Stereoselective synthesis of a new class of potent and selective inhibitors of human Δ8,7-sterol isomerase

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 7, 2013, Pages 1925-1943

  König, Mathias ^a   Müller, Christoph ^a   Bracher, Franz ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Amino alcohols; Cholesterol biosynthesis inhibitors; HL 60 cells; Human 8,7 sterol isomerase; Stereoselective synthesis

Indexed keywords

1 (1,5 DIMETHYLHEXYL) 3A,7A DIMETHYL 5 (4 METHYLPIPERAZINE 1 YL)OCTAHYDROINDEN 4 OL; 1 (1,5 DIMETHYLHEXYL) 3A,7A DIMETHYL 5 (4 METHYLPIPERAZINE 1 YL)OCTAHYDROINDEN 4 ONE; 1 (1,5 DIMETHYLHEXYL) 3A,7A DIMETHYL 5 [(PYRIDIN 3 YLMETHYL)AMINO]OCTAHYDROINDEN 4 ONE; 1 (1,5 DIMETHYLHEXYL) 3A,7A DIMETHYL [(PYRIDINE 3 YLMETHYL)AMINO]OCTAHYDROINDEN 4 OL; 1 (1,5 DIMETHYLHEXYL) 3A,7A DIMETHYLOCTAHYDROINDEN 4 OL; 1 (1,5 DIMETHYLHEXYL) 3A,7A DIMETHYLOCTAHYDROINDEN 4 ONE; 1 (1,5 DIMETHYLHEXYL) 5 (2,3 DIMETHYLPHENYLAMINO) 3A,7A DIMETHYLOCTAHYDROINDEN 4 OL; 1 (1,5 DIMETHYLHEXYL) 5 (2,3 DIMETHYLPHENYLAMINO) 3A,7A DIMETHYLOCTAHYDROINDEN 4 ONE; 1 (1,5 DIMETHYLHEXYL) 5 (2,6 DIMETHYLMORPHOLINE 4 YL) 3A,7A DIMETHYLOCTAHYDROINDEN 4 OL; 1 (1,5 DIMETHYLHEXYL) 5 (2,6 DIMETHYLMORPHOLINE 4 YL) 3A,7A DIMETHYLOCTAHYDROINDEN 4 ONE; 3 (1,5 DIMETHYLHEXYL) 3A,7A DIMETHYL 2,3,3A,6,7,7A HEXAHYDRO 1H INDENE; 3A,6A DIMETHYL 4 (1,5 DIMETHYLHEXYL)OCTAHYDRO 1AH INDENO[5,4 B]OXIRENE; 5 AMINO 1 (1,5 DIMETHYLHEXYL) 3A,7A DIMETHYLOCTAHYDROINDEN 4 OL; 5 AZIDO 1 (1,5 DIMETHYLHEXYL) 3A,7A DIMETHYLOCTAHYDROINDEN 4 OL; 5 AZIDO 1 (1,5 DIMETHYLHEXYL) 3A,7A DIMETHYLOCTAHYDROINDEN 4 ONE; 5 BENZYLAMINO 1 (1,5 DIMETHYLHEXYL) 3A,7A DIMETHYLOCTAHYDROINDEN 4 OL; 5 BROMO 1 (1,5 DIMETHYLHEXYL) 3A,7A DIMETHYLOCTAHYDROINDEN 4 ONE; 5 DIMETHYLAMINO 1 (1,5 DIMETHYLHEXYL) 3A,7A DIMETHYLOCTAHYDROINDEN 4 OL; 5 DIMETHYLAMINO 1 (1,5 DIMETHYLHEXYL) 3A,7A DIMETHYLOCTAHYDROINDEN 4 ONE; [1 (1,5 DIMETHYLHEXYL) 3A,7A DIMETHYL 2,3,3A,6,7,7A HEXAHYDRO 1H INDEN 4 YLOXY]TRIMETHYLSILANE; [1 (1,5 DIMETHYLHEXYL) 7A METHYL 2,3,5,6,7,7A HEXAHYDRO 1H INDEN 4 YLOXY]TRIMETHYLSILANE; [1 (1,5 DIMETHYLHEXYL) 7A METHYLHEXAHYDROCYCLOPROPA[D]INDEN 4 YLOXY]TRIMETHYLSILANE; ANTIFUNGAL AGENT; CLOTRIMAZOLE; CYTOTOXIC AGENT; DELTA 8,7 STEROL ISOMERASE; ISOMERASE; ISOMERASE INHIBITOR; KETOCONAZOLE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA GLABRATA; CELL SCREENING; CHOLESTEROL SYNTHESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; SACCHAROMYCES CEREVISIAE; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; YARROWIA LIPOLYTICA;

AMINO ALCOHOLS; ANTIFUNGAL AGENTS; CELL SURVIVAL; CHOLESTEROL; ERGOSTEROL; HL-60 CELLS; HUMANS; METHYLATION; SECOSTEROIDS; STEREOISOMERISM; STEROID ISOMERASES;

EID: 84875222998     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.01.041     Document Type: Article

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