-
1
-
-
84863922124
-
Comprehensive molecular characterization of human colon and rectal cancer
-
Network TCGA.Comprehensive molecular characterization of human colon and rectal cancer.Nature. 2012;487:330-7.
-
(2012)
Nature
, vol.487
, pp. 330-337
-
-
Network, T.C.G.A.1
-
2
-
-
0030975671
-
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
-
Korinek V,Barker N,Morin PJ,van Wichen D,de Weger R,Kinzler KW,Vogelstein B,Clevers H.Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma.Science. 1997;275:1784-7.
-
(1997)
Science
, vol.275
, pp. 1784-1787
-
-
Korinek, V.1
Barker, N.2
Morin, P.J.3
van Wichen, D.4
de Weger, R.5
Kinzler, K.W.6
Vogelstein, B.7
Clevers, H.8
-
3
-
-
0030592517
-
Lessons from hereditary colorectal cancer
-
Kinzler KW,Vogelstein B.Lessons from hereditary colorectal cancer.Cell. 1996;87:159-70.
-
(1996)
Cell
, vol.87
, pp. 159-170
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
4
-
-
79957467315
-
Molecular identification and targeting of colorectal cancer stem cells
-
Kemper K,Grandela C,Medema JP.Molecular identification and targeting of colorectal cancer stem cells.Oncotarget. 2010;1:387-95.
-
(2010)
Oncotarget
, vol.1
, pp. 387-395
-
-
Kemper, K.1
Grandela, C.2
Medema, J.P.3
-
6
-
-
84861194295
-
Cancer stem cells and metastasis
-
Sampieri K,Fodde R.Cancer stem cells and metastasis.Semin Cancer Biol. 2012;22:187-93.
-
(2012)
Semin Cancer Biol
, vol.22
, pp. 187-193
-
-
Sampieri, K.1
Fodde, R.2
-
7
-
-
84862517728
-
Cancer stem cells: current status and evolving complexities
-
Visvader JE,Lindeman GJ.Cancer stem cells: current status and evolving complexities.Cell Stem Cell. 2012;10:717-28.
-
(2012)
Cell Stem Cell
, vol.10
, pp. 717-728
-
-
Visvader, J.E.1
Lindeman, G.J.2
-
8
-
-
79959238013
-
Microenvironmental regulation of stem cells in intestinal homeostasis and cancer
-
Medema JP,Vermeulen L.Microenvironmental regulation of stem cells in intestinal homeostasis and cancer.Nature. 2011;474:318-26.
-
(2011)
Nature
, vol.474
, pp. 318-326
-
-
Medema, J.P.1
Vermeulen, L.2
-
10
-
-
79957989939
-
Drug discovery approaches to target Wnt signaling in cancer stem cells
-
Curtin JC,Lorenzi MV.Drug discovery approaches to target Wnt signaling in cancer stem cells.Oncotarget. 2012;1:563-77.
-
(2012)
Oncotarget
, vol.1
, pp. 563-577
-
-
Curtin, J.C.1
Lorenzi, M.V.2
-
11
-
-
77951975325
-
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
-
Vermeulen L,De Sousa EMF,van der Heijden M,Cameron K,de Jong JH,Borovski T,Tuynman JB,Todaro M,Merz C,Rodermond H,Sprick MR,Kemper K,Richel DJ,Stassi G,Medema JP.Wnt activity defines colon cancer stem cells and is regulated by the microenvironment.Nat Cell Biol. 2010;12:468-76.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 468-476
-
-
Vermeulen, L.1
de Sousa, E.M.F.2
van der Heijden, M.3
Cameron, K.4
de Jong, J.H.5
Borovski, T.6
Tuynman, J.B.7
Todaro, M.8
Merz, C.9
Rodermond, H.10
Sprick, M.R.11
Kemper, K.12
Richel, D.J.13
Stassi, G.14
Medema, J.P.15
-
12
-
-
84864877553
-
Wnt/beta-catenin signalling in prostate cancer
-
Kypta RM,Waxman J.Wnt/beta-catenin signalling in prostate cancer.Nat Rev Urol. 2012;9:418-28.
-
(2012)
Nat Rev Urol
, vol.9
, pp. 418-428
-
-
Kypta, R.M.1
Waxman, J.2
-
13
-
-
84859032134
-
Small molecule antagonists of the Wnt/beta-catenin signaling pathway target breast tumor-initiating cells in a Her2/Neu mouse model of breast cancer
-
Hallett RM,Kondratyev MK,Giacomelli AO,Nixon AM,Girgis-Gabardo A,Ilieva D,Hassell JA.Small molecule antagonists of the Wnt/beta-catenin signaling pathway target breast tumor-initiating cells in a Her2/Neu mouse model of breast cancer.PLoS One. 2012;7:e33976-e33976.
