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Volumn 35, Issue 5, 2014, Pages 1162-1176

Pomegranate juice exacerbates oxidative stress and nigrostriatal degeneration in Parkinson's disease

Author keywords

Inflammation; Mitochondria; Neuroprotection; Neurotoxicity; Oxidative stress; Parkinson's disease; Polyphenols; Pomegranate juice; Rotenone

Indexed keywords

INFLAMMATION; MITOCHONDRIA; NEUROPROTECTION; NEUROTOXICITY; OXIDATIVE STRESS; PARKINSON'S DISEASE; POLYPHENOLS; POMEGRANATE JUICE; ROTENONE;

EID: 84893779492     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2013.10.077     Document Type: Article
Times cited : (84)

References (77)
  • 1
    • 0025078156 scopus 로고
    • Effects of L-dopa on extracellular dopamine in striatum of normal and 6-hydroxydopamine-treated rats
    • Abercrombie E.D., Bonatz A.E., Zigmond M.J. Effects of L-dopa on extracellular dopamine in striatum of normal and 6-hydroxydopamine-treated rats. Brain Res. 1990, 525:36-44.
    • (1990) Brain Res. , vol.525 , pp. 36-44
    • Abercrombie, E.D.1    Bonatz, A.E.2    Zigmond, M.J.3
  • 2
    • 80051855181 scopus 로고    scopus 로고
    • Pomegranate phenolics from the peels, arils, and flowers are antiatherogenic: studies in vivo in atherosclerotic apolipoprotein e-deficient (E 0) mice and in vitro in cultured macrophages and lipoproteins
    • Aviram M., Volkova N., Coleman R., Dreher M., Reddy M.K., Ferreira D., Rosenblat M. Pomegranate phenolics from the peels, arils, and flowers are antiatherogenic: studies in vivo in atherosclerotic apolipoprotein e-deficient (E 0) mice and in vitro in cultured macrophages and lipoproteins. J. Agric. Food Chem. 2008, 56:1148-1157.
    • (2008) J. Agric. Food Chem. , vol.56 , pp. 1148-1157
    • Aviram, M.1    Volkova, N.2    Coleman, R.3    Dreher, M.4    Reddy, M.K.5    Ferreira, D.6    Rosenblat, M.7
  • 3
    • 80052653019 scopus 로고    scopus 로고
    • Research strategies in the study of the pro-oxidant nature of polyphenol nutraceuticals
    • Babich H., Schuck A.G., Weisburg J.H., Zuckerbraun H.L. Research strategies in the study of the pro-oxidant nature of polyphenol nutraceuticals. J. Toxicol. 2011, 2011:467305.
    • (2011) J. Toxicol. , vol.2011 , pp. 467305
    • Babich, H.1    Schuck, A.G.2    Weisburg, J.H.3    Zuckerbraun, H.L.4
  • 4
    • 34547190796 scopus 로고    scopus 로고
    • Glutathione as a mediator of the in vitro cytotoxicity of a green tea polyphenol extract
    • Babich H., Selevan A.R., Ravkin E.R. Glutathione as a mediator of the in vitro cytotoxicity of a green tea polyphenol extract. Toxicol. Mech. Methods 2007, 17:357-369.
    • (2007) Toxicol. Mech. Methods , vol.17 , pp. 357-369
    • Babich, H.1    Selevan, A.R.2    Ravkin, E.R.3
  • 5
    • 1542513224 scopus 로고    scopus 로고
    • Chronic administration of rotenone increases levels of nitric oxide and lipid peroxidation products in rat brain
    • Bashkatova V., Alam M., Vanin A., Schmidt W.J. Chronic administration of rotenone increases levels of nitric oxide and lipid peroxidation products in rat brain. Exp. Neurol. 2004, 186:235-241.
    • (2004) Exp. Neurol. , vol.186 , pp. 235-241
    • Bashkatova, V.1    Alam, M.2    Vanin, A.3    Schmidt, W.J.4
  • 6
    • 25444474703 scopus 로고    scopus 로고
    • Mitochondria take center stage in aging and neurodegeneration
    • Beal M.F. Mitochondria take center stage in aging and neurodegeneration. Ann. Neurol. 2005, 58:495-505.
    • (2005) Ann. Neurol. , vol.58 , pp. 495-505
    • Beal, M.F.1
  • 7
    • 0025189864 scopus 로고
    • Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide
    • Beckman J.S., Beckman T.W., Chen J., Marshall P.A., Freeman B.A. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. U. S. A 1990, 87:1620-1624.
