-
1
-
-
78650990540
-
The mammalian target of rapamycin pathway is widely activated without PTEN deletion in renal cell carcinoma metastases
-
Abou Youssif T, Fahmy MA, Koumakpayi IH, Ayala F, Al Marzooqi S, Chen G, Tamboli P, Squire J, Tanguay S, Sircar K (2011) The mammalian target of rapamycin pathway is widely activated without PTEN deletion in renal cell carcinoma metastases. Cancer 117: 290-300
-
(2011)
Cancer
, vol.117
, pp. 290-300
-
-
Abou Youssif, T.1
Fahmy, M.A.2
Koumakpayi, I.H.3
Ayala, F.4
Al Marzooqi, S.5
Chen, G.6
Tamboli, P.7
Squire, J.8
Tanguay, S.9
Sircar, K.10
-
2
-
-
84866761624
-
Serum lactate dehydrogenase predicts for overall survival benefit in patients with metastatic renal cell carcinoma treated with inhibition of mammalian target of rapamycin
-
e-pub ahead of print 13 August 2012
-
Armstrong AJ, George DJ, Halabi S (2012) Serum lactate dehydrogenase predicts for overall survival benefit in patients with metastatic renal cell carcinoma treated with inhibition of mammalian target of rapamycin. J Clin Oncol; e-pub ahead of print 13 August 2012
-
(2012)
J Clin Oncol
-
-
Armstrong, A.J.1
George, D.J.2
Halabi, S.3
-
3
-
-
21044442672
-
Carbonic anhydrase IX expression predicts outcome of interleukin 2 therapy for renal cancer
-
Atkins M, Regan M, McDermott D, Mier J, Stanbridge E, Youmans A, Febbo P, Upton M, Lechpammer M, Signoretti S (2005) Carbonic anhydrase IX expression predicts outcome of interleukin 2 therapy for renal cancer.Clin Cancer Res 11: 3714-3721
-
(2005)
Clin Cancer Res
, vol.11
, pp. 3714-3721
-
-
Atkins, M.1
Regan, M.2
McDermott, D.3
Mier, J.4
Stanbridge, E.5
Youmans, A.6
Febbo, P.7
Upton, M.8
Lechpammer, M.9
Signoretti, S.10
-
4
-
-
47949099628
-
Modes of resistance to anti-angiogenic therapy
-
Bergers G, Hanahan D (2008) Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 8: 592-603
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 592-603
-
-
Bergers, G.1
Hanahan, D.2
-
5
-
-
77954899030
-
Phase i study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
-
Brahmer JR, Drake CG, Wollner I, Powderly JD, Picus J, Sharfman WH, Stankevich E, Pons A, Salay TM, McMiller TL, Gilson MM, Wang C, Selby M, Taube JM, Anders R, Chen L, Korman AJ, Pardoll DM, Lowy I, Topalian SL (2010) Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol 28: 3167-3175
-
(2010)
J Clin Oncol
, vol.28
, pp. 3167-3175
-
-
Brahmer, J.R.1
Drake, C.G.2
Wollner, I.3
Powderly, J.D.4
Picus, J.5
Sharfman, W.H.6
Stankevich, E.7
Pons, A.8
Salay, T.M.9
McMiller, T.L.10
Gilson, M.M.11
Wang, C.12
Selby, M.13
Taube, J.M.14
Anders, R.15
Chen, L.16
Korman, A.J.17
Pardoll, D.M.18
Lowy, I.19
Topalian, S.L.20
more..
-
6
-
-
77952238828
-
Molecular stratification of clear cell renal cell carcinoma by consensus clustering reveals distinct subtypes and survival patterns
-
Brannon AR, Reddy A, Seiler M, Arreola A, Moore DT, Pruthi RS, Wallen EM, Nielsen ME, Liu H, Nathanson KL, Ljungberg B, Zhao H, Brooks JD, Ganesan S, Bhanot G, Rathmell WK (2010) Molecular stratification of clear cell renal cell carcinoma by consensus clustering reveals distinct subtypes and survival patterns. Genes Cancer 1: 152-163
-
(2010)
Genes Cancer
, vol.1
, pp. 152-163
-
-
Brannon, A.R.1
Reddy, A.2
Seiler, M.3
Arreola, A.4
Moore, D.T.5
Pruthi, R.S.6
Wallen, E.M.7
Nielsen, M.E.8
Liu, H.9
Nathanson, K.L.10
Ljungberg, B.11
Zhao, H.12
Brooks, J.D.13
Ganesan, S.14
Bhanot, G.15
Rathmell, W.K.16
-
7
-
-
84866918066
-
FDG-PET as a predictive marker for therapy with everolimus in metastatic renal cell cancer
-
abstr e15047
-
Chen JL, Appelbaum DE, Kocherginsky Rathmell K, McDermott DF, Stadler WM (2011) FDG-PET as a predictive marker for therapy with everolimus in metastatic renal cell cancer. J Clin Oncol 29, (suppl; abstr e15047)
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Chen, J.L.1
Appelbaum, D.E.2
Kocherginsky Rathmell, K.3
McDermott, D.F.4
Stadler, W.M.5
-
8
-
-
35348858663
-
Potential histologic and molecular predictors of response to temsirolimus in patients with advanced renal cell carcinoma