-
(2012)
PLoS One
, vol.7
-
-
Hallett, R.M.1
Kondratyev, M.K.2
Giacomelli, A.O.3
Nixon, A.M.4
Girgis-Gabardo, A.5
Ilieva, D.6
Hassell, J.A.7
-
14
-
-
85027928015
-
Wnt pathway activity confers chemoresistance to cancer stem-like cells in a neuroblastoma cell line
-
Vangipuram SD,Buck SA,Lyman WD.Wnt pathway activity confers chemoresistance to cancer stem-like cells in a neuroblastoma cell line.Tumour Biol. 2012;33:2173-83.
-
(2012)
Tumour Biol
, vol.33
, pp. 2173-2183
-
-
Vangipuram, S.D.1
Buck, S.A.2
Lyman, W.D.3
-
15
-
-
84859612119
-
Nuclear translocation of beta-catenin during mesenchymal stem cells differentiation into hepatocytes is associated with a tumoral phenotype
-
Herencia C,Martinez-Moreno JM,Herrera C,Corrales F,Santiago-Mora R,Espejo I,Barco M,Almaden Y,de la Mata M,Rodriguez-Ariza A,Munoz-Castaneda JR.Nuclear translocation of beta-catenin during mesenchymal stem cells differentiation into hepatocytes is associated with a tumoral phenotype.PLoS One. 2012;7:e34656-e34656.
-
(2012)
PLoS One
, vol.7
-
-
Herencia, C.1
Martinez-Moreno, J.M.2
Herrera, C.3
Corrales, F.4
Santiago-Mora, R.5
Espejo, I.6
Barco, M.7
Almaden, Y.8
de la Mata, M.9
Rodriguez-Ariza, A.10
Munoz-Castaneda, J.R.11
-
16
-
-
84863756127
-
Wnt signaling, stem cells, and cancer of the gastrointestinal tract
-
Schepers A,Clevers H.Wnt signaling, stem cells, and cancer of the gastrointestinal tract.Cold Spring Harb Perspect Biol. 2012;4:a007989-a007989.
-
(2012)
Cold Spring Harb Perspect Biol
, vol.4
-
-
Schepers, A.1
Clevers, H.2
-
17
-
-
84862170024
-
Drugging Wnt signalling in cancer
-
Polakis P.Drugging Wnt signalling in cancer.EMBO J. 2012;31:2737-46.
-
(2012)
EMBO J
, vol.31
, pp. 2737-2746
-
-
Polakis, P.1
-
19
-
-
4544286987
-
Repression of the vertebrate organizer by Wnt8 is mediated by Vent and Vox
-
Ramel MC,Lekven AC.Repression of the vertebrate organizer by Wnt8 is mediated by Vent and Vox.Development. 2004;131:3991-4000.
-
(2004)
Development
, vol.131
, pp. 3991-4000
-
-
Ramel, M.C.1
Lekven, A.C.2
-
20
-
-
0034787347
-
Wnt8 is required in lateral mesendodermal precursors for neural posteriorization in vivo
-
Erter CE,Wilm TP,Basler N,Wright CV,Solnica-Krezel L.Wnt8 is required in lateral mesendodermal precursors for neural posteriorization in vivo.Development. 2001;128:3571-83.
-
(2001)
Development
, vol.128
, pp. 3571-3583
-
-
Erter, C.E.1
Wilm, T.P.2
Basler, N.3
Wright, C.V.4
Solnica-Krezel, L.5
-
21
-
-
0034098352
-
The homeobox gene bozozok promotes anterior neuroectoderm formation in zebrafish through negative regulation of BMP2/4 and Wnt pathways
-
Fekany-Lee K,Gonzalez E,Miller-Bertoglio V,Solnica-Krezel L.The homeobox gene bozozok promotes anterior neuroectoderm formation in zebrafish through negative regulation of BMP2/4 and Wnt pathways.Development. 2000;127:2333-45.
-
(2000)
Development
, vol.127
, pp. 2333-2345
-
-
Fekany-Lee, K.1
Gonzalez, E.2
Miller-Bertoglio, V.3
Solnica-Krezel, L.4
-
22
-
-
0035404840
-
Zebrafish wnt8 encodes two wnt8 proteins on a bicistronic transcript and is required for mesoderm and neurectoderm patterning
-
Lekven AC,Thorpe CJ,Waxman JS,Moon RT.Zebrafish wnt8 encodes two wnt8 proteins on a bicistronic transcript and is required for mesoderm and neurectoderm patterning.Dev Cell. 2001;1:103-14.
