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Volumn 44, Issue 2, 2014, Pages 123-132

Mitochondrial reactive oxygen species as a mystery voice in hepatitis C

Author keywords

Calcium signaling; Hepcidin; Insulin resistance; Iron metabolism; Mitochondrial electron transport; Mitophagy

Indexed keywords

CALCIUM ION; CCAAT ENHANCER BINDING PROTEIN; CORE PROTEIN; GLUTATHIONE; HEPCIDIN; HISTONE DEACETYLASE; HYPOXIA INDUCIBLE FACTOR; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; IRON; METALLOTHIONEIN; PARKIN; PEROXIDASE; POLYPROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; STAT3 PROTEIN; THIOREDOXIN; VIRUS PROTEIN;

EID: 84893764764     PISSN: 13866346     EISSN: 1872034X     Source Type: Journal    
DOI: 10.1111/hepr.12247     Document Type: Review
Times cited : (22)

References (77)
  • 2
    • 0036829816 scopus 로고    scopus 로고
    • Natural history of chronic hepatitis C
    • Seeff LB. Natural history of chronic hepatitis C. Hepatology 2002; 36: S35-46.
    • (2002) Hepatology , vol.36
    • Seeff, L.B.1
  • 3
    • 0028946727 scopus 로고
    • Iron storage, lipid peroxidation and glutathione turnover in chronic anti-HCV positive hepatitis
    • Farinati F, Cardin R, De Maria N etal. Iron storage, lipid peroxidation and glutathione turnover in chronic anti-HCV positive hepatitis. J Hepatol 1995; 22: 449-456.
    • (1995) J Hepatol , vol.22 , pp. 449-456
    • Farinati, F.1    Cardin, R.2    De Maria, N.3
  • 4
    • 48949101743 scopus 로고    scopus 로고
    • Hepatocellular mitochondrial alterations in patients with chronic hepatitis C: ultrastructural and biochemical findings
    • Barbaro G, Di Lorenzo G, Asti AM etal. Hepatocellular mitochondrial alterations in patients with chronic hepatitis C: ultrastructural and biochemical findings. Am J Gastroenterol 1999; 942: 198-205.
    • (1999) Am J Gastroenterol , vol.942 , pp. 198-205
    • Barbaro, G.1    Di Lorenzo, G.2    Asti, A.M.3
  • 5
    • 0036023302 scopus 로고    scopus 로고
    • Oxidative stress EPR measurement in human liver by radical-probe technique. Correlation with etiology, histology and cell proliferation
    • Valgimigli M, Valgimigli L, Trere D etal. Oxidative stress EPR measurement in human liver by radical-probe technique. Correlation with etiology, histology and cell proliferation. Free Radic Res 2002; 36: 939-948.
    • (2002) Free Radic Res , vol.36 , pp. 939-948
    • Valgimigli, M.1    Valgimigli, L.2    Trere, D.3
  • 6
    • 22844447076 scopus 로고    scopus 로고
    • In situ detection of oxidized n-3 polyunsaturated fatty acids in chronic hepatitis C: correlation with hepatic steatosis
    • Kitase A, Hino K, Furutani T etal. In situ detection of oxidized n-3 polyunsaturated fatty acids in chronic hepatitis C: correlation with hepatic steatosis. J Gastroenterol 2005; 40: 617-624.
    • (2005) J Gastroenterol , vol.40 , pp. 617-624
    • Kitase, A.1    Hino, K.2    Furutani, T.3
  • 7
    • 0035360859 scopus 로고    scopus 로고
    • Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis
    • Moriya K, Nakagawa K, Santa T etal. Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis. Cancer Res 2001; 61: 4365-4370.
    • (2001) Cancer Res , vol.61 , pp. 4365-4370
    • Moriya, K.1    Nakagawa, K.2    Santa, T.3
  • 8
    • 0036165333 scopus 로고    scopus 로고
    • Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein
    • Okuda M, Li K, Beard MR etal. Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology 2002; 122: 366-375.
    • (2002) Gastroenterology , vol.122 , pp. 366-375
    • Okuda, M.1    Li, K.2    Beard, M.R.3
  • 9
    • 11144342818 scopus 로고    scopus 로고
    • Hepatitis C virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells
    • Otani K, Korenaga M, Beard MR etal. Hepatitis C virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells. Gastroenterology 2005; 128: 96-107.