    • (1990) Proc. Natl. Acad. Sci. U. S. A , vol.87 , pp. 1620-1624
    • Beckman, J.S.1    Beckman, T.W.2    Chen, J.3    Marshall, P.A.4    Freeman, B.A.5
  • 9
    • 33846565752 scopus 로고    scopus 로고
    • Prooxidant DNA breakage induced by caffeic acid in human peripheral lymphocytes: involvement of endogenous copper and a putative mechanism for anticancer properties
    • Bhat S.H., Azmi A.S., Hadi S.M. Prooxidant DNA breakage induced by caffeic acid in human peripheral lymphocytes: involvement of endogenous copper and a putative mechanism for anticancer properties. Toxicol. Appl. Pharmacol. 2007, 218:249-255.
    • (2007) Toxicol. Appl. Pharmacol. , vol.218 , pp. 249-255
    • Bhat, S.H.1    Azmi, A.S.2    Hadi, S.M.3
  • 10
    • 24144453087 scopus 로고    scopus 로고
    • Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism
    • Block M.L., Hong J.S. Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog. Neurobiol. 2005, 76:77-98.
    • (2005) Prog. Neurobiol. , vol.76 , pp. 77-98
    • Block, M.L.1    Hong, J.S.2
  • 11
    • 0028364696 scopus 로고
    • Immunocytochemical analysis of tumor necrosis factor and its receptors in Parkinson's disease
    • Boka G., Anglade P., Wallach D., Javoy-Agid F., Agid Y., Hirsch E.C. Immunocytochemical analysis of tumor necrosis factor and its receptors in Parkinson's disease. Neurosci. Lett. 1994, 172:151-154.
    • (1994) Neurosci. Lett. , vol.172 , pp. 151-154
    • Boka, G.1    Anglade, P.2    Wallach, D.3    Javoy-Agid, F.4    Agid, Y.5    Hirsch, E.C.6
  • 12
    • 77957363916 scopus 로고    scopus 로고
    • Exogenous antioxidants - Double-edged swords in cellular redox state: Health beneficial effects at physiologic doses versus deleterious effects at high doses
    • Bouayed J., Bohn T. Exogenous antioxidants - Double-edged swords in cellular redox state: Health beneficial effects at physiologic doses versus deleterious effects at high doses. Oxid. Med. Cell Longev. 2010, 3:228-237.
    • (2010) Oxid. Med. Cell Longev. , vol.3 , pp. 228-237
    • Bouayed, J.1    Bohn, T.2
  • 13
    • 0031200869 scopus 로고    scopus 로고
    • Free radicals and the pathobiology of brain dopamine systems
    • Cadet J.L., Brannock C. Free radicals and the pathobiology of brain dopamine systems. Neurochem. Int. 1998, 32:117-131.
    • (1998) Neurochem. Int. , vol.32 , pp. 117-131
    • Cadet, J.L.1    Brannock, C.2
  • 15
    • 0037449191 scopus 로고    scopus 로고
    • Contribution of hydrogen peroxide to the cytotoxicity of green tea and red wines
    • Chai P.C., Long L.H., Halliwell B. Contribution of hydrogen peroxide to the cytotoxicity of green tea and red wines. Biochem. Biophys. Res. Commun. 2003, 304:650-654.
    • (2003) Biochem. Biophys. Res. Commun. , vol.304 , pp. 650-654
    • Chai, P.C.1    Long, L.H.2    Halliwell, B.3
  • 16
    • 38449097902 scopus 로고    scopus 로고
    • Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration
    • Chinta S.J., Kumar M.J., Hsu M., Rajagopalan S., Kaur D., Rane A., Nicholls D.G., Choi J., Andersen J.K. Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration. J. Neurosci. 2007, 27:13997-14006.
    • (2007) J. Neurosci. , vol.27 , pp. 13997-14006
    • Chinta, S.J.1    Kumar, M.J.2    Hsu, M.3    Rajagopalan, S.4    Kaur, D.5    Rane, A.6    Nicholls, D.G.7    Choi, J.8    Andersen, J.K.9
  • 17
    • 78651367197 scopus 로고    scopus 로고
    • Effects of intrastriatal GDNF on the response of dopamine neurons to 6-hydroxydopamine: time course of protection and neurorestoration
    • Cohen A.D., Zigmond M.J., Smith A.D. Effects of intrastriatal GDNF on the response of dopamine neurons to 6-hydroxydopamine: time course of protection and neurorestoration. Brain Res. 2011, 1370:80-88.
