
(2012)
Lancet Oncol
, vol.13
, Issue.10
, pp. 1055-1062
-
-
Eisen, T.1
Joensuu, H.2
Nathan, P.D.3
-
58
-
-
84885599759
-
Phase II efficacy and safety study of nintedanib versus sunitinib in previously untreated renal cell carcinoma (RCC) patients
-
Suppl
-
Eisen T, Shparyk Y, Jones R, et al. Phase II efficacy and safety study of nintedanib versus sunitinib in previously untreated renal cell carcinoma (RCC) patients. J Clin Oncol (ASCO Annual Meeting Abstracts) 2013;31(Suppl):4506
-
(2013)
J Clin Oncol (ASCO Annual Meeting Abstracts
, vol.31
, pp. 4506
-
-
Eisen, T.1
Shparyk, Y.2
Jones, R.3
-
59
-
-
84880916561
-
A phase ii study of cediranib (azd 2171) in treatment naive patients with progressive unresectable recurrent or metastatic renal cell carcinoma a trial of the pmh phase 2 consortium
-
Sridhar SS, Mackenzie MJ, Hotte SJ, et al. A phase II study of cediranib (AZD 2171) in treatment naive patients with progressive unresectable recurrent or metastatic renal cell carcinoma. A trial of the PMH phase 2 consortium. Invest New Drugs 2013;31(4):1008-15
-
(2013)
Invest New Drugs
, vol.31
, Issue.4
, pp. 1008-1015
-
-
Sridhar, S.S.1
Mackenzie, M.J.2
Hotte, S.J.3
-
60
-
-
84857052966
-
Cediranib monotherapy in patients with advanced renal cell carcinoma: Results of a randomised phase II study
-
Mulders P, Hawkins R, Nathan P, et al. Cediranib monotherapy in patients with advanced renal cell carcinoma: Results of a randomised phase II study. Eur J Cancer 2012;48(4):527-37
-
(2012)
Eur J Cancer
, vol.48
, Issue.4
, pp. 527-537
-
-
Mulders, P.1
Hawkins, R.2
Nathan, P.3
-
61
-
-
53049085556
-
Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R) 2 and VEGF-R3 kinase
-
Matsui J, Funahashi Y, Uenaka T, et al. Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R) 2 and VEGF-R3 kinase. Clin Cancer Res 2008;14(17):5459-65
-
(2008)
Clin Cancer Res
, vol.14
, Issue.17
, pp. 5459-5465
-
-
Matsui, J.1
Funahashi, Y.2
Uenaka, T.3
-
62
-
-
37349105704
-
E7080 a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition
-
Matsui J, Yamamoto Y, Funahashi Y, et al. E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition. Int J Cancer 2008;122(3):664-71
-
(2008)
Int J Cancer
, vol.122
, Issue.3
, pp. 664-671
-
-
Matsui, J.1
Yamamoto, Y.2
Funahashi, Y.3
-
63
-
-
84894087863
-
A phase Ib clinical trial of the multitargeted kinase inhibitor lenvatinib (E7080) in combination with everolimus for treatment of metastatic renal cell carcinoma (RCC
-
Molina AM, Hutson TE, Larkin J, et al. A phase Ib clinical trial of the multitargeted kinase inhibitor lenvatinib (E7080) in combination with everolimus for treatment of metastatic renal cell carcinoma (RCC). Ann Oncol (ESMO Annual Meeting Abstracts) 2012;23(Suppl 9):814P
-
(2012)
Ann Oncol (ESMO Annual Meeting Abstracts
, vol.23
, Issue.SUPPL. 9
-
-
Molina, A.M.1
Hutson, T.E.2
Larkin, J.3
-
64
-
-
84856199835
-
A phase II study of dovitinib (TKI258), an FGFR- and VEGFRinhibitor, in patients with advanced or metastatic renal cell cancer (mRCC
-
Suppl
-
Angevin E, Grunwald V, Ravaud A, et al. A phase II study of dovitinib (TKI258), an FGFR- and VEGFRinhibitor, in patients with advanced or metastatic renal cell cancer (mRCC). J Clin Oncol (ASCO Annual Meeting Abstracts) 2011;29(Suppl):4551
-
(2011)
J Clin Oncol (ASCO Annual Meeting Abstracts
, vol.29
, pp. 4551
-
-
Angevin, E.1
Grunwald, V.2
Ravaud, A.3
-
65
-
-
84894079898
-
Phase 3 trial of dovitinib vs sorafenib in patients with metastatic renal cell carcinoma after 1 prior VEGF pathway-targeted and 1 prior mTOR inhibitor therapy [abstract 34LBA
-
(ECCO-ESMO-ESTRO
-
Motzer RJ, Szczylik C, Vogelzang N, et al. Phase 3 trial of dovitinib vs sorafenib in patients with metastatic renal cell carcinoma after 1 prior VEGF pathway-targeted and 1 prior mTOR inhibitor therapy [abstract 34LBA]. European Cancer Congress 2013 (ECCO-ESMO-ESTRO); 2013
-
(2013)
European Cancer Congress 2013
-
-
Motzer, R.J.1
Szczylik, C.2
Vogelzang, N.3
-
66
-
-
84884583240
-
The role of aberrant vhlhif pathway elements in predicting clinical outcome to pazopanib therapy in patients with metastatic clear-cell renal cell carcinoma
-
Choueiri TK, Fay A, Gagnon R, et al. The role of aberrant VHL/HIF pathway elements in predicting clinical outcome to pazopanib therapy in patients with metastatic clear-cell renal cell carcinoma. Clin Cancer Res 2013;19(18):5218-26
