Betaine supplementation protects against high-fructose-induced renal injury in rats

Journal of Nutritional Biochemistry

Volumn 25, Issue 3, 2014, Pages 353-362

  Fan, Chen Yu ^a   Wang, Ming Xing ^a   Ge, Chen Xu ^a   Wang, Xing ^a   Li, Jian Mei ^a   Kong, Ling Dong ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Betaine; Fructose; Insulin resistance; Renal inflammation; Renal injury

Indexed keywords

BETAINE; FRUCTOSE; INSULIN RESISTANCE; RENAL INFLAMMATION; RENAL INJURY;

ANIMALS; BETAINE; CYTOKINES; DIETARY SUPPLEMENTS; DYSLIPIDEMIAS; FRUCTOSE; HYPERURICEMIA; INFLAMMATION; INSULIN RESISTANCE; KIDNEY; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84893775535     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2013.11.010     Document Type: Article

References (56)

1. Lustig R.H., Schmidt L.A., Brindis C.D. Public health: the toxic truth about sugar. Nature 2012, 482:27-29.
2. Lustig R.H. Fructose: it's "alcohol without the buzz". Adv Nutr 2013, 4:226-235.
3. Basu S., Yoffe P., Hills N., Lustig R.H. The relationship of sugar to population-level diabetes prevalence: an econometric analysis of repeated cross-sectional data. PLoS ONE 2013, 8:e57873.
4. Perito E.R., Rodriguez L.A., Lustig R.H. Dietary treatment of nonalcoholic steatohepatitis. Curr Opin Gastroenterol 2013, 29:170-176.
5. Stanhope K.L., Schwarz J.M., Keim N.L., Griffen S.C., Bremer A.A., Graham J.L., et al. Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest 2009, 119:1322-1334.
6. Vasiljevic A., Velickovic N., Bursac B., Djordjevic A., Milutinovic D.V., Nestorovic N., et al. Enhanced prereceptor glucocorticoid metabolism and lipogenesis impair insulin signaling in the liver of fructose-fed rats. J Nutr Biochem 2013, 24:1790-1797.
7. Vila L., Rebollo A., Adalsteisson G.S., Alegret M., Merlos M., Roglans N., et al. Reduction of liver fructokinase expression and improved hepatic inflammation and metabolism in liquid fructose-fed rats after atorvastatin treatment. Toxicol Appl Pharmacol 2011, 251:32-40.
8. Vilà L., Roglans N., Alegret M., Sánchez R.M., Vázquez-Carrera M., Laguna J.C. Suppressor of cytokine signaling-3 (SOCS-3) and a deficit of serine/threonine (Ser/Thr) phosphoproteins involved in leptin transduction mediate the effect of fructose on rat liver lipid metabolism. Hepatology 2008, 48:1506-1516.
9. Johnson R.J., Sanchez-Lozada L.G., Nakagawa T. The effect of fructose on renal biology and disease. J Am Soc Nephrol 2010, 21:2036-2039.
10. Nakayama T., Kosugi T., Gersch M., Connor T., Sanchez-Lozada L.G., Lanaspa M.A., et al. Dietary fructose causes tubulointerstitial injury in the normal rat kidney. Am J Physiol Renal Physiol 2010, 298:F712-F720.
11. Sánchez-Lozada L.G., Tapia E., Jiménez A., Bautista P., Cristóbal M., Nepomuceno T., et al. Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats. Am J Physiol Renal Physiol 2007, 292:F423-F429.
12. Lecoultre V., Egli L., Theytaz F., Despland C., Schneiter P., Tappy L. Fructose-induced hyperuricemia is associated with a decreased renal uric acid excretion in humans. Diabetes Care 2013, 36:e149-e150.
13. Hu Q.H., Zhang X., Pan Y., Li Y.C., Kong L.D. Allopurinol, quercetin and rutin ameliorate renal NLRP3 inflammasome activation and lipid accumulation in fructose-fed rats. Biochem Pharmacol 2012, 84:113-125.
14. Miao Z., Yan S., Wang J., Wang B., Li Y., Xing X., et al. Insulin resistance acts as an independent risk factor exacerbating high-purine diet induced renal injury and knee joint gouty lesions. Inflamm Res 2009, 58:659-668.
15. Cappuccio F.P., Strazzullo P., Farinaro E., Trevisan M. Uric acid metabolism and tubular sodium handling. Results from a population-based study. JAMA 1993, 270:354-359.
16. Nakagawa T., Tuttle K.R., Short R.A., Johnson R.J. Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome. Nat Clin Pract Nephrol 2005, 1:80-86.
17. Nakagawa T., Hu H., Zharikov S., Tuttle K.R., Short R.A., Glushakova O., et al. A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol Renal Physiol 2006, 290:F625-F631.