    • (2005) Gastroenterology , vol.128 , pp. 96-107
    • Otani, K.1    Korenaga, M.2    Beard, M.R.3
  • 10
    • 27844604269 scopus 로고    scopus 로고
    • Hepatitis C virus core protein inhibits mitochondrial electron transport and increases reactive oxygen species (ROS) production
    • Korenaga M, Wang T, Li Y etal. Hepatitis C virus core protein inhibits mitochondrial electron transport and increases reactive oxygen species (ROS) production. J Biol Chem 2005; 280: 37481-37488.
    • (2005) J Biol Chem , vol.280 , pp. 37481-37488
    • Korenaga, M.1    Wang, T.2    Li, Y.3
  • 11
    • 48949103979 scopus 로고    scopus 로고
    • Mitochondrial electron transport inhibition in full genomic hepatitis C virus replicon cells is restored by reducing viral replication
    • Ando M, Korenaga M, Hino K etal. Mitochondrial electron transport inhibition in full genomic hepatitis C virus replicon cells is restored by reducing viral replication. Liver Int 2008; 28: 1158-1166.
    • (2008) Liver Int , vol.28 , pp. 1158-1166
    • Ando, M.1    Korenaga, M.2    Hino, K.3
  • 12
    • 0028618516 scopus 로고
    • Evidence for a link between hepatitis C virus infection and diabetes mellitus in a cirrhotic population
    • Allison ME, Wreghitt T, Palmer CR, Alexander GJ. Evidence for a link between hepatitis C virus infection and diabetes mellitus in a cirrhotic population. J Hepatol 1994; 21: 1135-1139.
    • (1994) J Hepatol , vol.21 , pp. 1135-1139
    • Allison, M.E.1    Wreghitt, T.2    Palmer, C.R.3    Alexander, G.J.4
  • 13
    • 0032835659 scopus 로고    scopus 로고
    • Further evidence for an association between non-insulin-dependent diabetes mellitus and chronic hepatitis C virus infection
    • Caronia S, Taylor K, Pagliaro L etal. Further evidence for an association between non-insulin-dependent diabetes mellitus and chronic hepatitis C virus infection. Hepatology 1999; 30: 1059-1063.
    • (1999) Hepatology , vol.30 , pp. 1059-1063
    • Caronia, S.1    Taylor, K.2    Pagliaro, L.3
  • 14
    • 0033025254 scopus 로고    scopus 로고
    • Association of diabetes mellitus and chronic hepatitis C virus infection
    • Mason AL, Lau JY, Hoang N etal. Association of diabetes mellitus and chronic hepatitis C virus infection. Hepatology 1999; 29: 328-333.
    • (1999) Hepatology , vol.29 , pp. 328-333
    • Mason, A.L.1    Lau, J.Y.2    Hoang, N.3
  • 15
    • 0030859121 scopus 로고    scopus 로고
    • Hepatitis C virus core protein induces hepatic steatosis in transgenic mice
    • Moriya K, Yotsuyanagi H, Shintani Y etal. Hepatitis C virus core protein induces hepatic steatosis in transgenic mice. J Gen Virol 1997; 78: 1527-1531.
    • (1997) J Gen Virol , vol.78 , pp. 1527-1531
    • Moriya, K.1    Yotsuyanagi, H.2    Shintani, Y.3
  • 16
    • 0033933140 scopus 로고    scopus 로고
    • Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3
    • Rubbia-Brandt L, Quadri R, Abid K etal. Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3. J Hepatol 2000; 33: 106-115.
    • (2000) J Hepatol , vol.33 , pp. 106-115
    • Rubbia-Brandt, L.1    Quadri, R.2    Abid, K.3
  • 17
    • 0034113670 scopus 로고    scopus 로고
    • Successful interferon therapy reverses enhanced hepatic iron accumulation and lipid peroxidation in chronic hepatitis C
    • Kageyama F, Kobayashi Y, Kawasaki T, Toyokuni S, Uchida K, Nakamura H. Successful interferon therapy reverses enhanced hepatic iron accumulation and lipid peroxidation in chronic hepatitis C. Am J Gastroenterol 2000; 95: 1041-1050.
