RNAi-mediated knockdown of IKK1 in transgenic mice using a transgenic construct containing the human H1 promoter

The Scientific World Journal

Volumn 2014, Issue , 2014, Pages

  Moreno Maldonado, Rodolfo ^a   Murillas, Rodolfo ^a   Navarro, Manuel ^a   Page, Angustias ^a   Suarez Cabrera, Cristian ^a   Alameda, Josefa P ^a   Bravo, Ana ^b   Casanova, M Llanos ^a   Ramirez, Angel ^a  

^a CIEMAT   (Spain)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CHUK PROTEIN, MOUSE; I KAPPA B KINASE; SMALL INTERFERING RNA;

ANIMAL; CELL LINE; GENE EXPRESSION REGULATION; GENE ORDER; GENE SILENCING; GENE TARGETING; GENETICS; HUMAN; MOUSE; PHENOTYPE; PROMOTER REGION; RNA INTERFERENCE; TRANSGENIC MOUSE;

ANIMALS; CELL LINE; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GENE ORDER; GENE SILENCING; GENE TARGETING; HUMANS; I-KAPPA B KINASE; MICE; MICE, TRANSGENIC; PHENOTYPE; PROMOTER REGIONS, GENETIC; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84893841142     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1155/2014/193803     Document Type: Article

References (41)

