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Volumn 23, Issue 3, 2014, Pages 305-315

Fibroblast growth factor receptors as therapeutic targets in clear-cell renal cell carcinoma

Author keywords

Angiogenesis; Cediranib; Dovitinib; Drug resistance; Fibroblast growth factor pathway; Lenvatinib; Nintedanib; Regorafenib; Renal cell carcinoma

Indexed keywords

ANGIOGENESIS INHIBITORS; ANIMALS; CARCINOMA, RENAL CELL; FIBROBLAST GROWTH FACTORS; HUMANS; KIDNEY NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PROTEIN KINASE INHIBITORS; RECEPTORS, FIBROBLAST GROWTH FACTOR;

EID: 84894069761     PISSN: 13543784     EISSN: 17447658     Source Type: Journal    
DOI: 10.1517/13543784.2014.871259     Document Type: Review
Times cited : (22)

References (75)
  • 2
    • 78149347499 scopus 로고    scopus 로고
    • Seer cancer statistics review
    • Editors Bethesda, MD. Available from Accessed 4 October 2013]
    • Altekruse SF, Kosary CL, Krapcho M, et al. editors. SEER cancer statistics review, 1975-2007. National Cancer Institute, Bethesda, MD. Available from: Http://seer.cancer.gov/csr/19752007/ [Accessed 4 October 2013]
    • National Cancer Institute , pp. 1975-2007
    • Altekruse, S.F.1    Kosary, C.L.2    Krapcho, M.3
  • 3
    • 34247385434 scopus 로고    scopus 로고
    • Evolving principles of surgical management and prognostic factors for outcome in renal cell carcinoma
    • Lam JS, Breda A, Belldegrun AS, Figlin RA. Evolving principles of surgical management and prognostic factors for outcome in renal cell carcinoma. J Clin Oncol 2006;24(35):5565-75
    • (2006) J Clin Oncol , vol.24 , Issue.35 , pp. 5565-5575
    • Lam, J.S.1    Breda, A.2    Belldegrun, A.S.3    Figlin, R.A.4
  • 4
    • 0027954044 scopus 로고
    • Mutations of the VHL tumour suppressor gene in renal carcinoma
    • Gnarra JR, Tory K, Weng Y, et al. Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat Genet 1994;7(1):85-90
    • (1994) Nat Genet , vol.7 , Issue.1 , pp. 85-90
    • Gnarra, J.R.1    Tory, K.2    Weng, Y.3
  • 5
    • 0028235907 scopus 로고
    • Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas
    • Shuin T, Kondo K, Torigoe S, et al. Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas. Cancer Res 1994;54(11):2852-5
    • (1994) Cancer Res , vol.54 , Issue.11 , pp. 2852-2855
    • Shuin, T.1    Kondo, K.2    Torigoe, S.3
  • 6
    • 0035394516 scopus 로고    scopus 로고
    • Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas
    • Wiesener MS, Munchenhagen PM, Berger I, et al. Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas. Cancer Res 2001;61(13):5215-22
    • (2001) Cancer Res , vol.61 , Issue.13 , pp. 5215-5222
    • Wiesener, M.S.1    Munchenhagen, P.M.2    Berger, I.3
  • 7
    • 0028072991 scopus 로고
    • Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma
    • Herman JG, Latif F, Weng Y, et al. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci USA 1994;91(21):9700-4
    • (1994) Proc Natl Acad Sci USA , vol.91 , Issue.21 , pp. 9700-9704
    • Herman, J.G.1    Latif, F.2    Weng, Y.3
  • 9
    • 28844484134 scopus 로고    scopus 로고
    • Renal-cell carcinoma
    • Cohen HT, McGovern FJ. Renal-cell carcinoma. N Engl J Med 2005;353(23):2477-90
    • (2005) N Engl J Med , vol.353 , Issue.23 , pp. 2477-2490
    • Cohen, H.T.1    McGovern, F.J.2
  • 10
    • 75149188170 scopus 로고    scopus 로고
    • Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
    • Dalgliesh GL, Furge K, Greenman C, et al. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature 2010;463(7279):360-3
    • (2010) Nature , vol.463 , Issue.7279 , pp. 360-363
    • Dalgliesh, G.L.1    Furge, K.2    Greenman, C.3
  • 11
    • 79251635938 scopus 로고    scopus 로고
    • Exome sequencing identifies frequent mutation of the swisnf complex gene pbrm1 in renal carcinoma