-
(2001)
Dev Cell
, vol.1
, pp. 103-114
-
-
Lekven, A.C.1
Thorpe, C.J.2
Waxman, J.S.3
Moon, R.T.4
-
23
-
-
33749023005
-
Identification of Clostridium difficile toxin B cardiotoxicity using a zebrafish embryo model of intoxication
-
Hamm EE,Voth DE,Ballard JD.Identification of Clostridium difficile toxin B cardiotoxicity using a zebrafish embryo model of intoxication.Proc Natl Acad Sci U S A. 2006;103:14176-81.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 14176-14181
-
-
Hamm, E.E.1
Voth, D.E.2
Ballard, J.D.3
-
24
-
-
79955107544
-
Zebrafish for drug toxicity screening: bridging the in vitro cell-based models and in vivo mammalian models
-
Sukardi H,Chng HT,Chan EC,Gong Z,Lam SH.Zebrafish for drug toxicity screening: bridging the in vitro cell-based models and in vivo mammalian models.Expert Opin Drug Metab Toxicol. 2011;7:579-89.
-
(2011)
Expert Opin Drug Metab Toxicol
, vol.7
, pp. 579-589
-
-
Sukardi, H.1
Chng, H.T.2
Chan, E.C.3
Gong, Z.4
Lam, S.H.5
-
25
-
-
74049121905
-
Fishing for intestinal cancer models: unraveling gastrointestinal homeostasis and tumorigenesis in zebrafish
-
Faro A,Boj SF,Clevers H.Fishing for intestinal cancer models: unraveling gastrointestinal homeostasis and tumorigenesis in zebrafish.Zebrafish. 2009;6:361-76.
-
(2009)
Zebrafish
, vol.6
, pp. 361-376
-
-
Faro, A.1
Boj, S.F.2
Clevers, H.3
-
26
-
-
77951986098
-
A novel Wilms tumor 1 (WT1) target gene negatively regulates the WNT signaling pathway
-
Kim MS,Yoon SK,Bollig F,Kitagaki J,Hur W,Whye NJ,Wu YP,Rivera MN,Park JY,Kim HS,Malik K,Bell DW,Englert C,Perantoni AO,Lee SB.A novel Wilms tumor 1 (WT1) target gene negatively regulates the WNT signaling pathway.J Biol Chem. 2010;285:14585-93.
-
(2010)
J Biol Chem
, vol.285
, pp. 14585-14593
-
-
Kim, M.S.1
Yoon, S.K.2
Bollig, F.3
Kitagaki, J.4
Hur, W.5
Whye, N.J.6
Wu, Y.P.7
Rivera, M.N.8
Park, J.Y.9
Kim, H.S.10
Malik, K.11
Bell, D.W.12
Englert, C.13
Perantoni, A.O.14
Lee, S.B.15
-
27
-
-
44349147745
-
Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet-Biedl syndrome
-
Tobin JL,Di Franco M,Eichers E,May-Simera H,Garcia M,Yan J,Quinlan R,Justice MJ,Hennekam RC,Briscoe J,Tada M,Mayor R,Burns AJ,Lupski JR,Hammond P,Beales PL.Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet-Biedl syndrome.Proc Natl Acad Sci U S A. 2008;105:6714-9.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 6714-6719
-
-
Tobin, J.L.1
Di Franco, M.2
Eichers, E.3
May-Simera, H.4
Garcia, M.5
Yan, J.6
Quinlan, R.7
Justice, M.J.8
Hennekam, R.C.9
Briscoe, J.10
Tada, M.11
Mayor, R.12
Burns, A.J.13
Lupski, J.R.14
Hammond, P.15
Beales, P.L.16
-
28
-
-
45849104800
-
LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin
-
Cselenyi CS,Jernigan KK,Tahinci E,Thorne CA,Lee LA,Lee E.LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin.Proc Natl Acad Sci U S A. 2008;105:8032-7.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 8032-8037
-
-
Cselenyi, C.S.1
Jernigan, K.K.2
Tahinci, E.3
Thorne, C.A.4
Lee, L.A.5
Lee, E.6
-
29
-
-
77954685213
-
Regulation of Lrp6 phosphorylation
-
Niehrs C,Shen J.Regulation of Lrp6 phosphorylation.Cell Mol Life Sci. 2010;67:2551-62.
-
(2010)
Cell Mol Life Sci
, vol.67
, pp. 2551-2562
-
-
Niehrs, C.1
Shen, J.2
-
30
-
-
67650230896
-
Wnt/beta-catenin signaling: components, mechanisms, and diseases
-
MacDonald BT,Tamai K,He X.Wnt/beta-catenin signaling: components, mechanisms, and diseases.Dev Cell. 2009;17:9-26.