18. Denoble A.E., Huffman K.M., Stabler T.V., Kelly S.J., Hershfield M.S., McDaniel G.E., et al. Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation. Proc Natl Acad Sci U S A 2011, 108:2088-2093.
19. Martinon F., Petrilli V., Mayor A., Tardivel A., Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 2006, 440:237-241.
20. Zhou R., Yazdi A.S., Menu P., Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature 2011, 469:221-225.
21. Dungey M., Hull K.L., Smith A.C., Burton J.O., Bishop N.C. Inflammatory factors and exercise in chronic kidney disease. Int J Endocrinol 2013, 2013:569831.
22. Vilaysane A., Chun J., Seamone M.E., Wang W., Chin R., Hirota S., et al. The NLRP3 inflammasome promotes renal inflammation and contributes to CKD. J Am Soc Nephrol 2010, 21:1732-1744.
23. Palanisamy N., Kannappan S., Anuradha C.V. Genistein modulates NF-kappaB-associated renal inflammation, fibrosis and podocyte abnormalities in fructose-fed rats. Eur J Pharmacol 2011, 667:355-364.
24. Jiang Y., Zhang Q., Soderland C., Steinle J.J. TNFalpha and SOCS3 regulate IRS-1 to increase retinal endothelial cell apoptosis. Cell Signal 2012, 24:1086-1092.
25. Wahli W., Michalik L. PPARs. Trends Endocrinol Metab 2012, 23:351-363.
26. Kang Y.S., Lee M.H., Song H.K., Ko G.J., Kwon O.S., Lim T.K., et al. CCR2 antagonism improves insulin resistance, lipid metabolism, and diabetic nephropathy in type 2 diabetic mice. Kidney Int 2010, 78:883-894.
27. Nam D.H., Lee M.H., Kim J.E., Song H.K., Kang Y.S., Lee J.E., et al. Blockade of cannabinoid receptor 1 improves insulin resistance, lipid metabolism, and diabetic nephropathy in db/db mice. Endocrinology 2012, 153:1387-1396.
28. Craig S.A. Betaine in human nutrition. Am J Clin Nutr 2004, 80:539-549.
29. Lever M., Slow S. The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism. Clin Biochem 2010, 43:732-744.
30. Go E.K., Jung K.J., Kim J.Y., Yu B.P., Chung H.Y. Betaine suppresses proinflammatory signaling during aging: the involvement of nuclear factor-kappaB via nuclear factor-inducing kinase/IkappaB kinase and mitogen-activated protein kinases. J Gerontol A Biol Sci Med Sci 2005, 60:1252-1264.
31. Lv S., Fan R., Du Y., Hou M., Tang Z., Ling W., et al. Betaine supplementation attenuates atherosclerotic lesion in apolipoprotein E-deficient mice. Eur J Nutr 2009, 48:205-212.
32. Olli K., Lahtinen S., Rautonen N., Tiihonen K. Betaine reduces the expression of inflammatory adipokines caused by hypoxia in human adipocytes. Br J Nutr 2013, 109:43-49.
33. Kathirvel E., Morgan K., Nandgiri G., Sandoval B.C., Caudill M.A., Bottiglieri T., et al. Betaine improves nonalcoholic fatty liver and associated hepatic insulin resistance: a potential mechanism for hepatoprotection by betaine. Am J Physiol Gastrointest Liver Physiol 2010, 299:G1068-G1077.
34. Schwahn B.C., Wang X.L., Mikael L.G., Wu Q., Cohn J., Jiang H., et al. Betaine supplementation improves the atherogenic risk factor profile in a transgenic mouse model of hyperhomocysteinemia. Atherosclerosis 2007, 195:e100-e107.
35. Wang L., Chen L., Tan Y., Wei J., Chang Y., Jin T., et al. Betaine supplement alleviates hepatic triglyceride accumulation of apolipoprotein E deficient mice via reducing methylation of peroxisomal proliferator-activated receptor alpha promoter. Lipids Health Dis 2013, 12:34.
36. Wang Z., Yao T., Pini M., Zhou Z., Fantuzzi G., Song Z. Betaine improved adipose tissue function in mice fed a high-fat diet: a mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease. Am J Physiol Gastrointest Liver Physiol 2010, 298:G634-G642.
37. Folch J., Lees M., Sloane Stanley G.H. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957, 226:497-509.
38. Hu Q.H., Wang C., Li J.M., Zhang D.M., Kong L.D. Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: renal organic ion transporter involvement. Am J Physiol Renal Physiol 2009, 297:F1080-F1091.
