메뉴 건너뛰기




Volumn 6, Issue 7, 2011, Pages

Increased IKKα expression in the basal layer of the epidermis of transgenic mice enhances the malignant potential of skin tumors

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA6 INTEGRIN; CYCLIN D1; HEMAGGLUTININ; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MASPIN; PHORBOL 13 ACETATE 12 MYRISTATE; TRANSCRIPTION FACTOR RELA; CHUK PROTEIN, MOUSE; I KAPPA B KINASE; SERINE PROTEINASE INHIBITOR; SERPIN B5; SERPIN-B5; TUMOR MARKER;

EID: 79959996678     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021984     Document Type: Article
Times cited : (18)

References (63)
  • 1
    • 0036234459 scopus 로고    scopus 로고
    • Missing pieces in the NF-kappaB puzzle
    • Ghosh S, Karin M, (2002) Missing pieces in the NF-kappaB puzzle. Cell 109: S81-S96.
    • (2002) Cell , vol.109 , pp. 81-96
    • Ghosh, S.1    Karin, M.2
  • 2
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NF-kappaB
    • Hayden MS, Ghosh S, (2004) Signaling to NF-kappaB. Genes Dev 18: 2195-2224.
    • (2004) Genes Dev , vol.18 , pp. 2195-2224
    • Hayden, M.S.1    Ghosh, S.2
  • 3
    • 78650907445 scopus 로고    scopus 로고
    • A single NFkappaB system for both canonical and non-canonical signaling
    • Shih VF, Tsui R, Caldwell A, Hoffmann A, (2011) A single NFkappaB system for both canonical and non-canonical signaling. Cell Res 21: 86-102.
    • (2011) Cell Res , vol.21 , pp. 86-102
    • Shih, V.F.1    Tsui, R.2    Caldwell, A.3    Hoffmann, A.4
  • 4
    • 33751217161 scopus 로고    scopus 로고
    • A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas
    • Liu B, Park E, Zhu F, Bustos T, Liu, J, et al. (2006) A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas. Proc Natl Acad Sci U S A 103: 17202-17207.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 17202-17207
    • Liu, B.1    Park, E.2    Zhu, F.3    Bustos, T.4    Liu, J.5
  • 5
    • 47749125369 scopus 로고    scopus 로고
    • IKKalpha enhances human keratinocyte differentiation and determines the histological variant of epidermal squamous cell carcinomas
    • Moreno-Maldonado R, Ramirez A, Navarro M, Fernandez-Acenero MJ, Villanueva C, et al. (2008) IKKalpha enhances human keratinocyte differentiation and determines the histological variant of epidermal squamous cell carcinomas. Cell Cycle 7: 2021-2029.
    • (2008) Cell Cycle , vol.7 , pp. 2021-2029
    • Moreno-Maldonado, R.1    Ramirez, A.2    Navarro, M.3    Fernandez-Acenero, M.J.4    Villanueva, C.5
  • 6
    • 0033563227 scopus 로고    scopus 로고
    • IKK1-deficient mice exhibit abnormal development of skin and skeleton
    • Li Q, Lu Q, Hwang JY, et al. (1999) IKK1-deficient mice exhibit abnormal development of skin and skeleton. Genes Dev 13: 1322-1328.
    • (1999) Genes Dev , vol.13 , pp. 1322-1328
    • Li, Q.1    Lu, Q.2    Hwang, J.Y.3
  • 7
  • 8
    • 0033537767 scopus 로고    scopus 로고
    • Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase
    • Hu Y, Baud V, Delhase M, Zhang P, Deerinck T, et al. (1999) Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. Science 284: 316-320.
    • (1999) Science , vol.284 , pp. 316-320
    • Hu, Y.1    Baud, V.2    Delhase, M.3    Zhang, P.4    Deerinck, T.5
  • 9
    • 0035809983 scopus 로고    scopus 로고
    • IKKalpha controls formation of the epidermis independently of NF-kappaB
    • Hu Y, Baud V, Oga T, Kim KI, Yoshida K, et al. (2001) IKKalpha controls formation of the epidermis independently of NF-kappaB. Nature 410: 710-714.