-
Cho D, Signoretti S, Dabora S, Regan M, Seeley A, Mariotti M, Youmans A, Polivy A, Mandato L, McDermott D, Stanbridge E, Atkins M (2007) Potential histologic and molecular predictors of response to temsirolimus in patients with advanced renal cell carcinoma. Clin Genitourin Cancer 5: 379-385
-
(2007)
Clin Genitourin Cancer
, vol.5
, pp. 379-385
-
-
Cho, D.1
Signoretti, S.2
Dabora, S.3
Regan, M.4
Seeley, A.5
Mariotti, M.6
Youmans, A.7
Polivy, A.8
Mandato, L.9
McDermott, D.10
Stanbridge, E.11
Atkins, M.12
-
9
-
-
37849001813
-
Efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma
-
Choueiri TK, Plantade A, Elson P, Negrier S, Ravaud A, Oudard S, Zhou M, Rini BI, Bukowski RM, Escudier B (2008a) Efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma. J Clin Oncol 26: 127-131
-
(2008)
J Clin Oncol
, vol.26
, pp. 127-131
-
-
Choueiri, T.K.1
Plantade, A.2
Elson, P.3
Negrier, S.4
Ravaud, A.5
Oudard, S.6
Zhou, M.7
Rini, B.I.8
Bukowski, R.M.9
Escudier, B.10
-
10
-
-
77956198463
-
Carbonic anhydrase IX and pathological features as predictors of outcome in patients with metastatic clear-cell renal cell carcinoma receiving vascular endothelial growth factor-targeted therapy
-
Choueiri TK, Regan MM, Rosenberg JE, Oh WK, Clement J, Amato AM, McDermott D, Cho DC, Atkins MB, Signoretti S (2010) Carbonic anhydrase IX and pathological features as predictors of outcome in patients with metastatic clear-cell renal cell carcinoma receiving vascular endothelial growth factor-targeted therapy. BJU Int 106: 772-778
-
(2010)
BJU Int
, vol.106
, pp. 772-778
-
-
Choueiri, T.K.1
Regan, M.M.2
Rosenberg, J.E.3
Oh, W.K.4
Clement, J.5
Amato, A.M.6
McDermott, D.7
Cho, D.C.8
Atkins, M.B.9
Signoretti, S.10
-
11
-
-
48649098245
-
Von Hippel-Lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal cell carcinoma
-
discussion 865-6
-
Choueiri TK, Vaziri SA, Jaeger E, Elson P, Wood L, Bhalla IP, Small EJ, Weinberg V, Sein N, Simko J, Golshayan AR, Sercia L, Zhou M, Waldman FM, Rini BI, Bukowski RM, Ganapathi R (2008b) Von Hippel-Lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal cell carcinoma. J Urol 180: 860-865. discussion 865-6
-
(2008)
J Urol
, vol.180
, pp. 860-865
-
-
Choueiri, T.K.1
Vaziri, S.A.2
Jaeger, E.3
Elson, P.4
Wood, L.5
Bhalla, I.P.6
Small, E.J.7
Weinberg, V.8
Sein, N.9
Simko, J.10
Golshayan, A.R.11
Sercia, L.12
Zhou, M.13
Waldman, F.M.14
Rini, B.I.15
Bukowski, R.M.16
Ganapathi, R.17
-
12
-
-
84863833971
-
Pneumonitis associated with mTOR therapy in patients with metastatic renal cell carcinoma: Incidence, radiographic findings, and correlation with clinical outcome
-
abstr e15176
-
Dabydeen DA, Jagannathan JP, Ramaiya NH, Krajewski KM, Schutz F, Cho DC, Pedrosa I, Choueiri TK (2011) Pneumonitis associated with mTOR therapy in patients with metastatic renal cell carcinoma: incidence, radiographic findings, and correlation with clinical outcome. J Clin Oncol 29 (suppl; abstr e15176)
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Dabydeen, D.A.1
Jagannathan, J.P.2
Ramaiya, N.H.3
Krajewski, K.M.4
Schutz, F.5
Cho, D.C.6
Pedrosa, I.7
Choueiri, T.K.8
-
13
-
-
34547779489
-
Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: Modulation of VEGF and VEGF-related proteins
-
Deprimo SE, Bello CL, Smeraglia J, Baum CM, Spinella D, Rini BI, Michaelson MD, Motzer RJ (2007) Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins. J Transl Med 5: 32 Di
-
(2007)
J Transl Med
, vol.5
, pp. 32
-
-
Deprimo, S.E.1
Bello, C.L.2
Smeraglia, J.3
Baum, C.M.4
Spinella, D.5
Rini, B.I.6
Michaelson, M.D.7
Motzer, R.J.8
-
14
-
-
65949111284
-
Tissue biomarkers in renal cell carcinoma: Issues and solutions
-
Napoli A, Signoretti S (2009) Tissue biomarkers in renal cell carcinoma: issues and solutions. Cancer 115: 2290-2297
-
(2009)
Cancer
, vol.115
, pp. 2290-2297
-
-
Napoli, A.1
Signoretti, S.2
-
15
-
-
70249097380
-
Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial
-