    • (2011) Brain Res. , vol.1370 , pp. 80-88
    • Cohen, A.D.1    Zigmond, M.J.2    Smith, A.D.3
  • 18
    • 77955123767 scopus 로고    scopus 로고
    • Melatonin prevents the decreased activity of antioxidant enzymes and activates nuclear erythroid 2-related factor 2 signaling in an animal model of fulminant hepatic failure of viral origin
    • Crespo I., Miguel B.S., Laliena A., Alvarez M., Culebras J.M., Gonzalez-Gallego J., Tunon M.J. Melatonin prevents the decreased activity of antioxidant enzymes and activates nuclear erythroid 2-related factor 2 signaling in an animal model of fulminant hepatic failure of viral origin. J. Pineal Res. 2010, 49:193-200.
    • (2010) J. Pineal Res. , vol.49 , pp. 193-200
    • Crespo, I.1    Miguel, B.S.2    Laliena, A.3    Alvarez, M.4    Culebras, J.M.5    Gonzalez-Gallego, J.6    Tunon, M.J.7
  • 19
    • 42649144101 scopus 로고    scopus 로고
    • Oxidative and nitrative protein modifications in Parkinson's disease
    • Danielson S.R., Andersen J.K. Oxidative and nitrative protein modifications in Parkinson's disease. Free Radic. Biol. Med. 2008, 44:1787-1794.
    • (2008) Free Radic. Biol. Med. , vol.44 , pp. 1787-1794
    • Danielson, S.R.1    Andersen, J.K.2
  • 20
    • 0029873904 scopus 로고    scopus 로고
    • Threshold effects and control of oxidative phosphorylation in nonsynaptic rat brain mitochondria
    • Davey G.P., Clark J.B. Threshold effects and control of oxidative phosphorylation in nonsynaptic rat brain mitochondria. J. Neurochem. 1996, 66:1617-1624.
    • (1996) J. Neurochem. , vol.66 , pp. 1617-1624
    • Davey, G.P.1    Clark, J.B.2
  • 21
    • 69249214137 scopus 로고    scopus 로고
    • Quercetin can act either as an inhibitor or an inducer of the mitochondrial permeability transition pore: A demonstration of the ambivalent redox character of polyphenols
    • De Marchi U., Biasutto L., Garbisa S., Toninello A., Zoratti M. Quercetin can act either as an inhibitor or an inducer of the mitochondrial permeability transition pore: A demonstration of the ambivalent redox character of polyphenols. Biochim. Biophys. Acta. 2009, 1787:1425-1432.
    • (2009) Biochim. Biophys. Acta. , vol.1787 , pp. 1425-1432
    • De Marchi, U.1    Biasutto, L.2    Garbisa, S.3    Toninello, A.4    Zoratti, M.5
  • 23
    • 18144407246 scopus 로고    scopus 로고
    • Green tea extract and (-)-epigallocatechin-3-gallate, the major tea catechin, exert oxidant but lack antioxidant activities
    • Elbling L., Weiss R.M., Teufelhofer O., Uhl M., Knasmueller S., Schulte-Hermann R., Berger W., Micksche M. Green tea extract and (-)-epigallocatechin-3-gallate, the major tea catechin, exert oxidant but lack antioxidant activities. FASEB J. 2005, 19:807-809.
    • (2005) FASEB J. , vol.19 , pp. 807-809
    • Elbling, L.1    Weiss, R.M.2    Teufelhofer, O.3    Uhl, M.4    Knasmueller, S.5    Schulte-Hermann, R.6    Berger, W.7    Micksche, M.8
  • 24
    • 0025814980 scopus 로고
    • Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
    • Esterbauer H., Schaur R.J., Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic. Biol. Med. 1991, 11:81-128.
    • (1991) Free Radic. Biol. Med. , vol.11 , pp. 81-128
    • Esterbauer, H.1    Schaur, R.J.2    Zollner, H.3
  • 25
    • 2442571064 scopus 로고    scopus 로고
    • Cytotoxicity, ROS-generation activity and radical-scavenging activity of curcumin and related compounds
    • Fujisawa S., Atsumi T., Ishihara M., Kadoma Y. Cytotoxicity, ROS-generation activity and radical-scavenging activity of curcumin and related compounds. Anticancer Res. 2004, 24:563-569.
    • (2004) Anticancer Res. , vol.24 , pp. 563-569
    • Fujisawa, S.1    Atsumi, T.2    Ishihara, M.3    Kadoma, Y.4
  • 26
    • 0033852366 scopus 로고    scopus 로고
    • Assessing antioxidant and prooxidant activities of phenolic compounds
    • Fukumoto L.R., Mazza G. Assessing antioxidant and prooxidant activities of phenolic compounds. J. Agric. Food Chem. 2000, 48:3597-3604.