-
(2009)
Dev Cell
, vol.17
, pp. 9-26
-
-
MacDonald, B.T.1
Tamai, K.2
He, X.3
-
31
-
-
16844386134
-
Wnt/frizzled signaling during vertebrate retinal development
-
Van Raay TJ,Vetter ML.Wnt/frizzled signaling during vertebrate retinal development.Dev Neurosci. 2004;26:352-8.
-
(2004)
Dev Neurosci
, vol.26
, pp. 352-358
-
-
van Raay, T.J.1
Vetter, M.L.2
-
32
-
-
17244376814
-
Wnt signalling in stem cells and cancer
-
Reya T,Clevers H.Wnt signalling in stem cells and cancer.Nature. 2005;434:843-50.
-
(2005)
Nature
, vol.434
, pp. 843-850
-
-
Reya, T.1
Clevers, H.2
-
33
-
-
42549164807
-
Wnt signalling and its impact on development and cancer
-
Klaus A,Birchmeier W.Wnt signalling and its impact on development and cancer.Nat Rev Cancer. 2008;8:387-98.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 387-398
-
-
Klaus, A.1
Birchmeier, W.2
-
35
-
-
0036148208
-
Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway
-
Jho EH,Zhang T,Domon C,Joo CK,Freund JN,Costantini F.Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway.Mol Cell Biol. 2002;22:1172-83.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 1172-1183
-
-
Jho, E.H.1
Zhang, T.2
Domon, C.3
Joo, C.K.4
Freund, J.N.5
Costantini, F.6
-
36
-
-
0037077266
-
Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling
-
Leung JY,Kolligs FT,Wu R,Zhai Y,Kuick R,Hanash S,Cho KR,Fearon ER.Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling.J Biol Chem. 2002;277:21657-65.
-
(2002)
J Biol Chem
, vol.277
, pp. 21657-21665
-
-
Leung, J.Y.1
Kolligs, F.T.2
Wu, R.3
Zhai, Y.4
Kuick, R.5
Hanash, S.6
Cho, K.R.7
Fearon, E.R.8
-
37
-
-
0035370984
-
Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling
-
Wharton KA,Zimmermann G,Rousset R,Scott MP.Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling.Dev Biol. 2001;234:93-106.
-
(2001)
Dev Biol
, vol.234
, pp. 93-106
-
-
Wharton, K.A.1
Zimmermann, G.2
Rousset, R.3
Scott, M.P.4
-
38
-
-
0035957382
-
Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd
-
Yan D,Wallingford JB,Sun TQ,Nelson AM,Sakanaka C,Reinhard C,Harland RM,Fantl WJ,Williams LT.Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd.Proc Natl Acad Sci U S A. 2001;98:3802-7.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 3802-3807
-
-
Yan, D.1
Wallingford, J.B.2
Sun, T.Q.3
Nelson, A.M.4
Sakanaka, C.5
Reinhard, C.6
Harland, R.M.7
Fantl, W.J.8
Williams, L.T.9
-
39
-
-
18244389736
-
Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta -catenin signaling is activated in human colon tumors
-
Yan D,Wiesmann M,Rohan M,Chan V,Jefferson AB,Guo L,Sakamoto D,Caothien RH,Fuller JH,Reinhard C,Garcia PD,Randazzo FM,Escobedo J,Fantl WJ,Williams LT.Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta -catenin signaling is activated in human colon tumors.Proc Natl Acad Sci U S A. 2001;98:14973-8.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 14973-14978
-
-
Yan, D.1
Wiesmann, M.2
Rohan, M.3
Chan, V.4
Jefferson, A.B.5
Guo, L.6
Sakamoto, D.7
Caothien, R.H.8
Fuller, J.H.9
Reinhard, C.10
Garcia, P.D.11
Randazzo, F.M.12
Escobedo, J.13
Fantl, W.J.14
Williams, L.T.15
-
40
-
-
34548400802
-
Zebrafish Naked1 and Naked2 antagonize both canonical and non-canonical Wnt signaling
-
Van Raay TJ,Coffey RJ,Solnica-Krezel L.Zebrafish Naked1 and Naked2 antagonize both canonical and non-canonical Wnt signaling.Dev Biol. 2007;309:151-68.
-
(2007)
Dev Biol
, vol.309
, pp. 151-168
-
-
van Raay, T.J.1
Coffey, R.J.2
Solnica-Krezel, L.3
-
41
-
-
64549129564
-
Developmental gene regulatory networks in the zebrafish embryo
-
Chan TM,Longabaugh W,Bolouri H,Chen HL,Tseng WF,Chao CH,Jang TH,Lin YI,Hung SC,Wang HD,Yuh CH.Developmental gene regulatory networks in the zebrafish embryo.Biochim Biophys Acta. 2009;1789:279-98.