Escudier B, Eisen T, Stadler WM, Szczylik C, Oudard S, Staehler M, Negrier S, Chevreau C, Desai AA, Rolland F, Demkow T, Hutson TE, Gore M, Anderson S, Hofilena G, Shan M, Pena C, Lathia C, Bukowski RM (2009) Sorafenib for treatment of renal cell carcinoma: final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial. J Clin Oncol 27: 3312-3318
-
(2009)
J Clin Oncol
, vol.27
, pp. 3312-3318
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
Szczylik, C.4
Oudard, S.5
Staehler, M.6
Negrier, S.7
Chevreau, C.8
Desai, A.A.9
Rolland, F.10
Demkow, T.11
Hutson, T.E.12
Gore, M.13
Anderson, S.14
Hofilena, G.15
Shan, M.16
Pena, C.17
Lathia, C.18
Bukowski, R.M.19
-
16
-
-
68549092780
-
Analysis of PTEN and HIF-1alpha and correlation with efficacy in patients with advanced renal cell carcinoma treated with temsirolimus versus interferon-alpha
-
Figlin RA, de Souza P, McDermott D, Dutcher JP, Berkenblit A, Thiele A, Krygowski M, Strahs A, Feingold J, Boni J, Hudes G (2009) Analysis of PTEN and HIF-1alpha and correlation with efficacy in patients with advanced renal cell carcinoma treated with temsirolimus versus interferon-alpha. Cancer 115: 3651-3660
-
(2009)
Cancer
, vol.115
, pp. 3651-3660
-
-
Figlin, R.A.1
De Souza, P.2
McDermott, D.3
Dutcher, J.P.4
Berkenblit, A.5
Thiele, A.6
Krygowski, M.7
Strahs, A.8
Feingold, J.9
Boni, J.10
Hudes, G.11
-
17
-
-
79958052123
-
MDSC as a mechanism of tumor escape from sunitinib mediated anti-angiogenic therapy
-
Finke J, Ko J, Rini B, Rayman P, Ireland J, Cohen P (2011) MDSC as a mechanism of tumor escape from sunitinib mediated anti-angiogenic therapy. Int Immunopharmacol 11: 856-861
-
(2011)
Int Immunopharmacol
, vol.11
, pp. 856-861
-
-
Finke, J.1
Ko, J.2
Rini, B.3
Rayman, P.4
Ireland, J.5
Cohen, P.6
-
18
-
-
84863393080
-
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
-
Gerlinger M, Rowan AJ, Horswell S, Larkin J, Endesfelder D, Gronroos E, Martinez P, Matthews N, Stewart A, Tarpey P, Varela I, Phillimore B, Begum S, McDonald NQ, Butler A, Jones D, Raine K, Latimer C, Santos CR, Nohadani M, Eklund AC, Spencer-Dene B, Clark G, Pickering L, Stamp G, Gore M, Szallasi Z, Downward J, Futreal PA, Swanton C (2012) Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 366: 883-892
-
(2012)
N Engl J Med
, vol.366
, pp. 883-892
-
-
Gerlinger, M.1
Rowan, A.J.2
Horswell, S.3
Larkin, J.4
Endesfelder, D.5
Gronroos, E.6
Martinez, P.7
Matthews, N.8
Stewart, A.9
Tarpey, P.10
Varela, I.11
Phillimore, B.12
Begum, S.13
McDonald, N.Q.14
Butler, A.15
Jones, D.16
Raine, K.17
Latimer, C.18
Santos, C.R.19
Nohadani, M.20
Eklund, A.C.21
Spencer-Dene, B.22
Clark, G.23
Pickering, L.24
Stamp, G.25
Gore, M.26
Szallasi, Z.27
Downward, J.28
Futreal, P.A.29
Swanton, C.30
more..
-
19
-
-
58249094490
-
Metastatic sarcomatoid renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy
-
Golshayan AR, George S, Heng DY, Elson P, Wood LS, Mekhail TM, Garcia JA, Aydin H, Zhou M, Bukowski RM, Rini BI (2009) Metastatic sarcomatoid renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy. J Clin Oncol 27: 235-241
-
(2009)
J Clin Oncol
, vol.27
, pp. 235-241
-
-
Golshayan, A.R.1
George, S.2
Heng, D.Y.3
Elson, P.4
Wood, L.S.5
Mekhail, T.M.6
Garcia, J.A.7
Aydin, H.8
Zhou, M.9
Bukowski, R.M.10
Rini, B.I.11
-
20
-
-
56849096837
-
HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma
-
Gordan JD, Lal P, Dondeti VR, Letrero R, Parekh KN, Oquendo CE, Greenberg RA, Flaherty KT, Rathmell WK, Keith B, Simon MC, Nathanson KL (2008) HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma. Cancer Cell 14: 435-446
-
(2008)
Cancer Cell
, vol.14
, pp. 435-446
-
-
Gordan, J.D.1
Lal, P.2
Dondeti, V.R.3
Letrero, R.4
Parekh, K.N.5
Oquendo, C.E.6
Greenberg, R.A.7
Flaherty, K.T.8
Rathmell, W.K.9
Keith, B.10
Simon, M.C.11
Nathanson, K.L.12
-
21
-
-
53749092242
-
Dynamic contrast-enhanced magnetic resonance imaging pharmacodynamic biomarker study of sorafenib in metastatic renal carcinoma
-
Hahn OM, Yang C, Medved M, Karczmar G, Kistner E, Karrison T, Manchen E, Mitchell M, Ratain MJ, Stadler WM (2008) Dynamic contrast-enhanced magnetic resonance imaging pharmacodynamic biomarker study of sorafenib in metastatic renal carcinoma. J Clin Oncol 26: 4572-4578