    • (2000) J. Agric. Food Chem. , vol.48 , pp. 3597-3604
    • Fukumoto, L.R.1    Mazza, G.2
  • 27
    • 31644435641 scopus 로고    scopus 로고
    • Cellular and in vivo hepatotoxicity caused by green tea phenolic acids and catechins
    • Galati G., Lin A., Sultan A.M., O'Brien P.J. Cellular and in vivo hepatotoxicity caused by green tea phenolic acids and catechins. Free Radic. Biol. Med. 2006, 40:570-580.
    • (2006) Free Radic. Biol. Med. , vol.40 , pp. 570-580
    • Galati, G.1    Lin, A.2    Sultan, A.M.3    O'Brien, P.J.4
  • 28
    • 3042574709 scopus 로고    scopus 로고
    • Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties
    • Galati G., O'Brien P.J. Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. Free Radic. Biol. Med. 2004, 37:287-303.
    • (2004) Free Radic. Biol. Med. , vol.37 , pp. 287-303
    • Galati, G.1    O'Brien, P.J.2
  • 29
    • 0037096193 scopus 로고    scopus 로고
    • The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer's and Parkinson's diseases
    • Giasson B.I., Ischiropoulos H., Lee V.M., Trojanowski J.Q. The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer's and Parkinson's diseases. Free Radic. Biol. Med. 2002, 32:1264-1275.
    • (2002) Free Radic. Biol. Med. , vol.32 , pp. 1264-1275
    • Giasson, B.I.1    Ischiropoulos, H.2    Lee, V.M.3    Trojanowski, J.Q.4
  • 30
    • 0033788223 scopus 로고    scopus 로고
    • Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing
    • Gil M.I., Tomas-Barberan F.A., Hess-Pierce B., Holcroft D.M., Kader A.A. Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J. Agric. Food Chem. 2000, 48:4581-4589.
    • (2000) J. Agric. Food Chem. , vol.48 , pp. 4581-4589
    • Gil, M.I.1    Tomas-Barberan, F.A.2    Hess-Pierce, B.3    Holcroft, D.M.4    Kader, A.A.5
  • 32
    • 34548416749 scopus 로고    scopus 로고
    • Differential regulation of CD11b on gammadelta T cells and monocytes in response to unripe apple polyphenols
    • Graff J.C., Jutila M.A. Differential regulation of CD11b on gammadelta T cells and monocytes in response to unripe apple polyphenols. J. Leukoc. Biol. 2007, 82:603-607.
    • (2007) J. Leukoc. Biol. , vol.82 , pp. 603-607
    • Graff, J.C.1    Jutila, M.A.2
  • 34
    • 36549060678 scopus 로고    scopus 로고
    • Protective effects of green tea polyphenols in the 6-OHDA rat model of Parkinson's disease through inhibition of ROS-NO pathway
    • Guo S., Yan J., Yang T., Yang X., Bezard E., Zhao B. Protective effects of green tea polyphenols in the 6-OHDA rat model of Parkinson's disease through inhibition of ROS-NO pathway. Biol. Psychiatry 2007, 62:1353-1362.
    • (2007) Biol. Psychiatry , vol.62 , pp. 1353-1362
    • Guo, S.1    Yan, J.2    Yang, T.3    Yang, X.4    Bezard, E.5    Zhao, B.6
  • 37
    • 0031771518 scopus 로고    scopus 로고
    • Interaction of alpha-phenyl-N-tert-butyl nitrone and alternative electron acceptors with complex I indicates a substrate reduction site upstream from the rotenone binding site
    • Hensley K., Pye Q.N., Maidt M.L., Stewart C.A., Robinson K.A., Jaffrey F., Floyd R.A. Interaction of alpha-phenyl-N-tert-butyl nitrone and alternative electron acceptors with complex I indicates a substrate reduction site upstream from the rotenone binding site. J. Neurochem. 1998, 71:2549-2557.
    • (1998) J. Neurochem. , vol.71 , pp. 2549-2557
    • Hensley, K.1    Pye, Q.N.2    Maidt, M.L.3    Stewart, C.A.4    Robinson, K.A.5    Jaffrey, F.6    Floyd, R.A.7
  • 38
    • 77953262917 scopus 로고    scopus 로고
    • Neuroprotective effectsof hydrogen sulfide on Parkinson's disease rat models
    • Hu L.F., Lu M., Tiong C.X., Dawe G.S., Hu G., Bian J.S. Neuroprotective effectsof hydrogen sulfide on Parkinson's disease rat models. Aging Cell 2010, 9:135-146.
    • (2010) Aging Cell , vol.9 , pp. 135-146
    • Hu, L.F.1    Lu, M.2    Tiong, C.X.3    Dawe, G.S.4    Hu, G.5    Bian, J.S.6
  • 40
    • 0037378026 scopus 로고    scopus 로고
    • Oxidative stress in Parkinson's disease
    • discussion S36-8
    • Jenner P. Oxidative stress in Parkinson's disease. Ann. Neurol. 2003, 53(Suppl 3):S26-S36. discussion S36-8.