    • Varela I, Tarpey P, Raine K, et al. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature 2011;469(7331):539-42
    • (2011) Nature , vol.469 , Issue.7331 , pp. 539-542
    • Varela, I.1    Tarpey, P.2    Raine, K.3
  • 12
    • 84873081430 scopus 로고    scopus 로고
    • Effects on survival of bap1 and pbrm1 mutations in sporadic clear-cell renal-cell carcinoma: A retrospective analysis with independent validation
    • Kapur P, Pena-Llopis S, Christie A, et al. Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: A retrospective analysis with independent validation. Lancet Oncol 2013;14(2):159-67
    • (2013) Lancet Oncol , vol.14 , Issue.2 , pp. 159-167
    • Kapur, P.1    Pena-Llopis, S.2    Christie, A.3
  • 13
    • 84655176646 scopus 로고    scopus 로고
    • Frequent mutations of genes encoding ubiquitinmediated proteolysis pathway components in clear cell renal cell carcinoma
    • Guo G, Gui Y, Gao S, et al. Frequent mutations of genes encoding ubiquitinmediated proteolysis pathway components in clear cell renal cell carcinoma. Nat Genet 2011;44(1):17-19
    • (2011) Nat Genet , vol.44 , Issue.1 , pp. 17-19
    • Guo, G.1    Gui, Y.2    Gao, S.3
  • 14
    • 49249087039 scopus 로고    scopus 로고
    • Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma
    • Rini BI, Michaelson MD, Rosenberg JE, et al. Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma. J Clin Oncol 2008;26(22):3743-8
    • (2008) J Clin Oncol , vol.26 , Issue.22 , pp. 3743-3748
    • Rini, B.I.1    Michaelson, M.D.2    Rosenberg, J.E.3
  • 15
    • 37349080670 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase III trial
    • Escudier B, Pluzanska A, Koralewski P, et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase III trial. Lancet 2007;370(9605):2103-11
    • (2007) Lancet , vol.370 , Issue.9605 , pp. 2103-2111
    • Escudier, B.1    Pluzanska, A.2    Koralewski, P.3
  • 16
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    • Motzer RJ, Hutson TE, Tomczak P, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007;356(2):115-24
    • (2007) N Engl J Med , vol.356 , Issue.2 , pp. 115-124
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 18
    • 7144227930 scopus 로고    scopus 로고
    • Recombinant human interleukin-2, recombinant human interferon alfa-2a, or both in metastatic renal-cell carcinoma Groupe Français d'Immunotherapie
    • Negrier S, Escudier B, Lasset C, et al. Recombinant human interleukin-2, recombinant human interferon alfa-2a, or both in metastatic renal-cell carcinoma. Groupe Français d'Immunotherapie. N Engl J Med 1998;338(18):1272-8
    • (1998) N Engl J Med , vol.338 , Issue.18 , pp. 1272-1278
    • Negrier, S.1    Escudier, B.2    Lasset, C.3
  • 19
    • 84894062473 scopus 로고    scopus 로고
    • Words of wisdom Re: Radical nephrectomy with and without lymph-node dissection: Final results of European Organization for Research and Treatment of Cancer (EORTC) randomized phase 3 trial 30881
    • Ljungberg B. Words of wisdom. Re: Radical nephrectomy with and without lymph-node dissection: Final results of European Organization for Research and Treatment of Cancer (EORTC) randomized phase 3 trial 30881. Eur Urol 2009;55(6):1486-7
    • (2009) Eur Urol , vol.55 , Issue.6 , pp. 1486-1487
    • Ljungberg, B.1
  • 20
    • 56749161699 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206
    • Rini BI, Halabi S, Rosenberg JE, et al. Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206. J Clin Oncol 2008;26(33):5422-8
    • (2008) J Clin Oncol , vol.26 , Issue.33 , pp. 5422-5428
    • Rini, B.I.1    Halabi, S.2    Rosenberg, J.E.3
  • 21
    • 77949890945 scopus 로고    scopus 로고
    • Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial
    • Sternberg CN, Davis ID, Mardiak J, et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial. J Clin Oncol 2010;28(6):1061-8
    • (2010) J Clin Oncol , vol.28 , Issue.6 , pp. 1061-1068
