Amelioration of uremic toxin indoxyl sulfate-induced endothelial cell dysfunction by Klotho protein

Toxicology Letters

Volumn 215, Issue 2, 2012, Pages 77-83

  Yang, Ke ^a   Nie, Ling ^a   Huang, Yunjian ^a   Zhang, Jingbo ^a   Xiao, Tangli ^a   Guan, Xu ^a   Zhao, Jinghong ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Dysfunction; Endothelial cells; Indoxyl sulfate; Klotho; Uremic toxin

Indexed keywords

ACETYLCYSTEINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDICAN; KLOTHO PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE;

ARTICLE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION;

APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; CHEMOKINE CCL2; FLOW CYTOMETRY; GLUCURONIDASE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; IMMUNOBLOTTING; INDICAN; NF-KAPPA B; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REACTIVE OXYGEN SPECIES; RENAL INSUFFICIENCY, CHRONIC;

EID: 84868497543     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.10.004     Document Type: Article

References (36)

1. Arking D.E., Krebsova A., Macek M., Macek M., Arking A., Mian I.S., Fried L., Hamosh A., Dey S., McIntosh I., Dietz H.C. Association of human aging with a functional variant of Klotho. Proceedings of the National Academy of Sciences of the United States of America 2002, 99:856-861.
2. Atoh K., Itoh H., Haneda M. Serum indoxyl sulfate levels in patients with diabetic nephropathy: relation to renal function. Diabetes Research and Clinical Practice 2009, 83:220-226.
3. Collins T. Endothelial nuclear factor-kappa B and the initiation of the atherosclerotic lesion. Laboratory Investigation 1993, 68:499-508.
4. Dou L., Bertrand E., Cerini C., Faure V., Sampol J., Vanholder R., Berland Y., Brunet P. The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair. Kidney International 2004, 65:442-451.
5. Elsayed E.F., Tighiouart H., Griffith J., Kurth T., Levey A.S., Salem D., Sarnak M.J., Weiner D.E. Cardiovascular disease and subsequent kidney disease. Archives of Internal Medicine 2007, 167:1130-1136.
6. Ganju L., Padwad Y., Singh R., Karan D., Chanda S., Chopra M.K., Bhatnagar P., Kashyap R., Sawhney R.C. Anti-inflammatory activity of seabuckthorn (hippophae rhamnoides) leaves. International Immunopharmacology 2005, 5:1675-1684.
7. Gosmanova E.O., Le N.A. Cardiovascular complications in CKD patients: role of oxidative stress. Cardiology Research and Practice 2011, 2:156326.
8. Green L.C., Wagner D.A., Glogowski J., Skipper P.L., Wishnok J.S. Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids. Analytical Biochemistry 1982, 126:131-138.
9. Hsieh C.C., Kuro-o M., Rosenblatt K.P., Brobey R., Papaconstantinou J. The ASK1-signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging. Aging (Albany NY) 2010, 2:597-611.
10. Kanters E., Pasparakis M., Gijbels M.J., Vergouwe M.N., Partouns-Hendriks I., Fijneman R.J., Clausen B.E., Förster I., Kockx M.M., Rajewsky K., Kraal G., Hofker M.H., de Winther M.P. Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice. Journal of Clinical Investigation 2003, 112:1176-1185.
11. Koh N., Fujimori T., Nishiguchi S., Tamori A., Shiomi S., Nakatani T., Sugimura K., Kishimoto T., Kinoshita S., Kuroki T., Nabeshima Y. Severely reduced production of klotho in human chronic renal failure kidney. Biochemical and Biophysical Research Communications 2001, 280:1015-1020.
12. Kuro-o M., Matsumura Y., Aizawa H., Kawaguchi H., Suga T., Utsugi T., Ohyama Y., Kurabayashi M., Kaname T., Kume E., Iwasaki H., Iida A., Shiraki-Iida T., Nishikawa S., Nagai R., Nabeshima Y.I. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997, 390:45-51.
13. Mallamaci F., Tripepi G., Cutrupi S., Malatino L.S., Zoccali C. Prognostic value of combined use of biomarkers of inflammation, endothelial dysfunction, and myocardiopathy in patients with ESRD. Kidney International 2005, 67:2330-2337.
14. Marczin N., Jilling T., Papapetropoulos A., Go C., Catravas J.D. Cytoskeleton-dependent activation of the inducible nitric oxide synthase in cultured aortic smooth muscle cells. British Journal of Pharmacology 1996, 118:1085-1094.
15. Masai N., Tatebe J., Yoshino G., Morita T. Indoxyl sulfate stimulates monocyte hemoattractant protein-1 expression in human umbilical vein. endothelial cells by inducing oxidative stress through activation of the NADPH oxidase-nuclear factor-κb pathway. Circulation Journal 2010, 74:2216-2224.
16. Miyamoto Y., Iwao Y., Tasaki Y., Sato K., Ishima Y., Watanabe H., Kadowaki D., Maruyama T., Otagiri M. The uremic solute indoxyl sulfate acts as an antioxidant against superoxide anion radicals under normal-physiological conditions. FEBS Letters 2010, 584:2816-2820.
