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Volumn 23, Issue 12, 2012, Pages 1685-1693

TNFα gene knockout differentially affects lipid deposition in liver and skeletal muscle of high-fat-diet mice

Author keywords

Fibrosis; High fat diet; Inflammation; Lipotoxicity; TNF KO mice

Indexed keywords

C REACTIVE PROTEIN; CERAMIDE; FATTY ACID; FATTY ACID TRANSPORTER; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; RESISTIN; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

EID: 84869089985     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2011.12.001     Document Type: Article
Times cited : (33)

References (51)
  • 1
    • 33845881411 scopus 로고    scopus 로고
    • Mechanisms linking obesity to insulin resistance and type 2 diabetes
    • Kahn S.E., Hull R.L., Utzschneider K.M. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 2006, 444:840-846.
    • (2006) Nature , vol.444 , pp. 840-846
    • Kahn, S.E.1    Hull, R.L.2    Utzschneider, K.M.3
  • 2
    • 0030855615 scopus 로고    scopus 로고
    • Weight change and diabetes incidence: findings from a national cohort of US adults
    • Ford E.S., Williamson D.F., Liu S. Weight change and diabetes incidence: findings from a national cohort of US adults. Am J Epidemiol 1997, 146:214-222.
    • (1997) Am J Epidemiol , vol.146 , pp. 214-222
    • Ford, E.S.1    Williamson, D.F.2    Liu, S.3
  • 4
    • 33845325476 scopus 로고    scopus 로고
    • Adipocyte differentiation from the inside out
    • Rosen E.D., MacDougald O.A. Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol 2006, 7:885-896.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 885-896
    • Rosen, E.D.1    MacDougald, O.A.2
  • 5
    • 33748942837 scopus 로고    scopus 로고
    • Transcriptional control of adipocyte formation
    • Farmer S.R. Transcriptional control of adipocyte formation. Cell Metab 2006, 4:263-273.
    • (2006) Cell Metab , vol.4 , pp. 263-273
    • Farmer, S.R.1
  • 6
    • 34250710450 scopus 로고    scopus 로고
    • Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation
    • Sethi J.K., Vidal-Puig A.J. Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation. J Lipid Res 2007, 48:1253-1262.
    • (2007) J Lipid Res , vol.48 , pp. 1253-1262
    • Sethi, J.K.1    Vidal-Puig, A.J.2
  • 7
    • 38149080635 scopus 로고    scopus 로고
    • Adipose tissue expandability and the metabolic syndrome
    • Slawik M., Vidal-Puig A.J. Adipose tissue expandability and the metabolic syndrome. Genes Nutr 2007, 2:41-45.
    • (2007) Genes Nutr , vol.2 , pp. 41-45
    • Slawik, M.1    Vidal-Puig, A.J.2
  • 8
    • 53849143606 scopus 로고    scopus 로고
    • Adipose tissue expandability: the metabolic problems of obesity may arise from the inability to become more obese
    • Tan C.Y., Vidal-Puig A. Adipose tissue expandability: the metabolic problems of obesity may arise from the inability to become more obese. Biochem Soc Trans 2008, 36:935-940.
    • (2008) Biochem Soc Trans , vol.36 , pp. 935-940
    • Tan, C.Y.1    Vidal-Puig, A.2
  • 9
    • 0035130102 scopus 로고    scopus 로고
    • Diseases of liporegulation: new perspective on obesity and related disorders
    • Unger R.H., Orci L. Diseases of liporegulation: new perspective on obesity and related disorders. Faseb J 2001, 15:312-321.
    • (2001) Faseb J , vol.15 , pp. 312-321
    • Unger, R.H.1    Orci, L.2
  • 10
    • 0038509036 scopus 로고    scopus 로고
    • Lipotoxicity: when tissues overeat
    • Schaffer J.E. Lipotoxicity: when tissues overeat. Curr Opin Lipidol 2003, 14:281-287.