    • (2000) Am J Gastroenterol , vol.95 , pp. 1041-1050
    • Kageyama, F.1    Kobayashi, Y.2    Kawasaki, T.3    Toyokuni, S.4    Uchida, K.5    Nakamura, H.6
  • 18
    • 15544382574 scopus 로고    scopus 로고
    • Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study
    • Davila JA, Morgan RO, Shaib Y, McGlynn KA, El-Serag HB. Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study. Gut 2005; 54: 533-539.
    • (2005) Gut , vol.54 , pp. 533-539
    • Davila, J.A.1    Morgan, R.O.2    Shaib, Y.3    McGlynn, K.A.4    El-Serag, H.B.5
  • 19
    • 0031712813 scopus 로고    scopus 로고
    • The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice
    • Moriya K, Fujie H, Shintani Y etal. The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nat Med 1998; 4: 1065-1067.
    • (1998) Nat Med , vol.4 , pp. 1065-1067
    • Moriya, K.1    Fujie, H.2    Shintani, Y.3
  • 20
    • 0036158719 scopus 로고    scopus 로고
    • Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus
    • Lerat H, Honda M, Beard MR etal. Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus. Gastroenterology 2002; 122: 352-365.
    • (2002) Gastroenterology , vol.122 , pp. 352-365
    • Lerat, H.1    Honda, M.2    Beard, M.R.3
  • 21
    • 35448952080 scopus 로고    scopus 로고
    • Long-term phlebotomy with low-iron diet therapy lowers risk of development of hepatocellular carcinoma from chronic hepatitis C
    • Kato J, Miyanishi K, Kobune M etal. Long-term phlebotomy with low-iron diet therapy lowers risk of development of hepatocellular carcinoma from chronic hepatitis C. J Gastroenterol 2007; 42: 830-836.
    • (2007) J Gastroenterol , vol.42 , pp. 830-836
    • Kato, J.1    Miyanishi, K.2    Kobune, M.3
  • 22
    • 84857687489 scopus 로고    scopus 로고
    • Linking mitochondrial bioenergetics to insulin resistance via redox biology
    • Fisher-Wellman KH, Neufer PD. Linking mitochondrial bioenergetics to insulin resistance via redox biology. Trends Endocrinol Metab 2012; 23: 142-153.
    • (2012) Trends Endocrinol Metab , vol.23 , pp. 142-153
    • Fisher-Wellman, K.H.1    Neufer, P.D.2
  • 23
    • 3242673323 scopus 로고    scopus 로고
    • Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif
    • Schwer B, Ren S, Pietschmann T etal. Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif. J Virol 2004; 78: 7958-7968.
    • (2004) J Virol , vol.78 , pp. 7958-7968
    • Schwer, B.1    Ren, S.2    Pietschmann, T.3
  • 24
    • 82555170658 scopus 로고    scopus 로고
    • Persistent expression of hepatitis C virus non-structural proteins leads to increased autophagy and mitochondrial injury in human hepatoma cells
    • Chu VC, Bhattacharya S, Nomoto A etal. Persistent expression of hepatitis C virus non-structural proteins leads to increased autophagy and mitochondrial injury in human hepatoma cells. PLoS ONE 2011; 6: e28551.
    • (2011) PLoS ONE , vol.6
    • Chu, V.C.1    Bhattacharya, S.2    Nomoto, A.3
  • 25
    • 79952197289 scopus 로고    scopus 로고
    • Role of Hepatitis C virus core protein in viral-induced mitochondrial dysfunction
    • Wang T, Campbell RV, Yi MK, Lemon SM, Weinman SA. Role of Hepatitis C virus core protein in viral-induced mitochondrial dysfunction. J Viral Hepat 2010; 17: 784-793.
    • (2010) J Viral Hepat , vol.17 , pp. 784-793
    • Wang, T.1    Campbell, R.V.2    Yi, M.K.3    Lemon, S.M.4    Weinman, S.A.5
  • 26
    • 33644781721 scopus 로고    scopus 로고
    • Subcellular localization of hepatitis C virus structural proteins in a cell culture system that efficiently replicates the virus
    • Rouille Y, Helle F, Delgrange D etal. Subcellular localization of hepatitis C virus structural proteins in a cell culture system that efficiently replicates the virus. J Virol 2006; 80: 2832-2841.