    • Sternberg, C.N.1    Davis, I.D.2    Mardiak, J.3
  • 22
    • 33846148701 scopus 로고    scopus 로고
    • Sorafenib in advanced clear-cell renal-cell carcinoma
    • Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007;356(2):125-34
    • (2007) N Engl J Med , vol.356 , Issue.2 , pp. 125-134
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 23
    • 84856211584 scopus 로고    scopus 로고
    • Everolimus in metastatic renal cell carcinoma: Subgroup analysis of patients with 1 or 2 previous vascular endothelial growth factor receptor-tyrosine kinase inhibitor therapies enrolled in the phase III RECORD-1 study
    • Calvo E, Escudier B, Motzer RJ, et al. Everolimus in metastatic renal cell carcinoma: Subgroup analysis of patients with 1 or 2 previous vascular endothelial growth factor receptor-tyrosine kinase inhibitor therapies enrolled in the phase III RECORD-1 study. Eur J Cancer 2012;48(3):333-9
    • (2012) Eur J Cancer , vol.48 , Issue.3 , pp. 333-339
    • Calvo, E.1    Escudier, B.2    Motzer, R.J.3
  • 24
    • 77951729433 scopus 로고    scopus 로고
    • Fda approval summary: Temsirolimus as treatment for advanced renal cell carcinoma
    • Kwitkowski VE, Prowell TM, Ibrahim A, et al. FDA approval summary: Temsirolimus as treatment for advanced renal cell carcinoma. Oncologist 2010;15(4):428-35
    • (2010) Oncologist , vol.15 , Issue.4 , pp. 428-435
    • Kwitkowski, V.E.1    Prowell, T.M.2    Ibrahim, A.3
  • 25
    • 70349385645 scopus 로고    scopus 로고
    • Resistance to targeted therapy in renal-cell carcinoma
    • Rini BI, Atkins MB. Resistance to targeted therapy in renal-cell carcinoma. Lancet Oncol 2009;10(10):992-1000
    • (2009) Lancet Oncol , vol.10 , Issue.10 , pp. 992-1000
    • Rini, B.I.1    Atkins, M.B.2
  • 26
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • Paez-Ribes M, Allen E, Hudock J, et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009;15(3):220-31
    • (2009) Cancer Cell , vol.15 , Issue.3 , pp. 220-231
    • Paez-Ribes, M.1    Allen, E.2    Hudock, J.3
  • 27
    • 76249133170 scopus 로고    scopus 로고
    • Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma
    • Huang D, Ding Y, Zhou M, et al. Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma. Cancer Res 2010;70(3):1063-71
    • (2010) Cancer Res , vol.70 , Issue.3 , pp. 1063-1071
    • Huang, D.1    Ding, Y.2    Zhou, M.3
  • 28
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    • Casanovas O, Hicklin DJ, Bergers G, Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 2005;8(4):299-309
    • (2005) Cancer Cell , vol.8 , Issue.4 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3    Hanahan, D.4
  • 30
    • 69249216604 scopus 로고    scopus 로고
    • The role of fibroblast growth factors in tumor growth
    • Korc M, Friesel RE. The role of fibroblast growth factors in tumor growth. Curr Cancer Drug Targets 2009;9(5):639-51
    • (2009) Curr Cancer Drug Targets , vol.9 , Issue.5 , pp. 639-651
    • Korc, M.1    Friesel, R.E.2
  • 31
    • 61649100307 scopus 로고    scopus 로고
    • The FGF family: Biology, pathophysiology and therapy
    • Beenken A, Mohammadi M. The FGF family: Biology, pathophysiology and therapy. Nat Rev Drug Discov 2009;8(3):235-53
    • (2009) Nat Rev Drug Discov , vol.8 , Issue.3 , pp. 235-253
    • Beenken, A.1    Mohammadi, M.2
  • 33
    • 39549084750 scopus 로고    scopus 로고
    • Novel therapeutic targets in bladder cancer: Mutation and expression of FGF receptors
    • Knowles MA. Novel therapeutic targets in bladder cancer: Mutation and expression of FGF receptors. Future Oncol 2008;4(1):71-83
    • (2008) Future Oncol , vol.4 , Issue.1 , pp. 71-83
    • Knowles, M.A.1
  • 34
    • 47249122523 scopus 로고    scopus 로고
    • Drug-sensitive FGFR2 mutations in endometrial carcinoma
    • Dutt A, Salvesen HB, Chen TH, et al. Drug-sensitive FGFR2 mutations in endometrial carcinoma. Proc Natl Acad Sci USA 2008;105(25):8713-17
