Decreased frequencies of CD4 +CD25 +Foxp3 + cells and the potent CD103 + subset in peripheral lymph nodes correlate with autoimmune disease predisposition in some strains of mice

Autoimmunity

Volumn 44, Issue 6, 2011, Pages 453-464

  Tucker, Colleen F ^a   Nebane Ambe, Doreen L ^a   Chhabra, Anita ^a   Parnell, Sarah A ^a   Zhao, Yuan ^a   Alard, Pascale ^a   Kosiewicz, Michele M ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

Autoimmune disease; CD103; Foxp3; Mice; Tregs

Indexed keywords

CD103 ANTIGEN; CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSCRIPTION FACTOR FOXP3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; DISEASE PREDISPOSITION; FEMALE; IN VITRO STUDY; LYMPHOID CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SPLEEN CELL; STRAIN DIFFERENCE; THYMOCYTE;

ANIMALS; ANTIGENS, CD; AUTOIMMUNE DISEASES; CD4-POSITIVE T-LYMPHOCYTES; DISEASE SUSCEPTIBILITY; FEMALE; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; INTEGRIN ALPHA CHAINS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPH NODES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, INBRED NZB;

EID: 80051517319     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.3109/08916934.2011.568553     Document Type: Article

References (50)

1. Sakaguchi S, Yamaguchi T, Nomura T, Ono M. Regulatory T cells and immune tolerance. Cell 2008;133:775-787. (Pubitemid 351707693)
2. Bennett CL, Christie J, Ramsdell F, Brunkow ME, Ferguson PJ, Whitesell L, Kelly TE, Saulsbury FT, Chance PF, Ochs HD. The immune dysregulation, polyendocrinopathy, entero-pathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet 2001;27:20-21. (Pubitemid 32044513)
3. \+ regulatory T cells. Nat Immunol 2003;4:330-336. (Pubitemid 36432314)
4. 2 regulatory T cells. Proc Natl Acad Sci USA 2002; 99:13031-13036.
5. Allakhverdi Z, Fitzpatrick D, Boisvert A, Baba N, Bouguer-mouh S, Sarfati M, Delespesse G. Expression of CD103 identifies human regulatory T-cell subsets. J Allergy Clin Immunol 2006;118:1342-1349. (Pubitemid 44854109)
6. \+ regulatory T cells. J Exp Med 2004;199:303-313. (Pubitemid 38252043)
7. \+ regulatory T cells controls wasting disease, IL-10 secretion and T cell homeostasis. Eur J Immunol 2003;33:2419-2428. (Pubitemid 37138974)
8. \+ immunoregulatory T cells: Gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 2002;16: 311-323. (Pubitemid 34211969)
9. \+ Treg and control of Leishmania major infection. J Immunol 2005;174:5444-5455. (Pubitemid 40593184)
10. Miyara M, Amoura Z, Parizot C, Badoual C, Dorgham K, Trad S, Nochy D, Debre P, Piette JC, Gorochov G. Global natural regulatory T cell depletion in active systemic lupus erythematosus. J Immunol 2005;175:8392-8400. (Pubitemid 41798406)
11. \+ regulatory T-cell subpopu-lations in systemic lupus erythematosus. Immunology 2009; 127:196-205.
12. \+ T cells of patients with systemic lupus erythematosus: A comparative phenotypic analysis. Ann Rheum Dis 2008;67:664-671. (Pubitemid 351571931)
13. Chen Y, Cuda C, Morel L. Genetic determination of T cell help in loss of tolerance to nuclear antigens. J Immunol 2005; 174:7692-7702. (Pubitemid 40806274)
14. Scalapino KJ, Tang Q, Bluestone JA, Bonyhadi ML, Daikh DI. Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells. J Immunol 2006;177: 1451-1459. (Pubitemid 44092478)
15. \+ regulatory T cells in patients with multiple sclerosis. J Exp Med 2004;199: 971-979. (Pubitemid 38481088)
16. high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis. Eur J Immunol 2005;35:3343-3352. (Pubitemid 41672538)
17. \+ T cells. Int Immunol 2006; 18:495-503.
18. \+ T-cells in type 1 diabetes. Diabetes 2005;54:1407-1414. (Pubitemid 40586671)
19. high regulatory T cells in human autoimmune diabetes. J Autoimmun 2005;24:55-62. (Pubitemid 40269495)
20. \+ T-cell-mediated regulation and type 1 diabetes development in NOD mice. Diabetes 2006;55:2098-2105. (Pubitemid 44509985)
21. \+ immunoregulatory T cells that control autoimmune diabetes. Immunity 2000;12: 431-440.
22. Berzins SP, Venanzi ES, Benoist C, Mathis D. T-cell compartments of prediabetic NOD mice. Diabetes 2003;52: 327-334. (Pubitemid 36173186)
23. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor a-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995;155:1151-1164.
