메뉴 건너뛰기




Volumn 47, Issue 2, 2014, Pages 105-112

Surge in regulatory cells does not prevent onset of hyperglycemia in NOD mice

Author keywords

Immune phenotype; Inflammatory insulitis; Mechanisms; NOD mouse; Regulatory T cells

Indexed keywords

FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; INTERLEUKIN 2; LEUKOCYTE ANTIGEN;

EID: 84893748811     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.3109/08916934.2013.866103     Document Type: Article
Times cited : (7)

References (64)
  • 1
    • 0141992907 scopus 로고    scopus 로고
    • Dynamics of pathogenic and suppressor T cells in autoimmune diabetes development
    • Gregori, S., N. Giarratana, S. Smiroldo, and L. Adorini. 2003. Dynamics of pathogenic and suppressor T cells in autoimmune diabetes development. J. Immunol. 171: 4040-4047.
    • (2003) J. Immunol. , vol.171 , pp. 4040-4047
    • Gregori, S.1    Giarratana, N.2    Smiroldo, S.3    Adorini, L.4
  • 2
    • 20944444896 scopus 로고    scopus 로고
    • Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells
    • You, S., M. Belghith, S. Cobbold, et al. 2005. Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells. Diabetes. 54: 1415-1422.
    • (2005) Diabetes. , vol.54 , pp. 1415-1422
    • You, S.1    Belghith, M.2    Cobbold, S.3
  • 3
    • 34047210905 scopus 로고    scopus 로고
    • Diabetes in non-obese diabetic mice is not associated with quantitative changes in CD4CD25Foxp3 regulatory T cells
    • Mellanby, R. J., D. Thomas, J. M. Phillips, and A. Cooke. 2007. Diabetes in non-obese diabetic mice is not associated with quantitative changes in CD4CD25Foxp3 regulatory T cells. Immunology. 121: 15-28.
    • (2007) Immunology. , vol.121 , pp. 15-28
    • Mellanby, R.J.1    Thomas, D.2    Phillips, J.M.3    Cooke, A.4
  • 4
    • 0035459382 scopus 로고    scopus 로고
    • Autoreactive diabetogenic T-cells in NOD mice can efficiently expand from a greatly reduced precursor pool
    • Serreze, D. V., E. A. Johnson, H. D. Chapman, et al. 2001. Autoreactive diabetogenic T-cells in NOD mice can efficiently expand from a greatly reduced precursor pool. Diabetes. 50: 1992-2000.
    • (2001) Diabetes. , vol.50 , pp. 1992-2000
    • Serreze, D.V.1    Johnson, E.A.2    Chapman, H.D.3
  • 5
    • 58149188480 scopus 로고    scopus 로고
    • The effector T cells of diabetic subjects are resistant to regulation via CD4FOXP3 regulatory T cells
    • Schneider, A., M. Rieck, S. Sanda, et al. 2008. The effector T cells of diabetic subjects are resistant to regulation via CD4FOXP3 regulatory T cells. J. Immunol. 181: 7350-7355.
    • (2008) J. Immunol. , vol.181 , pp. 7350-7355
    • Schneider, A.1    Rieck, M.2    Sanda, S.3
  • 6
    • 78751505478 scopus 로고    scopus 로고
    • Natural regulatory T cells in autoimmunity
    • Lourenço, E. V., and A. La Cava. 2011. Natural regulatory T cells in autoimmunity. Autoimmunity. 44: 33-42.
    • (2011) Autoimmunity. , vol.44 , pp. 33-42
    • Lourenço, E.V.1    La Cava, A.2
  • 7
    • 84858072808 scopus 로고    scopus 로고
    • IL-2-targeted therapy ameliorates the severity of graft-versus-host disease: Ex vivo selective depletion of host-reactive T cells and in vivo therapy
    • Yarkoni, S., T. B. Prigozhina, S. Slavin, and N. Askenasy. 2012. IL-2-targeted therapy ameliorates the severity of graft-versus-host disease: Ex vivo selective depletion of host-reactive T cells and in vivo therapy. Biol. Blood Marrow Transplant. 18: 523-535.