    • (2006) J Virol , vol.80 , pp. 2832-2841
    • Rouille, Y.1    Helle, F.2    Delgrange, D.3
  • 27
    • 84875540463 scopus 로고    scopus 로고
    • Hepatitis C virus-induced mitochondrial dysfunctions
    • Brault C, Levy PL, Bartosch B. Hepatitis C virus-induced mitochondrial dysfunctions. Viruses 2013; 5: 954-980.
    • (2013) Viruses , vol.5 , pp. 954-980
    • Brault, C.1    Levy, P.L.2    Bartosch, B.3
  • 28
    • 68949196124 scopus 로고    scopus 로고
    • Proteomics analysis of mitochondrial proteins reveals overexpression of a mitochondrial protein chaperon, prohibitin, in cells expressing hepatitis C virus core protein
    • Tsutsumi T, Matsuda M, Aizaki H etal. Proteomics analysis of mitochondrial proteins reveals overexpression of a mitochondrial protein chaperon, prohibitin, in cells expressing hepatitis C virus core protein. Hepatology 2009; 50: 378-386.
    • (2009) Hepatology , vol.50 , pp. 378-386
    • Tsutsumi, T.1    Matsuda, M.2    Aizaki, H.3
  • 29
    • 21744438136 scopus 로고    scopus 로고
    • Hepatitis C virus-core and nonstructural proteins lead to different effects on cellular antioxidant defenses
    • Abdalla MY, Ahmad IM, Spitz DR, Schmidt WN, Britigan BE. Hepatitis C virus-core and nonstructural proteins lead to different effects on cellular antioxidant defenses. J Med Virol 2005; 76: 489-497.
    • (2005) J Med Virol , vol.76 , pp. 489-497
    • Abdalla, M.Y.1    Ahmad, I.M.2    Spitz, D.R.3    Schmidt, W.N.4    Britigan, B.E.5
  • 30
    • 15744376980 scopus 로고    scopus 로고
    • Expression of gastrointestinal glutathione peroxidase is inversely correlated to the presence of hepatitis C virus subgenomic RNA in human liver cells
    • Morbitzer M, Herget T. Expression of gastrointestinal glutathione peroxidase is inversely correlated to the presence of hepatitis C virus subgenomic RNA in human liver cells. J Biol Chem 2005; 280: 8831-8841.
    • (2005) J Biol Chem , vol.280 , pp. 8831-8841
    • Morbitzer, M.1    Herget, T.2
  • 31
    • 33745797050 scopus 로고    scopus 로고
    • Hepatitis C virus triggers mitochondrial permeability transition with production of reactive oxygen species, leading to DNA damage and STAT3 activation
    • Machida K, Cheng KT, Lai CK, Jeng KS, Sung VM, Lai MM. Hepatitis C virus triggers mitochondrial permeability transition with production of reactive oxygen species, leading to DNA damage and STAT3 activation. J Virol 2006; 80: 7199-7207.
    • (2006) J Virol , vol.80 , pp. 7199-7207
    • Machida, K.1    Cheng, K.T.2    Lai, C.K.3    Jeng, K.S.4    Sung, V.M.5    Lai, M.M.6
  • 32
    • 0036236226 scopus 로고    scopus 로고
    • Cellular response to conditional expression of hepatitis C virus core protein in Huh7 cultured human hepatoma cells
    • Li K, Prow T, Lemon SM, Beard MR. Cellular response to conditional expression of hepatitis C virus core protein in Huh7 cultured human hepatoma cells. Hepatology 2002; 35: 1237-1246.
    • (2002) Hepatology , vol.35 , pp. 1237-1246
    • Li, K.1    Prow, T.2    Lemon, S.M.3    Beard, M.R.4
  • 33
    • 72849147487 scopus 로고    scopus 로고
    • Hepatitis C virus (HCV) proteins induce NADPH oxidase 4 expression in a transforming growth factor beta-dependent manner: a new contributor to HCV-induced oxidative stress
    • Boudreau HE, Emerson SU, Korzeniowska A, Jendrysik MA, Leto TL. Hepatitis C virus (HCV) proteins induce NADPH oxidase 4 expression in a transforming growth factor beta-dependent manner: a new contributor to HCV-induced oxidative stress. J Virol 2009; 83: 12934-12946.