1. Harborth J., Elbashir S. M., Bechert K., Tuschl T., Weber K., Identification of essential genes in cultured mammalian cells using small interfering RNAs. Journal of Cell Science 2001 114 24 4557 4565 2-s2.0-0035694237 (Pubitemid 34086890)
2. Podolska K., Svoboda P., Targeting genes in living mammals by RNA interference. Briefings in Functional Genomics 2011 10 4 238 247 2-s2.0-80051902207 10.1093/bfgp/elr013
3. Kunath T., Gish G., Lickert H., Jones N., Pawson T., Rossant J., Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype. Nature Biotechnology 2003 21 5 559 561 2-s2.0-0038708339 10.1038/nbt813 (Pubitemid 36532022)
4. Hemann M. T., Fridman J. S., Zilfou J. T., Hernando E., Paddison P. J., Cordon-Cardo C., Hannon G. J., Lowe S. W., An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Nature Genetics 2003 33 3 396 400 2-s2.0-0037370309 10.1038/ng1091 (Pubitemid 36278857)
5. Tiscornia G., Tergaonkar V., Galimi F., Verma I. M., CRE recombinase-inducible RNA interference mediated by lentiviral vectors. Proceedings of the National Academy of Sciences of the United States of America 2004 101 19 7347 7351 2-s2.0-2442584612 10.1073/pnas.0402107101 (Pubitemid 38638035)
6. Premsrirut P. K., Dow L. E., Kim S. Y., Camiolo M., Malone C. D., Miething C., Scuoppo C., Zuber J., Dickins R. A., Kogan S. C., Shroyer K. R., Sordella R., Hannon G. J., Lowe S. W., A rapid and scalable system for studying gene function in mice using conditional RNA interference. Cell 2011 145 1 145 158 2-s2.0-79952696452 10.1016/j.cell.2011.03.012
7. McJunkin K., Mazurek A., Premsrirut P. K., Zuber J., Dow L. E., Simon J., Stillman B., Lowe S. W., Reversible suppression of an essential gene in adult mice using transgenic RNA interference. Proceedings of the National Academy of Sciences of the United States of America 2011 108 17 7113 7118 2-s2.0-79955561070 10.1073/pnas.1104097108
8. Dickins R. A., McJunkin K., Hernando E., Premsrirut P. K., Krizhanovsky V., Burgess D. J., Kim S. Y., Cordon-Cardo C., Zender L., Hannon G. J., Lowe S. W., Tissue-specific and reversible RNA interference in transgenic mice. Nature Genetics 2007 39 7 914 921 2-s2.0-34347344980 10.1038/ng2045 (Pubitemid 47014488)
9. Jiang L., Zhang H., Dizhoor A. M., Boye S. E., Hauswirth W. W., Frederick J. M., Baehr W., Long-term RNA interference gene therapy in a dominant retinitis pigmentosa mouse model. Proceedings of the National Academy of Sciences of the United States of America 2011 108 45 18476 18481 2-s2.0-81055141290 10.1073/pnas.1112758108
10. Nobrega C., Nascimento-Ferreira I., Onofre I., Albuquerque D., Hirai H., Deglon N., de Almeida L. P., Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice. PLoS One 2013 8 e52396
11. Sobczak K., Wheeler T. M., Wang W., Thornton C. A., RNA interference targeting CUG repeats in a mouse model of myotonic dystrophy. Molecular Therapy 2013 21 380 387 10.1038/mt.2012.222
12. Davis M. E., Zuckerman J. E., Choi C. H. J., Seligson D., Tolcher A., Alabi C. A., Yen Y., Heidel J. D., Ribas A., Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature 2010 464 7291 1067 1070 2-s2.0-77951132901 10.1038/nature08956
13. White R. J., Transcription by RNA polymerase III: more complex than we thought. Nature Reviews Genetics 2011 12 7 459 463 2-s2.0-79959373574 10.1038/nrg3001
14. Dieci G., Fiorino G., Castelnuovo M., Teichmann M., Pagano A., The expanding RNA polymerase III transcriptome. Trends in Genetics 2007 23 12 614 622 2-s2.0-36549073601 10.1016/j.tig.2007.09.001 (Pubitemid 350180140)
15. Xia X.-G., Zhou H., Samper E., Melov S., Xu Z., Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice. PLoS genetics 2006 2 1 e10 2-s2.0-33646464597 10.1371/journal.pgen.0020010
16. Palmiter R. D., Brinster R. L., Germ-line transformation of mice. Annual Review of Genetics 1986 20 465 499 2-s2.0-0022965278
17. Li Q., Lu Q., Hwang J. Y., Büscher D., Lee K.-F., Izpisua-Belmonte J. C., Verma I. M., IKK1-deficient mice exhibit abnormal development of skin and skeleton. Genes and Development 1999 13 10 1322 1328 2-s2.0-0033563227 (Pubitemid 29250199)
18. Takeda K., Takeuchi O., Tsujimura T., Itami S., Adachi O., Kawai T., Sanjo H., Yoshikawa K., Terada N., Akira S., Limb and skin abnormalities in mice lacking IKKalpha. Science 1999 284 313 316
19. Gareus R., Huth M., Breiden B., Nenci A., Rösch N., Haase I., Bloch W., Sandhoff K., Pasparakis M., Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation. Nature Cell Biology 2007 9 4 461 469 2-s2.0-34047189274 10.1038/ncb1560 (Pubitemid 46511080)
20. Park E., Zhu F., Liu B., Xia O., Shen J., Bustos T., Fischer S. M., Hu Y., Reduction in I B kinase expression promotes the development of skin papillomas and carcinomas. Cancer Research 2007 67 19 9158 9168 2-s2.0-35148897233 10.1158/0008-5472.CAN-07-0590 (Pubitemid 47535902)
21. Liu B., Park E., Zhu F., Bustos T., Liu J., Shen J., Fischer S. M., Hu Y., A critical role for I B kinase in the development of human and mouse squamous cell carcinomas. Proceedings of the National Academy of Sciences of the United States of America 2006 103 46 17202 17207 2-s2.0-33751217161 10.1073/pnas.0604481103 (Pubitemid 44788947)