    • (2012) Biol. Blood Marrow Transplant. , vol.18 , pp. 523-535
    • Yarkoni, S.1    Prigozhina, T.B.2    Slavin, S.3    Askenasy, N.4
  • 8
    • 0037125972 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha regulation of CD4CD25 T cell levels in NOD mice
    • Wu, A. J., H. Hua, S. H. Munson, and H. O. McDevitt. 2002. Tumor necrosis factor-alpha regulation of CD4CD25 T cell levels in NOD mice. Proc. Natl. Acad. Sci. USA. 99: 12287-12292.
    • (2002) Proc. Natl. Acad. Sci. USA. , vol.99 , pp. 12287-12292
    • Wu, A.J.1    Hua, H.2    Munson, S.H.3    McDevitt, H.O.4
  • 9
    • 18244400088 scopus 로고    scopus 로고
    • Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4CD25 regulatory T cells during autoimmune diabetes
    • Pop, S. M., C. P. Wong, D. A. Culton, et al. 2005. Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4CD25 regulatory T cells during autoimmune diabetes. J. Exp. Med. 201: 1333-1346.
    • (2005) J. Exp. Med. , vol.201 , pp. 1333-1346
    • Pop, S.M.1    Wong, C.P.2    Culton, D.A.3
  • 10
    • 33747030655 scopus 로고    scopus 로고
    • Deficiency in NOD antigen-presenting cell function may be responsible for suboptimal CD4CD25 T-cell-mediated regulation and type 1 diabetes development in NOD mice
    • Alard, P., J. N. Manirarora, S. A. Parnell, et al. 2006. Deficiency in NOD antigen-presenting cell function may be responsible for suboptimal CD4CD25 T-cell-mediated regulation and type 1 diabetes development in NOD mice. Diabetes. 55: 2098-2105.
    • (2006) Diabetes. , vol.55 , pp. 2098-2105
    • Alard, P.1    Manirarora, J.N.2    Parnell, S.A.3
  • 11
    • 70449392430 scopus 로고    scopus 로고
    • Islet lymphocyte subsets in male and female NOD mice are qualitatively similar but quantitatively distinct
    • Youngm, E. F., P. R. Hess, L. W. Arnold, et al. 2009. Islet lymphocyte subsets in male and female NOD mice are qualitatively similar but quantitatively distinct. Autoimmunity. 42: 678-691.
    • (2009) Autoimmunity. , vol.42 , pp. 678-691
    • Youngm, E.F.1    Hess, P.R.2    Arnold, L.W.3
  • 12
    • 80051517319 scopus 로고    scopus 로고
    • Decreased frequencies of CD4CD25Foxp3 cells and the potent CD103 subset in peripheral lymph nodes correlate with autoimmune disease predisposition in some strains of mice
    • Tucker, C. F., D. L. Nebane-Ambe, and A. Chhabra. 2011. Decreased frequencies of CD4CD25Foxp3 cells and the potent CD103 subset in peripheral lymph nodes correlate with autoimmune disease predisposition in some strains of mice. Autoimmunity. 44: 453-464.
    • (2011) Autoimmunity. , vol.44 , pp. 453-464
    • Tucker, C.F.1    Nebane-Ambe, D.L.2    Chhabra, A.3
  • 13
    • 0036141438 scopus 로고    scopus 로고
    • Multiple immunoregulatory defects in type-1 diabetes
    • Kukreja, A., G. Cost, J. Marker, et al. 2002. Multiple immunoregulatory defects in type-1 diabetes. J. Clin. Invest. 109: 131-140.
    • (2002) J. Clin. Invest. , vol.109 , pp. 131-140
    • Kukreja, A.1    Cost, G.2    Marker, J.3
  • 14
    • 12144249838 scopus 로고    scopus 로고
    • Defective suppressor function in CD4CD25 T-cells from patients with type 1 diabetes
    • Lindley, S., C. M. Dayan, A. Bishop, et al. 2005. Defective suppressor function in CD4CD25 T-cells from patients with type 1 diabetes. Diabetes. 54: 92-99.
    • (2005) Diabetes. , vol.54 , pp. 92-99
    • Lindley, S.1    Dayan, C.M.2    Bishop, A.3
  • 15
    • 13944270218 scopus 로고    scopus 로고
    • CD4CD25high regulatory T cells in human autoimmune diabetes
    • Putnam, A. L., F. Vendrame, F. Dotta, and P. A. Gottlieb. 2005. CD4CD25high regulatory T cells in human autoimmune diabetes. J. Autoimmun. 24: 55-62.