    • (2001) Nature , vol.410 , pp. 710-714
    • Hu, Y.1    Baud, V.2    Oga, T.3    Kim, K.I.4    Yoshida, K.5
  • 10
    • 1942484963 scopus 로고    scopus 로고
    • IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis
    • Sil AK, Maeda S, Sano Y, Roop DR, Karin M, (2004) IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis. Nature 428: 660-664.
    • (2004) Nature , vol.428 , pp. 660-664
    • Sil, A.K.1    Maeda, S.2    Sano, Y.3    Roop, D.R.4    Karin, M.5
  • 11
    • 34047189274 scopus 로고    scopus 로고
    • Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation
    • Gareus R, Huth M, Breiden B, Nenci A, Rosch N, et al. (2007) Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation. Nat Cell Biol 9: 461-469.
    • (2007) Nat Cell Biol , vol.9 , pp. 461-469
    • Gareus, R.1    Huth, M.2    Breiden, B.3    Nenci, A.4    Rosch, N.5
  • 12
    • 50349089030 scopus 로고    scopus 로고
    • IKKalpha is required to maintain skin homeostasis and prevent skin cancer
    • Liu B, Xia X, Zhu F, Park E, Carbajal S, et al. (2008) IKKalpha is required to maintain skin homeostasis and prevent skin cancer. Cancer Cell 14: 212-225.
    • (2008) Cancer Cell , vol.14 , pp. 212-225
    • Liu, B.1    Xia, X.2    Zhu, F.3    Park, E.4    Carbajal, S.5
  • 13
    • 35148897233 scopus 로고    scopus 로고
    • Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas
    • Park E, Zhu F, Liu B, Xia X, Shen J, et al. (2007) Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas. Cancer Res 67: 9158-9168.
    • (2007) Cancer Res , vol.67 , pp. 9158-9168
    • Park, E.1    Zhu, F.2    Liu, B.3    Xia, X.4    Shen, J.5
  • 14
    • 77649190700 scopus 로고    scopus 로고
    • Her2 activates NF-kappaB and induces invasion through the canonical pathway involving IKKalpha
    • Merkhofer EC, Cogswell P, Baldwin AS, (2010) Her2 activates NF-kappaB and induces invasion through the canonical pathway involving IKKalpha. Oncogene 29: 1238-1248.
    • (2010) Oncogene , vol.29 , pp. 1238-1248
    • Merkhofer, E.C.1    Cogswell, P.2    Baldwin, A.S.3
  • 15
    • 74049104750 scopus 로고    scopus 로고
    • High expression levels of IKKalpha and IKKbeta are necessary for the malignant properties of liver cancer
    • Jiang R, Xia Y, Li J, Deng L, Zhao L, et al. (2010) High expression levels of IKKalpha and IKKbeta are necessary for the malignant properties of liver cancer. Int J Cancer 126: 1263-1274.
    • (2010) Int J Cancer , vol.126 , pp. 1263-1274
    • Jiang, R.1    Xia, Y.2    Li, J.3    Deng, L.4    Zhao, L.5
  • 16
    • 79959999256 scopus 로고    scopus 로고
    • Blocking IKKalpha Expression Inhibits Prostate Cancer Invasiveness
    • Pharm Res; Epub ahead of print
    • Mahato R, Qin B, Cheng K, (2010) Blocking IKKalpha Expression Inhibits Prostate Cancer Invasiveness. Pharm Res; Epub ahead of print.
    • (2010)
    • Mahato, R.1    Qin, B.2    Cheng, K.3
  • 17
    • 34247274248 scopus 로고    scopus 로고
    • Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin
    • Luo JL, Tan W, Ricono JM, Korchynskyi O, Zhang M, et al. (2007) Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. Nature 446: 690-694.
    • (2007) Nature , vol.446 , pp. 690-694
    • Luo, J.L.1    Tan, W.2    Ricono, J.M.3    Korchynskyi, O.4    Zhang, M.5
  • 18
    • 67649846427 scopus 로고    scopus 로고
    • Expression of COX-2, NF-kappaB-p65, NF-kappaB-p50 and IKKalpha in malignant and adjacent normal human colorectal tissue
    • Charalambous MP, Lightfoot T, Speirs V, Horgan K, Gooderham NJ, (2009) Expression of COX-2, NF-kappaB-p65, NF-kappaB-p50 and IKKalpha in malignant and adjacent normal human colorectal tissue. Br J Cancer 101: 106-115.