-
(2013)
Clin Cancer Res
, vol.19
, Issue.18
, pp. 5218-5226
-
-
Choueiri, T.K.1
Fay, A.2
Gagnon, R.3
-
67
-
-
48649098245
-
Von Hippel-Lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal cell carcinoma
-
8605 discussion
-
Choueiri TK, Vaziri SA, Jaeger E, et al. von Hippel-Lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal cell carcinoma. J Urol 2008;180(3):860,5; discussion 865-6
-
(2008)
J Urol
, vol.180
, Issue.3
, pp. 865-866
-
-
Choueiri, T.K.1
Vaziri, S.A.2
Jaeger, E.3
-
68
-
-
84866948962
-
Biomarkers: The next therapeutic hurdle in metastatic renal cell carcinoma
-
Sonpavde G, Choueiri TK. Biomarkers: The next therapeutic hurdle in metastatic renal cell carcinoma. Br J Cancer 2012;107(7):1009-16
-
(2012)
Br J Cancer
, vol.107
, Issue.7
, pp. 1009-1016
-
-
Sonpavde, G.1
Choueiri, T.K.2
-
69
-
-
84872548337
-
Phase II and biomarker study of the dual MET/ VEGFR2 inhibitor foretinib in patients with papillary renal cell carcinoma
-
Choueiri TK, Vaishampayan U, Rosenberg JE, et al. Phase II and biomarker study of the dual MET/ VEGFR2 inhibitor foretinib in patients with papillary renal cell carcinoma. J Clin Oncol 2013;31(2):181-6
-
(2013)
J Clin Oncol
, vol.31
, Issue.2
, pp. 181-186
-
-
Choueiri, T.K.1
Vaishampayan, U.2
Rosenberg, J.E.3
-
70
-
-
34250177269
-
PD-1 is expressed by tumorinfiltrating immune cells and is associated with poor outcome for patients with renal cell carcinoma
-
Thompson RH, Dong H, Lohse CM, et al. PD-1 is expressed by tumorinfiltrating immune cells and is associated with poor outcome for patients with renal cell carcinoma. Clin Cancer Res 2007;13(6):1757-61
-
(2007)
Clin Cancer Res
, vol.13
, Issue.6
, pp. 1757-1761
-
-
Thompson, R.H.1
Dong, H.2
Lohse, C.M.3
-
71
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012;366(26):2443-54
-
(2012)
N Engl J Med
, vol.366
, Issue.26
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
-
72
-
-
84862903106
-
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
-
Brahmer JR, Tykodi SS, Chow LQ, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 2012;366(26):2455-65
-
(2012)
N Engl J Med
, vol.366
, Issue.26
, pp. 2455-2465
-
-
Brahmer, J.R.1
Tykodi, S.S.2
Chow, L.Q.3
-
73
-
-
84880706331
-
Survival safety and response duration results of nivolumab (anti-PD-1; BMS-936558; ONO-4538) in a phase I trial in patients with previously treated metastatic renal cell carcinoma (mRCC): Long-term patient follow-up
-
Suppl
-
Drake CG, McDermott DF, Sznol M, et al. Survival, safety, and response duration results of nivolumab (anti-PD-1; BMS-936558; ONO-4538) in a phase I trial in patients with previously treated metastatic renal cell carcinoma (mRCC): Long-term patient follow-up. J Clin Oncol (ASCO Annual Meeting Abstracts) 2013;31(Suppl):4514
-
(2013)
J Clin Oncol (ASCO Annual Meeting Abstracts
, vol.31
, pp. 4514
-
-
Drake, C.G.1
McDermott, D.F.2
Sznol, M.3
-
74
-
-
84894030522
-
A phase III comparative study of nivolumab (anti-PD-1; BMS-936558; ONO-4538) versus everolimus in patients (pts) with advanced or metastatic renal cell carcinoma (mRCC) previously treated with antiangiogenic therapy
-
Suppl
-
Motzer RJ, Bono P, Hudes GR, et al. A phase III comparative study of nivolumab (anti-PD-1; BMS-936558; ONO-4538) versus everolimus in patients (pts) with advanced or metastatic renal cell carcinoma (mRCC) previously treated with antiangiogenic therapy. J Clin Oncol (ASCO Annual Meeting Abstracts) 2013;31(Suppl):TPS4592
-
(2013)
J Clin Oncol (ASCO Annual Meeting Abstracts
, vol.31
-
-
Motzer, R.J.1
Bono, P.2
Hudes, G.R.3
-
75
-
-
84896730538
-
A phase 1 study of nivolumab (anti-PD-1; BMS-936558; ONO-4538) in combination with sunitinib, pazopanib, or ipilumumab in patients (pts) with metastatic renal cell carcinoma (mRCC
-
Suppl
-
Amin A, Ernstoff MS, Infante JR, et al. A phase 1 study of nivolumab (anti-PD-1; BMS-936558; ONO-4538) in combination with sunitinib, pazopanib, or ipilumumab in patients (pts) with metastatic renal cell carcinoma (mRCC). J Clin Oncol (ASCO Annual Meeting Abstracts) 2013;31(Suppl):TPS4593
-
(2013)
J Clin Oncol (ASCO Annual Meeting Abstracts
, vol.31
-
-
Amin, A.1
Ernstoff, M.S.2
Infante, J.R.3
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