39. Nakayama A., Matsuo H., Takada T., Ichida K., Nakamura T., Ikebuchi Y., et al. ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humans. Nucleosides Nucleotides Nucleic Acids 2011, 30:1091-1097.
40. Serrano-Marco L., Rodriguez-Calvo R., El Kochairi I., Palomer X., Michalik L., Wahli W., et al. Activation of peroxisome proliferator-activated receptor-beta/-delta (PPAR-beta/-delta) ameliorates insulin signaling and reduces SOCS3 levels by inhibiting STAT3 in interleukin-6-stimulated adipocytes. Diabetes 2011, 60:1990-1999.
41. Kim J.E., Lee M.H., Nam D.H., Song H.K., Kang Y.S., Lee J.E., et al. Celastrol, an NF-kappaB inhibitor, improves insulin resistance and attenuates renal injury in db/db mice. PLoS ONE 2013, 8:e62068.
42. Cirillo P., Gersch M.S., Mu W., Scherer P.M., Kim K.M., Gesualdo L., et al. Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. J Am Soc Nephrol 2009, 20:545-553.
43. Collino M., Benetti E., Rogazzo M., Mastrocola R., Yaqoob M.M., Aragno M., et al. Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR-delta agonism correlates with impaired NLRP3 inflammasome activation. Biochem Pharmacol 2013, 85:257-264.
44. Solini A., Menini S., Rossi C., Ricci C., Santini E., Blasetti Fantauzzi C., et al. The purinergic 2X receptor participates in renal inflammation and injury induced by high-fat diet: possible role of NLRP3 inflammasome activation. J Pathol 2013, 231:342-353.
45. Shigeoka A.A., Mueller J.L., Kambo A., Mathison J.C., King A.J., Hall W.F., et al. An inflammasome-independent role for epithelial-expressed Nlrp3 in renal ischemia-reperfusion injury. J Immunol 2010, 185:6277-6285.
46. Yang K., Nie L., Huang Y., Zhang J., Xiao T., Guan X., et al. Amelioration of uremic toxin indoxyl sulfate-induced endothelial cell dysfunction by Klotho protein. Toxicol Lett 2012, 215:77-83.
47. Caballo C., Palomo M., Cases A., Galan A.M., Molina P., Vera M., et al. NFkappaB in the development of endothelial activation and damage in uremia: an in vitro approach. PLoS ONE 2012, 7:e43374.
48. Du P., Fan B., Han H., Zhen J., Shang J., Wang X., et al. NOD2 promotes renal injury by exacerbating inflammation and podocyte insulin resistance in diabetic nephropathy. Kidney Int 2013, 84:265-276.
49. Crescenzo R., Bianco F., Coppola P., Mazzoli A., Cigliano L., Liverini G., et al. Increased skeletal muscle mitochondrial efficiency in rats with fructose-induced alteration in glucose tolerance. Br J Nutr 2013, 1-8.
50. Hashikawa-Hobara N., Hashikawa N., Inoue Y., Sanda H., Zamami Y., Takatori S., et al. Candesartan cilexetil improves angiotensin II type 2 receptor-mediated neurite outgrowth via the PI3K-Akt pathway in fructose-induced insulin-resistant rats. Diabetes 2012, 61:925-932.
51. Xu Z.E., Chen Y., Huang A., Varghese Z., Moorhead J.F., Yan F., et al. Inflammatory stress exacerbates lipid-mediated renal injury in ApoE/CD36/SRA triple knockout mice. Am J Physiol Renal Physiol 2011, 301:F713-F722.
52. Iacobini C., Menini S., Ricci C., Scipioni A., Sansoni V., Mazzitelli G., et al. Advanced lipoxidation end-products mediate lipid-induced glomerular injury: role of receptor-mediated mechanisms. J Pathol 2009, 218:360-369.
53. Zhang G.F., Li Q., Wang L., Chen Y.X., Zhang W., Yang H.P. The effects of inflammation on lipid accumulation in the kidneys of children with primary nephrotic syndrome. Inflammation 2011, 34:645-652.
54. Salles J., Tardif N., Landrier J.F., Mothe-Satney I., Guillet C., Boue-Vaysse C., et al. TNF alpha gene knockout differentially affects lipid deposition in liver and skeletal muscle of high-fat-diet mice. J Nutr Biochem 2012, 23:1685-1693.
55. Stienstra R., Saudale F., Duval C., Keshtkar S., Groener J.E., van Rooijen N., et al. Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity. Hepatology 2010, 51:511-522.
56. Kanuri G., Spruss A., Wagnerberger S., Bischoff S.C., Bergheim I. Role of tumor necrosis factor alpha (TNFalpha) in the onset of fructose-induced nonalcoholic fatty liver disease in mice. J Nutr Biochem 2011, 22:527-534.