    • (2005) J. Autoimmun. , vol.24 , pp. 55-62
    • Putnam, A.L.1    Vendrame, F.2    Dotta, F.3    Gottlieb, P.A.4
  • 16
    • 33847373481 scopus 로고    scopus 로고
    • No alterations in the frequency of FOXP3 regulatory T-cells in type 1 diabetes
    • Brusko, T., C. Wasserfall, K. McGrail, et al. 2007. No alterations in the frequency of FOXP3 regulatory T-cells in type 1 diabetes. Diabetes. 56: 604-612.
    • (2007) Diabetes. , vol.56 , pp. 604-612
    • Brusko, T.1    Wasserfall, C.2    McGrail, K.3
  • 17
    • 43049174722 scopus 로고    scopus 로고
    • Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction
    • Tang, Q., J. Y. Adams, C. Penaranda, et al. 2008. Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity. 28: 687-697.
    • (2008) Immunity. , vol.28 , pp. 687-697
    • Tang, Q.1    Adams, J.Y.2    Penaranda, C.3
  • 18
    • 38449090623 scopus 로고    scopus 로고
    • Functional waning of naturally occurring CD4 regulatory T-cells contributes to the onset of autoimmune diabetes
    • Tritt, M., E. Sgouroudis, E. dHennezel, et al. 2008. Functional waning of naturally occurring CD4 regulatory T-cells contributes to the onset of autoimmune diabetes. Diabetes. 57: 113-123.
    • (2008) Diabetes. , vol.57 , pp. 113-123
    • Tritt, M.1    Sgouroudis, E.2    Dhennezel Et Al, E.3
  • 20
    • 80051497493 scopus 로고    scopus 로고
    • The effect of regulatory T-cell depletion on the spectrum of organ-specific autoimmune diseases in nonobese diabetic mice at different ages
    • Nakahara, M., Y. Nagayama, T. Ichikawa, et al. 2011. The effect of regulatory T-cell depletion on the spectrum of organ-specific autoimmune diseases in nonobese diabetic mice at different ages. Autoimmunity. 44: 504-510.
    • (2011) Autoimmunity. , vol.44 , pp. 504-510
    • Nakahara, M.1    Nagayama, Y.2    Ichikawa, T.3
  • 21
    • 10344245538 scopus 로고    scopus 로고
    • A sudden decline in active membrane-bound TGF-beta impairs both T regulatory cell function and protection against autoimmune diabetes
    • Gregg, R. K., R. Jain, S. J. Schoenleber, et al. 2004. A sudden decline in active membrane-bound TGF-beta impairs both T regulatory cell function and protection against autoimmune diabetes. J. Immunol. 173: 7308-7316.
    • (2004) J. Immunol. , vol.173 , pp. 7308-7316
    • Gregg, R.K.1    Jain, R.2    Schoenleber, S.J.3
  • 22
    • 84859864752 scopus 로고    scopus 로고
    • Downregulation of TGF-bRII in T effector cells leads to increased resistance to TGF-b-mediated suppression of autoimmune responses in type i diabetes
    • Kawamotom, K., A. Pahuja, A. Nettles, et al. 2012. Downregulation of TGF-bRII in T effector cells leads to increased resistance to TGF-b-mediated suppression of autoimmune responses in type I diabetes. Autoimmunity. 45: 310-319.
    • (2012) Autoimmunity. , vol.45 , pp. 310-319
    • Kawamotom, K.1    Pahuja, A.2    Nettles, A.3
  • 23
    • 0038062649 scopus 로고    scopus 로고
    • Defect in activation induced cell death in non-obese diabetic (NOD) T lymphocytes
    • Decallonne, B., E. Van Etten, A. Giulietti, et al. 2003. Defect in activation induced cell death in non-obese diabetic (NOD) T lymphocytes. J. Autoimmun. 20: 219-226.
    • (2003) J. Autoimmun. , vol.20 , pp. 219-226
    • Decallonne, B.1    Van Etten, E.2    Giulietti, A.3
  • 24
    • 0037562908 scopus 로고    scopus 로고
    • Deficient activation and resistance to activation-induced apoptosis of CD8 T cells is associated with defective peripheral tolerance in nonobese diabetic mice
    • Arreaza, G., K. Salojin, W. Yang, et al. 2003. Deficient activation and resistance to activation-induced apoptosis of CD8 T cells is associated with defective peripheral tolerance in nonobese diabetic mice. Clin. Immunol. 107: 103-115.