    • (2009) J Virol , vol.83 , pp. 12934-12946
    • Boudreau, H.E.1    Emerson, S.U.2    Korzeniowska, A.3    Jendrysik, M.A.4    Leto, T.L.5
  • 34
    • 77954236285 scopus 로고    scopus 로고
    • Hepatocyte NAD(P)H oxidases as an endogenous source of reactive oxygen species during hepatitis C virus infection
    • deMochel NS, Seronello S, Wang SH etal. Hepatocyte NAD(P)H oxidases as an endogenous source of reactive oxygen species during hepatitis C virus infection. Hepatology 2010; 52: 47-59.
    • (2010) Hepatology , vol.52 , pp. 47-59
    • deMochel, N.S.1    Seronello, S.2    Wang, S.H.3
  • 35
    • 84883281733 scopus 로고    scopus 로고
    • Disruption of cyclophilin d-mediated calcium transfer from the ER to mitochondria contributes to hepatic ER stress and insulin resistance
    • Rieusset J, Fauconnier J, Paillard M etal. Disruption of cyclophilin d-mediated calcium transfer from the ER to mitochondria contributes to hepatic ER stress and insulin resistance. Hepatology 2013; 58: 1195.
    • (2013) Hepatology , vol.58 , pp. 1195
    • Rieusset, J.1    Fauconnier, J.2    Paillard, M.3
  • 36
    • 0036773295 scopus 로고    scopus 로고
    • Cardiac energy metabolism homeostasis: role of cytosolic calcium
    • Balaban RS. Cardiac energy metabolism homeostasis: role of cytosolic calcium. J Mol Cell Cardiol 2002; 34: 1259-1271.
    • (2002) J Mol Cell Cardiol , vol.34 , pp. 1259-1271
    • Balaban, R.S.1
  • 37
    • 0035859871 scopus 로고    scopus 로고
    • Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B
    • Gong G, Waris G, Tanveer R, Siddiqui A. Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B. Proc Natl Acad Sci U S A 2001; 98: 9599-9604.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 9599-9604
    • Gong, G.1    Waris, G.2    Tanveer, R.3    Siddiqui, A.4
  • 38
    • 34547739644 scopus 로고    scopus 로고
    • Hepatitis C virus core protein increases mitochondrial ROS production by stimulation of Ca2+ uniporter activity
    • Li Y, Boehning DF, Qian T, Popov VL, Weinman SA. Hepatitis C virus core protein increases mitochondrial ROS production by stimulation of Ca2+ uniporter activity. FASEB J 2007; 21: 2474-2485.
    • (2007) FASEB J , vol.21 , pp. 2474-2485
    • Li, Y.1    Boehning, D.F.2    Qian, T.3    Popov, V.L.4    Weinman, S.A.5
  • 39
    • 34547415672 scopus 로고    scopus 로고
    • Hepatitis C virus protein expression causes calcium-mediated mitochondrial bioenergetic dysfunction and nitro-oxidative stress
    • Piccoli C, Scrima R, Quarato G etal. Hepatitis C virus protein expression causes calcium-mediated mitochondrial bioenergetic dysfunction and nitro-oxidative stress. Hepatology 2007; 46: 58-65.
    • (2007) Hepatology , vol.46 , pp. 58-65
    • Piccoli, C.1    Scrima, R.2    Quarato, G.3
  • 40
    • 33947612587 scopus 로고    scopus 로고
    • Redox control of neural function: background, mechanisms, and significance
    • Maher P. Redox control of neural function: background, mechanisms, and significance. Antioxid Redox Signal 2006; 8: 1941-1970.
    • (2006) Antioxid Redox Signal , vol.8 , pp. 1941-1970
    • Maher, P.1
  • 41
    • 58149314211 scopus 로고    scopus 로고
    • Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
    • Narendra D, Tanaka A, Suen DF etal. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 2008; 183: 795-803.
    • (2008) J Cell Biol , vol.183 , pp. 795-803
    • Narendra, D.1    Tanaka, A.2    Suen, D.F.3
  • 43
    • 84856244072 scopus 로고    scopus 로고
    • Mitophagy plays an essential role in reducing mitochondrial production of reactive oxygen species and mutation of mitochondrial DNA by maintaining mitochondrial quantity and quality in yeast
    • Kurihara Y, Kanki T, Aoki Y etal. Mitophagy plays an essential role in reducing mitochondrial production of reactive oxygen species and mutation of mitochondrial DNA by maintaining mitochondrial quantity and quality in yeast. J Biol Chem 2012; 287: 3265-3272.