-
(2008)
J Clin Oncol
, vol.26
, pp. 4572-4578
-
-
Hahn, O.M.1
Yang, C.2
Medved, M.3
Karczmar, G.4
Kistner, E.5
Karrison, T.6
Manchen, E.7
Mitchell, M.8
Ratain, M.J.9
Stadler, W.M.10
-
22
-
-
84875242002
-
Hypertension is associated with clinical outcome for patients(pts) with metastatic renal cell carcinoma (RCC) treated with interferon and bevacizumab on CALGB 90206
-
(abstr 351)
-
Harzstark AL, Halabi S, Stadler WM et al. (2010) Hypertension is associated with clinical outcome for patients(pts) with metastatic renal cell carcinoma (RCC) treated with interferon and bevacizumab on CALGB 90206. Genitourinary Cancer Symposium. (abstr 351)
-
(2010)
Genitourinary Cancer Symposium
-
-
Harzstark, A.L.1
Halabi, S.2
Stadler, W.M.3
-
23
-
-
73349084973
-
Prognostic factors for overall survival in patients with metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted agents: Results from a large, multicenter study
-
Heng DY, Xie W, Regan MM, Warren MA, Golshayan AR, Sahi C, Eigl BJ, Ruether JD, Cheng T, North S, Venner P, Knox JJ, Chi KN, Kollmannsberger C, McDermott DF, Oh WK, Atkins MB, Bukowski RM, Rini BI, Choueiri TK (2009) Prognostic factors for overall survival in patients with metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted agents: results from a large, multicenter study. J Clin Oncol 27: 5794-5799
-
(2009)
J Clin Oncol
, vol.27
, pp. 5794-5799
-
-
Heng, D.Y.1
Xie, W.2
Regan, M.M.3
Warren, M.A.4
Golshayan, A.R.5
Sahi, C.6
Eigl, B.J.7
Ruether, J.D.8
Cheng, T.9
North, S.10
Venner, P.11
Knox, J.J.12
Chi, K.N.13
Kollmannsberger, C.14
McDermott, D.F.15
Oh, W.K.16
Atkins, M.B.17
Bukowski, R.M.18
Rini, B.I.19
Choueiri, T.K.20
more..
-
24
-
-
34547220487
-
MDM2 SNP309 polymorphism as risk factor for susceptibility and poor prognosis in renal cell carcinoma
-
Hirata H, Hinoda Y, Kikuno N, Kawamoto K, Suehiro Y, Tanaka Y, Dahiya R (2007) MDM2 SNP309 polymorphism as risk factor for susceptibility and poor prognosis in renal cell carcinoma. Clin Cancer Res 13: 4123-4129
-
(2007)
Clin Cancer Res
, vol.13
, pp. 4123-4129
-
-
Hirata, H.1
Hinoda, Y.2
Kikuno, N.3
Kawamoto, K.4
Suehiro, Y.5
Tanaka, Y.6
Dahiya, R.7
-
25
-
-
76249133170
-
Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma
-
Huang D, Ding Y, Zhou M, Rini BI, Petillo D, Qian CN, Kahnoski R, Futreal PA, Furge KA, Teh BT (2010) Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma. Cancer Res 70: 1063-1071
-
(2010)
Cancer Res
, vol.70
, pp. 1063-1071
-
-
Huang, D.1
Ding, Y.2
Zhou, M.3
Rini, B.I.4
Petillo, D.5
Qian, C.N.6
Kahnoski, R.7
Futreal, P.A.8
Furge, K.A.9
Teh, B.T.10
-
26
-
-
34249779568
-
Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
-
Hudes G, Carducci M, Tomczak P, Dutcher J, Figlin R, Kapoor A, Staroslawska E, Sosman J, McDermott D, Bodrogi I, Kovacevic Z, Lesovoy V, Schmidt-Wolf IG, Barbarash O, Gokmen E, O'Toole T, Lustgarten S, Moore L, Motzer RJ (2007) Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 356: 2271-2281
-
(2007)
N Engl J Med
, vol.356
, pp. 2271-2281
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
Dutcher, J.4
Figlin, R.5
Kapoor, A.6
Staroslawska, E.7
Sosman, J.8
McDermott, D.9
Bodrogi, I.10
Kovacevic, Z.11
Lesovoy, V.12
Schmidt-Wolf, I.G.13
Barbarash, O.14
Gokmen, E.15
O'Toole, T.16
Lustgarten, S.17
Moore, L.18
Motzer, R.J.19
-
27
-
-
55349124241
-
Biomarker analysis and final efficacy and safety results of a phase II renal cell carcinoma trial with pazopanib (GW786034), a multi-kinase angiogenesis inhibitor
-
Hutson TE, Davis I, Machiels JH, de Souza PL, Baker K, Bordogna W, Westlund R, Crofts T, Pandite L, Figlin RA (2008) Biomarker analysis and final efficacy and safety results of a phase II renal cell carcinoma trial with pazopanib (GW786034), a multi-kinase angiogenesis inhibitor. J Clin Oncol 26: 5046
-
(2008)
J Clin Oncol
, vol.26
, pp. 5046
-
-
Hutson, T.E.1
Davis, I.2
MacHiels, J.H.3
De Souza, P.L.4
Baker, K.5
Bordogna, W.6
Westlund, R.7
Crofts, T.8
Pandite, L.9
Figlin, R.A.10