22. Alameda J. P., Moreno-Maldonado R., Fernández-Aceñero M. J., Navarro M., Page A., Jorcano J. L., Bravo A., Ramírez Á., Casanova M. L., Increased IKK expression in the basal layer of the epidermis of transgenic mice enhances the malignant potential of skin tumors. PLoS ONE 2011 6 7 2-s2.0-79959996678 10.1371/journal.pone.0021984 e21984
23. Didonato J. A., Hayakawa M., Rothwarf D. M., Zandi E., Karin M., A cytokine-responsive I B kinase that activates the transcription factor NF- B. Nature 1997 388 6642 548 554 2-s2.0-0030610362 10.1038/41493 (Pubitemid 27339997)
24. Hogan B., Beddington R., Costantini F., Lacy E., Manipulating the Mouse Embryo. A Laboratory Manual 1994 New York, NY, USA Cold Spring Harbor Laboratory Press
25. Pérez P., Page A., Bravo A., Del Río M., Giménez-Conti I., Budunova I., Slaga T. J., Jorcano J. L., Altered skin development and impaired proliferative and inflammatory responses in transgenic mice overexpressing the glucocorticoid receptor. The FASEB Journal 2001 15 11 2030 2032 2-s2.0-0035464779
26. Chomczynski P., Sacchi N., Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analytical Biochemistry 1987 162 1 156 159 2-s2.0-0023277545 (Pubitemid 17064313)
27. Li K., Williams R. S., Cloning and characterization of three new murine genes encoding short homologues of RNase P RNA. The Journal of Biological Chemistry 1995 270 42 25281 25285 2-s2.0-0028808110 10.1074/jbc.270.42.25281
28. Tinkle C. L., Pasolli H. A., Stokes N., Fuchs E., New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity. Proceedings of the National Academy of Sciences of the United States of America 2008 105 40 15405 15410 2-s2.0-55749101603 10.1073/pnas.0807374105
29. Berlivet S., Guiraud V., Houlard M., Gérard M., pHYPER, a shRNA vector for high-efficiency RNA interference in embryonic stem cells. BioTechniques 2007 42 6 738 743 2-s2.0-34447128161 10.2144/000112454 (Pubitemid 47035981)
30. Xia X. G., Zhou H., Ding H., Affar E. B., Shi Y., Xu Z., An enhanced U6 promoter for synthesis of short hairpin RNA. Nucleic Acids Research 2003 31 17 e100 2-s2.0-1542604807
31. Frazar T. F., Weisbein J. L., Anderson S. M., Cline A. P., Garrett L. J., Felsenfeld G., Gallagher P. G., Bodine D. M., Variegated expression from the murine band 3 (AE1) promoter in transgenic mice is associated with mRNA transcript initiation at upstream start sites and can be suppressed by the addition of the chicken β -globin 5′ HS4 insulator element. Molecular and Cellular Biology 2003 23 14 4753 4763 2-s2.0-0038451470 10.1128/MCB.23.14.4753-4763.2003 (Pubitemid 36793323)
32. Moltó E., Fernández A., Montoliu L., Boundaries in vertebrate genomes: different solutions to adequately insulate gene expression domains. Briefings in Functional Genomics and Proteomics 2009 8 4 283 296 2-s2.0-70349521671 10.1093/bfgp/elp031
33. Cao W., Hunter R., Strnatka D., McQueen C. A., Erickson R. P., DNA constructs designed to produce short hairpin, interfering RNAs in transgenic mice sometimes show early lethality and an interferon response. Journal of Applied Genetics 2005 46 2 217 225 2-s2.0-20544452589 (Pubitemid 40840277)
34. Peng S., York J. P., Zhang P., A transgenic approach for RNA interference-based genetic screening in mice. Proceedings of the National Academy of Sciences of the United States of America 2006 103 7 2252 2256 2-s2.0-33144460778 10.1073/pnas.0511034103 (Pubitemid 43271656)
35. Oberdoerffer P., Kanellopoulou C., Heissmeyer V., Paeper C., Borowski C., Aifantis I., Rao A., Rajewsky K., Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages. Molecular and Cellular Biology 2005 25 10 3896 3905 2-s2.0-18144393469 10.1128/MCB.25.10.3896-3905.2005 (Pubitemid 40617641)
36. Seibler J., Küter-Luks B., Kern H., Streu S., Plum L., Mauer J., Kühn R., Brüning J. C., Schwenk F., Single copy shRNA configuration for ubiquitous gene knockdown in mice. Nucleic Acids Research 2005 33 7 e67 2-s2.0-20244368346
37. Stahl R., Walcher T., de Juan Romero C., Pilz, Gregor A., Cappello S., Irmler M., Sanz-Aquela, José M., Beckers J., Blum R., Borrell V., Götz M., Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate. Cell 2013 153 535 549
38. Yumi Y., Verma U. N., Prajapati S., Youn-Tae K., Gaynor R. B., Histone H3 phosphorylation by ikk- is critical for cytokine-induced gene expression. Nature 2003 423 6940 655 659 2-s2.0-0038511129 10.1038/nature01576 (Pubitemid 36713227)
39. Anest V., Hanson J. L., Cogswell P. C., Steinbrecher K. A., Strahl B. D., Baldwin A. S., A nucleosomal function for i b kinase- in nf- b-dependent gene expression. Nature 2003 423 6940 659 663 2-s2.0-0037497184 10.1038/nature01648 (Pubitemid 36713228)
40. Hu Y., Baud V., Oga T., Kim K. I., Yoshida K., Karin M., IKK controls formation of the epidermis independently of NF- B. Nature 2001 410 6829 710 714 2-s2.0-0035809983 10.1038/35070605 (Pubitemid 32290360)
41. Scacheri P. C., Rozenblatt-Rosen O., Caplen N. J., Wolfsberg T. G., Umayam L., Lee J. C., Hughes C. M., Shanmugam K. S., Bhattacharjee A., Meyerson M., Collins F. S., Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America 2004 101 7 1892 1897 2-s2.0-10744219688 10.1073/pnas.0308698100 (Pubitemid 38228987)