    • (2003) Clin. Immunol. , vol.107 , pp. 103-115
    • Arreaza, G.1    Salojin, K.2    Yang, W.3
  • 25
    • 58149386381 scopus 로고    scopus 로고
    • The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors
    • DAlise, A. M., V. Auyeung, M. Feuerer, et al. 2008. The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors. Proc. Natl. Acad. Sci. USA. 105: 19857-19862.
    • (2008) Proc. Natl. Acad. Sci. USA. , vol.105 , pp. 19857-19862
    • Dalise, A.M.1    Auyeung, V.2    Feuerer, M.3
  • 26
    • 79959609103 scopus 로고    scopus 로고
    • Effector and naturally occurring regulatory T cells display no abnormalities in activation induced cell death in NOD mice
    • Kaminitz, A., E. S. Yolcu, E. M. Askenasy, et al. 2011. Effector and naturally occurring regulatory T cells display no abnormalities in activation induced cell death in NOD mice. PLoS One. 6: E21630.
    • (2011) PLoS One. , vol.6
    • Kaminitz, A.1    Yolcu, E.S.2    Askenasy, E.M.3
  • 27
    • 77949276812 scopus 로고    scopus 로고
    • Targeting of IL-2 receptor with a caspase fusion protein disrupts autoimmunity in prediabetic and diabetic NOD mice
    • Yarkoni, S., A. Kaminitz, Y. Sagiv, and N. Askenasy. 2010. Targeting of IL-2 receptor with a caspase fusion protein disrupts autoimmunity in prediabetic and diabetic NOD mice. Diabetologia. 53: 356-368.
    • (2010) Diabetologia. , vol.53 , pp. 356-368
    • Yarkoni, S.1    Kaminitz, A.2    Sagiv, Y.3    Askenasy, N.4
  • 28
    • 68249109933 scopus 로고    scopus 로고
    • Low levels of allogeneic but not syngeneic hematopoietic chimerism reverse autoimmune insulitis in prediabetic NOD mice
    • Kaminitz, A., K. Mizrahi, I. Yaniv, et al. 2009. Low levels of allogeneic but not syngeneic hematopoietic chimerism reverse autoimmune insulitis in prediabetic NOD mice. J. Autoimmun. 33: 83-91.
    • (2009) J. Autoimmun. , vol.33 , pp. 83-91
    • Kaminitz, A.1    Mizrahi, K.2    Yaniv, I.3
  • 29
    • 84880590239 scopus 로고    scopus 로고
    • Killer Treg cells ameliorate inflammatory insulitis in non-obese diabetic mice through local and systemic immunomodulation
    • Kaminitz, A., E. S. Yolcu, K. Mizrahi, et al. 2013. Killer Treg cells ameliorate inflammatory insulitis in non-obese diabetic mice through local and systemic immunomodulation. Int. Immunol. 25: 485-494.
    • (2013) Int. Immunol. , vol.25 , pp. 485-494
    • Kaminitz, A.1    Yolcu, E.S.2    Mizrahi, K.3
  • 30
    • 79958022977 scopus 로고    scopus 로고
    • Killer Treg restore immune homeostasis and suppress autoimmune diabetes in prediabetic NOD mice
    • Kaminitz, A., E. S. Yolcu, J. Stein, et al. 2011. Killer Treg restore immune homeostasis and suppress autoimmune diabetes in prediabetic NOD mice. J. Autoimmun. 37: 39-47.
    • (2011) J. Autoimmun. , vol.37 , pp. 39-47
    • Kaminitz, A.1    Yolcu, E.S.2    Stein, J.3
  • 31
    • 0034665514 scopus 로고    scopus 로고
    • CD25 is a marker for CD4 thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25 and CD25-subpopulations
    • Stephens, L. A., and D. Mason. 2000. CD25 is a marker for CD4 thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25 and CD25-subpopulations. J. Immunol. 165: 3105-3110.