-
28
-
-
75749090050
-
Efficacy and safety of pazopanib in patients with metastatic renal cell carcinoma
-
Hutson TE, Davis ID, Machiels JP, De Souza PL, Rottey S, Hong BF, Epstein RJ, Baker KL, McCann L, Crofts T, Pandite L, Figlin RA (2010) Efficacy and safety of pazopanib in patients with metastatic renal cell carcinoma. J Clin Oncol 28: 475-480
-
(2010)
J Clin Oncol
, vol.28
, pp. 475-480
-
-
Hutson, T.E.1
Davis, I.D.2
MacHiels, J.P.3
De Souza, P.L.4
Rottey, S.5
Hong, B.F.6
Epstein, R.J.7
Baker, K.L.8
McCann, L.9
Crofts, T.10
Pandite, L.11
Figlin, R.A.12
-
29
-
-
77953179499
-
Phase II presurgical study of bevacizumab plus erlotinib in untreated patients with metastatic renal cell carcinoma
-
(suppl; abstr 5004)
-
Jonasch E, Tsavachdidou D, Wood CG, Matin SF, Corn PG, Tamboli P, Wang X, Tannir N (2009) Phase II presurgical study of bevacizumab plus erlotinib in untreated patients with metastatic renal cell carcinoma. J Clin Oncol 27: 15s (suppl; abstr 5004)
-
(2009)
J Clin Oncol
, vol.27
-
-
Jonasch, E.1
Tsavachdidou, D.2
Wood, C.G.3
Matin, S.F.4
Corn, P.G.5
Tamboli, P.6
Wang, X.7
Tannir, N.8
-
30
-
-
54549113030
-
The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer
-
Kaelin Jr. WG (2008) The Von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer. Nat Rev Cancer 8: 865-873
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 865-873
-
-
Kaelin Jr., W.G.1
-
31
-
-
80052840491
-
Sequential FDG-PET/CT as a biomarker of response to sunitinib in metastatic clear cell renal cancer
-
Katani I, Avril NE, Bomanji J, Chowdhury S, Rockall A, Sahdev A, Nathan P, Wilson P, Shamash J, Sharpe K, Lim L, Dickson J, Ell P, Reynolds AR, Powles T (2011) Sequential FDG-PET/CT as a biomarker of response to sunitinib in metastatic clear cell renal cancer. Clin Cancer Res 17: 6021-6028
-
(2011)
Clin Cancer Res
, vol.17
, pp. 6021-6028
-
-
Katani, I.1
Avril, N.E.2
Bomanji, J.3
Chowdhury, S.4
Rockall, A.5
Sahdev, A.6
Nathan, P.7
Wilson, P.8
Shamash, J.9
Sharpe, K.10
Lim, L.11
Dickson, J.12
Ell, P.13
Reynolds, A.R.14
Powles, T.15
-
32
-
-
34548256390
-
Associations of single nucleotide polymorphisms in the vascular endothelial growth factor gene with the characteristics and prognosis of renal cell carcinomas
-
Kawai Y, Sakano S, Korenaga Y, Eguchi S, Naito K (2007) Associations of single nucleotide polymorphisms in the vascular endothelial growth factor gene with the characteristics and prognosis of renal cell carcinomas. Eur Urol 52: 1147-1155
-
(2007)
Eur Urol
, vol.52
, pp. 1147-1155
-
-
Kawai, Y.1
Sakano, S.2
Korenaga, Y.3
Eguchi, S.4
Naito, K.5
-
33
-
-
84863338437
-
Association of VEGF and VEGFR2 single nucleotide polymorphisms with hypertension and clinical outcome in metastatic clear cell renal cell carcinoma patients treated with sunitinib
-
Kim JJ, Vaziri SA, Rini BI, Elson P, Garcia JA, Wirka R, Dreicer R, Ganapathi MK, Ganapathi R (2012) Association of VEGF and VEGFR2 single nucleotide polymorphisms with hypertension and clinical outcome in metastatic clear cell renal cell carcinoma patients treated with sunitinib. Cancer 118: 1946-1954
-
(2012)
Cancer
, vol.118
, pp. 1946-1954
-
-
Kim, J.J.1
Vaziri, S.A.2
Rini, B.I.3
Elson, P.4
Garcia, J.A.5
Wirka, R.6
Dreicer, R.7
Ganapathi, M.K.8
Ganapathi, R.9
-
34
-
-
33947545950
-
Interleukin-4 promoter polymorphisms: A genetic prognostic factor for survival in metastatic renal cell carcinoma
-
Kleinrath T, Gassner C, Lackner P, Thurnher M, Ramoner R (2007) Interleukin-4 promoter polymorphisms: a genetic prognostic factor for survival in metastatic renal cell carcinoma. J Clin Oncol 25: 845-851
-
(2007)
J Clin Oncol
, vol.25
, pp. 845-851
-
-
Kleinrath, T.1
Gassner, C.2
Lackner, P.3
Thurnher, M.4
Ramoner, R.5
-
35
-
-
76749170854
-
Metastatic renal cell carcinoma treated with sunitinib: Early evaluation of treatment response using dynamic contrast-enhanced ultrasonography
-
Lassau N, Koscielny S, Albiges L, Chami L, Benatsou B, Chebil M, Roche A, Escudier BJ (2010) Metastatic renal cell carcinoma treated with sunitinib: early evaluation of treatment response using dynamic contrast-enhanced ultrasonography. Clin Cancer Res 16: 1216-1225
