메뉴 건너뛰기




Volumn 67, Issue 19, 2007, Pages 9158-9168

Reduction in IκB kinase α expression promotes the development of skin papillomas and carcinomas

Author keywords

[No Author keywords available]

Indexed keywords

ACETONE; AMPHIREGULIN; DIMETHYLBENZ[A]ANTHRACENE; DNA; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 13; FIBROBLAST GROWTH FACTOR 2; H RAS PROTEIN; I KAPPA B KINASE ALPHA; INTERLEUKIN 1ALPHA; PHORBOL 13 ACETATE 12 MYRISTATE; RAS PROTEIN; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN A; 7,12 DIMETHYLBENZ[A]ANTHRACENE; CARCINOGEN; I KAPPA B KINASE;

EID: 35148897233     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-0590     Document Type: Article
Times cited : (63)

References (36)
  • 1
    • 33751217161 scopus 로고    scopus 로고
    • A critical role for IκB kinase α in the development of human and mouse squamous cell carcinomas
    • Liu B, Park E, Zhu F, et al. A critical role for IκB kinase α in the development of human and mouse squamous cell carcinomas. Proc Natl Acad Sci U S A 2006;103:17202-7.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 17202-17207
    • Liu, B.1    Park, E.2    Zhu, F.3
  • 2
    • 0034084163 scopus 로고    scopus 로고
    • Phosphorylation meets ubiquitination: The control of NF-κB activity
    • Karin M, Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu Rev Immunol 2000;18:621-63.
    • (2000) Annu Rev Immunol , vol.18 , pp. 621-663
    • Karin, M.1    Ben-Neriah, Y.2
  • 3
    • 17944378526 scopus 로고    scopus 로고
    • Activation by IKKα of a second, evolutionary conserved, NF-κB signaling pathway
    • Senftleben U, Cao Y, Xiao G, et al. Activation by IKKα of a second, evolutionary conserved, NF-κB signaling pathway. Science 2001;293:1495-9.
    • (2001) Science , vol.293 , pp. 1495-1499
    • Senftleben, U.1    Cao, Y.2    Xiao, G.3
  • 4
    • 33846237346 scopus 로고    scopus 로고
    • -/- mice that express an IKKα transgene in keratin 5+ thymic epithelial cells
    • -/- mice that express an IKKα transgene in keratin 5+ thymic epithelial cells. J Immunol 2007;178:829-37.
    • (2007) J Immunol , vol.178 , pp. 829-837
    • Lomada, D.1    Liu, B.2    Coghlan, L.3    Hu, Y.4    Richie, E.R.5
  • 5
    • 0033537767 scopus 로고    scopus 로고
    • Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase
    • Hu Y, Baud V, Delhase M, et al. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase. Science 1999;284:316-20.
    • (1999) Science , vol.284 , pp. 316-320
    • Hu, Y.1    Baud, V.2    Delhase, M.3
  • 6
    • 0033563227 scopus 로고    scopus 로고
    • IKK1-deficient mice exhibit abnormal development of skin and skeleton
    • Li Q, Lu Q, Hwang JY, et al. IKK1-deficient mice exhibit abnormal development of skin and skeleton. Genes Dev 1999;13:1322-8.
    • (1999) Genes Dev , vol.13 , pp. 1322-1328
    • Li, Q.1    Lu, Q.2    Hwang, J.Y.3
  • 7
    • 0033537757 scopus 로고    scopus 로고
    • Limb and skin abnormalities in mice lacking IKKα
    • Takeda K, Takeuchi O, Tsujimura T, et al. Limb and skin abnormalities in mice lacking IKKα. Science 1999; 284:313-6.
    • (1999) Science , vol.284 , pp. 313-316
    • Takeda, K.1    Takeuchi, O.2    Tsujimura, T.3
  • 8
    • 0035809983 scopus 로고    scopus 로고
    • IKKα controls formation of the epidermis independently of NF-κB
    • Hu Y, Baud V, Oga T, Kim KI, Yoshida K, Karin M. IKKα controls formation of the epidermis independently of NF-κB. Nature 2001;410:710-4.
    • (2001) Nature , vol.410 , pp. 710-714
    • Hu, Y.1    Baud, V.2    Oga, T.3    Kim, K.I.4    Yoshida, K.5    Karin, M.6
  • 9
