-
1
-
-
4043091960
-
Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY)
-
Barker, J.M. et al. 2004. Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY). J. Clin. Endocrinol. Metab. 89: 3896-3902.
-
(2004)
J. Clin. Endocrinol. Metab.
, vol.89
, pp. 3896-3902
-
-
Barker, J.M.1
-
2
-
-
18744366947
-
Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
-
Nakayama, M. et al. 2005. Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature 435: 220-223.
-
(2005)
Nature
, vol.435
, pp. 220-223
-
-
Nakayama, M.1
-
3
-
-
33845316086
-
Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP
-
Krishnamurthy, B. et al. 2006. Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP. J. Clin. Invest. 116: 3258-3265.
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 3258-3265
-
-
Krishnamurthy, B.1
-
4
-
-
84856825977
-
Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients
-
Coppieters, K.T. et al. 2012. Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients. J. Exp. Med. 209: 51-60.
-
(2012)
J. Exp. Med.
, vol.209
, pp. 51-60
-
-
Coppieters, K.T.1
-
5
-
-
79251634951
-
The pancreas in human type 1 diabetes
-
Rowe, P.A. et al. 2011. The pancreas in human type 1 diabetes. Semin. Immunopathol. 33: 29-43.
-
(2011)
Semin. Immunopathol.
, vol.33
, pp. 29-43
-
-
Rowe, P.A.1
-
6
-
-
78751561859
-
Interleukin-1beta produced in response to islet autoantigen presentation differentiates T-helper 17 cells at the expense of regulatory T-cells: implications for the timing of tolerizing immunotherapy
-
Bertin-Maghit, S. et al. 2011. Interleukin-1beta produced in response to islet autoantigen presentation differentiates T-helper 17 cells at the expense of regulatory T-cells: implications for the timing of tolerizing immunotherapy. Diabetes 60: 248-257.
-
(2011)
Diabetes
, vol.60
, pp. 248-257
-
-
Bertin-Maghit, S.1
-
7
-
-
70449105119
-
Beta cell apoptosis in diabetes
-
Thomas, H.E. et al. 2009. Beta cell apoptosis in diabetes. Apoptosis 14: 1389-1404.
-
(2009)
Apoptosis
, vol.14
, pp. 1389-1404
-
-
Thomas, H.E.1
-
8
-
-
80051950689
-
TNF receptor 1 deficiency increases regulatory T cell function in nonobese diabetic mice
-
Chee, J. et al. 2011. TNF receptor 1 deficiency increases regulatory T cell function in nonobese diabetic mice. J. Immunol. 187: 1702-1712.
-
(2011)
J. Immunol.
, vol.187
, pp. 1702-1712
-
-
Chee, J.1
-
9
-
-
0347360367
-
IL-1 receptor deficiency slows progression to diabetes in the NOD mouse
-
Thomas, H.E. et al. 2004. IL-1 receptor deficiency slows progression to diabetes in the NOD mouse. Diabetes 53: 113-121.
-
(2004)
Diabetes
, vol.53
, pp. 113-121
-
-
Thomas, H.E.1
-
10
-
-
0032531099
-
IFN-gamma action on pancreatic beta cells causes class I MHC upregulation but not diabetes
-
Thomas, H.E. et al. 1998. IFN-gamma action on pancreatic beta cells causes class I MHC upregulation but not diabetes. J. Clin. Invest. 102: 1249-1257.
-
(1998)
J. Clin. Invest.
, vol.102
, pp. 1249-1257
-
-
Thomas, H.E.1
-
11
-
-
85047692516
-
Signalling pathways of the TNF superfamily: a double-edged sword
-
Aggarwal, B.B. 2003. Signalling pathways of the TNF superfamily: a double-edged sword. Nat. Rev. Immunol. 3: 745-756.
-
(2003)
Nat. Rev. Immunol.
, vol.3
, pp. 745-756
-
-
Aggarwal, B.B.1
-
12
-
-
34250864955
-
Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells
-
Chen, X. et al. 2007. Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells. J. Immunol. 179: 154-161.
-
(2007)
J. Immunol.
, vol.179
, pp. 154-161
-
-
Chen, X.1
-
13
-
-
0032214715
-
Local expression of TNF alpha in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens
-
Green, E.A. et al. 1998. Local expression of TNF alpha in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens. Immunity 9: 733-743.
-
(1998)
Immunity
, vol.9
, pp. 733-743
-
-
Green, E.A.1
-
14
-
-
27644470987
-
The role of TNF-alpha in the pathogenesis of type 1 diabetes in the nonobese diabetic mouse: analysis of dendritic cell maturation
-
Lee, L.F. et al. 2005. The role of TNF-alpha in the pathogenesis of type 1 diabetes in the nonobese diabetic mouse: analysis of dendritic cell maturation. Proc. Natl. Acad. Sci. USA 102: 15995-16000.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 15995-16000
-
-
Lee, L.F.1
-
15
-
-
0025020303
-
Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1
-
Jacob, C.O. et al. 1990. Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1. Proc. Natl. Acad. Sci. USA 87: 968-972.