    • (2009) Br J Cancer , vol.101 , pp. 106-115
    • Charalambous, M.P.1    Lightfoot, T.2    Speirs, V.3    Horgan, K.4    Gooderham, N.J.5
  • 21
    • 33846216922 scopus 로고    scopus 로고
    • Maspin: the new frontier
    • Khalkhali-Ellis Z, (2006) Maspin: the new frontier. Clin Cancer Res 12: 7279-7283.
    • (2006) Clin Cancer Res , vol.12 , pp. 7279-7283
    • Khalkhali-Ellis, Z.1
  • 22
    • 0035884506 scopus 로고    scopus 로고
    • Blocking tumor growth, invasion, and metastasis by maspin in a syngeneic breast cancer model
    • Shi HY, Zhang W, Liang R, Abraham S, Kittrell FS, et al. (2001) Blocking tumor growth, invasion, and metastasis by maspin in a syngeneic breast cancer model. Cancer Res 61: 6945-6951.
    • (2001) Cancer Res , vol.61 , pp. 6945-6951
    • Shi, H.Y.1    Zhang, W.2    Liang, R.3    Abraham, S.4    Kittrell, F.S.5
  • 23
    • 3142671918 scopus 로고    scopus 로고
    • Aberrant methylation of the maspin promoter is an early event in human breast cancer
    • Futscher BW, O'Meara MM, Kim CJ, Rennels MA, Lu D, et al. (2004) Aberrant methylation of the maspin promoter is an early event in human breast cancer. Neoplasia 6: 380-389.
    • (2004) Neoplasia , vol.6 , pp. 380-389
    • Futscher, B.W.1    O'Meara, M.M.2    Kim, C.J.3    Rennels, M.A.4    Lu, D.5
  • 24
    • 0037362833 scopus 로고    scopus 로고
    • Maspin functions as tumor suppressor by increasing cell adhesion to extracellular matrix in prostate tumor cells
    • Abraham S, Zhang W, Greenberg N, Zhang M, (2003) Maspin functions as tumor suppressor by increasing cell adhesion to extracellular matrix in prostate tumor cells. J Urol 69: 1157-1161.
    • (2003) J Urol , vol.69 , pp. 1157-1161
    • Abraham, S.1    Zhang, W.2    Greenberg, N.3    Zhang, M.4
  • 25
  • 26
    • 13544263527 scopus 로고    scopus 로고
    • Loss of maspin is a helpful prognosticator in colorectal cancer: a tissue microarray analysis
    • Boltze C, (2005) Loss of maspin is a helpful prognosticator in colorectal cancer: a tissue microarray analysis. Pathol Res Pract 200: 783-790.
    • (2005) Pathol Res Pract , vol.200 , pp. 783-790
    • Boltze, C.1
  • 27
    • 67650754249 scopus 로고    scopus 로고
    • Loss of maspin is a negative prognostic factor for invasion and metastasis in oral squamous cell carcinoma
    • Yoshizawa K, Nozaki S, Okamune A, Rennels MA, Lu D, et al. (2009) Loss of maspin is a negative prognostic factor for invasion and metastasis in oral squamous cell carcinoma. J Oral Pathol Med 38: 535-539.
    • (2009) J Oral Pathol Med , vol.38 , pp. 535-539
    • Yoshizawa, K.1    Nozaki, S.2    Okamune, A.3    Rennels, M.A.4    Lu, D.5
  • 28
    • 55949118992 scopus 로고    scopus 로고
    • Cytoplasmic and nuclear maspin expression in lung carcinomas: an immunohistochemical study using tissue microarrays
    • Zheng HC, Saito H, Masuda S, Wang ZG, Takano Y, (2008) Cytoplasmic and nuclear maspin expression in lung carcinomas: an immunohistochemical study using tissue microarrays. Appl Immunohistochem Mol Morphol 16: 459-465.
    • (2008) Appl Immunohistochem Mol Morphol , vol.16 , pp. 459-465
    • Zheng, H.C.1    Saito, H.2    Masuda, S.3    Wang, Z.G.4    Takano, Y.5
  • 29
    • 18244409898 scopus 로고    scopus 로고
    • Nuclear expression of maspin is associated with a lower recurrence rate and a longer disease-free interval after surgery for squamous cell carcinoma of the larynx
    • Marioni G, Blandamura S, Giacomelli L, Calgaro N, Segato P, et al. (2005) Nuclear expression of maspin is associated with a lower recurrence rate and a longer disease-free interval after surgery for squamous cell carcinoma of the larynx. Histopathology 46: 576-582.