    • (2003) Ann. Neurol. , vol.53 , Issue.SUPPL 3
    • Jenner, P.1
  • 41
    • 0034520395 scopus 로고    scopus 로고
    • Inflammatory regulators in Parkinson's disease: iNOS, lipocortin-1, and cyclooxygenases-1 and -2
    • Knott C., Stern G., Wilkin G.P. Inflammatory regulators in Parkinson's disease: iNOS, lipocortin-1, and cyclooxygenases-1 and -2. Mol. Cell Neurosci. 2000, 16:724-739.
    • (2000) Mol. Cell Neurosci. , vol.16 , pp. 724-739
    • Knott, C.1    Stern, G.2    Wilkin, G.P.3
  • 44
    • 0036145435 scopus 로고    scopus 로고
    • Attenuation of 6-hydroxydopamine (6-OHDA)-induced nuclear factor-kappaB (NF-kappaB) activation and cell death by tea extracts in neuronal cultures
    • Levites Y., Youdim M.B., Maor G., Mandel S. Attenuation of 6-hydroxydopamine (6-OHDA)-induced nuclear factor-kappaB (NF-kappaB) activation and cell death by tea extracts in neuronal cultures. Biochem. Pharmacol. 2002, 63:21-29.
    • (2002) Biochem. Pharmacol. , vol.63 , pp. 21-29
    • Levites, Y.1    Youdim, M.B.2    Maor, G.3    Mandel, S.4
  • 45
    • 34247359586 scopus 로고    scopus 로고
    • An orally active catalytic metalloporphyrin protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in vivo
    • Liang L.P., Huang J., Fulton R., Day B.J., Patel M. An orally active catalytic metalloporphyrin protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in vivo. J. Neurosci. 2007, 27:4326-4333.
    • (2007) J. Neurosci. , vol.27 , pp. 4326-4333
    • Liang, L.P.1    Huang, J.2    Fulton, R.3    Day, B.J.4    Patel, M.5
  • 47
    • 78650525484 scopus 로고    scopus 로고
    • ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease
    • Maher P., Dargusch R., Bodai L., Gerard P.E., Purcell J.M., Marsh J.L. ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease. Hum. Mol. Genet. 2011, 20:261-270.
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 261-270
    • Maher, P.1    Dargusch, R.2    Bodai, L.3    Gerard, P.E.4    Purcell, J.M.5    Marsh, J.L.6
  • 48
    • 0023789193 scopus 로고
    • Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
    • McGeer P.L., Itagaki S., Boyes B.E., McGeer E.G. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 1988, 38:1285-1291.
    • (1988) Neurology , vol.38 , pp. 1285-1291
    • McGeer, P.L.1    Itagaki, S.2    Boyes, B.E.3    McGeer, E.G.4
  • 49
    • 0345148810 scopus 로고    scopus 로고
    • Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product
    • Metodiewa D., Jaiswal A.K., Cenas N., Dickancaite E., Segura-Aguilar J. Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product. Free Radic. Biol. Med. 1999, 26:107-116.
    • (1999) Free Radic. Biol. Med. , vol.26 , pp. 107-116
    • Metodiewa, D.1    Jaiswal, A.K.2    Cenas, N.3    Dickancaite, E.4    Segura-Aguilar, J.5
  • 50
    • 0030582991 scopus 로고    scopus 로고
    • Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease
    • Mogi M., Harada M., Narabayashi H., Inagaki H., Minami M., Nagatsu T. Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease. Neurosci. Lett. 1996, 211:13-16.
    • (1996) Neurosci. Lett. , vol.211 , pp. 13-16
    • Mogi, M.1    Harada, M.2    Narabayashi, H.3    Inagaki, H.4    Minami, M.5    Nagatsu, T.6
  • 51
    • 4544236944 scopus 로고    scopus 로고
    • Generation of hydrogen peroxide primarily contributes to the induction of Fe(II)-dependent apoptosis in Jurkat cells by (-)-epigallocatechin gallate
    • Nakagawa H., Hasumi K., Woo J.T., Nagai K., Wachi M. Generation of hydrogen peroxide primarily contributes to the induction of Fe(II)-dependent apoptosis in Jurkat cells by (-)-epigallocatechin gallate. Carcinogenesis 2004, 25:1567-1574.