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 968-972
-
-
Jacob, C.O.1
-
16
-
-
0024446609
-
Recombinant human tumor necrosis factor alpha suppresses autoimmune diabetes in nonobese diabetic mice
-
Satoh, J. et al. 1989. Recombinant human tumor necrosis factor alpha suppresses autoimmune diabetes in nonobese diabetic mice. J. Clin. Invest. 84: 1345-1348.
-
(1989)
J. Clin. Invest.
, vol.84
, pp. 1345-1348
-
-
Satoh, J.1
-
17
-
-
75649096002
-
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
-
Zhou, R. et al. 2010. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat. Immunol. 11: 136-140.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 136-140
-
-
Zhou, R.1
-
18
-
-
42449141905
-
Association of IL-1ra and adiponectin with C-peptide and remission in patients with type 1 diabetes
-
Pfleger, C. et al. 2008. Association of IL-1ra and adiponectin with C-peptide and remission in patients with type 1 diabetes. Diabetes 57: 929-937.
-
(2008)
Diabetes
, vol.57
, pp. 929-937
-
-
Pfleger, C.1
-
19
-
-
40749100302
-
Identification of a molecular signature in human type 1 diabetes mellitus using serum and functional genomics
-
Wang, X. et al. 2008. Identification of a molecular signature in human type 1 diabetes mellitus using serum and functional genomics. J. Immunol. 180: 1929-1937.
-
(2008)
J. Immunol.
, vol.180
, pp. 1929-1937
-
-
Wang, X.1
-
20
-
-
0033561630
-
TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes
-
Kagi, D. et al. 1999. TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes. J. Immunol. 162: 4598-4605.
-
(1999)
J. Immunol.
, vol.162
, pp. 4598-4605
-
-
Kagi, D.1
-
21
-
-
39449126502
-
The Foxp3+ regulatory T cell: a jack of all trades, master of regulation
-
Tang, Q. et al. 2008. The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat. Immunol. 9: 239-244.
-
(2008)
Nat. Immunol.
, vol.9
, pp. 239-244
-
-
Tang, Q.1
-
22
-
-
33846446041
-
Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta
-
Nadkarni, S. et al. 2007. Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta. J. Exp. Med. 204: 33-39.
-
(2007)
J. Exp. Med.
, vol.204
, pp. 33-39
-
-
Nadkarni, S.1
-
23
-
-
33646370647
-
TNF downmodulates the function of human CD4+CD25hi T-regulatory cells
-
Valencia, X. et al. 2006. TNF downmodulates the function of human CD4+CD25hi T-regulatory cells. Blood 108: 253-261.
-
(2006)
Blood
, vol.108
, pp. 253-261
-
-
Valencia, X.1
-
24
-
-
0037125972
-
Tumor necrosis factor-alpha regulation of CD4+CD25+ T cell levels in NOD mice
-
Wu, A.J. et al. 2002. Tumor necrosis factor-alpha regulation of CD4+CD25+ T cell levels in NOD mice. Proc. Natl. Acad. Sci. USA 99: 12287-12292.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 12287-12292
-
-
Wu, A.J.1
-
25
-
-
67650079482
-
Etanercept treatment in children with new-onset type 1 diabetes: pilot randomized, placebo-controlled, double-blind study
-
Mastrandrea, L. et al. 2009. Etanercept treatment in children with new-onset type 1 diabetes: pilot randomized, placebo-controlled, double-blind study. Diabetes Care 32: 1244-1249.
-
(2009)
Diabetes Care
, vol.32
, pp. 1244-1249
-
-
Mastrandrea, L.1
-
26
-
-
0036838536
-
Cutting edge: CD4+CD25+regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis
-
Kohm, A.P. et al. 2002. Cutting edge: CD4+CD25+regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis. J. Immunol. 169: 4712-4716.
-
(2002)
J. Immunol.
, vol.169
, pp. 4712-4716
-
-
Kohm, A.P.1
-
27
-
-
0036006693
-
Elevated NF-kappaB activation in nonobese diabetic mouse dendritic cells results in enhanced APC function
-
Poligone, B. et al. 2002. Elevated NF-kappaB activation in nonobese diabetic mouse dendritic cells results in enhanced APC function. J. Immunol. 168: 188-196.
-
(2002)
J. Immunol.
, vol.168
, pp. 188-196
-
-
Poligone, B.1
-
28
-
-
33744921639
-
IL-1 beta breaks tolerance through expansion of CD25+ effector T cells
-
O'Sullivan, B.J. et al. 2006. IL-1 beta breaks tolerance through expansion of CD25+ effector T cells. J. Immunol. 176: 7278-7287.
-
(2006)
J. Immunol.
, vol.176
, pp. 7278-7287
-
-
O'Sullivan, B.J.1
-
29
-
-
84555188737
-
Synergistic reversal of type 1 diabetes in NOD mice with anti-CD3 and interleukin-1 blockade: evidence of improved immune regulation
-
Ablamunits, V. et al. 2012. Synergistic reversal of type 1 diabetes in NOD mice with anti-CD3 and interleukin-1 blockade: evidence of improved immune regulation. Diabetes 61: 145-154.
-
(2012)
Diabetes
, vol.61
, pp. 145-154
-
-
Ablamunits, V.1
|