Hepatitis C virus-core and non structural proteins lead to different effects on cellular antioxidant defenses

Journal of Medical Virology

Volumn 76, Issue 4, 2005, Pages 489-497

  Abdalla, Maher Y ^c   Ahmad, Iman M ^b   Spitz, Douglas R ^b   Schmidt, Warren N ^a,c   Britigan, Bradley E ^a,b,c,d,e  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b Free Radical and Radiation Biology Program   (United States)

^c UNIVERSITY OF IOWA   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Hepatitis C; Hepatitis C core protein; Hepatitis C nonstructural proteins; Oxidative stress

Indexed keywords

5 CHLOROMETHYL 2',7' DICHLORODIHYDROFLUORESCEIN DIACETATE; 6 CHLOROMETHYL 2',7' DICHLORODIHYDROFLUORESCEIN DIACETATE; ANTIOXIDANT; CORE PROTEIN; FLUORESCEIN DIACETATE; GLUTATHIONE; HEME OXYGENASE 1; MANGANESE SUPEROXIDE DISMUTASE; THIOREDOXIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL DAMAGE; CHRONIC HEPATITIS; CONTROLLED STUDY; FLUORESCENCE; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; LIVER CELL; OXIDATION; OXIDATIVE STRESS;

CATALASE; CELL LINE, TUMOR; FLUORESCEINS; GLUTATHIONE; HEME OXYGENASE (DECYCLIZING); HEPACIVIRUS; HEPATOCYTES; HUMANS; OXIDATION-REDUCTION; OXIDATIVE STRESS; SUPEROXIDE DISMUTASE; THIOREDOXIN; TRANSFECTION; VIRAL CORE PROTEINS; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 21744438136     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/jmv.20388     Document Type: Article

References (46)