    • (2000) J. Immunol. , vol.165 , pp. 3105-3110
    • Stephens, L.A.1    Mason, D.2
  • 32
    • 0036144888 scopus 로고    scopus 로고
    • Homeostasis and anergy of CD4CD25 suppressor T cells in vivo
    • Gavin, M. A., S. R. Clarke, E. Negrou, et al. 2002. Homeostasis and anergy of CD4CD25 suppressor T cells in vivo. Nat. Immunol. 3: 33-41.
    • (2002) Nat. Immunol. , vol.3 , pp. 33-41
    • Gavin, M.A.1    Clarke, S.R.2    Negrou, E.3
  • 33
    • 67649801094 scopus 로고    scopus 로고
    • CD25 shedding by human natural occurring CD4CD25 regulatory T cells does not inhibit the action of IL-2
    • Pedersen, A. E. and J. P. Lauritsen. 2009. CD25 shedding by human natural occurring CD4CD25 regulatory T cells does not inhibit the action of IL-2. Scand. J. Immunol. 70: 40-43.
    • (2009) Scand. J. Immunol. , vol.70 , pp. 40-43
    • Pedersen, A.E.1    Lauritsen, J.P.2
  • 34
    • 79251472114 scopus 로고    scopus 로고
    • Apoptosis of purified CD4 T cell subsets is dominated by cytokine deprivation and absence of other cells in new onset diabetic NOD mice
    • Kaminitz, A., E. M. Askenasy, I. Yaniv, et al. 2010. Apoptosis of purified CD4 T cell subsets is dominated by cytokine deprivation and absence of other cells in new onset diabetic NOD mice. PLoS One. 5: E15684.
    • (2010) PLoS One. , vol.5
    • Kaminitz, A.1    Askenasy, E.M.2    Yaniv, I.3
  • 35
    • 84875248649 scopus 로고    scopus 로고
    • Is autoimmune diabetes caused by aberrant immune activity or defective suppression of physiological self-reactivity
    • Askenasy, E. M., and N. Askenasy. 2012. Is autoimmune diabetes caused by aberrant immune activity or defective suppression of physiological self-reactivity Autoimmun. Rev. 12: 633-637.
    • (2012) Autoimmun Rev. , vol.12 , pp. 633-637
    • Askenasy, E.M.1    Askenasy, N.2
  • 36
    • 36749031198 scopus 로고    scopus 로고
    • Enhanced thymic selection of FoxP3 regulatory T cells in the NOD mouse model of autoimmune diabetes
    • Feuerer, M., W. Jiang, P. D. Holler, et al. 2007. Enhanced thymic selection of FoxP3 regulatory T cells in the NOD mouse model of autoimmune diabetes. Proc. Natl. Acad. Sci. USA. 104: 18181-18186.
    • (2007) Proc. Natl. Acad. Sci. USA. , vol.104 , pp. 18181-18186
    • Feuerer, M.1    Jiang, W.2    Holler, P.D.3
  • 37
    • 84876856969 scopus 로고    scopus 로고
    • Increased thymic development of regulatory T cells in NOD mice is functionally dissociated from type i diabetes susceptibility
    • Tellier, J., A. Andrianjaka, R. Vincente, et al. 2013. Increased thymic development of regulatory T cells in NOD mice is functionally dissociated from type I diabetes susceptibility. Eur. J. Immunol. 43: 1356-1362.
    • (2013) Eur. J. Immunol. , vol.43 , pp. 1356-1362
    • Tellier, J.1    Andrianjaka, A.2    Vincente, R.3
  • 38
    • 15244340167 scopus 로고    scopus 로고
    • Foxp3 CD25-CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion
    • Zelenay, S., T. Lopes-Carvalho, I. Caramalho, et al. 2005. Foxp3 CD25-CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion. Proc. Natl. Acad. Sci. USA. 102: 4091-4096.
    • (2005) Proc. Natl. Acad. Sci. USA. , vol.102 , pp. 4091-4096
    • Zelenay, S.1    Lopes-Carvalho, T.2    Caramalho, I.3
  • 39
    • 60549115770 scopus 로고    scopus 로고
    • Heterogeneity of natural Foxp3 T cells: A committed regulatory Tcell lineage and an uncommitted minor population retaining plasticity
    • Komatsu, N., M. E. Mariotti-Ferrandiz, Y. Wang, et al. 2009. Heterogeneity of natural Foxp3 T cells: A committed regulatory Tcell lineage and an uncommitted minor population retaining plasticity. Proc. Natl. Acad. Sci. USA. 106: 1903-1908.