    • (2005) Histopathology , vol.46 , pp. 576-582
    • Marioni, G.1    Blandamura, S.2    Giacomelli, L.3    Calgaro, N.4    Segato, P.5
  • 30
    • 64749097427 scopus 로고    scopus 로고
    • Maspin expression, angiogenesis, prognostic parameters, and outcome in malignant melanoma
    • Chua R, Setzer S, Govindarajan B, Sexton D, Cohen C, et al. (2009) Maspin expression, angiogenesis, prognostic parameters, and outcome in malignant melanoma. J Am Acad Dermatol 60: 758-766.
    • (2009) J Am Acad Dermatol , vol.60 , pp. 758-766
    • Chua, R.1    Setzer, S.2    Govindarajan, B.3    Sexton, D.4    Cohen, C.5
  • 31
    • 74249106460 scopus 로고    scopus 로고
    • BRCA1 185delAG mutant protein, BRAt, up-regulates maspin in ovarian epithelial cells
    • O'Donnell JD, Linger RJ, Kruk PA, (2010) BRCA1 185delAG mutant protein, BRAt, up-regulates maspin in ovarian epithelial cells. Gynecol Oncol 116: 262-268.
    • (2010) Gynecol Oncol , vol.116 , pp. 262-268
    • O'Donnell, J.D.1    Linger, R.J.2    Kruk, P.A.3
  • 32
    • 34247382565 scopus 로고    scopus 로고
    • Prognostic significance of maspin in pancreatic ductal adenocarcinoma: tissue microarray analysis of 223 surgically resected cases
    • Cao D, Zhang Q, Wu LS, Salaria SN, Winter JW, et al. (2007) Prognostic significance of maspin in pancreatic ductal adenocarcinoma: tissue microarray analysis of 223 surgically resected cases. Mod Pathol 20: 570-578.
    • (2007) Mod Pathol , vol.20 , pp. 570-578
    • Cao, D.1    Zhang, Q.2    Wu, L.S.3    Salaria, S.N.4    Winter, J.W.5
  • 33
    • 33645687141 scopus 로고    scopus 로고
    • Nuclear Maspin expression is associated with response to adjuvant 5-fluorouracil based chemotherapy in patients with stage III colon cancer
    • Dietmaier W, Bettstetter M, Wild PJ, Woenckhaus M, Rummele P, et al. (2006) Nuclear Maspin expression is associated with response to adjuvant 5-fluorouracil based chemotherapy in patients with stage III colon cancer. Int J Cancer 118: 2247-2254.
    • (2006) Int J Cancer , vol.118 , pp. 2247-2254
    • Dietmaier, W.1    Bettstetter, M.2    Wild, P.J.3    Woenckhaus, M.4    Rummele, P.5
  • 34
    • 77951229800 scopus 로고    scopus 로고
    • Expression of metastasis suppressor gene maspin is reduced in breast cancer brain metastases and correlates with the estrogen receptor status
    • Stark AM, Schem C, Maass N, Hugo HH, Jonat W, et al. (2010) Expression of metastasis suppressor gene maspin is reduced in breast cancer brain metastases and correlates with the estrogen receptor status. Neurol Res 32: 303-308.
    • (2010) Neurol Res , vol.32 , pp. 303-308
    • Stark, A.M.1    Schem, C.2    Maass, N.3    Hugo, H.H.4    Jonat, W.5
  • 35
    • 40249109853 scopus 로고    scopus 로고
    • The IkappaB kinase - a bridge between inflammation and cancer
    • Karin M, (2008) The IkappaB kinase- a bridge between inflammation and cancer. Cell Res 18: 334-342.
    • (2008) Cell Res , vol.18 , pp. 334-342
    • Karin, M.1
  • 36
    • 2942707848 scopus 로고    scopus 로고
    • Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    • Yang J, Mani SA, Donaher JL, Ramaswamy S, Itzykson RA, et al. (2004) Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 117: 927-939.
    • (2004) Cell , vol.117 , pp. 927-939
    • Yang, J.1    Mani, S.A.2    Donaher, J.L.3    Ramaswamy, S.4    Itzykson, R.A.5
  • 38
    • 45849087087 scopus 로고    scopus 로고
    • Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence
    • Ansieau S, Bastid J, Doreau A, Morel AP, Bouchet BP, et al. (2008) Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence. Cancer Cell 14: 79-89.