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.25 , pp. 8713-8717
    • Dutt, A.1    Salvesen, H.B.2    Chen, T.H.3
  • 35
    • 34250829395 scopus 로고    scopus 로고
    • Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes
    • Pollock PM, Gartside MG, Dejeza LC, et al. Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes. Oncogene 2007;26(50):7158-62
    • (2007) Oncogene , vol.26 , Issue.50 , pp. 7158-7162
    • Pollock, P.M.1    Gartside, M.G.2    Dejeza, L.C.3
  • 36
    • 42049120475 scopus 로고    scopus 로고
    • FGFR2-Amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival
    • Kunii K, Davis L, Gorenstein J, et al. FGFR2-Amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival. Cancer Res 2008;68(7):2340-8
    • (2008) Cancer Res , vol.68 , Issue.7 , pp. 2340-2348
    • Kunii, K.1    Davis, L.2    Gorenstein, J.3
  • 37
    • 77950278598 scopus 로고    scopus 로고
    • FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer
    • Turner N, Pearson A, Sharpe R, et al. FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer. Cancer Res 2010;70(5):2085-94
    • (2010) Cancer Res , vol.70 , Issue.5 , pp. 2085-2094
    • Turner, N.1    Pearson, A.2    Sharpe, R.3
  • 38
    • 59449094654 scopus 로고    scopus 로고
    • Molecular characterization of breast cancer with high-resolution oligonucleotide comparative genomic hybridization array
    • Andre F, Job B, Dessen P, et al. Molecular characterization of breast cancer with high-resolution oligonucleotide comparative genomic hybridization array. Clin Cancer Res 2009;15(2):441-51
    • (2009) Clin Cancer Res , vol.15 , Issue.2 , pp. 441-451
    • Andre, F.1    Job, B.2    Dessen, P.3
  • 39
    • 79952116987 scopus 로고    scopus 로고
    • Amplification of fibroblast growth factor receptor-1 in breast cancer and the effects of brivanib alaninate
    • Shiang CY, Qi Y, Wang B, et al. Amplification of fibroblast growth factor receptor-1 in breast cancer and the effects of brivanib alaninate. Breast Cancer Res Treat 2010;123(3):747-55
    • (2010) Breast Cancer Res Treat , vol.123 , Issue.3 , pp. 747-755
    • Shiang, C.Y.1    Qi, Y.2    Wang, B.3
  • 40
    • 0343355828 scopus 로고    scopus 로고
    • High incidence of translocations t(11;14) (q13;q32) and t(4;14)(p16;q32) in patients with plasma cell malignancies
    • Avet-Loiseau H, Li JY, Facon T, et al. High incidence of translocations t(11;14) (q13;q32) and t(4;14)(p16;q32) in patients with plasma cell malignancies. Cancer Res 1998;58(24):5640-5
    • (1998) Cancer Res , vol.58 , Issue.24 , pp. 5640-5645
    • Avet-Loiseau, H.1    Li, J.Y.2    Facon, T.3
  • 41
    • 0030922231 scopus 로고    scopus 로고
    • Frequent translocation t (4; 14)(p16. 3; q32. 3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3
    • Chesi M, Nardini E, Brents LA, et al. Frequent translocation t (4; 14)(p16. 3; q32. 3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3. Nat Genet 1997;16(3):260-4
    • (1997) Nat Genet , vol.16 , Issue.3 , pp. 260-264
    • Chesi, M.1    Nardini, E.2    Brents, L.A.3
  • 42
    • 39049092267 scopus 로고    scopus 로고
    • Fibroblast growth factors, fibroblast growth factor receptors, diseases, and drugs
    • Chen GJ, Forough R. Fibroblast growth factors, fibroblast growth factor receptors, diseases, and drugs. Recent Patent Cardiovasc Drug Discov 2006;1(2):211-24
    • (2006) Recent Patent Cardiovasc Drug Discov , vol.1 , Issue.2 , pp. 211-224
    • Chen, G.J.1    Forough, R.2
  • 43
    • 18144364350 scopus 로고    scopus 로고
    • Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis
    • Presta M, Dell'Era P, Mitola S, et al. Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis. Cytokine Growth Factor Rev 2005;16(2):159-78
    • (2005) Cytokine Growth Factor Rev , vol.16 , Issue.2 , pp. 159-178
    • Presta, M.1    Dell'Era, P.2    Mitola, S.3