    • (2009) Proc. Natl. Acad. Sci. USA. , vol.106 , pp. 1903-1908
    • Komatsu, N.1    Mariotti-Ferrandiz, M.E.2    Wang, Y.3
  • 40
    • 84864008955 scopus 로고    scopus 로고
    • Intra-islet proliferation of cytotoxic T lymphocytes contributes to insulitis progression
    • Graham, K. L., B. Krishnamurthy, S. Fynch, et al. 2012. Intra-islet proliferation of cytotoxic T lymphocytes contributes to insulitis progression. Eur. J. Immunol. 42: 1717-1722.
    • (2012) Eur. J. Immunol. , vol.42 , pp. 1717-1722
    • Graham, K.L.1    Krishnamurthy, B.2    Fynch, S.3
  • 41
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4CD25-naive T cells to CD4CD25 regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • Chen, W., W. Jin, N. Hardegen, et al. 2003. Conversion of peripheral CD4CD25-naive T cells to CD4CD25 regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 198: 1875-1886.
    • (2003) J. Exp. Med. , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3
  • 42
    • 10344220512 scopus 로고    scopus 로고
    • CD25-T cells generate CD25Foxp3 regulatory T cells by peripheral expansion
    • Curotto De Lafaille, M. A., A. C. Lino, N. Kutchukhidze, and J. J. Lafaille. 2004. CD25-T cells generate CD25Foxp3 regulatory T cells by peripheral expansion. J. Immunol. 173: 7259-7268.
    • (2004) J. Immunol. , vol.173 , pp. 7259-7268
    • Curotto De Lafaille, M.A.1    Lino, A.C.2    Kutchukhidze, N.3    Lafaille, J.J.4
  • 43
    • 12344307563 scopus 로고    scopus 로고
    • Conversion of CD4 CD25-cells into CD4 CD25 regulatory T cells in vivo requires B7 costimulation, but not the thymus
    • Liang, S., P. Alard, Y. Zhao, et al. 2005. Conversion of CD4 CD25-cells into CD4 CD25 regulatory T cells in vivo requires B7 costimulation, but not the thymus. J. Exp. Med. 201: 127-137.
    • (2005) J. Exp. Med. , vol.201 , pp. 127-137
    • Liang, S.1    Alard, P.2    Zhao, Y.3
  • 44
    • 78751499888 scopus 로고    scopus 로고
    • Therapeutic potential of TGF-b-induced CD4 Foxp3 regulatory T cells in autoimmune diseases
    • Zhou, X., N. Kong, H. Zou, et al. 2011. Therapeutic potential of TGF-b-induced CD4 Foxp3 regulatory T cells in autoimmune diseases. Autoimmunity. 44: 43-50.
    • (2011) Autoimmunity. , vol.44 , pp. 43-50
    • Zhou, X.1    Kong, N.2    Zou, H.3
  • 45
    • 84876796565 scopus 로고    scopus 로고
    • Proinflammatory cytokines contribute to development and function of regulatory T cells in type 1 diabetes
    • Thomas, H. E., K. L. Graham, J. Chee, et al. 2013. Proinflammatory cytokines contribute to development and function of regulatory T cells in type 1 diabetes. Ann. N. Y. Acad. Sci. 1283: 81-86.
    • (2013) Ann. N. Y. Acad. Sci. , vol.1283 , pp. 81-86
    • Thomas, H.E.1    Graham, K.L.2    Chee, J.3
  • 46
    • 50249091720 scopus 로고    scopus 로고
    • Involvement of IL-2 in homeostasis of regulatory T cells: The IL-2 cycle
    • Yarkoni, S., A. Kaminitz, Y. Sagiv, et al. 2008. Involvement of IL-2 in homeostasis of regulatory T cells: The IL-2 cycle. Bioessays. 30: 875-888.
    • (2008) Bioessays. , vol.30 , pp. 875-888
    • Yarkoni, S.1    Kaminitz, A.2    Sagiv, Y.3
  • 47
    • 79960129382 scopus 로고    scopus 로고
    • IL-2 production by dendritic cells promotes Foxp3 regulatory T-cell expansion in autoimmune-resistant NOD congenic mice
    • Sgouroudis, E., M. Kornete, and C. A. Piccirillo. 2011. IL-2 production by dendritic cells promotes Foxp3 regulatory T-cell expansion in autoimmune-resistant NOD congenic mice. Autoimmunity. 44: 406-414.
