Steroidomimetic aminomethyl spiroacetals as novel inhibitors of the enzyme Δ8,7-sterol isomerase in cholesterol biosynthesis

Archiv der Pharmazie

Volumn 347, Issue 2, 2014, Pages 108-122

  Krojer, Melanie ^a   Müller, Christoph ^a   Bracher, Franz ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Acetal; Cholesterol biosynthesis; Enzyme inhibitors; Isomerase; Steroidomimetic

Indexed keywords

1',2',3',4' TETRAHYDRO 5 HYDROXYMETHYL 5 NITROSPIRO[1,3 DIOXANE 2,1' NAPHTHALINE]; 5 (N BENZYLPIPERIDIN 4 YL) N METHYLAMINOMETHYL 7A' METHYL 1' (1,5 DIMETHYLHEXYL) 5 NITROSPIRO[1,3 DIOXANE 2,4' OCTRAHYDROINDENE]; 5 (N BENZYLPIPERIDIN 4 YL)AMINOMETHYL 7A' METHYL 1' (1,5 DIMETHYLHEXYL) 5 NITROSPIRO[1,3 DIOXANE 2,4' OCTRAHYDROINDENE]; 5 AMINO 5 HYDROXYMETHYL 7A' (1,5 DIMETHYLHEXYL) SPIRO[1,3 DIOXANE 2,4 OCTAHYDROINDENE]; 5 BENZOYLOXYMETHYL 7A' METHYL 1' (1,5 DIMETHYLHEXYL) 5 NITROSPIRO[1,3 DIOXANE 2,4' OCTAHYDROINDENE]; 5 HYDROXYMETHYL 7A' METHYL 1 (1,5 DIMETHYLHEXYL) 5 NITROSPIRO[1,3 DIOXANE 2,4' OCTAHYDROINDENE]; 7A' METHYL 1 (1,5 DIMETHYLHEXYL) 5 ( METHYLPIPERAZIN 1 YL) METHYL 5 NITROSPIRO[1,3 DIOXANE 2,4' OCTRAHYDROINDENE]; 7A' METHYL 1 (1,5 DIMETHYLHEXYL) 5 NITRO 5 (3 PYRIDINYL)METHYLAMINOMETHYL SPIRO[1,3 DIOXANE 2,4' OCTRAHYDROINDENE]; 7A' METHYL 1 (1,5 DIMETHYLHEXYL) 5 NITRO 5 [N METHYL N (PHENYLPROP 1 EN 3 YL) AMINOMERTHYL]SPIRO[1,3 DIOXANE 2,4' OCTRAHYDROINDENE]; 7A' METHYL 1 (1,5 DIMETHYLHEXYL)SPIRO[1,3 DIOXANE 2,4' OCTAHYDROINDEN] 5 ONE; 7A' METHYL 1' (1,5 DIMETHYLHEXYL) 5 (MORPHOLIN 4 YL CARBONYLOXYMETHYL) 5 NITROSPIRO[1,3 DIOXANE 2,4' OCTRAHYDROINDENE]; 7A' METHYL 1' (1,5 DIMETHYLHEXYL) 5 NITRO 5 (PYRIDIN 3 YL CARBONYLOXYMETHYL)SPIRO[1,3 DIOXANE 2,4' OCTRAHYDROINDENE]; 7A' METHYL 1' (1,5 DIMETHYLHEXYL) 5 NITRO 5 [4 (3 TRIFLUOROMETHYLPHENYL)PIPERAZIN 1 YLMETHYL] SPIRO[1,3 DIOXANE 2,4' OCTAHYDROINDENE]; 7A' METHYL 1' (1,5 DIMETHYLHEXYL) 5 NITRO 5 [[2 (PIPERIDIN 1 YL)ETHYL]AMINOMETHYL]SPIRO[1,3 DIOXANE 2,4' OCTAHYDROINDENE]; 7A' METHYL 1' (1,5 DIMETHYLHEXYL) 5 NITRO 5 [[2 (PYRROLIDIN 1 YL)ETHYL]AMINOMETHYL]SPIRO[1,3 DIOXANE 2,4' OCTAHYDROINDENE]; 7A' METHYL 1' (1,5 DIMETHYLHEXYL) 5(2,6 DIMETHYLMORPHOLIN 4 YL) METHYL 5 NITROSPIRO[1,3 DIOXANE 2,4 -OCTAHYDROINDENE]; 7A' METHYL 1' (1,5 DIMETHYLHEXYL)SPIRO[1,3 DIOXOLANE 2,4' OCTAHYDROINDENE]; 7A' METHYL 5 (N METHYLAMINO) METHYL 1' (1,5 DIMETHYLHEXYL) 5 NITROSPIRO[1,3 DIOXANE 2,4' OCTAHYDROINDENE]; 7A' METHYL 5 (N,N DIMETHYLAMINOMETHY) 1' (1,5 DIMETHYLHEXYL) 5 NITROSPIRO[1,3 DIOXANE 2,4' OCTAHYDROINDENE]; 7A' METHYL 5 [N (N,N DIMETHYLAMINOETH 2 YL AMINOMETHYL)] 1' (1,5 DIMETHYLHEXYL) 5 NITROSPIRO[1,3 DIOXANE 2,4' OCTAHYDROINDENE]; 7A' METHYL 5 [N (N,N DIMETHYLAMINOETH 2 YL) N METHYLAMINOMETHYL 1 (1,5 DIMETHYLHEXYL) 5 NITROSPIRO[1,3 DIOXANE 2,4' OCTAHYDROINDENE]; 7A' METHYL 5 METHYLENE 1 (1,5 DIMETHYLHEXYL) SPIRO[1,3 DIOXANE 2,4' OCTAHYDROINDENE]; CISPLATIN; COLECALCIFEROL; DELTA 8,7 STEROL ISOMERASE; ERGOSTEROL; ISOMERASE; ISOMERASE INHIBITOR; KETONE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ACETALIZATION; ALKYLATION; ARTICLE; CELL STRAIN HL 60; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; CYTOTOXICITY; ESTERIFICATION; HUMAN; HUMAN CELL; IC 50; MTT ASSAY; NONHUMAN; OZONOLYSIS; PRIORITY JOURNAL; STEREOSPECIFICITY; STEROL SYNTHESIS;

ACETAL; CHOLESTEROL BIOSYNTHESIS; ENZYME INHIBITORS; ISOMERASE; STEROIDOMIMETIC;

ACETALS; ANTICHOLESTEREMIC AGENTS; CELL SURVIVAL; CHOLESTEROL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; HL-60 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; STEROID ISOMERASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84893768824     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201300296     Document Type: Article

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