    • 1942484963 scopus 로고    scopus 로고
    • IKKα acts in the epidermis to control skeletal and craniofacial morphogenesis
    • Sil AK, Maeda S, Sano Y, Roop DR, Karin M. IKKα acts in the epidermis to control skeletal and craniofacial morphogenesis. Nature 2004;428:660-4.
    • (2004) Nature , vol.428 , pp. 660-664
    • Sil, A.K.1    Maeda, S.2    Sano, Y.3    Roop, D.R.4    Karin, M.5
  • 11
    • 0029073913 scopus 로고
    • Activated ras genes occur in human actinic keratoses, premalignant precursors to squamous cell carcinomas
    • Spencer JM, Kahn SM, Jiang W, DeLeo VA, Weinstein IB. Activated ras genes occur in human actinic keratoses, premalignant precursors to squamous cell carcinomas. Arch Dermatol 1995;131:796-800.
    • (1995) Arch Dermatol , vol.131 , pp. 796-800
    • Spencer, J.M.1    Kahn, S.M.2    Jiang, W.3    DeLeo, V.A.4    Weinstein, I.B.5
  • 12
    • 0030893214 scopus 로고    scopus 로고
    • Analysis of the ability of 12-O-tetradecanoylphorbol-13-acetate to induce epidermal hyperplasia, transforming growth factor-α, and skin tumor promotion in wa-1 mice
    • Kiguchi K, Beltran L, Dubowski A, DiGiovanni J. Analysis of the ability of 12-O-tetradecanoylphorbol-13-acetate to induce epidermal hyperplasia, transforming growth factor-α, and skin tumor promotion in wa-1 mice. J Invest Dermatol 1997;108:784-91.
    • (1997) J Invest Dermatol , vol.108 , pp. 784-791
    • Kiguchi, K.1    Beltran, L.2    Dubowski, A.3    DiGiovanni, J.4
  • 13
    • 0020979072 scopus 로고
    • Molecular and cellular basis for tumor promotion in mouse skin
    • Yuspa SH. Molecular and cellular basis for tumor promotion in mouse skin. Princess Takamatsu Symp 1983;14:315-26.
    • (1983) Princess Takamatsu Symp , vol.14 , pp. 315-326
    • Yuspa, S.H.1
  • 14
    • 0027203921 scopus 로고
    • Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors
    • Kemp CJ, Donehower LA, Bradley A, Balmain A. Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell 1993;74:813-22.
    • (1993) Cell , vol.74 , pp. 813-822
    • Kemp, C.J.1    Donehower, L.A.2    Bradley, A.3    Balmain, A.4
  • 15
    • 0027496668 scopus 로고
    • FVB/N mice: An inbred strain sensitive to the chemical induction of squamous cell carcinomas in the skin
    • Hennings H, Glick AB, Lowry DT, Krsmanovic LS, Sly LM, Yuspa SH. FVB/N mice: an inbred strain sensitive to the chemical induction of squamous cell carcinomas in the skin. Carcinogenesis 1993;14:2353-8.
    • (1993) Carcinogenesis , vol.14 , pp. 2353-2358
    • Hennings, H.1    Glick, A.B.2    Lowry, D.T.3    Krsmanovic, L.S.4    Sly, L.M.5    Yuspa, S.H.6
  • 16
    • 0034659849 scopus 로고    scopus 로고
    • Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis
    • Ise K, Nakamura K, Nakao K, et al. Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis. Oncogene 2000;19:2951-6.
    • (2000) Oncogene , vol.19 , pp. 2951-2956
    • Ise, K.1    Nakamura, K.2    Nakao, K.3
  • 17
    • 3543056881 scopus 로고    scopus 로고
    • Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression
    • Mao JH, To MD, Perez-Losada J, Wu D, Del Rosario R, Balmain A. Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression. Genes Dev 2004;18:1800-5.
    • (2004) Genes Dev , vol.18 , pp. 1800-1805
    • Mao, J.H.1    To, M.D.2    Perez-Losada, J.3    Wu, D.4    Del Rosario, R.5    Balmain, A.6
  • 18
    • 3142676732 scopus 로고    scopus 로고
    • Lupeol modulates NF-κB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice
    • Saleem M, Afaq F, Adhami VM, Mukhtar H. Lupeol modulates NF-κB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice. Oncogene 2004;23:5203-14.