-
(2010)
Clin Cancer Res
, vol.16
, pp. 1216-1225
-
-
Lassau, N.1
Koscielny, S.2
Albiges, L.3
Chami, L.4
Benatsou, B.5
Chebil, M.6
Roche, A.7
Escudier, B.J.8
-
36
-
-
84861768887
-
Increase in cholesterol predicts survival advantage in renal cell carcinoma patients treated with temsirolimus
-
Lee CK, Marschner I, Simes J, Voysey M, Egleston BL, Hudes G, de Souza PL (2012a) Increase in cholesterol predicts survival advantage in renal cell carcinoma patients treated with temsirolimus. Clin Cancer Res 18: 3188-3196
-
(2012)
Clin Cancer Res
, vol.18
, pp. 3188-3196
-
-
Lee, C.K.1
Marschner, I.2
Simes, J.3
Voysey, M.4
Egleston, B.L.5
Hudes, G.6
De Souza, P.L.7
-
37
-
-
84864922628
-
Multicenter phase II study of sunitinib in patients with non-clear cell renal cell carcinoma
-
Lee JL, Ahn JH, Lim HY, Park SH, Lee SH, Kim TM, Lee DH, Cho YM, Song C, Hong JH, Kim CS, Ahn H (2012b) Multicenter phase II study of sunitinib in patients with non-clear cell renal cell carcinoma. Ann Oncol 23: 2108-2114
-
(2012)
Ann Oncol
, vol.23
, pp. 2108-2114
-
-
Lee, J.L.1
Ahn, J.H.2
Lim, H.Y.3
Park, S.H.4
Lee, S.H.5
Kim, T.M.6
Lee, D.H.7
Cho, Y.M.8
Song, C.9
Hong, J.H.10
Kim, C.S.11
Ahn, H.12
-
38
-
-
0345098465
-
Scoring algorithm to predict survival after nephrectomy and immunotherapy in patients with metastatic renal cell carcinoma: A stratification tool for prospective clinical trials
-
Leibovich BC, Han KR, Bui MH, Pantuck AJ, Dorey FJ, Figlin RA, Belldegrun A (2003) Scoring algorithm to predict survival after nephrectomy and immunotherapy in patients with metastatic renal cell carcinoma: a stratification tool for prospective clinical trials. Cancer 98: 2566-2575
-
(2003)
Cancer
, vol.98
, pp. 2566-2575
-
-
Leibovich, B.C.1
Han, K.R.2
Bui, M.H.3
Pantuck, A.J.4
Dorey, F.J.5
Figlin, R.A.6
Belldegrun, A.7
-
39
-
-
66849095262
-
[18F] fluorodeoxyglucose positron emission tomography correlates with Akt pathway activity but is not predictive of clinical outcome during mTOR inhibitor therapy
-
Ma WW, Jacene H, Song D, Vilardell F, Messersmith WA, Laheru D, Wahl R, Endres C, Jimeno A, Pomper MG, Hidalgo M (2009) [18F]fluorodeoxyglucose positron emission tomography correlates with Akt pathway activity but is not predictive of clinical outcome during mTOR inhibitor therapy. J Clin Oncol 27: 2697-2704
-
(2009)
J Clin Oncol
, vol.27
, pp. 2697-2704
-
-
Ma, W.W.1
Jacene, H.2
Song, D.3
Vilardell, F.4
Messersmith, W.A.5
Laheru, D.6
Wahl, R.7
Endres, C.8
Jimeno, A.9
Pomper, M.G.10
Hidalgo, M.11
-
40
-
-
78650630648
-
The high-dose aldesleukin (HD IL-2 'SELECT' trial in patients with metastatic renal cell carcinoma
-
(suppl; abstr 4514)
-
McDermott DF, Ghebremichael MS, Signoretti S, Margolin KA, Clark J, Sosman JA, Dutcher JP, Logan T, Figlin RA, Atkins MB (2010) The high-dose aldesleukin (HD IL-2) 'SELECT' trial in patients with metastatic renal cell carcinoma. J Clin Oncol 28: 15s (suppl; abstr 4514)
-
(2010)
J Clin Oncol
, vol.28
-
-
McDermott, D.F.1
Ghebremichael, M.S.2
Signoretti, S.3
Margolin, K.A.4
Clark, J.5
Sosman, J.A.6
Dutcher, J.P.7
Logan, T.8
Figlin, R.A.9
Atkins, M.B.10
-
41
-
-
80054999231
-
Hand-foot syndrome as a potential biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib
-
(suppl 7; abstract 320)
-
Michaelson MD, Cohen DP, Li S, Motzer RJ, Escudier B, Barrios CH, Burnett PE, Puzanov I (2011) Hand-foot syndrome as a potential biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib. J Clin Oncol 29(suppl 7; abstract 320)
-
(2011)
J Clin Oncol
, vol.29
-
-
Michaelson, M.D.1
Cohen, D.P.2
Li, S.3
Motzer, R.J.4
Escudier, B.5
Barrios, C.H.6
Burnett, P.E.7
Puzanov, I.8
-
42
-
-
0036138580
-
Interferonalfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma
-
Motzer RJ, Bacik J, Murphy BA, Russo P, Mazumdar M (2002) Interferonalfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol 20: 289-296
-
(2002)
J Clin Oncol
, vol.20
, pp. 289-296
-
-
Motzer, R.J.1
