Betaine reduces the expression of inflammatory adipokines caused by hypoxia in human adipocytes

British Journal of Nutrition

Volumn 109, Issue 1, 2013, Pages 43-49

  Olli, K ^a   Lahtinen, S ^a   Rautonen, N ^a   Tiihonen, K ^a  

^a DUPONT COMPANY   (United States)

Author keywords

Adipocytes; Betaine; Hypoxia; Inflammation; Obesity

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; BETAINE; INTERLEUKIN 6; LEPTIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ADIPOSE TISSUE; ADULT; ARTICLE; CELL DIFFERENTIATION; CELL HYPOXIA; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; FEMALE; GENE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IL6 GENE; LEPTIN GENE; OBESITY; OXYGEN TISSUE LEVEL; POLYMERASE CHAIN REACTION; PPAR GAMMA GENE; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; TNF ALPHA GENE; TRANSCRIPTION REGULATION;

ADIPOGENESIS; ADIPOKINES; ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BETAINE; BIOLOGICAL MARKERS; CELL HYPOXIA; CELLS, CULTURED; CYTOKINES; DIETARY SUPPLEMENTS; DOWN-REGULATION; FEMALE; HUMANS; INTRA-ABDOMINAL FAT; PPAR GAMMA; RNA, MESSENGER; UP-REGULATION;

EID: 84872034829     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114512000888     Document Type: Article

References (38)

1. Ahima RS (2006) Adipose tissue as an endocrine organ. Obesity 14, 242S-249S.
2. Hosogai N, Fukuhara A, Oshima K, et al. (2007) Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes 56, 901-911.
3. Ye J, Gao Z, Yin J, et al. (2007) Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab 293, E1118-E1128.
4. Pasarica M, Sereda MR, Redman LM, et al. (2009) Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response. Diabetes 58, 718-725.
5. Trayhurn P, Wang B & Wood IS (2008) Hypoxia and the endocrine and signalling role of white adipose tissue. Arch Physiol Biochem 114, 267-276.
6. Trayhurn P & Wood IS (2004) Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 92, 347-355.
7. Wang B, Wood IS & Trayhurn P (2007) Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes. Pflugers Arch 455, 479-492.
8. Hauner H (2005) Secretory factors from human adipose tissue and their functional role. Proc Nutr Soc 64, 163-169.
9. Trayhurn P, Wang B & Wood IS (2008) Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity? Br J Nutr 100, 227-235.
10. Rosen ED & Spiegelman BM (2006) Adipocytes as regulators of energy balance and glucose homeostasis. Nature 444, 847-853.
11. Rajala MW & Scherer PE (2003) Minireview: the adipocyte-at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 144, 3765-3773.
12. Zeisel SH, Mar M-H, Howe JC, et al. (2003) Concentrations of choline-containing compounds and betaine in common foods. J Nutr 133, 1302-1307.
13. Slow S, Donaggio M, Cressey PJ, et al. (2005) The betaine content of New Zealand foods and estimated intake in the New Zealand diet. J Food Compost Anal 18, 473-485.
14. Kamal-Eldin A, Larke HN, Knudsen KEB, et al. (2009) Physical, microscopic and chemical characterisation of industrial rye and wheat brans from the Nordic countries. Food Nutr Res 53, article 14.
15. Craig SA (2004) Betaine in human nutrition. Am J Clin Nutr 80, 539-549.
16. Lever M & Slow S (2010) The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism. Clin Biochem 43, 732-744.
17. Eklund M, Bauer E, Wamatu J, et al. (2005) Potential nutritional and physiological functions of betaine in livestock. Nutr Res Rev 18, 31-48.
18. Fernandez-Figares I, Wray-Cahen D, Steele NC, et al. (2002) Effect of dietary betaine on nutrient utilization and partitioning in the young growing feed-restricted pig. J Anim Sci 80, 421-428.
19. Wang Z, Yao T, Pini M, et al. (2010) Betaine improved adipose tissue function in mice fed a high-fat diet: a mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease. Am J Physiol Gastrointest Liver Physiol 298, G634-G642.
20. Song Z, Deaciuc I, Zhou Z, et al. (2007) Involvement of AMP-activated protein kinase in beneficial effects of betaine on high-sucrose diet-induced hepatic steatosis. Am J Physiol Gastrointest Liver Physiol 293, G894-G902.
21. Schwab U, Törrönen A, Meririnne E, et al. (2006) Orally administered betaine has an acute and dose-dependent effect on serum betaine and plasma homocysteine concentrations in healthy humans. J Nutr 136, 34-38.
22. Livak KJ & Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25, 402-408.
23. Gorzelniak K, Janke J, Engeli S, et al. (2001) Validation of endogenous controls for gene expression studies in human adipocytes and preadipocytes. Horm Metab Res 33, 625-627.
24. Ouchi N, Kihara S, Funahashi T, et al. (2003) Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue. Circulation 107, 671-674.
25. Detopoulou P, Panagiotakos DB, Antonopoulou S, et al. (2008) Dietary choline and betaine intakes in relation to concentrations of inflammatory markers in healthy adults: the ATTICA study. Am J Clin Nutr 87, 424-430.
26. Wang B, Wood IS & Trayhurn P (2008) Hypoxia induces leptin gene expression and secretion in human preadipocytes: differential effects of hypoxia on adipokine expression by preadipocytes. J Endocrinol 198, 127-134.
27. Zhou S, Lechpammer S, Greenberger JS, et al. (2005) Hypoxia inhibition of adipocytogenesis in human bone marrow stromal cells requires transforming growth factorb/Smad3 signaling. J Biol Chem 280, 22688-22696.
28. Yun Z, Maecker HL, Johnson RS, et al. (2002) Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia. Dev Cell 2, 331-341.
29. Wang B, Jenkins JR & Trayhurn P (2005) Expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture: integrated response to TNF-alpha. Am J Physiol Endocrinol Metab 288, E731-E740.
30. Fernandez-Real JM & Ricart W (2003) Insulin resistance and chronic cardiovascular inflammatory syndrome. Endocr Rev 24, 278-301.
31. Tiihonen K, Ouwehand AC & Rautonen N (2010) Effect of overweight on gastrointestinal microbiology and immunology: correlation with blood biomarkers. Br J Nutr 103, 1070-1078.
32. Wang B & Trayhurn P (2006) Acute and prolonged effects of TNF-alpha on the expression and secretion of inflammationrelated adipokines by human adipocytes differentiated in culture. Pflugers Arch 452, 418-427.
33. Considine RV, Sinha MK, Heiman ML, et al. (1996) Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334, 292-295.
34. Friedman JM & Halaas JL (1998) Leptin and the regulation of body weight in mammals. Nature 395, 763-770.
35. Frederich RC, Hamann A, Anderson S, et al. (1995) Leptin levels reflect body lipid-content in mice-evidence for dietinduced resistance to leptin action. Nat Med 1, 1311-1314.
36. Ambrosini G, Nath AK, Sierra-Honigmann MR, et al. (2002) Transcriptional activation of the human leptin gene in response to hypoxia. Involvement of hypoxia-inducible factor 1. J Biol Chem 277, 34601-34609.
37. Warskulat U, Zhang F & Haussinger D (1996) Modulation of phagocytosis by anisoosmolarity and betaine in rat liver macrophages (Kupffer cells) and RAW 264. 7 mouse macrophages. FEBS Lett 391, 287-292.
38. Song ZY, Zhou ZX, Deaciuc I, et al. (2008) Inhibition of adiponectin production by homocysteine: a potential mechanism for alcoholic liver disease. Hepatology 47, 867-879.