    • (2003) Curr Opin Lipidol , vol.14 , pp. 281-287
    • Schaffer, J.E.1
  • 11
    • 42949116365 scopus 로고    scopus 로고
    • Lipid accumulation in non-adipose tissue and lipotoxicity
    • van Herpen N.A., Schrauwen-Hinderling V.B. Lipid accumulation in non-adipose tissue and lipotoxicity. Physiol Behav 2008, 94:231-241.
    • (2008) Physiol Behav , vol.94 , pp. 231-241
    • van Herpen, N.A.1    Schrauwen-Hinderling, V.B.2
  • 12
    • 0035487317 scopus 로고    scopus 로고
    • Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle
    • Virkamäki A., Korsheninnikova E., Seppälä-Lindroos A., Vehkavaara S., Goto T., Halavaara J., et al. Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle. Diabetes 2001, 50:2337-2343.
    • (2001) Diabetes , vol.50 , pp. 2337-2343
    • Virkamäki, A.1    Korsheninnikova, E.2    Seppälä-Lindroos, A.3    Vehkavaara, S.4    Goto, T.5    Halavaara, J.6
  • 13
    • 0032934826 scopus 로고    scopus 로고
    • Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study
    • Krssak M., Falk Petersen K., Dresner A., DiPietro L., Vogel S.M., Rothman D.L., et al. Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia 1999, 42:113-116.
    • (1999) Diabetologia , vol.42 , pp. 113-116
    • Krssak, M.1    Falk Petersen, K.2    Dresner, A.3    DiPietro, L.4    Vogel, S.M.5    Rothman, D.L.6
  • 14
    • 0032764784 scopus 로고    scopus 로고
    • Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents
    • Perseghin G., Scifo P., De Cobelli F., Pagliato E., Mattezzati A., Arcelloni C., et al. Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes 1999, 48:1600-1606.
    • (1999) Diabetes , vol.48 , pp. 1600-1606
    • Perseghin, G.1    Scifo, P.2    De Cobelli, F.3    Pagliato, E.4    Mattezzati, A.5    Arcelloni, C.6
  • 16
    • 25644448266 scopus 로고    scopus 로고
    • Fat in the liver and insulin resistance
    • Yki-Jarvinen H. Fat in the liver and insulin resistance. Ann Med 2005, 37:347-356.
    • (2005) Ann Med , vol.37 , pp. 347-356
    • Yki-Jarvinen, H.1
  • 17
    • 34249894505 scopus 로고    scopus 로고
    • Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance
    • Liu L., Zhang Y., Chen N., Shi X., Tsang B., Yu Y.H. Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance. J Clin Invest 2007, 117:1679-1689.
    • (2007) J Clin Invest , vol.117 , pp. 1679-1689
    • Liu, L.1    Zhang, Y.2    Chen, N.3    Shi, X.4    Tsang, B.5    Yu, Y.H.6
  • 18
    • 33745841299 scopus 로고    scopus 로고
    • Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content
    • Bruce C.R., Thrush A.B., Mertz V.A., Bezaire V., Chabowski A., Heigenhause G.J., et al. Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content. Am J Physiol Endocrinol Metab 2006, 291:E99-E107.
    • (2006) Am J Physiol Endocrinol Metab , vol.291
    • Bruce, C.R.1    Thrush, A.B.2    Mertz, V.A.3    Bezaire, V.4    Chabowski, A.5    Heigenhause, G.J.6
  • 19
    • 34447130778 scopus 로고    scopus 로고
    • Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance
    • Choi C.S., Fillmore J.J., Kim J.K., Liu Z.X., Kim S., Collier E.F., et al. Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance. J Clin Invest 2007, 117:1995-2003.
    • (2007) J Clin Invest , vol.117 , pp. 1995-2003
    • Choi, C.S.1    Fillmore, J.J.2    Kim, J.K.3    Liu, Z.X.4    Kim, S.5    Collier, E.F.6
  • 20
    • 34347235098 scopus 로고    scopus 로고
    • Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver
    • Monetti M., Levin M.C., Watt M.J., Sajan M.P., Marmor S., Hubbard B.K., et al. Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab 2007, 6:69-78.