    • (2004) Oncogene , vol.23 , pp. 5203-5214
    • Saleem, M.1    Afaq, F.2    Adhami, V.M.3    Mukhtar, H.4
  • 19
    • 24644433852 scopus 로고    scopus 로고
    • Enhanced NF-κB activation and cellular function in macrophages lacking IκB kinase 1 (IKK1)
    • Li Q, Lu Q, Bottero V, et al. Enhanced NF-κB activation and cellular function in macrophages lacking IκB kinase 1 (IKK1). Proc Natl Acad Sci U S A 2005;102:12425-30.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 12425-12430
    • Li, Q.1    Lu, Q.2    Bottero, V.3
  • 20
    • 0030613551 scopus 로고    scopus 로고
    • The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation
    • Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M. The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation. Cell 1997;91:243-52.
    • (1997) Cell , vol.91 , pp. 243-252
    • Zandi, E.1    Rothwarf, D.M.2    Delhase, M.3    Hayakawa, M.4    Karin, M.5
  • 21
    • 22744431655 scopus 로고    scopus 로고
    • Zebrafish IκB kinase 1 negatively regulates NF-κB activity
    • Correa RG, Matsui T, Tergaonkar V, et al. Zebrafish IκB kinase 1 negatively regulates NF-κB activity. Curr Biol 2005;15:1291-5.
    • (2005) Curr Biol , vol.15 , pp. 1291-1295
    • Correa, R.G.1    Matsui, T.2    Tergaonkar, V.3
  • 22
    • 0036054742 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Regulation in the mouse skin carcinogenesis model and use in antiangiogenesis cancer therapy
    • Conti CJ. Vascular endothelial growth factor: regulation in the mouse skin carcinogenesis model and use in antiangiogenesis cancer therapy. The Oncologist 2002;7 Suppl 3:4-11.
    • (2002) The Oncologist , vol.7 , Issue.SUPPL. 3 , pp. 4-11
    • Conti, C.J.1
  • 23
    • 8544249876 scopus 로고    scopus 로고
    • Comparison of VEGF, VEGF-B, VEGF-C, and Ang-1 mRNA regulation by serum, growth factors, oncoproteins, and hypoxia
    • Enholm B, Paavonen K, Ristimaki A, et al. Comparison of VEGF, VEGF-B, VEGF-C, and Ang-1 mRNA regulation by serum, growth factors, oncoproteins, and hypoxia. Oncogene 1997;14:2475-83.
    • (1997) Oncogene , vol.14 , pp. 2475-2483
    • Enholm, B.1    Paavonen, K.2    Ristimaki, A.3
  • 24
    • 0034017757 scopus 로고    scopus 로고
    • Transgenic coexpression of v-Ha-ras and transforming growth factor α increases epidermal hyperproliferation and tumorigenesis and predisposes to malignant conversion via endogenous c-Ha-ras activation
    • Wang X J, Greenhalgh DA, Roop DR. Transgenic coexpression of v-Ha-ras and transforming growth factor α increases epidermal hyperproliferation and tumorigenesis and predisposes to malignant conversion via endogenous c-Ha-ras activation. Mol Carcinog 2000;27:200-9.
    • (2000) Mol Carcinog , vol.27 , pp. 200-209
    • Wang, X.J.1    Greenhalgh, D.A.2    Roop, D.R.3
  • 25
    • 0030447757 scopus 로고    scopus 로고
    • Up-regulation of vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels
    • Larcher F, Robles AI, Duran H, et al. Up-regulation of vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels. Cancer Res 1996;56:5391-6.
    • (1996) Cancer Res , vol.56 , pp. 5391-5396
    • Larcher, F.1    Robles, A.I.2    Duran, H.3
  • 26
    • 25844459154 scopus 로고    scopus 로고
    • NF-κB: Linking inflammation and immunity to cancer development and progression
    • Karin M, Greten FR. NF-κB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005;5:749-59.
    • (2005) Nat Rev Immunol , vol.5 , pp. 749-759
    • Karin, M.1    Greten, F.R.2
  • 27
    • 11144357466 scopus 로고    scopus 로고
    • IκB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