Bacik, J.2
Murphy, B.A.3
Russo, P.4
Mazumdar, M.5
-
43
-
-
60649106195
-
Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
-
Paez-Ribes M, Allen E, Hudock J, Takeda T, Okuyama H, Vinals F, Inoue M, Bergers G, Hanahan D, Casanovas O (2009) Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 15: 220-231
-
(2009)
Cancer Cell
, vol.15
, pp. 220-231
-
-
Paez-Ribes, M.1
Allen, E.2
Hudock, J.3
Takeda, T.4
Okuyama, H.5
Vinals, F.6
Inoue, M.7
Bergers, G.8
Hanahan, D.9
Casanovas, O.10
-
44
-
-
65349119014
-
Hypoxia-inducible factor (HIF) 1a and 2a levels in cell lines and human tumor predicts response to sunitinib in renal cell carcinoma (RCC
-
(suppl; abstr 5008)
-
Patel PH, Chadalavada RS, Ishill NM, Patil S, Reuter VE, Motzer RJ, Chaganti RS (2008) Hypoxia-inducible factor (HIF) 1a and 2a levels in cell lines and human tumor predicts response to sunitinib in renal cell carcinoma (RCC). J Clin Oncol 26: 15s (suppl; abstr 5008)
-
(2008)
J Clin Oncol
, vol.26
-
-
Patel, P.H.1
Chadalavada, R.S.2
Ishill, N.M.3
Patil, S.4
Reuter, V.E.5
Motzer, R.J.6
Chaganti, R.S.7
-
45
-
-
77957570088
-
Biomarkers predicting outcome in patients with advanced renal cell carcinoma: Results from sorafenib phase III Treatment Approaches in Renal Cancer Global Evaluation Trial
-
Pena C, Lathia C, Shan M, Escudier B, Bukowski RM (2010) Biomarkers predicting outcome in patients with advanced renal cell carcinoma: Results from sorafenib phase III Treatment Approaches in Renal Cancer Global Evaluation Trial. Clin Cancer Res 16: 4853-4863
-
(2010)
Clin Cancer Res
, vol.16
, pp. 4853-4863
-
-
Pena, C.1
Lathia, C.2
Shan, M.3
Escudier, B.4
Bukowski, R.M.5
-
46
-
-
77951093888
-
Predictive value of baseline serum vascular endothelial growth factor and neutrophil gelatinase-associated lipocalin in advanced kidney cancer patients receiving sunitinib
-
Porta C, Paglino C, De Amici M, Quaglini S, Sacchi L, Imarisio I, Canipari C (2010) Predictive value of baseline serum vascular endothelial growth factor and neutrophil gelatinase-associated lipocalin in advanced kidney cancer patients receiving sunitinib. Kidney Int 77: 809-815
-
(2010)
Kidney Int
, vol.77
, pp. 809-815
-
-
Porta, C.1
Paglino, C.2
De Amici, M.3
Quaglini, S.4
Sacchi, L.5
Imarisio, I.6
Canipari, C.7
-
47
-
-
84866913949
-
Carbonic anhydrase IX (CAIX) as a potential biomarker of efficacy in metastatic clear-cell renal cell carcinoma (mccRCC) in patients (pts) receiving sorafenib: Analysis of a randomized controlled trial (TARGET
-
(suppl 5; abstr 352)
-
Qu AQ, Cheng S, Atkins MB, Signoretti S, Choueiri TK (2012) Carbonic anhydrase IX (CAIX) as a potential biomarker of efficacy in metastatic clear-cell renal cell carcinoma (mccRCC) in patients (pts) receiving sorafenib: Analysis of a randomized controlled trial (TARGET). J Clin Oncol 30 (suppl 5; abstr 352)
-
(2012)
J Clin Oncol
, vol.30
-
-
Qu, A.Q.1
Cheng, S.2
Atkins, M.B.3
Signoretti, S.4
Choueiri, T.K.5
-
48
-
-
79955767772
-
Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib
-
Rini BI, Cohen DP, Lu DR, Chen I, Hariharan S, Gore ME, Figlin RA, Baum MS, Motzer RJ (2011a) Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib. J Natl Cancer Inst 103: 763-773
-
(2011)
J Natl Cancer Inst
, vol.103
, pp. 763-773
-
-
Rini, B.I.1
Cohen, D.P.2
Lu, D.R.3
Chen, I.4
Hariharan, S.5
Gore, M.E.6
Figlin, R.A.7
Baum, M.S.8
Motzer, R.J.9
-
49
-
-
49249087039
-
Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma
-
Rini BI, Michaelson MD, Rosenberg JE, Bukowski RM, Sosman JA, Stadler WM, Hutson TE, Margolin K, Harmon CS, DePrimo SE, Kim ST, Chen I, George DJ (2008) Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma. J Clin Oncol 26: 3743-3748
-
(2008)
J Clin Oncol
, vol.26
, pp. 3743-3748
-
-
Rini, B.I.1
Michaelson, M.D.2
Rosenberg, J.E.3
Bukowski, R.M.4
Sosman, J.A.5
Stadler, W.M.6
Hutson, T.E.7
Margolin, K.8
Harmon, C.S.9
Deprimo, S.E.10
Kim, S.T.11
Chen, I.12
George, D.J.13
-
50
-
-
79957909038
-
Diastolic blood pressure as a biomarker of axitinib efficacy in solid tumors
-
