Persistent expression of hepatitis C virus non-structural proteins leads to increased autophagy and mitochondrial injury in human hepatoma cells

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Chu, Victor C ^a   Bhattacharya, Sayanti ^a   Nomoto, Ann ^b   Lin, Jiahui ^a   Zaidi, Syed Kashif ^b   Oberley, Terry D ^c,d   Weinman, Steven A ^e   Azhar, Salman ^b   Huang, Ting Ting ^a,b  

^a STANFORD UNIVERSITY   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d WILLIAM S MIDDLETON MEMORIAL VETERANS HOSPITAL   (United States)

^e UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; CYCLIN D1; MANGANESE SUPEROXIDE DISMUTASE; PEROXIREDOXIN 1; PEROXIREDOXIN 3; REACTIVE OXYGEN METABOLITE; STRUCTURAL PROTEIN; THIOREDOXIN 1; THIOREDOXIN 2; VIRUS PROTEIN; VIRUS RNA; ANTIBODY; ANTIOXIDANT;

ANTIOXIDANT ACTIVITY; ARTICLE; AUTOPHAGY; CELL GROWTH; CELL POPULATION; CELL VACUOLE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; CYTOSOL; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENDOPLASMIC RETICULUM; HEPATITIS C; HEPATITIS C VIRUS; HEPATOMA CELL; HUMAN; HUMAN CELL; MITOCHONDRION; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; UPREGULATION; VIRUS REPLICATION; ANIMAL; CELL LINE; CHEMISTRY; GENOME; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; METHODOLOGY; MOUSE; OXIDATION REDUCTION REACTION; TIME; TRANSGENIC MOUSE; TUMOR CELL LINE; VIROLOGY;

ANIMALS; ANTIBODIES; ANTIOXIDANTS; AUTOPHAGY; CARCINOMA, HEPATOCELLULAR; CELL LINE; CELL LINE, TUMOR; CYCLIN D1; GENOME; HEPACIVIRUS; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; MICE; MICE, TRANSGENIC; MITOCHONDRIA; OXIDATION-REDUCTION; TIME FACTORS; UP-REGULATION;

EID: 82555170658     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028551     Document Type: Article

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