    • (2008) Cancer Cell , vol.14 , pp. 79-89
    • Ansieau, S.1    Bastid, J.2    Doreau, A.3    Morel, A.P.4    Bouchet, B.P.5
  • 39
    • 0141502120 scopus 로고    scopus 로고
    • Suprabasal alpha6beta4 integrin expression in epidermis results in enhanced tumourigenesis and disruption of TGFbeta signalling
    • Owens DM, Romero MR, Gardner C, Watt FM, (2003) Suprabasal alpha6beta4 integrin expression in epidermis results in enhanced tumourigenesis and disruption of TGFbeta signalling. J Cell Sci 116: 3783-3791.
    • (2003) J Cell Sci , vol.116 , pp. 3783-3791
    • Owens, D.M.1    Romero, M.R.2    Gardner, C.3    Watt, F.M.4
  • 40
    • 0027491154 scopus 로고
    • The suprabasal expression of alpha 6 beta 4 integrin is associated with a high risk for malignant progression in mouse skin carcinogenesis
    • Tennenbaum T, Weiner AK, Belanger AJ, Glick AB, Hennings H, et al. (1993) The suprabasal expression of alpha 6 beta 4 integrin is associated with a high risk for malignant progression in mouse skin carcinogenesis. Cancer Res 53: 4803-4810.
    • (1993) Cancer Res , vol.53 , pp. 4803-4810
    • Tennenbaum, T.1    Weiner, A.K.2    Belanger, A.J.3    Glick, A.B.4    Hennings, H.5
  • 41
    • 78650305124 scopus 로고    scopus 로고
    • An inactivating CYLD mutation promotes skin tumor progression by conferring enhanced proliferative, survival and angiogenic properties to epidermal cancer cells
    • Alameda JP, Moreno-Maldonado R, Navarro M, Bravo A, Ramirez A, et al. (2010) An inactivating CYLD mutation promotes skin tumor progression by conferring enhanced proliferative, survival and angiogenic properties to epidermal cancer cells. Oncogene 29: 6522-6532.
    • (2010) Oncogene , vol.29 , pp. 6522-6532
    • Alameda, J.P.1    Moreno-Maldonado, R.2    Navarro, M.3    Bravo, A.4    Ramirez, A.5
  • 42
    • 0025647881 scopus 로고
    • v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid
    • Leder A, Kuo A, Cardiff RD, Sinn E, Leder P, (1990) v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid. Proc Natl Acad Sci U S A 87: 9178-9182.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 9178-9182
    • Leder, A.1    Kuo, A.2    Cardiff, R.D.3    Sinn, E.4    Leder, P.5
  • 43
    • 0027973880 scopus 로고
    • Sequences 5′ of the bovine keratin 5 gene direct tissue- and cell-type-specific expression of a lacZ gene in the adult and during development
    • Ramirez A, Bravo A, Jorcano JL, Vidal M, (1994) Sequences 5′ of the bovine keratin 5 gene direct tissue- and cell-type-specific expression of a lacZ gene in the adult and during development. Differentiation 58: 53-64.
    • (1994) Differentiation , vol.58 , pp. 53-64
    • Ramirez, A.1    Bravo, A.2    Jorcano, J.L.3    Vidal, M.4
  • 44
    • 0037096880 scopus 로고    scopus 로고
    • A critical role for ras-mediated, epidermal growth factor receptor-dependent angiogenesis in mouse skin carcinogenesis
    • Casanova ML, Larcher F, Casanova B, Murillas R, Fernandez-Acenero MJ, et al. (2002) A critical role for ras-mediated, epidermal growth factor receptor-dependent angiogenesis in mouse skin carcinogenesis. Cancer Res 62: 3402-3407.
    • (2002) Cancer Res , vol.62 , pp. 3402-3407
    • Casanova, M.L.1    Larcher, F.2    Casanova, B.3    Murillas, R.4    Fernandez-Acenero, M.J.5
  • 45
    • 0033762498 scopus 로고    scopus 로고
    • The EGF receptor - an essential regulator of multiple epidermal functions
    • Jost M, Kari C, Rodeck U, (2000) The EGF receptor- an essential regulator of multiple epidermal functions. Eur J Dermatol 10: 505-510.