24. \+ T cells permits the development of spontaneous lupus-like disease in mice, and can be reversed by induction of mucosal tolerance to histone peptide autoantigen. Lupus 2004;13:192-200. (Pubitemid 38478647)
25. 1 mice. Int J Exp Pathol 2005;86: 289-296. (Pubitemid 41413624)
26. Scalapino KJ, Daikh DI. Suppression of glomerulonephritis in NZB/NZW lupus prone mice by adoptive transfer of ex vivo expanded regulatory T cells. PLoS One 2009;4:e6031.
27. Roubinian JR, Talal N, Greenspan JS, Goodman JR, Siiteri PK. Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in NZB/NZW F1 mice. J Exp Med 1978;147:1568-1583. (Pubitemid 8372952)
28. 2 responder T cells than C57BL/6 mice. J Leukoc Biol 2005;78:114-121. (Pubitemid 40979950)
29. Helyer BJ, Howie JB. Renal disease associated with positive lupus erythematosus tests in a cross-bred strain of mice. Nature 1963;197:197.
30. Coffer PJ, Burgering BM. Forkhead-box transcription factors and their role in the immune system. Nat Rev Immunol 2004; 4:889-899. (Pubitemid 39490764)
31. \+ T cell suppressor function. Eur J Immunol 2004;34:366-376. (Pubitemid 39255947)
32. \+ regulatory T cell function. Science 2008;322: 271-275.
33. E subunit. Unusual structure and restricted RNA distribution. J Biol Chem 1994;269: 6016-6025.
34. 7 mediates adhesion of T lymphocytes to epithelial cells. J Immunol 1993;150:3459-3470. (Pubitemid 23129726)
35. \+ regulatory T cells induced by an agonist self-peptide. Nat Immunol 2001;2:301-306. (Pubitemid 33706340)
36. \+ suppressor T cells in vivo. Nat Immunol 2002;3:33-41. (Pubitemid 34065615)
37. McFarland RD, Douek DC, Koup RA, Picker LJ. Identifi¬cation of a human recent thymic emigrant phenotype. Proc Natl Acad Sci USA 2000;97:4215-4220. (Pubitemid 30226113)
38. \+ regulatory T cells participate in the control of immune responses. J Immunol 2007;178:6901-6911. (Pubitemid 46847416)
39. Chen Y, Perry D, Boackle SA, Sobel ES, Molina H, Croker BP, Morel L. Several genes contribute to the production of autoreactive B and T cells in the murine lupus susceptibility locus Sle1c. J Immunol 2005;175:1080-1089. (Pubitemid 41094994)
40. Cuda CM, Wan S, Sobel ES, Croker BP, Morel L. Murine lupus susceptibility locus Sle1a controls regulatory T cell number and function through multiple mechanisms. J Immunol 2007;179:7439-7447.
41. \+ T cell regulatory functions. J Immunol 2007;178:271-279. (Pubitemid 46033610)
42. Ferreira C, Singh Y, Furmanski AL, Wong FS, Garden OA, Dyson J. Non-obese diabetic mice select a low-diversity repertoire of natural regulatory T cells. Proc Natl Acad Sci USA 2009;106:8320-8325.
43. Okuda Y, Okuda M, Bernard CC. Gender does not influence the susceptibility of C57BL/6 mice to develop chronic experimental autoimmune encephalomyelitis induced by myelin oligodendrocyte glycoprotein. Immunol Lett 2002; 81:25-29. (Pubitemid 34159037)
44. Farkas B, Boldizsar F, Tarjanyi O, Laszlo A, Lin SM, Hutas G, Tryniszewska B, Mangold A, Nagyeri G, Rosenzweig HL, Finnegan A, Mikecz K, Glant TT. BALB/c mice genetically susceptible to proteoglycan-induced arthritis and spondylitis show colony-dependent differences in disease penetrance. Arthritis Res Ther 2009;11:R21.
45. Smith-Bouvier DL, Divekar AA, Sasidhar M, Du S, Tiwari-Woodruff SK, King JK, Arnold AP, Singh RR, Voskuhl RR. A role for sex chromosome complement in the female bias in autoimmune disease. J Exp Med 2008;205:1099-1108. (Pubitemid 351679685)
46. You S, Belghith M, Cobbold S, Alyanakian MA, Gouarin C, Barriot S, Garcia C, Waldmann H, Bach JF, Chatenoud L. Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells. Diabetes 2005;54:1415-1422. (Pubitemid 40586672)
47. \+ regulatory T cells in NOD mice that can prevent diabetes development. PLoS One 2008;3:e3739.
48. Mullins DW, Engelhard VH. Limited infiltration of exogenous dendritic cells and naive T cells restricts immune responses in peripheral lymph nodes. J Immunol 2006;176:4535-4542.
49. Del Rio R, Sun Y, Alard P, Tung KS, Teuscher C. H2 control of natural T regulatory cell frequency in the lymph node correlates with susceptibility to day 3 thymectomy-induced autoimmune disease. J Immunol 2011;186:382-389.
50. Siegmund K, Feuerer M, Siewert C, Ghani S, Haubold U, Dankof A, Krenn V, Schon MP, Scheffold A, Lowe JB, Hamann A, Syrbe U, Huehn J. Migration matters: Regulatory T-cell compartmentalization determines suppressive activity in vivo. Blood 2005;106:3097-3104. (Pubitemid 41565906)