  • 44
    • 0026608650 scopus 로고
    • Correlation of basic fibroblast growth factor expression levels with the degree of malignancy and vascularity in human gliomas
    • Takahashi JA, Fukumoto M, Igarashi K, et al. Correlation of basic fibroblast growth factor expression levels with the degree of malignancy and vascularity in human gliomas. J Neurosurg 1992;76(5):792-8
    • (1992) J Neurosurg , vol.76 , Issue.5 , pp. 792-798
    • Takahashi, J.A.1    Fukumoto, M.2    Igarashi, K.3
  • 45
    • 11244283209 scopus 로고    scopus 로고
    • The role of fibroblast growth factors and their receptors in prostate cancer
    • Kwabi-Addo B, Ozen M, Ittmann M. The role of fibroblast growth factors and their receptors in prostate cancer. Endocr Relat Cancer 2004;11(4):709-24
    • (2004) Endocr Relat Cancer , vol.11 , Issue.4 , pp. 709-724
    • Kwabi-Addo, B.1    Ozen, M.2    Ittmann, M.3
  • 46
    • 0034055006 scopus 로고    scopus 로고
    • Differential response to transforming growth factor (TGF)-Alpha and fibroblast growth factor (FGF) in human renal cell carcinomas of the clear cell and papillary types
    • Ramp U, Reinecke P, Gabbert HE, Gerharz CD. Differential response to transforming growth factor (TGF)-Alpha and fibroblast growth factor (FGF) in human renal cell carcinomas of the clear cell and papillary types. Eur J Cancer 2000;36(7):932-41
    • (2000) Eur J Cancer , vol.36 , Issue.7 , pp. 932-941
    • Ramp, U.1    Reinecke, P.2    Gabbert, H.E.3    Gerharz, C.D.4
  • 47
    • 0031012779 scopus 로고    scopus 로고
    • Induction of tubulogenesis of microvascular endothelial cells by basic fibroblast growth factor from human SN12C renal cancer cells
    • Emoto A, Nakagawa M, Wakabayashi Y, et al. Induction of tubulogenesis of microvascular endothelial cells by basic fibroblast growth factor from human SN12C renal cancer cells. J Urol 1997;157(2):699-703
    • (1997) J Urol , vol.157 , Issue.2 , pp. 699-703
    • Emoto, A.1    Nakagawa, M.2    Wakabayashi, Y.3
  • 48
    • 0036558290 scopus 로고    scopus 로고
    • Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1alpha-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2-binding sites
    • Li J, Shworak NW, Simons M. Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1alpha-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2-binding sites. J Cell Sci 2002;115(Pt 9):1951-9
    • (2002) J Cell Sci , vol.115 , Issue.PART 9 , pp. 1951-1959
    • Li, J.1    Shworak, N.W.2    Simons, M.3
  • 49
    • 0027482301 scopus 로고
    • Expression of basic fibroblast growth factor in primary human renal tumors: Correlation with poor survival
    • Nanus DM, Schmitz-Drager BJ, Motzer RJ, et al. Expression of basic fibroblast growth factor in primary human renal tumors: Correlation with poor survival. J Natl Cancer Inst 1993;85(19):1597-9
    • (1993) J Natl Cancer Inst , vol.85 , Issue.19 , pp. 1597-1599
    • Nanus, D.M.1    Schmitz-Drager, B.J.2    Motzer, R.J.3
  • 50
    • 78650508926 scopus 로고    scopus 로고
    • Fibroblast growth factor pathway in renal cell carcinoma
    • Suppl
    • Tsimafeyeu I, Demidov H, Ta H, et al. Fibroblast growth factor pathway in renal cell carcinoma. J Clin Oncol (Meeting Abstracts) 2010;28(15s Suppl):4621
    • (2010) J Clin Oncol (Meeting Abstracts , vol.28 , Issue.15 , pp. 4621
    • Tsimafeyeu, I.1    Demidov, H.2    Ta, H.3
  • 51
    • 84868712956 scopus 로고    scopus 로고
    • Changes in circulating pro-Angiogenic cytokines other than vegf before progression to sunitinib therapy in advanced renal cell carcinoma patients
    • Porta C, Paglino C, Imarisio I, et al. Changes in circulating pro-Angiogenic cytokines, other than VEGF, before progression to sunitinib therapy in advanced renal cell carcinoma patients. Oncology 2013;84(2):115-22
    • (2013) Oncology , vol.84 , Issue.2 , pp. 115-122
