메뉴 건너뛰기




Volumn 54, Issue 3, 1998, Pages 591-598

Pharmacological analysis of sterol Δ8=Δ7 isomerase proteins with [3H]fenprodil

Author keywords

[No Author keywords available]

Indexed keywords

AMIODARONE; BINDING PROTEIN; EMOPAMIL; HALOPERIDOL; IFENPRODIL; ISOMERASE; OPIPRAMOL; TAMOXIFEN; TRIFLUOPERAZINE; VERAPAMIL;

EID: 0031663773     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.54.3.591     Document Type: Article
Times cited : (75)

References (41)
  • 1
    • 0030858044 scopus 로고    scopus 로고
    • Cholesterol biosynthesis from lanosterol: Development of a novel assay method and characterization of rat liver microsomal lanosterol Δ24-reductase
    • Bae S-H and Paik Y-K (1997) Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol Δ24-reductase. Biochem J 326:609-616.
    • (1997) Biochem J , vol.326 , pp. 609-616
    • Bae, S.-H.1    Paik, Y.-K.2
  • 3
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 4
    • 3543097750 scopus 로고
    • Butyrophenones as inhibitors of cholesterol biosynthesis
    • Braun GA (1969) Butyrophenones as inhibitors of cholesterol biosynthesis. Adv Exp Med Biol 4:473-482.
    • (1969) Adv Exp Med Biol , vol.4 , pp. 473-482
    • Braun, G.A.1
  • 5
    • 0030970833 scopus 로고    scopus 로고
    • L-type calcium channels: Binding domains for dihydropyridines and benzothiazepines are located in close proximity to each other
    • Brauns T, Prinz H, Kimball SD, Haugland RP, Striessnig J, and Glossmann H (1997) L-type calcium channels: binding domains for dihydropyridines and benzothiazepines are located in close proximity to each other. Biochemistry 36:3625-3631.
    • (1997) Biochemistry , vol.36 , pp. 3625-3631
    • Brauns, T.1    Prinz, H.2    Kimball, S.D.3    Haugland, R.P.4    Striessnig, J.5    Glossmann, H.6
  • 7
    • 0023239318 scopus 로고
    • Triphenylethylene antiestrogen binding sites (TABS) specificity
    • Clark JH, Mitchell WC, and Guthrie SC (1987) Triphenylethylene antiestrogen binding sites (TABS) specificity. J Steroid Biochem 26:433-437.
    • (1987) J Steroid Biochem , vol.26 , pp. 433-437
    • Clark, J.H.1    Mitchell, W.C.2    Guthrie, S.C.3
  • 8
    • 0031895371 scopus 로고    scopus 로고
    • Disorders of cholesterol biosynthesis
    • Clayton PT (1998) Disorders of cholesterol biosynthesis. Arch Dis Child 73:185-189.
    • (1998) Arch Dis Child , vol.73 , pp. 185-189
    • Clayton, P.T.1
  • 9
    • 0018001339 scopus 로고
    • Simultaneous analysis of families of sigmoid curves: Application to bioassays, radioligand assay and physiological dose-response curves
    • DeLean A, Munson PJ, and Rodbard D (1978) Simultaneous analysis of families of sigmoid curves: application to bioassays, radioligand assay and physiological dose-response curves. Am J Physiol 4:E97-E102.
    • (1978) Am J Physiol , vol.4
    • DeLean, A.1    Munson, P.J.2    Rodbard, D.3
  • 10
    • 0023257528 scopus 로고
    • Calmodulin antagonists suppress cholesterol biosynthesis by inhibiting sterol Δ24 reductase
    • Filipovic I and Buddecke E (1987) Calmodulin antagonists suppress cholesterol biosynthesis by inhibiting sterol Δ24 reductase. Lipids 22:261-265.
    • (1987) Lipids , vol.22 , pp. 261-265
    • Filipovic, I.1    Buddecke, E.2
  • 12
    • 0029871365 scopus 로고    scopus 로고
    • Interactions between ifenprodil and the NR2B subunit of the N-methyl-D-aspartate receptor
    • Gallagher MJ, Huang H, Pritchett DB, and Lynch DR (1996) Interactions between ifenprodil and the NR2B subunit of the N-methyl-D-aspartate receptor. J Biol Chem 271:9603-9611.
    • (1996) J Biol Chem , vol.271 , pp. 9603-9611
    • Gallagher, M.J.1    Huang, H.2    Pritchett, D.B.3    Lynch, D.R.4
  • 13
    • 0028835120 scopus 로고