    • (2007) Cell Metab , vol.6 , pp. 69-78
    • Monetti, M.1    Levin, M.C.2    Watt, M.J.3    Sajan, M.P.4    Marmor, S.5    Hubbard, B.K.6
  • 21
    • 34250356015 scopus 로고    scopus 로고
    • Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis
    • Yamaguchi K., Yang L., McCall S., Huang J., Yu X.X., Pandey S.K., et al. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology 2007, 45:1366-1374.
    • (2007) Hepatology , vol.45 , pp. 1366-1374
    • Yamaguchi, K.1    Yang, L.2    McCall, S.3    Huang, J.4    Yu, X.X.5    Pandey, S.K.6
  • 23
    • 0036154215 scopus 로고    scopus 로고
    • Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes
    • Resjö S., Göransson O., Härndahl L., Zolnierowicz S., Manganiello V., Degerman E. Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes. Cell Signal 2002, 14:231-238.
    • (2002) Cell Signal , vol.14 , pp. 231-238
    • Resjö, S.1    Göransson, O.2    Härndahl, L.3    Zolnierowicz, S.4    Manganiello, V.5    Degerman, E.6
  • 24
    • 4344614649 scopus 로고    scopus 로고
    • Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B
    • Stratford S., Hoehn K.L., Liu F., Summers S.A. Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B. J Biol Chem 2004, 279:36608-36615.
    • (2004) J Biol Chem , vol.279 , pp. 36608-36615
    • Stratford, S.1    Hoehn, K.L.2    Liu, F.3    Summers, S.A.4
  • 25
    • 0142091454 scopus 로고    scopus 로고
    • Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism
    • Powell D.J., Hajduch E., Kular G., Hundal H.S. Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism. Mol Cell Biol 2003, 23:7794-7808.
    • (2003) Mol Cell Biol , vol.23 , pp. 7794-7808
    • Powell, D.J.1    Hajduch, E.2    Kular, G.3    Hundal, H.S.4
  • 26
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
    • Hotamisligil G.S., Shargill N.S., Spiegelman B.M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993, 259:87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 27
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
    • Uysal K.T., Wiesbrock S.M., Marino M.W., Hotamisligil G.S. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 1997, 389:610-614.
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 28
    • 0031757099 scopus 로고    scopus 로고
    • Functional analysis of tumor necrosis factor (TNF) receptors in TNF-alpha-mediated insulin resistance in genetic obesity
    • Uysal K.T., Wiesbrock S.M., Hotamisligil G.S. Functional analysis of tumor necrosis factor (TNF) receptors in TNF-alpha-mediated insulin resistance in genetic obesity. Endocrinology 1998, 139:4832-4838.
    • (1998) Endocrinology , vol.139 , pp. 4832-4838
    • Uysal, K.T.1    Wiesbrock, S.M.2    Hotamisligil, G.S.3
  • 29
    • 69249154762 scopus 로고    scopus 로고
    • Receptors for tumor necrosis factor-alpha play a protective role against obesity and alter adipose tissue macrophage status
    • Pamir N., McMillen T.S., Kaiyala K.J., Schwartz M.W., LeBoeuf R.C. Receptors for tumor necrosis factor-alpha play a protective role against obesity and alter adipose tissue macrophage status. Endocrinology 2009, 150:4124-4134.
    • (2009) Endocrinology , vol.150 , pp. 4124-4134
    • Pamir, N.1    McMillen, T.S.2    Kaiyala, K.J.3    Schwartz, M.W.4    LeBoeuf, R.C.5
  • 30
    • 65649098029 scopus 로고    scopus 로고
    • Phosphorylation of IRS proteins, insulin action, and insulin resistance
    • Boura-Halfon S., Zick Y. Phosphorylation of IRS proteins, insulin action, and insulin resistance. Am J Physiol Endocrinol Metab 2009, 296:E581-E591.