    • (2012) J Biol Chem , vol.287 , pp. 3265-3272
    • Kurihara, Y.1    Kanki, T.2    Aoki, Y.3
  • 44
    • 0035487007 scopus 로고    scopus 로고
    • The mitochondrial permeability transition initiates autophagy in rat hepatocytes
    • Elmore SP, Qian T, Grissom S etal. The mitochondrial permeability transition initiates autophagy in rat hepatocytes. FASEB J 2001; 15: 2286-2287.
    • (2001) FASEB J , vol.15 , pp. 2286-2287
    • Elmore, S.P.1    Qian, T.2    Grissom, S.3
  • 45
    • 75949130828 scopus 로고    scopus 로고
    • PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
    • Geisler S, Holmstrom KM, Skujat D etal. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol 2010; 12: 119-131.
    • (2010) Nat Cell Biol , vol.12 , pp. 119-131
    • Geisler, S.1    Holmstrom, K.M.2    Skujat, D.3
  • 46
    • 84875993938 scopus 로고    scopus 로고
    • Hepatitis C virus induces the mitochondrial translocation of Parkin and subsequent mitophagy
    • Kim SJ, Syed GH, Siddiqui A. Hepatitis C virus induces the mitochondrial translocation of Parkin and subsequent mitophagy. PLoS Pathog 2013; 9: e1003285.
    • (2013) PLoS Pathog , vol.9
    • Kim, S.J.1    Syed, G.H.2    Siddiqui, A.3
  • 47
    • 0345655291 scopus 로고    scopus 로고
    • Insulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression
    • Hui JM, Sud A, Farrell GC etal. Insulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression. Gastroenterology 2003; 125: 1695-1704.
    • (2003) Gastroenterology , vol.125 , pp. 1695-1704
    • Hui, J.M.1    Sud, A.2    Farrell, G.C.3
  • 48
    • 0345017776 scopus 로고    scopus 로고
    • Impaired IRS-1/PI3-kinase signaling in patients with HCV: a mechanism for increased prevalence of type 2 diabetes
    • Aytug S, Reich D, Sapiro LE, Bernstein D, Begum N. Impaired IRS-1/PI3-kinase signaling in patients with HCV: a mechanism for increased prevalence of type 2 diabetes. Hepatology 2003; 38: 1384-1392.
    • (2003) Hepatology , vol.38 , pp. 1384-1392
    • Aytug, S.1    Reich, D.2    Sapiro, L.E.3    Bernstein, D.4    Begum, N.5
  • 49
    • 1542287381 scopus 로고    scopus 로고
    • Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance
    • Shintani Y, Fujie H, Miyoshi H etal. Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance. Gastroenterology 2004; 126: 840-848.
    • (2004) Gastroenterology , vol.126 , pp. 840-848
    • Shintani, Y.1    Fujie, H.2    Miyoshi, H.3
  • 50
    • 7244243810 scopus 로고    scopus 로고
    • Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 3
    • Kawaguchi T, Yoshida T, Harada M etal. Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 3. Am J Pathol 2004; 165: 1499-1508.
    • (2004) Am J Pathol , vol.165 , pp. 1499-1508
    • Kawaguchi, T.1    Yoshida, T.2    Harada, M.3
  • 51
    • 84866368309 scopus 로고    scopus 로고
    • The metabolic regulator PGC-1alpha links hepatitis C virus infection to hepatic insulin resistance
    • Shlomai A, Rechtman MM, Burdelova EO etal. The metabolic regulator PGC-1alpha links hepatitis C virus infection to hepatic insulin resistance. J Hepatol 2012; 57: 867-873.
    • (2012) J Hepatol , vol.57 , pp. 867-873
    • Shlomai, A.1    Rechtman, M.M.2    Burdelova, E.O.3
  • 53
    • 2942628012 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms
    • Ueki K, Kondo T, Kahn CR. Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol Cell Biol 2004; 24: 5434-5446.
    • (2004) Mol Cell Biol , vol.24 , pp. 5434-5446
    • Ueki, K.1    Kondo, T.2    Kahn, C.R.3
  • 54
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance
    • Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science 1996; 271: 665-668.
    • (1996) Science , vol.271 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis, R.4    White, M.F.5    Spiegelman, B.M.6
  • 55
    • 0037059330 scopus 로고    scopus 로고
    • Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action
    • Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE, White MF. Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem 2002; 277: 1531-1537.