17. Münzel T., Sinning C., Post F., Warnholtz A., Schulz E. Pathophysiology, diagnosis and prognostic implications of endothelial dysfunction. Annals of Medicine 2008, 40:180-196.
18. Namikoshi T., Tomita N., Satoh M., Sakuta T., Kuwabara A., Kobayashi S. Oral adsorbent AST-120 ameliorates endothelial dysfunction independent of renal function in rats with subtotal nephrectomy. Hypertension Research 2009, 32:194-200.
19. Oberg B.P., McMenamin E., Lucas F.L., McMonagle E., Morrow J., Ikizler T.A., Himmelfarb J. Increased prevalence of oxidant stress and inflammation in patients with moderate to severe chronic kidney disease. Kidney International 2004, 65:1009-1016.
20. Rakugi H., Matsukawa N., Ishikawa K., Yang J., Imai M., Ikushima M., Maekawa Y., Kida I., Miyazaki J., Ogihara T. Anti-oxidative effect of Klotho on endothelial cells through cAMP activation. Endocrine 2007, 31:82-87.
21. Rodriguez-Iturbe B., Correa-Rotter R. Cardiovascular risk factors and prevention of cardiovascular disease in patients with chronic renal disease. Expert Opinion on Pharmacotherapy 2010, 11:2687-2698.
22. Rudic R.D., Shesely E.G., Maeda N., Smithies O., Segal S.S., Sessa W.C. Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling. The Journal of Clinical Investigation 1998, 101:731-736.
23. Saito Y., Yamagishi T., Nakamura T., Ohyama Y., Aizawa H., Suga T., Matsumura Y., Masuda H., Kurabayashi M., Kuro-o M., Nabeshima Y., Nagai R. Klotho protein protects against endothelial dysfunction. Biochemical and Biophysical Research Communication 1998, 248:324-329.
24. Saito Y., Nakamura T., Ohyama Y., Suzuki T., Iida A., Shiraki-Iida T., Kuro-o M., Nabeshima Y., Kurabayashi M., Nagai R. In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome. Biochemical and Biophysical Research Communication 2000, 276:767-772.
25. Sarnak M.J., Levey A.S., Schoolwerth A.C., Coresh J., Culleton B., Hamm L.L., McCullough P.A., Kasiske B.L., Kelepouris E., Klag M.J., Parfrey P., Pfeffer M., Raij L., Spinosa D.J., Wilson P.W. Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on kidney in cardiovascular disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Hypertension 2003, 42:1050-1065.
26. Shimoishi K., Anraku M., Kitamura K., Tasaki Y., Taguchi K., Hashimoto M., Fukunaga E., Maruyama T., Otagiri M. An oral adsorbent, AST-120 protects against the progression of oxidative stress by reducing the accumulation of indoxyl sulfate in the systemic circulation in renal failure. Pharmaceutical Research 2007, 24:1283-1289.
27. Taki K., Tsuruta Y., Niwa T. Indoxyl sulfate and atherosclerotic risk factors in hemodialysis patients. American Journal of Nephrology 2007, 27:30-35.
28. Toborek M., Lee Y.W., Garrido R., Kaiser S., Hennig B. Unsaturated fatty acids selectively induce an inflammatory environment in human endothelial cells. The American Journal of Clinical Nutrition 2002, 75:119-125.
29. Tonelli M., Wiebe N., Culleton B., House A., Rabbat C., Fok M., McAlister F., Garg A.X. Chronic kidney disease and mortality risk: a systematic review. Journal of the American Society of Nephrology 2006, 17:2034-2047.
30. Trepels T., Zeiher A.M., Fichtlscherer S. The endothelium and inflammation. Endothelium 2006, 13:423-429.
31. Tumur Z., Niwa T. Indoxyl sulfate inhibits nitric oxide production and cell viability by inducing oxidative stress in vascular endothelial cells. American Journal of Nephrology 2009, 29:551-557.
32. Tumur Z., Shimizu H., Enomoto A., Miyazaki H., Niwa T. Indoxyl sulfate upregulates expression of ICAM-1 and MCP-1 by oxidative stress-induced NF-κB activation. American Journal of Nephrology 2010, 31:435-441.
33. Vanholder R., De Smet R., Glorieux G., Argilés A., Baurmeister U., Brunet P., Clark W., Cohen G., De Deyn P.P., Deppisch R., Descamps-Latscha B., Henle T., Jörres A., Lemke H.D., Massy Z.A., Passlick-Deetjen J., Rodriguez M., Stegmayr B., Stenvinkel P., Tetta C., Wanner C., Zidek W. European uremic toxin work group (eutox) review on uremic toxins: classification, concentration, and interindividual variability. Kidney International 2003, 63:1934-1943.
34. Xie Q.W., Cho H.J., Calaycay J., Mumford R.A., Swiderek K.M., Lee T.D., Ding A., Troso T., Nathan C. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science 1992, 256:225-228.
35. Yu J., Deng M., Zhao J., Huang L. Decreased expression of klotho gene in uremic atherosclerosis in apolipoprotein E-deficient mice. Biochemical and Biophysical Research Communications 2010, 391:261-266.
36. Zhao J., Huang Y., Song Y., Zhao X., Jin J., Wang J., Huang L. Low osmolar contrast medium induces cellular injury and disruption of calcium homeostasis in rat glomerular endothelial cells in vitro. Toxicology Letters 2009, 185:124-131.