    • Hu MC, Lee DF, Xia W, et al. IκB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 2004;117:225-37.
    • (2004) Cell , vol.117 , pp. 225-237
    • Hu, M.C.1    Lee, D.F.2    Xia, W.3
  • 28
    • 4043088499 scopus 로고    scopus 로고
    • IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    • Greten FR, Eckmann L, Greten TF, et al. IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 2004;118:285-96.
    • (2004) Cell , vol.118 , pp. 285-296
    • Greten, F.R.1    Eckmann, L.2    Greten, T.F.3
  • 29
    • 0033539885 scopus 로고    scopus 로고
    • Increased expression of p50-NF-κB and constitutive activation of NF-κB transcription factors during mouse skin carcinogenesis
    • Budunova IV, Perez P, Vaden VR, Spiegelman VS, Slaga TJ, Jorcano JL. Increased expression of p50-NF-κB and constitutive activation of NF-κB transcription factors during mouse skin carcinogenesis. Oncogene 1999;18:7423-31.
    • (1999) Oncogene , vol.18 , pp. 7423-7431
    • Budunova, I.V.1    Perez, P.2    Vaden, V.R.3    Spiegelman, V.S.4    Slaga, T.J.5    Jorcano, J.L.6
  • 30
    • 33947101019 scopus 로고    scopus 로고
    • Patterns of somatic mutation in human cancer genomes
    • Greenman C, Stephens P, Smith R, et al. Patterns of somatic mutation in human cancer genomes. Nature 2007;446:153-8.
    • (2007) Nature , vol.446 , pp. 153-158
    • Greenman, C.1    Stephens, P.2    Smith, R.3
  • 31
    • 0025941759 scopus 로고
    • In vivo formation of oxidized DNA bases in tumor promoter-treated mouse skin
    • Wei H, Frenkel K. In vivo formation of oxidized DNA bases in tumor promoter-treated mouse skin. Cancer Res 1991;51:4443-9.
    • (1991) Cancer Res , vol.51 , pp. 4443-4449
    • Wei, H.1    Frenkel, K.2
  • 32
    • 33847623675 scopus 로고    scopus 로고
    • p63 induces key target genes required for epidermal morphogenesis
    • Koster MI, Dai D, Marinari B, et al. p63 induces key target genes required for epidermal morphogenesis. Proc Natl Acad Sci U S A 2007;104:3255-60.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 3255-3260
    • Koster, M.I.1    Dai, D.2    Marinari, B.3
  • 33
    • 33845689232 scopus 로고    scopus 로고
    • p63 is upstream of IKKα in epidermal development
    • Candi E, Terrinoni A, Rufini A, et al. p63 is upstream of IKKα in epidermal development. J Cell Sci 2006;119:4617-22.
    • (2006) J Cell Sci , vol.119 , pp. 4617-4622
    • Candi, E.1    Terrinoni, A.2    Rufini, A.3
  • 34
    • 33646245191 scopus 로고    scopus 로고
    • Reactivation of developmentally expressed p63 isoforms predisposes to tumor development and progression
    • Koster MI, Lu SL, White LD, Wang XJ, Roop DR. Reactivation of developmentally expressed p63 isoforms predisposes to tumor development and progression. Cancer Res 2006;66:3981-6.
    • (2006) Cancer Res , vol.66 , pp. 3981-3986
    • Koster, M.I.1    Lu, S.L.2    White, L.D.3    Wang, X.J.4    Roop, D.R.5
  • 35
    • 28944432805 scopus 로고    scopus 로고
    • Hill R, Song Y, Cardiff RD, Van Dyke T. Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis. Cell 2005;123:1001-11.
    • Hill R, Song Y, Cardiff RD, Van Dyke T. Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis. Cell 2005;123:1001-11.
  • 36
    • 17244367849 scopus 로고    scopus 로고
    • DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
    • Bartkova J, Horejsi Z, Koed K, et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 2005;434:864-70.
    • (2005) Nature , vol.434 , pp. 864-870
    • Bartkova, J.1    Horejsi, Z.2    Koed, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.