    • (2004) Carcinogenesis , vol.25 , pp. 1567-1574
    • Nakagawa, H.1    Hasumi, K.2    Woo, J.T.3    Nagai, K.4    Wachi, M.5
  • 52
    • 0042195863 scopus 로고    scopus 로고
    • Catechins induce oxidative damage to cellular and isolated DNA through the generation of reactive oxygen species
    • Oikawa S., Furukawaa A., Asada H., Hirakawa K., Kawanishi S. Catechins induce oxidative damage to cellular and isolated DNA through the generation of reactive oxygen species. Free Radic. Res. 2003, 37:881-890.
    • (2003) Free Radic. Res. , vol.37 , pp. 881-890
    • Oikawa, S.1    Furukawaa, A.2    Asada, H.3    Hirakawa, K.4    Kawanishi, S.5
  • 53
    • 33747286388 scopus 로고    scopus 로고
    • Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets
    • Ramassamy C. Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets. Eur. J. Pharmacol. 2006, 545:51-64.
    • (2006) Eur. J. Pharmacol. , vol.545 , pp. 51-64
    • Ramassamy, C.1
  • 54
    • 23944513613 scopus 로고    scopus 로고
    • Green tea polyphenol epigallocatechin-3-gallate differentially modulates oxidative stress in PC12 cell compartments
    • Raza H., John A. Green tea polyphenol epigallocatechin-3-gallate differentially modulates oxidative stress in PC12 cell compartments. Toxicol. Appl. Pharmacol. 2005, 207:212-220.
    • (2005) Toxicol. Appl. Pharmacol. , vol.207 , pp. 212-220
    • Raza, H.1    John, A.2
  • 55
    • 0028293038 scopus 로고
    • Time course of recovery of extracellular dopamine following partial damage to the nigrostriatal dopamine system
    • Robinson T.E., Mocsary Z., Camp D.M., Whishaw I.Q. Time course of recovery of extracellular dopamine following partial damage to the nigrostriatal dopamine system. J. Neurosci. 1994, 14:2687-2696.
    • (1994) J. Neurosci. , vol.14 , pp. 2687-2696
    • Robinson, T.E.1    Mocsary, Z.2    Camp, D.M.3    Whishaw, I.Q.4
  • 56
    • 77951546947 scopus 로고    scopus 로고
    • The major green tea polyphenol, (-)-epigallocatechin-3-gallate, induces heme oxygenase in rat neurons and acts as an effective neuroprotective agent against oxidative stress
    • Romeo L., Intrieri M., D'Agata V., Mangano N.G., Oriani G., Ontario M.L., Scapagnini G. The major green tea polyphenol, (-)-epigallocatechin-3-gallate, induces heme oxygenase in rat neurons and acts as an effective neuroprotective agent against oxidative stress. J. Am. Coll. Nutr. 2009, 28(Suppl):492S-499S.
    • (2009) J. Am. Coll. Nutr. , vol.28 , Issue.SUPPL
    • Romeo, L.1    Intrieri, M.2    D'Agata, V.3    Mangano, N.G.4    Oriani, G.5    Ontario, M.L.6    Scapagnini, G.7
  • 57
    • 32944475325 scopus 로고    scopus 로고
    • Synthesis and structure identification of thiol conjugates of (-)-epigallocatechin gallate and their urinary levels in mice
    • Sang S., Lambert J.D., Hong J., Tian S., Lee M.J., Stark R.E., Ho C.T., Yang C.S. Synthesis and structure identification of thiol conjugates of (-)-epigallocatechin gallate and their urinary levels in mice. Chem. Res. Toxicol. 2005, 18:1762-1769.
    • (2005) Chem. Res. Toxicol. , vol.18 , pp. 1762-1769
    • Sang, S.1    Lambert, J.D.2    Hong, J.3    Tian, S.4    Lee, M.J.5    Stark, R.E.6    Ho, C.T.7    Yang, C.S.8
  • 58
    • 0000431473 scopus 로고    scopus 로고
    • Intervention strategies for degeneration of dopamine neurons in parkinsonism: optimizing behavioral assessment of outcome
    • Humana Press, Totowa, New Jersey, United States, R.L. Dean, D.F. Emerich, P.R. Sanberg (Eds.)
    • Schallert T., Tillerson J.L. Intervention strategies for degeneration of dopamine neurons in parkinsonism: optimizing behavioral assessment of outcome. Central Nervous System Diseases: Innovative models of CNS diseases from molecule to therapy 2000, 131-151. Humana Press, Totowa, New Jersey, United States. R.L. Dean, D.F. Emerich, P.R. Sanberg (Eds.).
