Aminopropylindenes derived from Grundmann's ketone as a novel chemotype of oxidosqualene cyclase inhibitors

European Journal of Medicinal Chemistry

Volumn 63, Issue , 2013, Pages 758-764

  Lange, Stefanie ^a   Keller, Marco ^a   Müller, Christoph ^a   Oliaro Bosso, Simonetta ^b   Balliano, Gianni ^b   Bracher, Franz ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF TURIN   (Italy)

Author keywords

Enzyme inhibitor; High energy intermediate; Oxidosqualene cyclase; Secosteroid; Species selectivity

Indexed keywords

2,3 OXIDOSQUALENE; ANTITRYPANOSOMAL AGENT; AZADECALINE; AZASQUALENE; BIBX 79; CHOLESTEROL; CISPLATIN; GRUNDMANN KETONE; INDENE DERIVATIVE; ISOMERASE; ISOMERASE INHIBITOR; KETONE DERIVATIVE; LANOSTEROL; OXIDOSQUALENE CYCLASE; OXIDOSQUALENE CYCLASE INHIBITOR; PYRIDINIUM DERIVATIVE; RO 488071; SQUALENE DERIVATIVE; SULFUR DERIVATIVE; UMBELLIFERONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL LINE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; CYCLIZATION; CYTOTOXICITY; DRUG INHIBITION; DRUG SCREENING; DRUG SELECTIVITY; ENERGY; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL; MOLECULAR MIMICRY; TRYPANOSOMA CRUZI;

ARABIDOPSIS; BIOCATALYSIS; CELL SURVIVAL; CHOLESTEROL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HL-60 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; INTRAMOLECULAR TRANSFERASES; KETONES; LANOSTEROL; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PLANT PROTEINS; PROTOZOAN PROTEINS; SQUALENE; TRYPANOSOMA CRUZI;

EID: 84875957401     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.03.002     Document Type: Article

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