1. Abdalla MY, Britigan BE, Wen F, Icardi M, McCormick ML, LaBrecque DR, Voigt M, Brown KE, Schmidt WN. 2004. Down regulation of heme oxygenase-1 by hepatitis C virus infection in vivo and hepatitis C core protein expression in vitro. J Infect Dis 190: 1109-1118.
2. Bianchi A, Becuwe P, Franck P, Dauca M. 2002. Induction of MnSOD gene by arachidonic acid is mediated by reactive oxygen species and p38 MAPK signaling pathway in human HepG2 hepatoma cells. Free Radic Biol Med 32:1132-1142.
3. Boya P, de la Pena A, Beloqui O, Larrea E, Conchillo M, Castelruiz Y, Civeira MP, Prieto J. 1999. Antioxidant status and glutathione metabolism in peripheral blood mononuclear cells from patients with chronic hepatitis C. J Hepatol 31:808-814.
4. Cederbaum AI, Wu D, Mari M, Bai J. 2001. CYP2E1-dependent toxicity and oxidative stress in HepG2 cells. Free Radic Biol Med 31:1539-1543.
5. Das KC, Lewis-Molock Y, White CW. 1997. Elevation of manganese superoxide dismutase gene expression by thioredoxin. Am J Respir Cell Mol Biol 17:713-726.
6. De Maria N, Calantoni A, Fagivoli S, Liu GJ, Rogers BK, Farinati F. 1996. Association between reactive oxygen species and disease activity in chronic hepatitis C. Free Radic Biol Med 21:291-295.
7. Farinati F, Cardin R, D'Errico A, De Maria N, Naccarato R, Cecchetto A, Grigioni W. 1996. Hepatocyte proliferative activity in chronic liver damage as assessed by the monoclonal antibody MIB1 Ki67 in archival material: The role of etiology, disease activity, iron, and lipid peroxidation. Hepatology 23:1468-1475.
8. Gong G, Waris G, Tanveer R, Siddiqui A. 2001. Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B. Proc Natl Acad Sci 98:9599-9604.
9. Griffith CW. 1980. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpridine. Anal Biochem 106:207-212.
10. Guo X, Shin VY, Cho CH. 2001. Modulation of heme oxygenase in tissue injury and its implication in protection against gastrointestinal diseases. Life Sci 69:3113-3119.
11. Halliwell B. 1994. Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? Lancet 344:721-724.
12. He Y, Nakao H, Tan SL, Polyak SJ, Neddermann P, Vijaysri S, Jacobs BL, Katze MG. 2002. Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase. J Virol 76:9207-9217.
13. Hempel SL, Buettner GR, O'Malley YQ, Wessels DA, Flaherty DM. 1999. Dihydroflorescein diacetate is superior for detecting intracellular oxidants: Comparison with 2′,7′-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2′,7′-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123. Free Radic Biol Med 27:146-159.
14. Hirota K, Murata M, Sachi Y, Nakamura H, Takeuchi J, Mori K, Yodoi J. 1999. Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-B. J Biol Chem 274:27891-27897.
15. Holmgren A. 1989. Thioredoxinand glutaredoxin systems. J Biol Chem 264:13963-13966.
16. Holmgren A, Fagerstedt M. 1982. The in vivo distribution of oxidized and reduced thioredoxin in E. coli. J Biol Chem 257:6926-6930.
17. Immenschuh S, Ramadori G. 2000. Gene regulation of heme oxygenase-1 as a therapeutic target. Biochem Pharmacol 60:1121-1128.
18. Kolykhalov AA, Agapov EV, Blight KJ, Mihalik K, Feinstone SM, Rice CM. 1997. Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA. Science 277:570-574.
19. Kosower NS, Kosower EM. 1978. The glutathione status of cells. Int Rev Cytol 54:109-157.
20. Kyoji M, Kiyotaka N, Tomofumi S, Yoshizumi S, Hajime F, Hideyuki M, Takeya T, Teruo M, Kotaro I, Toshiharu H, Kazuhiro I, Toru T, Satoshi K, Kazuhiko K. 2001. Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis. Cancer Res 61:4365-4370.
21. Larrea E, Beloqui O, Munoz-Navas MA, Civeira MP, Prieto J. 1998. Superoxide dismutase in patients with chronic hepatitis C virus infection. Free Radic Biol Med 24:1235-1241.
22. Li K, Prow T, Lemon SM, Beard MR. 2002. Cellular response to conditional expression of hepatitis C virus core protein in Huh7 cultured human hepatoma cells. Hepatology 35:1237-1246.
23. Lieber CS. 1997. Role of oxidative stress and antioxidant therapy in alcoholic and nonalcoholic liver diseases. Adv Pharmacol 38:601-628.
24. Lohmann V, Korner F, Koch JO, Herian U, Theilmann L, Bartenschlager R. 1999. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 285:110-113.
25. Lowry OH, Rosenbrough NJ, Farr AL, Randell RJ. 1951. Protein measurement using the folin phenol reagent. J Biol Chem 193:265-275.
26. Mari M, Cederbaum AI. 2000. CYP2E1 Overexpression in HepG2 cells induces glutathione synthesis by transcriptional activation of γ-glutamylcysteine synthetase. J Biol Chem 275:15563-15571.
27. Meister A, Anderson ME. 1983. Glutathione. Annu Rev Biochem 52: 711-760.
28. Morbitzer M, Herget T. 2005. Expression of gastrointestinal glutathione peroxidase is inversely correlated to the presence of hepatitis C virus subgenomic RNA in human liver cells. J Biol Chem 280:8831-8841.
29. Oberley LW, Buettner GR. 1979. Role of superoxide dismutase in cancer: A review. Cancer Res 39:1141-1149.
30. Okuda M, Li K, Beard MR, Showalter LA, Scholle F, Lemon SM, Weinman SA. 2002. Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology 122:366-375.
31. Otsuka M, Kato N, Lan K, Yoshida H, Kato J, Goto T, Shiratori Y, Omata M. 2000. Hepatitis C virus core protein enhances p53 function through augmentation of DNA binding affinity and transcriptional ability. J Biol Chem 275:34122-34130.
32. Packer JE, Slater TF, Wilson RL. 1979. Direct observation of a free radical interaction between vitamin E and vitamin C. Nature 278:737-738.
33. Paradis V, Mathurin P, Kollinger M, Imbert-Bismut F, Charlotte F, Piton A, Opolon P, Holstege A, Poynard T, Bedossa P. 1997. In situ detection of lipid peroxidation in chronic hepatitis C: Correlation with pathological features. J Clin Pathol 50:401-406.
34. Qadri I, Iwahashi M, Capasso JM, Hopken MW, Flores S, Schaack J, Simon FR. 2004. Induced oxidative stress and activated expression of manganese superoxide dismutase during hepatitis C virus replication: Role of JNK, p38 MAPK and AP-1. Biochem J 378: 919-928.
35. Ray RB, Lagging LM, Meyer K, Ray R. 1996. Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype. J Virol 70:4438-4443.
36. Rhee SG, Kang SW, Chang TS, Jeong W, Kim K. 2001. Peroxiredoxin, a novel family of peroxidases. IUBMB Life 52:35-41.
37. Seeff LB. 1997. Natural history of hepatitis C. Hepatology 21S-28S.
38. St Clair DK, Porntadavity S, Xu Y, Kiningham K. 2002. Transcription regulation of human manganese superoxide dismutase gene. Methods Enzymol 349:306-312.
39. Tsan MF. 1989. Superoxide dismutase and pulmonary oxygen toxicity. Proc Soc Exp Biol Med 203:286-290.
40. Ueno M, Masutani H, Arai RJ, Yamauchi A, Hirota K, Sakai T, Inamoto T, Yamaoka Y, Yodoi J, Nikaido T. 1999. Thioredoxin dependent redox regulation of p53-mediated p21 activation. J Biol Chem 274: 35809-35815.
41. Waris G, Livolsi A, Imbert V, Peyron JF, Siddiqui A. 2003. Hepatitis C virus NS5A and subgenomic replicon activate NF-kappaB via tyrosine phosphorylation of IkappaBalpha and its degradation by calpain protease. J Biol Chem 278:40778-40787.
42. Watson WH, Pohl J, Montfort WR, Stuchlik O, Reed MS, Powis G, Jones DP. 2003. Redox potential of human thioredoxin 1 and identification of a second dithiol/disulfide motif. J Biol Chem 278:33408-33415.
43. Wen F, Abdalla MY, Aloman C, Xiang JH, Ahmad IM, Walewski J, McCormick ML, Brown KE, Branch AD, Spitz DR, Britigan BE, Schmidt WN. 2004. Increased prooxidant production and enhanced susceptibility to glutathione depletion in HepG2 cells co-expressing HCV core protein and CYP2E1. J Med Virol 72:230-240.
44. Winterbourn CC, Metodiewa D. 1999. Reactivity of biologically important thiol compounds with superoxide and hydrogen peroxide. Free Radic Biol Med 27:322-328.
45. Wong GH, Elwell JH, Oberley LW, Goeddel DV. 1989. Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor. Cell 58:923-931.
46. Yoshida H, Kato N, Shiratori Y, Otsuka M, Maeda S, Kato J, Omata M. 2001. Hepatitis C virus core protein activates nuclear factor β-dependent signaling through tumor necrosis factor receptor-associated factor. J Biol Chem 276:16399-16405.