-
(2009)
Biochim Biophys Acta
, vol.1789
, pp. 279-298
-
-
Chan, T.M.1
Longabaugh, W.2
Bolouri, H.3
Chen, H.L.4
Tseng, W.F.5
Chao, C.H.6
Jang, T.H.7
Lin, Y.I.8
Hung, S.C.9
Wang, H.D.10
Yuh, C.H.11
-
43
-
-
33646155329
-
Essential and opposing roles of zebrafish beta-catenins in the formation of dorsal axial structures and neurectoderm
-
Bellipanni G,Varga M,Maegawa S,Imai Y,Kelly C,Myers AP,Chu F,Talbot WS,Weinberg ES.Essential and opposing roles of zebrafish beta-catenins in the formation of dorsal axial structures and neurectoderm.Development. 2006;133:1299-1309.
-
(2006)
Development
, vol.133
, pp. 1299-1309
-
-
Bellipanni, G.1
Varga, M.2
Maegawa, S.3
Imai, Y.4
Kelly, C.5
Myers, A.P.6
Chu, F.7
Talbot, W.S.8
Weinberg, E.S.9
-
44
-
-
0034984056
-
A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon
-
Heisenberg CP,Houart C,Take-Uchi M,Rauch GJ,Young N,Coutinho P,Masai I,Caneparo L,Concha ML,Geisler R,Dale TC,Wilson SW,Stemple DL.A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon.Genes Dev. 2001;15:1427-34.
-
(2001)
Genes Dev
, vol.15
, pp. 1427-1434
-
-
Heisenberg, C.P.1
Houart, C.2
Take-Uchi, M.3
Rauch, G.J.4
Young, N.5
Coutinho, P.6
Masai, I.7
Caneparo, L.8
Concha, M.L.9
Geisler, R.10
Dale, T.C.11
Wilson, S.W.12
Stemple, D.L.13
-
45
-
-
0034755394
-
Ectopic Wnt signal determines the eyeless phenotype of zebrafish masterblind mutant
-
van de Water S,van de Wetering M,Joore J,Esseling J,Bink R,Clevers H,Zivkovic D.Ectopic Wnt signal determines the eyeless phenotype of zebrafish masterblind mutant.Development. 2001;128:3877-88.
-
(2001)
Development
, vol.128
, pp. 3877-3888
-
-
van de Water, S.1
van de Wetering, M.2
Joore, J.3
Esseling, J.4
Bink, R.5
Clevers, H.6
Zivkovic, D.7
-
46
-
-
0034687424
-
Repressor activity of Headless/Tcf3 is essential for vertebrate head formation
-
Kim CH,Oda T,Itoh M,Jiang D,Artinger KB,Chandrasekharappa SC,Driever W,Chitnis AB.Repressor activity of Headless/Tcf3 is essential for vertebrate head formation.Nature. 2000;407:913-6.
-
(2000)
Nature
, vol.407
, pp. 913-916
-
-
Kim, C.H.1
Oda, T.2
Itoh, M.3
Jiang, D.4
Artinger, K.B.5
Chandrasekharappa, S.C.6
Driever, W.7
Chitnis, A.B.8
-
47
-
-
21544452772
-
Early stages of zebrafish eye formation require the coordinated activity of Wnt11, Fz5, and the Wnt/beta-catenin pathway
-
Cavodeassi F,Carreira-Barbosa F,Young RM,Concha ML,Allende ML,Houart C,Tada M,Wilson SW.Early stages of zebrafish eye formation require the coordinated activity of Wnt11, Fz5, and the Wnt/beta-catenin pathway.Neuron. 2005;47:43-56.
-
(2005)
Neuron
, vol.47
, pp. 43-56
-
-
Cavodeassi, F.1
Carreira-Barbosa, F.2
Young, R.M.3
Concha, M.L.4
Allende, M.L.5
Houart, C.6
Tada, M.7
Wilson, S.W.8
-
48
-
-
0037382285
-
Analysis of Wnt8 for neural posteriorizing factor by identifying Frizzled 8c and Frizzled 9 as functional receptors for Wnt8
-
Momoi A,Yoda H,Steinbeisser H,Fagotto F,Kondoh H,Kudo A,Driever W,Furutani-Seiki M.Analysis of Wnt8 for neural posteriorizing factor by identifying Frizzled 8c and Frizzled 9 as functional receptors for Wnt8.Mech Dev. 2003;120:477-89.
-
(2003)
Mech Dev
, vol.120
, pp. 477-489
-
-
Momoi, A.1
Yoda, H.2
Steinbeisser, H.3
Fagotto, F.4
Kondoh, H.5
Kudo, A.6
Driever, W.7
Furutani-Seiki, M.8
-
50
-
-
79551600015
-
Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways
-
Takebe N,Harris PJ,Warren RQ,Ivy SP.Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways.Nat Rev Clin Oncol. 2010;8:97-106.