    • Tamoxifen and toremifene lower serum cholesterol by inhibition of Δ8-cholestenol conversion to lathosterol in women with breast cancer
    • Gylling H, Pyrhönen S, Mäntylä E, Mäenpää H, Kangas L, and Miettinen TA. Tamoxifen and toremifene lower serum cholesterol by inhibition of Δ8-cholestenol conversion to lathosterol in women with breast cancer. J Clin Oncol 13:2900-2905, (1995).
    • (1995) J Clin Oncol , vol.13 , pp. 2900-2905
    • Gylling, H.1    Pyrhönen, S.2    Mäntylä, E.3    Mäenpää, H.4    Kangas, L.5    Miettinen, T.A.6
  • 16
    • 0027335978 scopus 로고
    • 3H]ifenprodil binding to sigma receptors in rat brain
    • 3H]ifenprodil binding to sigma receptors in rat brain. Eur J Pharmacol 236:159-163.
    • (1993) Eur J Pharmacol , vol.236 , pp. 159-163
    • Hashimoto, K.1    London, E.D.2
  • 17
    • 0025098896 scopus 로고
    • High-affinity binding sites for oxygenated sterols in rat liver microsomes: Possible identity with antiestrogen binding sites
    • Hwang PLH (1990) High-affinity binding sites for oxygenated sterols in rat liver microsomes: possible identity with antiestrogen binding sites. Biochem Biophys Acta 1033:154-161.
    • (1990) Biochem Biophys Acta , vol.1033 , pp. 154-161
    • Hwang, P.L.H.1
  • 18
    • 0028920880 scopus 로고
    • Cholesterol biosynthesis from lanosterol: Regulation and purification of rat hepatic sterol 8-isomerase
    • Kang M, Kim C, Johng T, and Paik Y (1995) Cholesterol biosynthesis from lanosterol: regulation and purification of rat hepatic sterol 8-isomerase. J Biochem 117:819-823.
    • (1995) J Biochem , vol.117 , pp. 819-823
    • Kang, M.1    Kim, C.2    Johng, T.3    Paik, Y.4
  • 19
    • 0029945013 scopus 로고    scopus 로고
    • An aspartate residue in the extracellular loop of the N-methyl-D-aspartate receptor controls sensitivity to spermine and protons
    • Kasiwagi K, Fukuchi J, Igarashi K, and Williams K (1996) An aspartate residue in the extracellular loop of the N-methyl-D-aspartate receptor controls sensitivity to spermine and protons. Mol Pharmacol 49:1131-1141.
    • (1996) Mol Pharmacol , vol.49 , pp. 1131-1141
    • Kasiwagi, K.1    Fukuchi, J.2    Igarashi, K.3    Williams, K.4
  • 20
    • 2642695321 scopus 로고
    • Inhibition of the conversion of 7-dehydrocholesterol to cholesterol by AY-9944
    • Kraml M, Bagli JF, and Dvornik D (1964) Inhibition of the conversion of 7-dehydrocholesterol to cholesterol by AY-9944. Biochem Biophys Res Commun 15:455-457.
    • (1964) Biochem Biophys Res Commun , vol.15 , pp. 455-457
    • Kraml, M.1    Bagli, J.F.2    Dvornik, D.3
  • 22
    • 0020446693 scopus 로고
    • Calculating the dissociation constant of an unlabeled compound from the concentration required to displace radioactive binding by 50%
    • Linden J (1982) Calculating the dissociation constant of an unlabeled compound from the concentration required to displace radioactive binding by 50%. J Cycl Nucleotide Res 8:163-172.
    • (1982) J Cycl Nucleotide Res , vol.8 , pp. 163-172
    • Linden, J.1
  • 23
    • 0021280874 scopus 로고
    • An embryotoxicity study of the fungicide tridemorph and its commercial formulation calixin
    • Merkle J, Schulz V, and Gelbke HP (1984) An embryotoxicity study of the fungicide tridemorph and its commercial formulation calixin. Teratology 29:259-269.
    • (1984) Teratology , vol.29 , pp. 259-269
    • Merkle, J.1    Schulz, V.2    Gelbke, H.P.3
  • 24
    • 0030022955 scopus 로고    scopus 로고
    • Role of multidrug resistance P-glycoprotein in cholesterol biosynthesis
    • Metherall JE and Huijan L (1996) Role of multidrug resistance P-glycoprotein in cholesterol biosynthesis. J Biol Chem 271:2634-2640.