    • (2002) J Biol Chem , vol.277 , pp. 1531-1537
    • Aguirre, V.1    Werner, E.D.2    Giraud, J.3    Lee, Y.H.4    Shoelson, S.E.5    White, M.F.6
  • 57
    • 18144383207 scopus 로고    scopus 로고
    • PTPs versus PTKs: the redox side of the coin
    • Chiarugi P. PTPs versus PTKs: the redox side of the coin. Free Radic Res 2005; 39: 353-364.
    • (2005) Free Radic Res , vol.39 , pp. 353-364
    • Chiarugi, P.1
  • 58
    • 20444400257 scopus 로고    scopus 로고
    • Redox redux: revisiting PTPs and the control of cell signaling
    • Tonks NK. Redox redux: revisiting PTPs and the control of cell signaling. Cell 2005; 121: 667-670.
    • (2005) Cell , vol.121 , pp. 667-670
    • Tonks, N.K.1
  • 59
    • 65649098029 scopus 로고    scopus 로고
    • Phosphorylation of IRS proteins, insulin action, and insulin resistance
    • Boura-Halfon S, Zick Y. Phosphorylation of IRS proteins, insulin action, and insulin resistance. Am J Physiol Endocrinol Metab 2009; 296: E581-591.
    • (2009) Am J Physiol Endocrinol Metab , vol.296
    • Boura-Halfon, S.1    Zick, Y.2
  • 60
    • 33645860825 scopus 로고    scopus 로고
    • Reactive oxygen species have a causal role in multiple forms of insulin resistance
    • Houstis N, Rosen ED, Lander ES. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006; 440: 944-948.
    • (2006) Nature , vol.440 , pp. 944-948
    • Houstis, N.1    Rosen, E.D.2    Lander, E.S.3
  • 61
    • 0033636523 scopus 로고    scopus 로고
    • Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
    • Michael MD, Kulkarni RN, Postic C etal. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell 2000; 6: 87-97.
    • (2000) Mol Cell , vol.6 , pp. 87-97
    • Michael, M.D.1    Kulkarni, R.N.2    Postic, C.3
  • 62
    • 0034805486 scopus 로고    scopus 로고
    • Increase in the concentration of carbon 18 monounsaturated fatty acids in the liver with hepatitis C: analysis in transgenic mice and humans
    • Moriya K, Todoroki T, Tsutsumi T etal. Increase in the concentration of carbon 18 monounsaturated fatty acids in the liver with hepatitis C: analysis in transgenic mice and humans. Biochem Biophys Res Commun 2001; 281: 1207-1212.
    • (2001) Biochem Biophys Res Commun , vol.281 , pp. 1207-1212
    • Moriya, K.1    Todoroki, T.2    Tsutsumi, T.3
  • 63
    • 18244365866 scopus 로고    scopus 로고
    • Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral-related steatosis
    • Perlemuter G, Sabile A, Letteron P etal. Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral-related steatosis. FASEB J 2002; 16: 185-194.
    • (2002) FASEB J , vol.16 , pp. 185-194
    • Perlemuter, G.1    Sabile, A.2    Letteron, P.3
  • 64
    • 33846850496 scopus 로고    scopus 로고
    • Critical role of PA28gamma in hepatitis C virus-associated steatogenesis and hepatocarcinogenesis
    • Moriishi K, Mochizuki R, Moriya K etal. Critical role of PA28gamma in hepatitis C virus-associated steatogenesis and hepatocarcinogenesis. Proc Natl Acad Sci U S A 2007; 104: 1661-1666.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 1661-1666
    • Moriishi, K.1    Mochizuki, R.2    Moriya, K.3
  • 65
    • 33744512454 scopus 로고    scopus 로고
    • Hepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein
    • Furutani T, Hino K, Okuda M etal. Hepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein. Gastroenterology 2006; 130: 2087-2098.
    • (2006) Gastroenterology , vol.130 , pp. 2087-2098
    • Furutani, T.1    Hino, K.2    Okuda, M.3
  • 66
    • 18544384019 scopus 로고
    • Oxidation of tartaric acid in presence of iron
    • Fenton HJH. Oxidation of tartaric acid in presence of iron. J Chem Soc 1894; 65: 899-910.
    • (1894) J Chem Soc , vol.65 , pp. 899-910
    • Fenton, H.J.H.1
  • 67
    • 0025981359 scopus 로고
    • Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG
    • Shibutani S, Takeshita M, Grollman AP. Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature 1991; 349: 431-434.