    • Porta, C.1    Paglino, C.2    Imarisio, I.3
  • 52
    • 84874851836 scopus 로고    scopus 로고
    • Phase i study of dovitinib (tki258) an oral fgfr vegfr and pdgfr inhibitor in advanced or metastatic renal cell carcinoma
    • Angevin E, Lopez-Martin J, Lin CC, et al. Phase I study of dovitinib (TKI258), an oral FGFR, VEGFR, and PDGFR inhibitor, in advanced or metastatic renal cell carcinoma. Clin Cancer Res 2013;19(5):1257-68
    • (2013) Clin Cancer Res , vol.19 , Issue.5 , pp. 1257-1268
    • Angevin, E.1    Lopez-Martin, J.2    Lin, C.C.3
  • 53
    • 79954499886 scopus 로고    scopus 로고
    • Regorafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
    • Wilhelm SM, Dumas J, Adnane L, et al. Regorafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer 2011;129(1):245-55
    • (2011) Int J Cancer , vol.129 , Issue.1 , pp. 245-255
    • Wilhelm, S.M.1    Dumas, J.2    Adnane, L.3
  • 54
    • 15944378835 scopus 로고    scopus 로고
    • CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma
    • Trudel S, Li ZH, Wei E, et al. CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma. Blood 2005;105(7):2941-8
    • (2005) Blood , vol.105 , Issue.7 , pp. 2941-2948
    • Trudel, S.1    Li, Z.H.2    Wei, E.3
  • 55
    • 21044443128 scopus 로고    scopus 로고
    • In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models
    • Lee SH, Lopes de Menezes D, Vora J, et al. In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models. Clin Cancer Res 2005;11(10):3633-41
    • (2005) Clin Cancer Res , vol.11 , Issue.10 , pp. 3633-3641
    • Lee, S.H.1    Lopes De Menezes, D.2    Vora, J.3
  • 56
    • 84862145477 scopus 로고    scopus 로고
    • A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma
    • Sivanand S, Pena-Llopis S, Zhao H, et al. A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma. Sci Transl Med 2012;4(137):137ra75
    • (2012) Sci Transl Med , vol.4 , Issue.137 , pp. 137-175
    • Sivanand, S.1    Pena-Llopis, S.2    Zhao, H.3
  • 57
    • 84866888498 scopus 로고    scopus 로고
    • Regorafenib for patients with previously untreated metastatic or unresectable renal-cell carcinoma: A single-group phase 2 trial
    • Eisen T, Joensuu H, Nathan PD, et al. Regorafenib for patients with previously untreated metastatic or unresectable renal-cell carcinoma: A single-group phase 2 trial. Lancet Oncol 2012;13(10):1055-62
    • (2012) Lancet Oncol , vol.13 , Issue.10 , pp. 1055-1062
    • Eisen, T.1    Joensuu, H.2    Nathan, P.D.3
  • 58
    • 84885599759 scopus 로고    scopus 로고
    • Phase II efficacy and safety study of nintedanib versus sunitinib in previously untreated renal cell carcinoma (RCC) patients
    • Suppl
    • Eisen T, Shparyk Y, Jones R, et al. Phase II efficacy and safety study of nintedanib versus sunitinib in previously untreated renal cell carcinoma (RCC) patients. J Clin Oncol (ASCO Annual Meeting Abstracts) 2013;31(Suppl):4506
    • (2013) J Clin Oncol (ASCO Annual Meeting Abstracts , vol.31 , pp. 4506
    • Eisen, T.1    Shparyk, Y.2    Jones, R.3
  • 59
    • 84880916561 scopus 로고    scopus 로고
    • A phase ii study of cediranib (azd 2171) in treatment naive patients with progressive unresectable recurrent or metastatic renal cell carcinoma a trial of the pmh phase 2 consortium
    • Sridhar SS, Mackenzie MJ, Hotte SJ, et al. A phase II study of cediranib (AZD 2171) in treatment naive patients with progressive unresectable recurrent or metastatic renal cell carcinoma. A trial of the PMH phase 2 consortium. Invest New Drugs 2013;31(4):1008-15
    • (2013) Invest New Drugs , vol.31 , Issue.4 , pp. 1008-1015
    • Sridhar, S.S.1    Mackenzie, M.J.2    Hotte, S.J.3
  • 60
    • 84857052966 scopus 로고    scopus 로고
    • Cediranib monotherapy in patients with advanced renal cell carcinoma: Results of a randomised phase II study