    • (2000) Eur J Dermatol , vol.10 , pp. 505-510
    • Jost, M.1    Kari, C.2    Rodeck, U.3
  • 46
    • 0030813551 scopus 로고    scopus 로고
    • Correlation between hyperproliferation and suprabasal integrin expression in human epidermis reconstituted in culture
    • Rikimaru K, Moles JP, Watt FM, (1997) Correlation between hyperproliferation and suprabasal integrin expression in human epidermis reconstituted in culture. Exp Dermatol 6: 214-221.
    • (1997) Exp Dermatol , vol.6 , pp. 214-221
    • Rikimaru, K.1    Moles, J.P.2    Watt, F.M.3
  • 47
    • 0020586334 scopus 로고
    • Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene
    • Balmain A, Pragnell IB, (1983) Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene. Nature 303: 72-74.
    • (1983) Nature , vol.303 , pp. 72-74
    • Balmain, A.1    Pragnell, I.B.2
  • 48
    • 9444263077 scopus 로고    scopus 로고
    • Epidermal abnormalities and increased malignancy of skin tumors in human epidermal keratin 8-expressing transgenic mice
    • Casanova ML, Bravo A, Martinez-Palacio J, Fernandez-Acenero MJ, Villanueva C, et al. (2004) Epidermal abnormalities and increased malignancy of skin tumors in human epidermal keratin 8-expressing transgenic mice. Faseb J 18: 1556-1558.
    • (2004) Faseb J , vol.18 , pp. 1556-1558
    • Casanova, M.L.1    Bravo, A.2    Martinez-Palacio, J.3    Fernandez-Acenero, M.J.4    Villanueva, C.5
  • 49
    • 0025333626 scopus 로고
    • Tissue-specific expression of murine keratin K13 in internal stratified squamous epithelia and its aberrant expression during two-stage mouse skin carcinogenesis is associated with the methylation state of a distinct CpG site in the remote 5′-flanking region of the gene
    • Winter H, Rentrop M, Nischt R, Schweizer J, (1990) Tissue-specific expression of murine keratin K13 in internal stratified squamous epithelia and its aberrant expression during two-stage mouse skin carcinogenesis is associated with the methylation state of a distinct CpG site in the remote 5′-flanking region of the gene. Differentiation 43: 105-114.
    • (1990) Differentiation , vol.43 , pp. 105-114
    • Winter, H.1    Rentrop, M.2    Nischt, R.3    Schweizer, J.4
  • 50
    • 55949089769 scopus 로고    scopus 로고
    • The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway
    • Marinari B, Moretti F, Botti E, Giustizieri ML, Descargues P, et al. (2008) The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway. Proc Natl Acad Sci U S A 105: 17091-17096.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 17091-17096
    • Marinari, B.1    Moretti, F.2    Botti, E.3    Giustizieri, M.L.4    Descargues, P.5
  • 51
    • 0037329233 scopus 로고    scopus 로고
    • IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf
    • Albanese C, Wu K, D'Amico M, Jarrett C, Joyce D, et al. (2003) IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf. Mol Biol Cell 14: 585-599.
    • (2003) Mol Biol Cell , vol.14 , pp. 585-599
    • Albanese, C.1    Wu, K.2    D'Amico, M.3    Jarrett, C.4    Joyce, D.5
  • 52
    • 33947142478 scopus 로고    scopus 로고
    • Twist, a novel oncogene, is upregulated in pancreatic cancer: clinical implication of Twist expression in pancreatic juice
    • Ohuchida K, Mizumoto K, Ohhashi S, Yamaguchi H, Konomi H, et al. (2007) Twist, a novel oncogene, is upregulated in pancreatic cancer: clinical implication of Twist expression in pancreatic juice. Int J Cancer 120: 1634-1640.
    • (2007) Int J Cancer , vol.120 , pp. 1634-1640
    • Ohuchida, K.1    Mizumoto, K.2    Ohhashi, S.3    Yamaguchi, H.4    Konomi, H.5
  • 53
    • 33749344520 scopus 로고    scopus 로고
    • Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition
    • Lee TK, Poon RT, Yuen AP, Ling MT, Kwok WK, et al. (2006) Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition. Clin Cancer Res 12: 5369-5376.
