Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Δ8- Δ7 sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity

Journal of Medicinal Chemistry

Volumn 51, Issue 23, 2008, Pages 7523-7531

  Berardi, Francesco ^a   Abate, Carmen ^a   Ferorelli, Savina ^a   De Robertis, Anna F ^a   Leopoldo, Marcello ^a   Colabufo, Nicola A ^a   Niso, Mauro ^a   Perrone, Roberto ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (2 METHOXYPHENYL)CYCLOHEXYL] 1 (2 PYRIDINYL)PIPERAZINE; 4 [4 (2 METHYLPHENYL)CYCLOHEXYL] 1 (2 PYRIDINYL)PIPERAZINE; 4 [4 (2,6 DIMETHOXYPHENYL)CYCLOHEXYL] 1 (2 PYRIDINYL)PIPERAZINE; 4 CYCLOHEXYL 1 (2 PYRIDYL)PIPERAZINE DERIVATIVE; EMOPAMIL; EMOPAMIL BINDING PROTEIN; STEROL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL PROLIFERATION; CHOLESTEROL SYNTHESIS; DRUG ACTIVITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; ISOMERIZATION; PROSTATE CANCER;

APOPTOSIS; BINDING SITES; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PIPERAZINES; PYRIDINES; STEREOISOMERISM; STEROID ISOMERASES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 57349101704     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800965b     Document Type: Article

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