Rini BI, Zhou M, Schiller JH, Fruehauf JP, Cohen EE, Tarazi JC, Rosbrook B, Bair AH, Ricart AD, Olszanski AJ, Letrent KJ, Kim S, Rixe O (2011b) Diastolic blood pressure as a biomarker of axitinib efficacy in solid tumors. Clin Cancer Res 17: 3841-3849
-
(2011)
Clin Cancer Res
, vol.17
, pp. 3841-3849
-
-
Rini, B.I.1
Zhou, M.2
Schiller, J.H.3
Fruehauf, J.P.4
Cohen, E.E.5
Tarazi, J.C.6
Rosbrook, B.7
Bair, A.H.8
Ricart, A.D.9
Olszanski, A.J.10
Letrent, K.J.11
Kim, S.12
Rixe, O.13
-
51
-
-
77957980222
-
Identification of prognostic genomic markers in patients with localized clear cell renal cell carcinoma
-
(suppl; abstr 4501)
-
Rini BIZM, Aydin H, Elson P, Maddala T, Knezevic D, Parodi L, Bukowski RM, Novotny WF, Cowens JW (2010) Identification of prognostic genomic markers in patients with localized clear cell renal cell carcinoma. J Clin Oncol 28: 15s (suppl; abstr 4501)
-
(2010)
J Clin Oncol
, vol.28
-
-
Bizm, R.1
Aydin, H.2
Elson, P.3
Maddala, T.4
Knezevic, D.5
Parodi, L.6
Bukowski, R.M.7
Novotny, W.F.8
Cowens, J.W.9
-
52
-
-
53749093040
-
Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100
-
Schneider BP, Wang M, Radovich M, Sledge GW, Badve S, Thor A, Flockhart DA, Hancock B, Davidson N, Gralow J, Dickler M, Perez EA, Cobleigh M, Shenkier T, Edgerton S, Miller KD (2008) Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100. J Clin Oncol 26: 4672-4678
-
(2008)
J Clin Oncol
, vol.26
, pp. 4672-4678
-
-
Schneider, B.P.1
Wang, M.2
Radovich, M.3
Sledge, G.W.4
Badve, S.5
Thor, A.6
Flockhart, D.A.7
Hancock, B.8
Davidson, N.9
Gralow, J.10
Dickler, M.11
Perez, E.A.12
Cobleigh, M.13
Shenkier, T.14
Edgerton, S.15
Miller, K.D.16
-
53
-
-
18844386435
-
Histologic predictors of renal cell carcinoma response to interleukin-2-based therapy
-
Upton MP, Parker RA, Youmans A, McDermott DF, Atkins MB (2005) Histologic predictors of renal cell carcinoma response to interleukin-2-based therapy. J Immunother 28: 488-495
-
(2005)
J Immunother
, vol.28
, pp. 488-495
-
-
Upton, M.P.1
Parker, R.A.2
Youmans, A.3
McDermott, D.F.4
Atkins, M.B.5
-
54
-
-
58149269742
-
Extensions to decision curve analysis, a novel method for evaluating diagnostic tests, prediction models and molecular markers
-
Vickers AJ, Cronin AM, Elkin EB, Gonen M (2008) Extensions to decision curve analysis, a novel method for evaluating diagnostic tests, prediction models and molecular markers. BMC Med Inform Decis Mak 8: 53
-
(2008)
BMC Med Inform Decis Mak
, vol.8
, pp. 53
-
-
Vickers, A.J.1
Cronin, A.M.2
Elkin, E.B.3
Gonen, M.4
-
55
-
-
79959316184
-
Pazopanib efficacy in renal cell carcinoma: Evidence for predictive genetic markers in angiogenesis-related and exposure-related genes
-
Xu CF, Bing NX, Ball HA, Rajagopalan D, Sternberg CN, Hutson TE, de Souza P, Xue ZG, McCann L, King KS, Ragone LJ, Whittaker JC, Spraggs CF, Cardon LR, Mooser VE, Pandite LN (2011) Pazopanib efficacy in renal cell carcinoma: evidence for predictive genetic markers in angiogenesis-related and exposure-related genes. J Clin Oncol 29: 2557-2564
-
(2011)
J Clin Oncol
, vol.29
, pp. 2557-2564
-
-
Xu, C.F.1
Bing, N.X.2
Ball, H.A.3
Rajagopalan, D.4
Sternberg, C.N.5
Hutson, T.E.6
De Souza, P.7
Xue, Z.G.8
McCann, L.9
King, K.S.10
Ragone, L.J.11
Whittaker, J.C.12
Spraggs, C.F.13
Cardon, L.R.14
Mooser, V.E.15
Pandite, L.N.16
-
56
-
-
84855173597
-
A cytokine and angiogenic factor (CAF) analysis in plasma for selection of sorafenib therapy in patients with metastatic renal cell carcinoma
-
Zurita AJ, Jonasch E, Wang X, Khajavi M, Yan S, Du DZ, Xu L, Herynk MH, McKee KS, Tran HT, Logothetis CJ, Tannir NM, Heymach JV (2012) A cytokine and angiogenic factor (CAF) analysis in plasma for selection of sorafenib therapy in patients with metastatic renal cell carcinoma. Ann Oncol 23: 46-52
-
(2012)
Ann Oncol
, vol.23
, pp. 46-52
-
-
Zurita, A.J.1
Jonasch, E.2
Wang, X.3
Khajavi, M.4
Yan, S.5
Du, D.Z.6
Xu, L.7
Herynk, M.H.8
McKee, K.S.9
Tran, H.T.10
Logothetis, C.J.11
Tannir, N.M.12
Heymach, J.V.13
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