A-CD estrogens. I. substituent effects, hormone potency, and receptor subtype selectivity in a new family of flexible estrogenic compounds

Journal of Medicinal Chemistry

Volumn 54, Issue 2, 2011, Pages 433-448

  Wright, James S ^a   Shadnia, Hooman ^a   Anderson, James M ^a   Durst, Tony ^b   Asim, Muhammad ^b   El Salfiti, Mohamed ^b   Choueiri, Christine ^b   Pratt, M A Christine ^b   Ruddy, Samantha C ^b   Lau, Rosanna ^b   Carlson, Kathryn E ^c   Katzenellenbogen, John A ^c   Obrien, Peter J ^d   Wan, Luke ^d  

^a CARLETON UNIVERSITY   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EQUILENIN; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTRONE; GENISTEIN; QUINONE DERIVATIVE; RECEPTOR SUBTYPE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; HORMONE SUBSTITUTION; MALE; NONHUMAN; RAT;

ANIMALS; BINDING, COMPETITIVE; CELL LINE; ESTRADIOL; ESTRADIOL CONGENERS; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FLUORINE; HEPATOCYTES; HUMANS; LIGANDS; MALE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; QUINONES; RATS; RATS, SPRAGUE-DAWLEY; RESPONSE ELEMENTS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; TRANSCRIPTIONAL ACTIVATION;

EID: 78751678808     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100513m     Document Type: Article

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