    • Mulders P, Hawkins R, Nathan P, et al. Cediranib monotherapy in patients with advanced renal cell carcinoma: Results of a randomised phase II study. Eur J Cancer 2012;48(4):527-37
    • (2012) Eur J Cancer , vol.48 , Issue.4 , pp. 527-537
    • Mulders, P.1    Hawkins, R.2    Nathan, P.3
  • 61
    • 53049085556 scopus 로고    scopus 로고
    • Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R) 2 and VEGF-R3 kinase
    • Matsui J, Funahashi Y, Uenaka T, et al. Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R) 2 and VEGF-R3 kinase. Clin Cancer Res 2008;14(17):5459-65
    • (2008) Clin Cancer Res , vol.14 , Issue.17 , pp. 5459-5465
    • Matsui, J.1    Funahashi, Y.2    Uenaka, T.3
  • 62
    • 37349105704 scopus 로고    scopus 로고
    • E7080 a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition
    • Matsui J, Yamamoto Y, Funahashi Y, et al. E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition. Int J Cancer 2008;122(3):664-71
    • (2008) Int J Cancer , vol.122 , Issue.3 , pp. 664-671
    • Matsui, J.1    Yamamoto, Y.2    Funahashi, Y.3
  • 63
    • 84894087863 scopus 로고    scopus 로고
    • A phase Ib clinical trial of the multitargeted kinase inhibitor lenvatinib (E7080) in combination with everolimus for treatment of metastatic renal cell carcinoma (RCC
    • Molina AM, Hutson TE, Larkin J, et al. A phase Ib clinical trial of the multitargeted kinase inhibitor lenvatinib (E7080) in combination with everolimus for treatment of metastatic renal cell carcinoma (RCC). Ann Oncol (ESMO Annual Meeting Abstracts) 2012;23(Suppl 9):814P
    • (2012) Ann Oncol (ESMO Annual Meeting Abstracts , vol.23 , Issue.SUPPL. 9
    • Molina, A.M.1    Hutson, T.E.2    Larkin, J.3
  • 64
    • 84856199835 scopus 로고    scopus 로고
    • A phase II study of dovitinib (TKI258), an FGFR- and VEGFRinhibitor, in patients with advanced or metastatic renal cell cancer (mRCC
    • Suppl
    • Angevin E, Grunwald V, Ravaud A, et al. A phase II study of dovitinib (TKI258), an FGFR- and VEGFRinhibitor, in patients with advanced or metastatic renal cell cancer (mRCC). J Clin Oncol (ASCO Annual Meeting Abstracts) 2011;29(Suppl):4551
    • (2011) J Clin Oncol (ASCO Annual Meeting Abstracts , vol.29 , pp. 4551
    • Angevin, E.1    Grunwald, V.2    Ravaud, A.3
  • 65
    • 84894079898 scopus 로고    scopus 로고
    • Phase 3 trial of dovitinib vs sorafenib in patients with metastatic renal cell carcinoma after 1 prior VEGF pathway-targeted and 1 prior mTOR inhibitor therapy [abstract 34LBA
    • (ECCO-ESMO-ESTRO
    • Motzer RJ, Szczylik C, Vogelzang N, et al. Phase 3 trial of dovitinib vs sorafenib in patients with metastatic renal cell carcinoma after 1 prior VEGF pathway-targeted and 1 prior mTOR inhibitor therapy [abstract 34LBA]. European Cancer Congress 2013 (ECCO-ESMO-ESTRO); 2013
    • (2013) European Cancer Congress 2013
    • Motzer, R.J.1    Szczylik, C.2    Vogelzang, N.3
  • 66
    • 84884583240 scopus 로고    scopus 로고
    • The role of aberrant vhlhif pathway elements in predicting clinical outcome to pazopanib therapy in patients with metastatic clear-cell renal cell carcinoma
    • Choueiri TK, Fay A, Gagnon R, et al. The role of aberrant VHL/HIF pathway elements in predicting clinical outcome to pazopanib therapy in patients with metastatic clear-cell renal cell carcinoma. Clin Cancer Res 2013;19(18):5218-26
    • (2013) Clin Cancer Res , vol.19 , Issue.18 , pp. 5218-5226
    • Choueiri, T.K.1    Fay, A.2    Gagnon, R.3
  • 67
    • 48649098245 scopus 로고    scopus 로고
    • Von Hippel-Lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal cell carcinoma
    • 8605 discussion
    • Choueiri TK, Vaziri SA, Jaeger E, et al. von Hippel-Lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal cell carcinoma. J Urol 2008;180(3):860,5; discussion 865-6
    • (2008) J Urol , vol.180 , Issue.3 , pp. 865-866
    • Choueiri, T.K.1    Vaziri, S.A.2    Jaeger, E.3
  • 68