-
(2010)
Nat Rev Clin Oncol
, vol.8
, pp. 97-106
-
-
Takebe, N.1
Harris, P.J.2
Warren, R.Q.3
Ivy, S.P.4
-
51
-
-
79955003400
-
Winning WNT: race to Wnt signaling inhibitors
-
Watanabe K,Dai X.Winning WNT: race to Wnt signaling inhibitors.Proc Natl Acad Sci U S A. 2011;108:5929-30.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 5929-5930
-
-
Watanabe, K.1
Dai, X.2
-
52
-
-
79955046668
-
An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway
-
Gonsalves FC,Klein K,Carson BB,Katz S,Ekas LA,Evans S,Nagourney R,Cardozo T,Brown AM,DasGupta R.An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway.Proc Natl Acad Sci U S A. 2011;108:5954-63.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 5954-5963
-
-
Gonsalves, F.C.1
Klein, K.2
Carson, B.B.3
Katz, S.4
Ekas, L.A.5
Evans, S.6
Nagourney, R.7
Cardozo, T.8
Brown, A.M.9
DasGupta, R.10
-
53
-
-
77955032181
-
A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription
-
Ewan K,Pajak B,Stubbs M,Todd H,Barbeau O,Quevedo C,Botfield H,Young R,Ruddle R,Samuel L,Battersby A,Raynaud F,Allen N,Wilson S,Latinkic B,Workman P,McDonald E,Blagg J,Aherne W,Dale T.A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription.Cancer Res. 2010;70:5963-73.
-
(2010)
Cancer Res
, vol.70
, pp. 5963-5973
-
-
Ewan, K.1
Pajak, B.2
Stubbs, M.3
Todd, H.4
Barbeau, O.5
Quevedo, C.6
Botfield, H.7
Young, R.8
Ruddle, R.9
Samuel, L.10
Battersby, A.11
Raynaud, F.12
Allen, N.13
Wilson, S.14
Latinkic, B.15
Workman, P.16
McDonald, E.17
Blagg, J.18
Aherne, W.19
Dale, T.20
more..
-
54
-
-
1642512639
-
Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex
-
Lepourcelet M,Chen YN,France DS,Wang H,Crews P,Petersen F,Bruseo C,Wood AW,Shivdasani RA.Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex.Cancer Cell. 2004;5:91-102.
-
(2004)
Cancer Cell
, vol.5
, pp. 91-102
-
-
Lepourcelet, M.1
Chen, Y.N.2
France, D.S.3
Wang, H.4
Crews, P.5
Petersen, F.6
Bruseo, C.7
Wood, A.W.8
Shivdasani, R.A.9
-
55
-
-
70349695861
-
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
-
Huang SM,Mishina YM,Liu S,Cheung A,Stegmeier F,Michaud GA,Charlat O,Wiellette E,Zhang Y,Wiessner S,Hild M,Shi X,Wilson CJ,Mickanin C,Myer V,Fazal A,Tomlinson R,Serluca F,Shao W,Cheng H,Shultz M,Rau C,Schirle M,Schlegl J,Ghidelli S,Fawell S,Lu C,Curtis D,Kirschner MW,Lengauer C,Finan PM,Tallarico JA,Bouwmeester T,Porter JA,Bauer A,Cong F.Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.Nature. 2009;461:614-20.
-
(2009)
Nature
, vol.461
, pp. 614-620
-
-
Huang, S.M.1
Mishina, Y.M.2
Liu, S.3
Cheung, A.4
Stegmeier, F.5
Michaud, G.A.6
Charlat, O.7
Wiellette, E.8
Zhang, Y.9
Wiessner, S.10
Hild, M.11
Shi, X.12
Wilson, C.J.13
Mickanin, C.14
Myer, V.15
Fazal, A.16
Tomlinson, R.17
Serluca, F.18
Shao, W.19
Cheng, H.20
Shultz, M.21
Rau, C.22
Schirle, M.23
Schlegl, J.24
Ghidelli, S.25
Fawell, S.26
Lu, C.27
Curtis, D.28
Kirschner, M.W.29
Lengauer, C.30
Finan, P.M.31
Tallarico, J.A.32
Bouwmeester, T.33
Porter, J.A.34
Bauer, A.35
Cong, F.36
more..
-
56
-
-
58249122326
-
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
-
Chen B,Dodge ME,Tang W,Lu J,Ma Z,Fan CW,Wei S,Hao W,Kilgore J,Williams NS,Roth MG,Amatruda JF,Chen C,Lum L.Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.Nat Chem Biol. 2009;5:100-07.