    • (2006) Clin Cancer Res , vol.12 , pp. 5369-5376
    • Lee, T.K.1    Poon, R.T.2    Yuen, A.P.3    Ling, M.T.4    Kwok, W.K.5
  • 54
    • 33947129096 scopus 로고    scopus 로고
    • Significance of TWIST expression and its association with E-cadherin in bladder cancer
    • Zhang Z, Xie D, Li X, Wong YC, Xin D, et al. (2007) Significance of TWIST expression and its association with E-cadherin in bladder cancer. Hum Pathol 38: 598-606.
    • (2007) Hum Pathol , vol.38 , pp. 598-606
    • Zhang, Z.1    Xie, D.2    Li, X.3    Wong, Y.C.4    Xin, D.5
  • 55
    • 0035834717 scopus 로고    scopus 로고
    • Regulation of beta-catenin function by the IkappaB kinases
    • Lamberti C, Lin KM, Yamamoto Y, Verma U, Verma IM, et al. (2001) Regulation of beta-catenin function by the IkappaB kinases. J Biol Chem 276: 42276-42286.
    • (2001) J Biol Chem , vol.276 , pp. 42276-42286
    • Lamberti, C.1    Lin, K.M.2    Yamamoto, Y.3    Verma, U.4    Verma, I.M.5
  • 56
    • 15944379896 scopus 로고    scopus 로고
    • Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation
    • Park KJ, Krishnan V, O'Malley BW, Yamamoto Y, Gaynor RB, (2005) Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation. Mol Cell 18: 71-82.
    • (2005) Mol Cell , vol.18 , pp. 71-82
    • Park, K.J.1    Krishnan, V.2    O'Malley, B.W.3    Yamamoto, Y.4    Gaynor, R.B.5
  • 57
    • 0036242554 scopus 로고    scopus 로고
    • Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase
    • Wu RC, Qin J, Hashimoto Y, Wong J, Xu J, et al. (2002) Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase. Mol Cell Biol 22: 3549-3561.
    • (2002) Mol Cell Biol , vol.22 , pp. 3549-3561
    • Wu, R.C.1    Qin, J.2    Hashimoto, Y.3    Wong, J.4    Xu, J.5
  • 58
    • 0038511129 scopus 로고    scopus 로고
    • Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression
    • Yamamoto Y, Verma UN, Prajapati S, Kwak YT, Gaynor RB, (2003) Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression. Nature 423: 655-659.
    • (2003) Nature , vol.423 , pp. 655-659
    • Yamamoto, Y.1    Verma, U.N.2    Prajapati, S.3    Kwak, Y.T.4    Gaynor, R.B.5
  • 59
    • 0037497184 scopus 로고    scopus 로고
    • A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression
    • Anest V, Hanson JL, Cogswell PC, Steinbrecher KA, Strahl BD, et al. (2003) A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression. Nature 423: 659-663.
    • (2003) Nature , vol.423 , pp. 659-663
    • Anest, V.1    Hanson, J.L.2    Cogswell, P.C.3    Steinbrecher, K.A.4    Strahl, B.D.5
  • 60
    • 34047248402 scopus 로고    scopus 로고
    • Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB
    • Huang WC, Ju TK, Hung MC, Chen CC, (2007) Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB. Mol Cell 26: 75-87.
    • (2007) Mol Cell , vol.26 , pp. 75-87
    • Huang, W.C.1    Ju, T.K.2    Hung, M.C.3    Chen, C.C.4
  • 61
    • 57749121470 scopus 로고    scopus 로고
    • IkappaB kinase-alpha regulates endothelial cell motility and tumor angiogenesis
    • DeBusk LM, Massion PP, Lin PC, (2008) IkappaB kinase-alpha regulates endothelial cell motility and tumor angiogenesis. Cancer Res 68: 10223-10228.
    • (2008) Cancer Res , vol.68 , pp. 10223-10228
    • DeBusk, L.M.1    Massion, P.P.2    Lin, P.C.3
  • 62
    • 0032559976 scopus 로고    scopus 로고
    • The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted
    • Brown K, Strathdee D, Bryson S, Lambie W, Balmain A, (1998) The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted. Curr Biol 8: 516-524.
    • (1998) Curr Biol , vol.8 , pp. 516-524
    • Brown, K.1    Strathdee, D.2    Bryson, S.3    Lambie, W.4    Balmain, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.