    • (2000) Central Nervous System Diseases: Innovative models of CNS diseases from molecule to therapy , pp. 131-151
    • Schallert, T.1    Tillerson, J.L.2
  • 60
    • 0037402801 scopus 로고    scopus 로고
    • Selective microglial activation in the rat rotenone model of Parkinson's disease
    • Sherer T.B., Betarbet R., Kim J.H., Greenamyre J.T. Selective microglial activation in the rat rotenone model of Parkinson's disease. Neurosci. Lett. 2003, 341:87-90.
    • (2003) Neurosci. Lett. , vol.341 , pp. 87-90
    • Sherer, T.B.1    Betarbet, R.2    Kim, J.H.3    Greenamyre, J.T.4
  • 62
    • 0028075410 scopus 로고
    • Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia
    • Sian J., Dexter D.T., Lees A.J., Daniel S., Agid Y., Javoy-Agid F., Jenner P., Marsden C.D. Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia. Ann. Neurol. 1994, 36:348-355.
    • (1994) Ann. Neurol. , vol.36 , pp. 348-355
    • Sian, J.1    Dexter, D.T.2    Lees, A.J.3    Daniel, S.4    Agid, Y.5    Javoy-Agid, F.6    Jenner, P.7    Marsden, C.D.8
  • 63
    • 74049134972 scopus 로고    scopus 로고
    • Melatonin treatment potentiates neurodegeneration in a rat rotenone Parkinson's disease model
    • Tapias V., Cannon J.R., Greenamyre J.T. Melatonin treatment potentiates neurodegeneration in a rat rotenone Parkinson's disease model. J. Neurosci. Res. 2010, 88:420-427.
    • (2010) J. Neurosci. Res. , vol.88 , pp. 420-427
    • Tapias, V.1    Cannon, J.R.2    Greenamyre, J.T.3
  • 65
    • 84876338056 scopus 로고    scopus 로고
    • Automated imaging system for fast quantitation of neurons, cell morphology and neurite morphometry in vivo and in vitro
    • Tapias V., Greenamyre J.T., Watkins S.C. Automated imaging system for fast quantitation of neurons, cell morphology and neurite morphometry in vivo and in vitro. Neurobiol. Dis. 2013, 54:158-168.
    • (2013) Neurobiol. Dis. , vol.54 , pp. 158-168
    • Tapias, V.1    Greenamyre, J.T.2    Watkins, S.C.3
  • 67
    • 0034284635 scopus 로고    scopus 로고
    • Dopamine transporter function assessed by antisense knockdown in the rat: protection from dopamine neurotoxicity
    • Van Kampen J.M., McGeer E.G., Stoessl A.J. Dopamine transporter function assessed by antisense knockdown in the rat: protection from dopamine neurotoxicity. Synapse 2000, 37:171-178.
    • (2000) Synapse , vol.37 , pp. 171-178
    • Van Kampen, J.M.1    McGeer, E.G.2    Stoessl, A.J.3
  • 68
    • 4644313472 scopus 로고    scopus 로고
    • Gene expression changes induced by green tea polyphenol (-)-epigallocatechin-3-gallate in human bronchial epithelial 21BES cells analyzed by DNA microarray
    • Vittal R., Selvanayagam Z.E., Sun Y., Hong J., Liu F., Chin K.V., Yang C.S. Gene expression changes induced by green tea polyphenol (-)-epigallocatechin-3-gallate in human bronchial epithelial 21BES cells analyzed by DNA microarray. Mol. Cancer Ther. 2004, 3:1091-1099.
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 1091-1099
    • Vittal, R.1    Selvanayagam, Z.E.2    Sun, Y.3    Hong, J.4    Liu, F.5    Chin, K.V.6    Yang, C.S.7
  • 69
    • 14944364739 scopus 로고    scopus 로고
    • Low concentrations of flavonoids are protective in rat H4IIE cells whereas high concentrations cause DNA damage and apoptosis
    • Watjen W., Michels G., Steffan B., Niering P., Chovolou Y., Kampkotter A., Tran-Thi Q.H., Proksch P., Kahl R. Low concentrations of flavonoids are protective in rat H4IIE cells whereas high concentrations cause DNA damage and apoptosis. J. Nutr. 2005, 135:525-531.
    • (2005) J. Nutr. , vol.135 , pp. 525-531
    • Watjen, W.1    Michels, G.2    Steffan, B.3    Niering, P.4    Chovolou, Y.5    Kampkotter, A.6    Tran-Thi, Q.H.7    Proksch, P.8    Kahl, R.9
  • 70
    • 43449119803 scopus 로고    scopus 로고
    • Enhanced function in the good forelimb of hemi-parkinson rats: compensatory adaptation for contralateral postural instability?