    • (1996) J Biol Chem , vol.271 , pp. 2634-2640
    • Metherall, J.E.1    Huijan, L.2
  • 26
    • 0027463541 scopus 로고
    • Biochemical characterization of a 22-kDa high affinity anti-ischemic drug-binding polypeptide in the endoplasmic reticulum of guinea pig liver: Potential common target for anti-ischemic drug action
    • Moebius FF, Burrows GG, Striessnig J, and Glossmann H (1993) Biochemical characterization of a 22-kDa high affinity anti-ischemic drug-binding polypeptide in the endoplasmic reticulum of guinea pig liver: potential common target for anti-ischemic drug action. Mol Pharmacol 43:139-148.
    • (1993) Mol Pharmacol , vol.43 , pp. 139-148
    • Moebius, F.F.1    Burrows, G.G.2    Striessnig, J.3    Glossmann, H.4
  • 29
    • 0030949390 scopus 로고    scopus 로고
    • The mysteries of sigma receptors: New family members reveal a role in cholesterol synthesis
    • Moebius FF, Striessnig J, and Glossmann H (1997b) The mysteries of sigma receptors: new family members reveal a role in cholesterol synthesis. Trends Pharmacol Sci 18:67-70.
    • (1997) Trends Pharmacol Sci , vol.18 , pp. 67-70
    • Moebius, F.F.1    Striessnig, J.2    Glossmann, H.3
  • 30
    • 0023031854 scopus 로고
    • Microsomal enzymes of cholesterol biosynthesis: Solubilization and purification of steroid 8-isomerase
    • Paik Y-K, Billheimer JT, Magolda RL, and Gaylor JL (1986) Microsomal enzymes of cholesterol biosynthesis: solubilization and purification of steroid 8-isomerase. J Biol Chem 261:6470-6477.
    • (1986) J Biol Chem , vol.261 , pp. 6470-6477
    • Paik, Y.-K.1    Billheimer, J.T.2    Magolda, R.L.3    Gaylor, J.L.4
  • 31
    • 0024512892 scopus 로고
    • Inhibition of cholesterol synthesis and cell growth by 24(R,S),25-iminolanosterol and triparanol in cultured rat hepatoma cells
    • Popják G, Meenan A, Parish EJ, and Nes WD (1989) Inhibition of cholesterol synthesis and cell growth by 24(R,S),25-iminolanosterol and triparanol in cultured rat hepatoma cells. J Biol Chem 264:6230-6238.
    • (1989) J Biol Chem , vol.264 , pp. 6230-6238
    • Popják, G.1    Meenan, A.2    Parish, E.J.3    Nes, W.D.4
  • 32
    • 0028823737 scopus 로고
    • Pharmacological properties of recombinant human N-methyl-D-aspartate receptors comprising NR1a/NR2A and NR1a/NR2B subunit assemblies expressed in permanently transfected mouse fibroblast cells
    • Priestley T, Laughton P, Myers J, Le Bourdelle B, Kerby J, and Whiting PJ (1995) Pharmacological properties of recombinant human N-methyl-D-aspartate receptors comprising NR1a/NR2A and NR1a/NR2B subunit assemblies expressed in permanently transfected mouse fibroblast cells. Mol Pharmacol 48:841-848.
    • (1995) Mol Pharmacol , vol.48 , pp. 841-848
    • Priestley, T.1    Laughton, P.2    Myers, J.3    Le Bourdelle, B.4    Kerby, J.5    Whiting, P.J.6
  • 33
    • 0029939653 scopus 로고    scopus 로고
    • Sterol biosynthesis: Strong inhibition of maize Δ5,7-sterol Δ7-reductase by novel 6-aza-B-homosteroids and other analogues of a presumptive carbocationic intermediate of the reduction reaction
    • Rahier A and Taton M (1996) Sterol biosynthesis: strong inhibition of maize Δ5,7-sterol Δ7-reductase by novel 6-aza-B-homosteroids and other analogues of a presumptive carbocationic intermediate of the reduction reaction. Biochemistry 35: 7069-7076.
    • (1996) Biochemistry , vol.35 , pp. 7069-7076
    • Rahier, A.1    Taton, M.2
  • 34
    • 0017725114 scopus 로고
    • Effect of zuclomiphene on cholesterol formation in the developing central nervous system of the rat
    • Ramsey RB, Fredericks M, and Fischer VW (1977) Effect of zuclomiphene on cholesterol formation in the developing central nervous system of the rat. J Neurochem 28:1317-1321.