-
(2009)
Nat Chem Biol
, vol.5
, pp. 100-107
-
-
Chen, B.1
Dodge, M.E.2
Tang, W.3
Lu, J.4
Ma, Z.5
Fan, C.W.6
Wei, S.7
Hao, W.8
Kilgore, J.9
Williams, N.S.10
Roth, M.G.11
Amatruda, J.F.12
Chen, C.13
Lum, L.14
-
57
-
-
78651385875
-
Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth
-
Waaler J,Machon O,von Kries JP,Wilson SR,Lundenes E,Wedlich D,Gradl D,Paulsen JE,Machonova O,Dembinski JL,Dinh H,Krauss S.Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth.Cancer Res. 2011;71:197-205.
-
(2011)
Cancer Res
, vol.71
, pp. 197-205
-
-
Waaler, J.1
Machon, O.2
von Kries, J.P.3
Wilson, S.R.4
Lundenes, E.5
Wedlich, D.6
Gradl, D.7
Paulsen, J.E.8
Machonova, O.9
Dembinski, J.L.10
Dinh, H.11
Krauss, S.12
-
58
-
-
79955613593
-
A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/beta-catenin signaling and colon cancer cell tumorigenesis
-
Wang W,Liu H,Wang S,Hao X,Li L.A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/beta-catenin signaling and colon cancer cell tumorigenesis.Cell Res. 2011;21:730-40.
-
(2011)
Cell Res
, vol.21
, pp. 730-740
-
-
Wang, W.1
Liu, H.2
Wang, S.3
Hao, X.4
Li, L.5
-
59
-
-
77955635157
-
Development of small molecules targeting the Wnt pathway for the treatment of colon cancer: a high-throughput screening approach
-
Chen W,Chen M,Barak LS.Development of small molecules targeting the Wnt pathway for the treatment of colon cancer: a high-throughput screening approach.Am J Physiol Gastrointest Liver Physiol. 2010;299:G293-300.
-
(2010)
Am J Physiol Gastrointest Liver Physiol
, vol.299
-
-
Chen, W.1
Chen, M.2
Barak, L.S.3
-
60
-
-
77958171338
-
Small-molecule inhibition of Wnt signaling through activation of casein kinase 1alpha
-
Thorne CA,Hanson AJ,Schneider J,Tahinci E,Orton D,Cselenyi CS,Jernigan KK,Meyers KC,Hang BI,Waterson AG,Kim K,Melancon B,Ghidu VP,Sulikowski GA,LaFleur B,Salic A,Lee LA,Miller DM,Lee E.Small-molecule inhibition of Wnt signaling through activation of casein kinase 1alpha.Nat Chem Biol. 2010;6:829-36.
-
(2010)
Nat Chem Biol
, vol.6
, pp. 829-836
-
-
Thorne, C.A.1
Hanson, A.J.2
Schneider, J.3
Tahinci, E.4
Orton, D.5
Cselenyi, C.S.6
Jernigan, K.K.7
Meyers, K.C.8
Hang, B.I.9
Waterson, A.G.10
Kim, K.11
Melancon, B.12
Ghidu, V.P.13
Sulikowski, G.A.14
LaFleur, B.15
Salic, A.16
Lee, L.A.17
Miller, D.M.18
Lee, E.19
-
61
-
-
84884132973
-
Selective small molecule targeting beta-catenin function discovered by in vivo chemical genetic screen
-
Hao J,Ao A,Zhou L,Murphy CK,Frist AY,Keel JJ,Thorne CA,Kim K,Lee E,Hong CC.Selective small molecule targeting beta-catenin function discovered by in vivo chemical genetic screen.Cell Rep. 2013;4:898-904.
-
(2013)
Cell Rep
, vol.4
, pp. 898-904
-
-
Hao, J.1
Ao, A.2
Zhou, L.3
Murphy, C.K.4
Frist, A.Y.5
Keel, J.J.6
Thorne, C.A.7
Kim, K.8
Lee, E.9
Hong, C.C.10
-
62
-
-
79956188899
-
Chemical screening with zebrafish embryos
-
Zhong H,Lin S.Chemical screening with zebrafish embryos.Meth Mol Biol. 2011;716:193-205.
-
(2011)
Meth Mol Biol
, vol.716
, pp. 193-205
-
-
Zhong, H.1
Lin, S.2
-
63
-
-
79951833085
-
Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells
-
Grinshtein N,Datti A,Fujitani M,Uehling D,Prakesch M,Isaac M,Irwin MS,Wrana JL,Al-Awar R,Kaplan DR.Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells.Cancer Res. 2011;71:1385-95.