    • (2011) Autoimmunity. , vol.44 , pp. 406-414
    • Sgouroudis, E.1    Kornete, M.2    Piccirillo, C.A.3
  • 48
    • 77956257716 scopus 로고    scopus 로고
    • IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells
    • Grinberg-Bleyer, Y., A. Baeyens, S. You, et al. 2010. IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells. J. Exp. Med. 207: 1871-1878.
    • (2010) J. Exp. Med. , vol.207 , pp. 1871-1878
    • Grinberg-Bleyer, Y.1    Baeyens, A.2    You, S.3
  • 49
    • 58149280846 scopus 로고    scopus 로고
    • Regulatory T cells prevent transfer of type 1 diabetes in NOD mice only when their antigen is present in vivo
    • Tonkin, D. R., J. He, G. Barbour, and K. Haskins. 2008. Regulatory T cells prevent transfer of type 1 diabetes in NOD mice only when their antigen is present in vivo. J. Immunol. 181: 4516-4522.
    • (2008) J. Immunol. , vol.181 , pp. 4516-4522
    • Tonkin, D.R.1    He, J.2    Barbour, G.3    Haskins, K.4
  • 50
    • 56249126742 scopus 로고    scopus 로고
    • Apoptosis as a mechanism of T-regulatory cell homeostasis and suppression
    • Yolcu, E. S., S. Ash, A. Kaminitz, et al. 2008. Apoptosis as a mechanism of T-regulatory cell homeostasis and suppression. Immunol. Cell. Biol. 86: 650-658.
    • (2008) Immunol. Cell. Biol. , vol.86 , pp. 650-658
    • Yolcu, E.S.1    Ash, S.2    Kaminitz, A.3
  • 51
    • 36248976097 scopus 로고    scopus 로고
    • CD4 CD25Foxp3 regulatory T cells induce cytokine deprivationmediated apoptosis of effector CD4 T cells
    • Pandiyan, P., L. Zheng, S. Ishihara, et al. 2007. CD4 CD25Foxp3 regulatory T cells induce cytokine deprivationmediated apoptosis of effector CD4 T cells. Nat. Immunol. 8: 1353-3162.
    • (2007) Nat. Immunol. , vol.8 , pp. 1353-3162
    • Pandiyan, P.1    Zheng, L.2    Ishihara, S.3
  • 52
    • 36849089218 scopus 로고    scopus 로고
    • The vicious cycle of apoptotic beta-cell death in type 1 diabetes
    • Kaminitz, A., J. Stein, I. Yaniv, and N. Askenasy. 2007. The vicious cycle of apoptotic beta-cell death in type 1 diabetes. Immunol. Cell. Biol. 85: 582-589.
    • (2007) Immunol. Cell. Biol. , vol.85 , pp. 582-589
    • Kaminitz, A.1    Stein, J.2    Yaniv, I.3    Askenasy, N.4
  • 53
    • 41149124867 scopus 로고    scopus 로고
    • The control of CD4CD25Foxp3 regulatory T cell survival
    • Pandiyan, P., and M. J. Lenardo. 2008. The control of CD4CD25Foxp3 regulatory T cell survival. Biol. Direct. 3
    • (2008) Biol. Direct. , vol.3
    • Pandiyan, P.1    Lenardo, M.J.2
  • 54
    • 84894561367 scopus 로고    scopus 로고
    • doi:10.1186/1745-6150-3-6
    • doi:10.1186/1745-6150-3-6.
  • 55
    • 78649900433 scopus 로고    scopus 로고
    • Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs
    • Grinberg-Bleyer, Y., D. Saadoun, A. Baeyens, et al. 2010. Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs. J. Clin. Invest. 120: 4558-4568.
    • (2010) J. Clin. Invest. , vol.120 , pp. 4558-4568
    • Grinberg-Bleyer, Y.1    Saadoun, D.2    Baeyens, A.3
  • 56
    • 33746933464 scopus 로고    scopus 로고
    • Regulatory and effector T cell activation levels are prime determinants of in vivo immune regulation
    • Billiard, F., E. Litvinova, D. Saadoun, et al. 2006. Regulatory and effector T cell activation levels are prime determinants of in vivo immune regulation. J. Immunol. 177: 2167-2174.