    • Woodlee M.T., Kane J.R., Chang J., Cormack L.K., Schallert T. Enhanced function in the good forelimb of hemi-parkinson rats: compensatory adaptation for contralateral postural instability?. Exp. Neurol. 2008, 211:511-517.
    • (2008) Exp. Neurol. , vol.211 , pp. 511-517
    • Woodlee, M.T.1    Kane, J.R.2    Chang, J.3    Cormack, L.K.4    Schallert, T.5
  • 71
    • 0036522967 scopus 로고    scopus 로고
    • Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease
    • Wu D.C., Jackson-Lewis V., Vila M., Tieu K., Teismann P., Vadseth C., Choi D.K., Ischiropoulos H., Przedborski S. Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. J. Neurosci. 2002, 22:1763-1771.
    • (2002) J. Neurosci. , vol.22 , pp. 1763-1771
    • Wu, D.C.1    Jackson-Lewis, V.2    Vila, M.3    Tieu, K.4    Teismann, P.5    Vadseth, C.6    Choi, D.K.7    Ischiropoulos, H.8    Przedborski, S.9
  • 72
    • 68949173926 scopus 로고    scopus 로고
    • Novel neuroprotective mechanisms of memantine: increase in neurotrophic factor release from astroglia and anti-inflammation by preventing microglial activation
    • Wu H.M., Tzeng N.S., Qian L., Wei S.J., Hu X., Chen S.H., Rawls S.M., Flood P., Hong J.S., Lu R.B. Novel neuroprotective mechanisms of memantine: increase in neurotrophic factor release from astroglia and anti-inflammation by preventing microglial activation. Neuropsychopharmacology 2009, 34:2344-2357.
    • (2009) Neuropsychopharmacology , vol.34 , pp. 2344-2357
    • Wu, H.M.1    Tzeng, N.S.2    Qian, L.3    Wei, S.J.4    Hu, X.5    Chen, S.H.6    Rawls, S.M.7    Flood, P.8    Hong, J.S.9    Lu, R.B.10
  • 73
    • 20344363680 scopus 로고    scopus 로고
    • Systematic administration of iptakalim, an ATP-sensitive potassium channel opener, prevents rotenone-induced motor and neurochemical alterations in rats
    • Yang Y., Liu X., Long Y., Wang F., Ding J.H., Liu S.Y., Sun Y.H., Yao H.H., Wang H., Wu J., Hu G. Systematic administration of iptakalim, an ATP-sensitive potassium channel opener, prevents rotenone-induced motor and neurochemical alterations in rats. J. Neurosci. Res. 2005, 80:442-449.
    • (2005) J. Neurosci. Res. , vol.80 , pp. 442-449
    • Yang, Y.1    Liu, X.2    Long, Y.3    Wang, F.4    Ding, J.H.5    Liu, S.Y.6    Sun, Y.H.7    Yao, H.H.8    Wang, H.9    Wu, J.10    Hu, G.11
  • 74
    • 0842302388 scopus 로고    scopus 로고
    • Modulation of tea and tea polyphenols on benzo(a)pyrene-induced DNA damage in Chang liver cells
    • Yen G.C., Ju J.W., Wu C.H. Modulation of tea and tea polyphenols on benzo(a)pyrene-induced DNA damage in Chang liver cells. Free Radic. Res. 2004, 38:193-200.
    • (2004) Free Radic. Res. , vol.38 , pp. 193-200
    • Yen, G.C.1    Ju, J.W.2    Wu, C.H.3
  • 76
    • 77949532182 scopus 로고    scopus 로고
    • Curcumin prevents dopaminergic neuronal death through inhibition of the c-Jun N-terminal kinase pathway
    • Yu S., Zheng W., Xin N., Chi Z.H., Wang N.Q., Nie Y.X., Feng W.Y., Wang Z.Y. Curcumin prevents dopaminergic neuronal death through inhibition of the c-Jun N-terminal kinase pathway. Rejuvenation Res. 2010, 13:55-64.
    • (2010) Rejuvenation Res. , vol.13 , pp. 55-64
    • Yu, S.1    Zheng, W.2    Xin, N.3    Chi, Z.H.4    Wang, N.Q.5    Nie, Y.X.6    Feng, W.Y.7    Wang, Z.Y.8
  • 77
    • 25444508963 scopus 로고    scopus 로고
    • Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease
    • Zbarsky V., Datla K.P., Parkar S., Rai D.K., Aruoma O.I., Dexter D.T. Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease. Free Radic. Res. 2005, 39:1119-1125.
    • (2005) Free Radic. Res. , vol.39 , pp. 1119-1125
    • Zbarsky, V.1    Datla, K.P.2    Parkar, S.3    Rai, D.K.4    Aruoma, O.I.5    Dexter, D.T.6


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