-
(2011)
Cancer Res
, vol.71
, pp. 1385-1395
-
-
Grinshtein, N.1
Datti, A.2
Fujitani, M.3
Uehling, D.4
Prakesch, M.5
Isaac, M.6
Irwin, M.S.7
Wrana, J.L.8
Al-Awar, R.9
Kaplan, D.R.10
-
64
-
-
4344587136
-
A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]
-
Emami KH,Nguyen C,Ma H,Kim DH,Jeong KW,Eguchi M,Moon RT,Teo JL,Kim HY,Moon SH,Ha JR,Kahn M.A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected].Proc Natl Acad Sci U S A. 2004;101:12682-7.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 12682-12687
-
-
Emami, K.H.1
Nguyen, C.2
Ma, H.3
Kim, D.H.4
Jeong, K.W.5
Eguchi, M.6
Moon, R.T.7
Teo, J.L.8
Kim, H.Y.9
Moon, S.H.10
Ha, J.R.11
Kahn, M.12
-
65
-
-
0027278279
-
Lithium perturbation and goosecoid expression identify a dorsal specification pathway in the pregastrula zebrafish
-
Stachel SE,Grunwald DJ,Myers PZ.Lithium perturbation and goosecoid expression identify a dorsal specification pathway in the pregastrula zebrafish.Development. 1993;117:1261-74.
-
(1993)
Development
, vol.117
, pp. 1261-1274
-
-
Stachel, S.E.1
Grunwald, D.J.2
Myers, P.Z.3
-
66
-
-
12644251995
-
Mutations affecting development of the midline and general body shape during zebrafish embryogenesis
-
Brand M,Heisenberg CP,Warga RM,Pelegri F,Karlstrom RO,Beuchle D,Picker A,Jiang YJ,Furutani-Seiki M,van Eeden FJ,Granato M,Haffter P,Hammerschmidt M,Kane DA,Kelsh RN,Mullins MC,Odenthal J,Nusslein-Volhard C.Mutations affecting development of the midline and general body shape during zebrafish embryogenesis.Development. 1996;123:129-42.
-
(1996)
Development
, vol.123
, pp. 129-142
-
-
Brand, M.1
Heisenberg, C.P.2
Warga, R.M.3
Pelegri, F.4
Karlstrom, R.O.5
Beuchle, D.6
Picker, A.7
Jiang, Y.J.8
Furutani-Seiki, M.9
van Eeden, F.J.10
Granato, M.11
Haffter, P.12
Hammerschmidt, M.13
Kane, D.A.14
Kelsh, R.N.15
Mullins, M.C.16
Odenthal, J.17
Nusslein-Volhard, C.18
-
67
-
-
0033515638
-
The EGF-CFC protein one-eyed pinhead is essential for nodal signaling
-
Gritsman K,Zhang J,Cheng S,Heckscher E,Talbot WS,Schier AF.The EGF-CFC protein one-eyed pinhead is essential for nodal signaling.Cell. 1999;97:121-32.
-
(1999)
Cell
, vol.97
, pp. 121-132
-
-
Gritsman, K.1
Zhang, J.2
Cheng, S.3
Heckscher, E.4
Talbot, W.S.5
Schier, A.F.6
-
68
-
-
84877752842
-
Araf kinase antagonizes Nodal-Smad2 activity in mesendoderm development by directly phosphorylating the Smad2 linker region
-
Liu X,Xiong C,Jia S,Zhang Y,Chen YG,Wang Q,Meng A.Araf kinase antagonizes Nodal-Smad2 activity in mesendoderm development by directly phosphorylating the Smad2 linker region.Nat Commun. 2013;4:1728-1728.
-
(2013)
Nat Commun
, vol.4
, pp. 1728
-
-
Liu, X.1
Xiong, C.2
Jia, S.3
Zhang, Y.4
Chen, Y.G.5
Wang, Q.6
Meng, A.7
-
69
-
-
0033768239
-
Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects
-
Bamford RN,Roessler E,Burdine RD,Saplakoglu U,dela Cruz J,Splitt M,Goodship JA,Towbin J,Bowers P,Ferrero GB,Marino B,Schier AF,Shen MM,Muenke M,Casey B.Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects.Nat Genet. 2000;26:365-9.
-
(2000)
Nat Genet
, vol.26
, pp. 365-369
-
-
Bamford, R.N.1
Roessler, E.2
Burdine, R.D.3
Saplakoglu, U.4
dela Cruz, J.5
Splitt, M.6
Goodship, J.A.7
Towbin, J.8
Bowers, P.9
Ferrero, G.B.10
Marino, B.11
Schier, A.F.12
Shen, M.M.13
Muenke, M.14
Casey, B.15
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