    • (2006) J. Immunol. , vol.177 , pp. 2167-2174
    • Billiard, F.1    Litvinova, E.2    Saadoun, D.3
  • 57
    • 72449142310 scopus 로고    scopus 로고
    • Regulation of immunity at tissue sites of inflammation
    • Sojka, D. K., C. A. Lazarski, Y. H. Huang, et al. 2009. Regulation of immunity at tissue sites of inflammation. Immunol. Res. 45: 239-250.
    • (2009) Immunol. Res. , vol.45 , pp. 239-250
    • Sojka, D.K.1    Lazarski, C.A.2    Huang, Y.H.3
  • 58
    • 43449120940 scopus 로고    scopus 로고
    • Mechanisms of T regulatory cell function
    • Askenasy, N., A. Kaminitz, and S. Yarkoni. 2008. Mechanisms of T regulatory cell function. Autoimmun. Rev. 7: 370-375.
    • (2008) Autoimmun. Rev. , vol.7 , pp. 370-375
    • Askenasy, N.1    Kaminitz, A.2    Yarkoni, S.3
  • 59
    • 84874201796 scopus 로고    scopus 로고
    • Mechanisms of Treg suppression: Still a long way to go
    • doi: 10.3389/fimmu.2012.00191
    • Vignali, D. A. A. 2012. Mechanisms of Treg suppression: Still a long way to go. Front. Immunol. 3: 191. doi: 10.3389/fimmu.2012.00191.
    • (2012) Front. Immunol. , vol.3 , pp. 191
    • Vignali, D.A.A.1
  • 60
    • 84877768710 scopus 로고    scopus 로고
    • Pancreatic islet cell phenotype and endocrine function throughout diabetes development in non-obese diabetic mice
    • Kornete, M., H. Beauchemin, C. Polychronakos, and C. A. Piccirillo. 2013. Pancreatic islet cell phenotype and endocrine function throughout diabetes development in non-obese diabetic mice. Autoimmunity. 46: 259-268.
    • (2013) Autoimmunity. , vol.46 , pp. 259-268
    • Kornete, M.1    Beauchemin, H.2    Polychronakos, C.3    Piccirillo, C.A.4
  • 61
    • 0031423760 scopus 로고    scopus 로고
    • The nonobese diabetic mouse as a model of autoimmune diabetes: Immune dysregulation gets the NOD
    • Delovitch, T. L., and B. Singh. 1997. The nonobese diabetic mouse as a model of autoimmune diabetes: Immune dysregulation gets the NOD. Immunity. 7: 727-738.
    • (1997) Immunity. , vol.7 , pp. 727-738
    • Delovitch, T.L.1    Singh, B.2
  • 62
    • 17644361955 scopus 로고    scopus 로고
    • The NOD mouse: A model of immune dysregulation
    • Anderson, M. S., and J. A. Bluestone. 2005. The NOD mouse: A model of immune dysregulation. Annu. Rev. Immunol. 23: 447-485.
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 447-485
    • Anderson, M.S.1    Bluestone, J.A.2
  • 63
    • 65649129352 scopus 로고    scopus 로고
    • Control of type 1 diabetes by CD4Foxp3 regulatory T cells: Lessons from mouse models and implications for human disease
    • Sgouroudis, E., and C. A. Piccirillo. 2009. Control of type 1 diabetes by CD4Foxp3 regulatory T cells: Lessons from mouse models and implications for human disease. Diabetes Metab. Res. Rev. 25: 208-218.
    • (2009) Diabetes Metab. Res. Rev. , vol.25 , pp. 208-218
    • Sgouroudis, E.1    Piccirillo, C.A.2
  • 64
    • 79251621206 scopus 로고    scopus 로고
    • Mouse models for the study of autoimmune type 1 diabetes: A NOD to similarities and differences to human disease
    • Driver, J. P., D. V. Serreze, and Y. G. Chen. 2011. Mouse models for the study of autoimmune type 1 diabetes: A NOD to similarities and differences to human disease. Semin. Immunopathol. 33: 67-87.
    • (2011) Semin. Immunopathol. , vol.33 , pp. 67-87
    • Driver, J.P.1    Serreze, D.V.2    Chen, Y.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.