    • (2009) Am J Physiol Endocrinol Metab , vol.296
    • Boura-Halfon, S.1    Zick, Y.2
  • 31
    • 33751552452 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling
    • Steinberg G.R., Michell B.J., van Denderen B.J., Watt M.J., Carey A.L., Farn B.C., et al. Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. Cell Metab 2006, 4:465-474.
    • (2006) Cell Metab , vol.4 , pp. 465-474
    • Steinberg, G.R.1    Michell, B.J.2    van Denderen, B.J.3    Watt, M.J.4    Carey, A.L.5    Farn, B.C.6
  • 33
    • 77952855128 scopus 로고    scopus 로고
    • Diet-genotype interactions in the early development of obesity and insulin resistance in mice with a genetic deficiency in tumor necrosis factor-alpha
    • Bouter B., Geary N., Langhans W., Asarian L. Diet-genotype interactions in the early development of obesity and insulin resistance in mice with a genetic deficiency in tumor necrosis factor-alpha. Metabolism 2010, 59:1065-1073.
    • (2010) Metabolism , vol.59 , pp. 1065-1073
    • Bouter, B.1    Geary, N.2    Langhans, W.3    Asarian, L.4
  • 35
    • 0033787688 scopus 로고    scopus 로고
    • Altered pathological progression of diaphragm and quadriceps muscle in TNF-deficient, dystrophin-deficient mice
    • Spencer M.J., Marino M.W., Winckler W.M. Altered pathological progression of diaphragm and quadriceps muscle in TNF-deficient, dystrophin-deficient mice. Neuromuscul Disord 2000, 10:612-619.
    • (2000) Neuromuscul Disord , vol.10 , pp. 612-619
    • Spencer, M.J.1    Marino, M.W.2    Winckler, W.M.3
  • 37
    • 0032821965 scopus 로고    scopus 로고
    • Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp
    • Matsuda M., DeFronzo R.A. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 1999, 22:1462-1470.
    • (1999) Diabetes Care , vol.22 , pp. 1462-1470
    • Matsuda, M.1    DeFronzo, R.A.2
  • 39
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh E.G., Dyer W.J. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959, 37:911-917.
    • (1959) Can J Biochem Physiol , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 40
    • 0028310839 scopus 로고
    • Hepatic lipase induces the formation of pre-beta 1 high density lipoprotein (HDL) from triacylglycerol-rich HDL2. A study comparing liver perfusion to in vitro incubation with lipases
    • Barrans A., Collet X., Barbaras R., Jaspard B., Manent J., Vieu C., et al. Hepatic lipase induces the formation of pre-beta 1 high density lipoprotein (HDL) from triacylglycerol-rich HDL2. A study comparing liver perfusion to in vitro incubation with lipases. J Biol Chem 1994, 269:11572-11577.
    • (1994) J Biol Chem , vol.269 , pp. 11572-11577
    • Barrans, A.1    Collet, X.2    Barbaras, R.3    Jaspard, B.4    Manent, J.5    Vieu, C.6
  • 41
    • 0036205388 scopus 로고    scopus 로고
    • Coupled assay of sphingomyelin and ceramide molecular species by gas liquid chromatography
    • Vieu C., Tercé F., Chevy F., Rolland C., Barbaras R., Chap H., et al. Coupled assay of sphingomyelin and ceramide molecular species by gas liquid chromatography. J Lipid Res 2002, 43:510-522.
    • (2002) J Lipid Res , vol.43 , pp. 510-522
    • Vieu, C.1    Tercé, F.2    Chevy, F.3    Rolland, C.4    Barbaras, R.5    Chap, H.6
  • 42
    • 0033545342 scopus 로고    scopus 로고
    • Acute-phase proteins and other systemic responses to inflammation
    • Gabay C., Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999, 340:448-454.