    • (1991) Nature , vol.349 , pp. 431-434
    • Shibutani, S.1    Takeshita, M.2    Grollman, A.P.3
  • 68
    • 33845944459 scopus 로고    scopus 로고
    • Hepatic oxidative DNA damage correlates with iron overload in chronic hepatitis C patients
    • Fujita N, Horiike S, Sugimoto R etal. Hepatic oxidative DNA damage correlates with iron overload in chronic hepatitis C patients. Free Radic Biol Med 2007; 42: 353-362.
    • (2007) Free Radic Biol Med , vol.42 , pp. 353-362
    • Fujita, N.1    Horiike, S.2    Sugimoto, R.3
  • 69
    • 2042546096 scopus 로고    scopus 로고
    • Balancing acts: molecular control of mammalian iron metabolism
    • Hentze MW, Muckenthaler MU, Andrews NC. Balancing acts: molecular control of mammalian iron metabolism. Cell 2004; 117: 285-297.
    • (2004) Cell , vol.117 , pp. 285-297
    • Hentze, M.W.1    Muckenthaler, M.U.2    Andrews, N.C.3
  • 70
    • 0034284595 scopus 로고    scopus 로고
    • LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
    • Krause A, Neitz S, Magert HJ etal. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett 2000; 480: 147-150.
    • (2000) FEBS Lett , vol.480 , pp. 147-150
    • Krause, A.1    Neitz, S.2    Magert, H.J.3
  • 71
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, a urinary antimicrobial peptide synthesized in the liver
    • Park CH, Valore EV, Waring AJ, Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2001; 276: 7806-7810.
    • (2001) J Biol Chem , vol.276 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3    Ganz, T.4
  • 72
    • 33847609799 scopus 로고    scopus 로고
    • Hepcidin expression in the liver: relatively low level in patients with chronic hepatitis C
    • Fujita N, Sugimoto R, Takeo M etal. Hepcidin expression in the liver: relatively low level in patients with chronic hepatitis C. Mol Med 2007; 13: 97-104.
    • (2007) Mol Med , vol.13 , pp. 97-104
    • Fujita, N.1    Sugimoto, R.2    Takeo, M.3
  • 73
    • 70349746734 scopus 로고    scopus 로고
    • Reduced serum hepcidin levels in patients with chronic hepatitis C
    • Girelli D, Pasino M, Goodnough JB etal. Reduced serum hepcidin levels in patients with chronic hepatitis C. J Hepatol 2009; 51: 845-852.
    • (2009) J Hepatol , vol.51 , pp. 845-852
    • Girelli, D.1    Pasino, M.2    Goodnough, J.B.3
  • 74
    • 33747359666 scopus 로고    scopus 로고
    • Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression
    • Harrison-Findik DD, Schafer D, Klein E etal. Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. J Biol Chem 2006; 281: 22974-22982.
    • (2006) J Biol Chem , vol.281 , pp. 22974-22982
    • Harrison-Findik, D.D.1    Schafer, D.2    Klein, E.3
  • 75
    • 37349065804 scopus 로고    scopus 로고
    • Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription
    • Nishina S, Hino K, Korenaga M etal. Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription. Gastroenterology 2008; 134: 226-238.
    • (2008) Gastroenterology , vol.134 , pp. 226-238
    • Nishina, S.1    Hino, K.2    Korenaga, M.3
  • 76
    • 30344445344 scopus 로고    scopus 로고
    • Expression and function of C/EBP homology protein (GADD153) in podocytes
    • Bek MF, Bayer M, Muller B etal. Expression and function of C/EBP homology protein (GADD153) in podocytes. Am J Pathol 2006; 168: 20-32.
    • (2006) Am J Pathol , vol.168 , pp. 20-32
    • Bek, M.F.1    Bayer, M.2    Muller, B.3
  • 77
    • 56149115918 scopus 로고    scopus 로고
    • Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity
    • Miura K, Taura K, Kodama Y, Schnabl B, Brenner DA. Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. Hepatology 2008; 48: 1420-1429.
    • (2008) Hepatology , vol.48 , pp. 1420-1429
    • Miura, K.1    Taura, K.2    Kodama, Y.3    Schnabl, B.4    Brenner, D.A.5


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