    • 84866948962 scopus 로고    scopus 로고
    • Biomarkers: The next therapeutic hurdle in metastatic renal cell carcinoma
    • Sonpavde G, Choueiri TK. Biomarkers: The next therapeutic hurdle in metastatic renal cell carcinoma. Br J Cancer 2012;107(7):1009-16
    • (2012) Br J Cancer , vol.107 , Issue.7 , pp. 1009-1016
    • Sonpavde, G.1    Choueiri, T.K.2
  • 69
    • 84872548337 scopus 로고    scopus 로고
    • Phase II and biomarker study of the dual MET/ VEGFR2 inhibitor foretinib in patients with papillary renal cell carcinoma
    • Choueiri TK, Vaishampayan U, Rosenberg JE, et al. Phase II and biomarker study of the dual MET/ VEGFR2 inhibitor foretinib in patients with papillary renal cell carcinoma. J Clin Oncol 2013;31(2):181-6
    • (2013) J Clin Oncol , vol.31 , Issue.2 , pp. 181-186
    • Choueiri, T.K.1    Vaishampayan, U.2    Rosenberg, J.E.3
  • 70
    • 34250177269 scopus 로고    scopus 로고
    • PD-1 is expressed by tumorinfiltrating immune cells and is associated with poor outcome for patients with renal cell carcinoma
    • Thompson RH, Dong H, Lohse CM, et al. PD-1 is expressed by tumorinfiltrating immune cells and is associated with poor outcome for patients with renal cell carcinoma. Clin Cancer Res 2007;13(6):1757-61
    • (2007) Clin Cancer Res , vol.13 , Issue.6 , pp. 1757-1761
    • Thompson, R.H.1    Dong, H.2    Lohse, C.M.3
  • 71
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012;366(26):2443-54
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 72
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer JR, Tykodi SS, Chow LQ, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 2012;366(26):2455-65
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 73
    • 84880706331 scopus 로고    scopus 로고
    • Survival safety and response duration results of nivolumab (anti-PD-1; BMS-936558; ONO-4538) in a phase I trial in patients with previously treated metastatic renal cell carcinoma (mRCC): Long-term patient follow-up
    • Suppl
    • Drake CG, McDermott DF, Sznol M, et al. Survival, safety, and response duration results of nivolumab (anti-PD-1; BMS-936558; ONO-4538) in a phase I trial in patients with previously treated metastatic renal cell carcinoma (mRCC): Long-term patient follow-up. J Clin Oncol (ASCO Annual Meeting Abstracts) 2013;31(Suppl):4514
    • (2013) J Clin Oncol (ASCO Annual Meeting Abstracts , vol.31 , pp. 4514
    • Drake, C.G.1    McDermott, D.F.2    Sznol, M.3
  • 74
    • 84894030522 scopus 로고    scopus 로고
    • A phase III comparative study of nivolumab (anti-PD-1; BMS-936558; ONO-4538) versus everolimus in patients (pts) with advanced or metastatic renal cell carcinoma (mRCC) previously treated with antiangiogenic therapy
    • Suppl
    • Motzer RJ, Bono P, Hudes GR, et al. A phase III comparative study of nivolumab (anti-PD-1; BMS-936558; ONO-4538) versus everolimus in patients (pts) with advanced or metastatic renal cell carcinoma (mRCC) previously treated with antiangiogenic therapy. J Clin Oncol (ASCO Annual Meeting Abstracts) 2013;31(Suppl):TPS4592
    • (2013) J Clin Oncol (ASCO Annual Meeting Abstracts , vol.31
    • Motzer, R.J.1    Bono, P.2    Hudes, G.R.3
  • 75
    • 84896730538 scopus 로고    scopus 로고
    • A phase 1 study of nivolumab (anti-PD-1; BMS-936558; ONO-4538) in combination with sunitinib, pazopanib, or ipilumumab in patients (pts) with metastatic renal cell carcinoma (mRCC
    • Suppl
    • Amin A, Ernstoff MS, Infante JR, et al. A phase 1 study of nivolumab (anti-PD-1; BMS-936558; ONO-4538) in combination with sunitinib, pazopanib, or ipilumumab in patients (pts) with metastatic renal cell carcinoma (mRCC). J Clin Oncol (ASCO Annual Meeting Abstracts) 2013;31(Suppl):TPS4593
    • (2013) J Clin Oncol (ASCO Annual Meeting Abstracts , vol.31
    • Amin, A.1    Ernstoff, M.S.2    Infante, J.R.3


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