    • (1999) N Engl J Med , vol.340 , pp. 448-454
    • Gabay, C.1    Kushner, I.2
  • 43
    • 0029989339 scopus 로고    scopus 로고
    • Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response
    • Pasparakis M., Alexopoulou L., Episkopou V., Kollias G. Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J Exp Med 1996, 184:1397-1411.
    • (1996) J Exp Med , vol.184 , pp. 1397-1411
    • Pasparakis, M.1    Alexopoulou, L.2    Episkopou, V.3    Kollias, G.4
  • 44
    • 34548565932 scopus 로고    scopus 로고
    • Involvement of sex, strain and age factors in high fat diet-induced obesity in C57BL/6J and BALB/cA mice
    • Nishikawa S., Yasoshima A., Doi K., et al. Involvement of sex, strain and age factors in high fat diet-induced obesity in C57BL/6J and BALB/cA mice. Exp Anim 2007, 56:263-272.
    • (2007) Exp Anim , vol.56 , pp. 263-272
    • Nishikawa, S.1    Yasoshima, A.2    Doi, K.3
  • 45
    • 37349006913 scopus 로고    scopus 로고
    • TNF-alpha and adipocyte biology
    • Cawthorn W.P., Sethi J.K. TNF-alpha and adipocyte biology. FEBS Lett 2008, 582:117-131.
    • (2008) FEBS Lett , vol.582 , pp. 117-131
    • Cawthorn, W.P.1    Sethi, J.K.2
  • 46
    • 34547699606 scopus 로고    scopus 로고
    • Metabolically healthy but obese women have an intermediate cardiovascular risk profile between healthy nonobese women and obese insulin-resistant women
    • Marini M.A., Succurro E., Frontoni S., et al. Metabolically healthy but obese women have an intermediate cardiovascular risk profile between healthy nonobese women and obese insulin-resistant women. Diabetes Care 2007, 30:2145-2147.
    • (2007) Diabetes Care , vol.30 , pp. 2145-2147
    • Marini, M.A.1    Succurro, E.2    Frontoni, S.3
  • 47
    • 49449092403 scopus 로고    scopus 로고
    • Identification and characterization of metabolically benign obesity in humans
    • Stefan N., Kantartzis K., Machann J., et al. Identification and characterization of metabolically benign obesity in humans. Arch Intern Med 2008, 168:1609-1616.
    • (2008) Arch Intern Med , vol.168 , pp. 1609-1616
    • Stefan, N.1    Kantartzis, K.2    Machann, J.3
  • 48
    • 0029847504 scopus 로고    scopus 로고
    • Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein
    • Hotamisligil G.S., Johnson R.S., Distel R.J., et al. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science 1996, 274:1377-1379.
    • (1996) Science , vol.274 , pp. 1377-1379
    • Hotamisligil, G.S.1    Johnson, R.S.2    Distel, R.J.3
  • 49
    • 34848872799 scopus 로고    scopus 로고
    • Obesity-associated improvements in metabolic profile through expansion of adipose tissue
    • Kim J.Y., van de Wall E., Laplante M., et al. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest 2007, 117:2621-2637.
    • (2007) J Clin Invest , vol.117 , pp. 2621-2637
    • Kim, J.Y.1    van de Wall, E.2    Laplante, M.3
  • 50
    • 36849037401 scopus 로고    scopus 로고
    • Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity
    • Koonen D.P., Jacobs R.L., Febbraio M., et al. Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity. Diabetes 2007, 56:2863-2871.
    • (2007) Diabetes , vol.56 , pp. 2863-2871
    • Koonen, D.P.1    Jacobs, R.L.2    Febbraio, M.3
  • 51
    • 0036828912 scopus 로고    scopus 로고
    • Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-alpha: implications for insulin resistance
    • Ruan H., Miles P.D., Ladd C.M., et al. Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-alpha: implications for insulin resistance. Diabetes 2002, 51:3176-3188.
    • (2002) Diabetes , vol.51 , pp. 3176-3188
    • Ruan, H.1    Miles, P.D.2    Ladd, C.M.3


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