    • (1977) J Neurochem , vol.28 , pp. 1317-1321
    • Ramsey, R.B.1    Fredericks, M.2    Fischer, V.W.3
  • 35
    • 3543050868 scopus 로고
    • Inhibition by triparanol of cholesterol formation in the brain of the newborn mouse
    • Scallen TJ, Condie RM, and Schroepfer GJ (1961) Inhibition by triparanol of cholesterol formation in the brain of the newborn mouse. J Neurochem 9:99-103.
    • (1961) J Neurochem , vol.9 , pp. 99-103
    • Scallen, T.J.1    Condie, R.M.2    Schroepfer, G.J.3
  • 36
    • 33845280171 scopus 로고
    • Significance of slow-binding enzyme inhibition and its relationship to reaction-intermediate analogues
    • Schloss JV (1988) Significance of slow-binding enzyme inhibition and its relationship to reaction-intermediate analogues. Accounts Chem Res 21:348-353.
    • (1988) Accounts Chem Res , vol.21 , pp. 348-353
    • Schloss, J.V.1
  • 37
    • 0022621281 scopus 로고
    • The effects of enclomiphene and zuclomiphene citrates on mouse embryos fertilized in vitro and in vivo
    • Schmidt GE, Moon HK, Mansour R, Torello L, and Friedman CI (1986) The effects of enclomiphene and zuclomiphene citrates on mouse embryos fertilized in vitro and in vivo. Am J Obstet Gynecol 154:727-736.
    • (1986) Am J Obstet Gynecol , vol.154 , pp. 727-736
    • Schmidt, G.E.1    Moon, H.K.2    Mansour, R.3    Torello, L.4    Friedman, C.I.5
  • 38
    • 9544223310 scopus 로고    scopus 로고
    • Emopamil-binding protein, a mammalian protein that binds a series of structurally diverse neuroprotective agents, exhibits Δ8-Δ7 isomerase activity in yeast
    • Silve S, Dupuy PH, Labit-Lebouteiller C, Kaghad M, Chalon P, Rahier A, Taton M, Lupker J, Shire D, and Loison G (1996) Emopamil-binding protein, a mammalian protein that binds a series of structurally diverse neuroprotective agents, exhibits Δ8-Δ7 isomerase activity in yeast. J Biol Chem 271:22434-22440.
    • (1996) J Biol Chem , vol.271 , pp. 22434-22440
    • Silve, S.1    Dupuy, P.H.2    Labit-Lebouteiller, C.3    Kaghad, M.4    Chalon, P.5    Rahier, A.6    Taton, M.7    Lupker, J.8    Shire, D.9    Loison, G.10
  • 39
    • 0026355311 scopus 로고
    • Identification of Δ5,7-sterol Δ7-reductase in higher plant microsomes
    • Taton M and Rahier A (1991) Identification of Δ5,7-sterol Δ7-reductase in higher plant microsomes. Biochem Biophys Res Commun 181:465-473.
    • (1991) Biochem Biophys Res Commun , vol.181 , pp. 465-473
    • Taton, M.1    Rahier, A.2
  • 40
    • 0027724310 scopus 로고
    • An alternative mechanism for the inhibition of cholesterol biosynthesis in hepG2 cells by n-[(1,5,9)-trimethyldecyl]-4α,10-dimethyl-8-aza-trans-decal-3β-ol (MDL 28,815)
    • van Sickle WA, Wilson PK, Wannamaker MW, Cooper JR, Flanagan MA, McCarthy JR, Bey P and Jackson RL (1993) An alternative mechanism for the inhibition of cholesterol biosynthesis in hepG2 cells by n-[(1,5,9)-trimethyldecyl]-4α,10-dimethyl-8-aza-trans-decal-3β-ol (MDL 28,815). J Pharmacol Exp Ther 267:1243-1249.
    • (1993) J Pharmacol Exp Ther , vol.267 , pp. 1243-1249
    • Van Sickle, W.A.1    Wilson, P.K.2    Wannamaker, M.W.3    Cooper, J.R.4    Flanagan, M.A.5    McCarthy, J.R.6    Bey, P.7    Jackson, R.L.8
  • 41
    • 0021320348 scopus 로고
    • High affinity specific antiestrogen binding sites are concentrated in rough microsomal membranes of rat liver
    • Watts CKW and Sutherland RL (1984) High affinity specific antiestrogen binding sites are concentrated in rough microsomal membranes of rat liver. Biochem Biophys Res Commun 120:109-115.
    • (1984) Biochem Biophys Res Commun , vol.120 , pp. 109-115
    • Watts, C.K.W.1    Sutherland, R.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.