A cascade leading to premature aging phenotypes including abnormal tumor profiles in Werner syndrome (Review)

International Journal of Molecular Medicine

Volumn 33, Issue 2, 2014, Pages 247-253

  Sugimoto, Masanobu ^a  

^a GeneCare Research Institute   (Japan)

Author keywords

Inflammation; Mitochondria; Oxidative stress; Premature aging; Telomere; Telomere crisis; Werner syndrome; WRN helicase

Indexed keywords

C REACTIVE PROTEIN; CYSTATHIONINE BETA SYNTHASE; CYSTATHIONINE GAMMA LYASE; DNA HELICASE; EXONUCLEASE; HOMOCYSTEINE; MAMMALIAN TARGET OF RAPAMYCIN; OXIDIZED LOW DENSITY LIPOPROTEIN; PENTOSIDINE; PROTEIN P53; REACTIVE OXYGEN METABOLITE; TELOMERASE REVERSE TRANSCRIPTASE; TELOMERIC REPEAT BINDING FACTOR 2; WERNER SYNDROME PROTEIN;

ALOPECIA; APOPTOSIS; ARTICLE; BIOGENESIS; BRAIN ATHEROSCLEROSIS; BRAIN ATROPHY; CARCINOGENESIS; CATARACT; CELL AGING; CELL CYCLE S PHASE; CELL DEATH; CELL GROWTH; CELL SURVIVAL; CHROMOSOMAL INSTABILITY; CHROMOSOME ABERRATION; DIABETES MELLITUS; DNA DAMAGE; DNA REPLICATION; DNA STRUCTURE; FATTY ACID OXIDATION; GENE MUTATION; GENETIC CODE; GENOMIC INSTABILITY; GLUCONEOGENESIS; GROWTH DISORDER; GROWTH RETARDATION; HOARSENESS; HUMAN; HYPOGONADISM; IMMUNE DEFICIENCY; MENINGIOMA; NON-EPITHELIAL TUMORS; NONHUMAN; OSTEOPOROSIS; OXIDATIVE STRESS; PHENOTYPE; PREMATURE AGING; PRIORITY JOURNAL; PROTEIN AGGREGATION; RESTRICTION FRAGMENT; SCLERODERMA; SKIN ULCER; SOFT TISSUE SARCOMA; SOMATIC CELL; TELOMERE; TELOMERE HOMEOSTASIS; WERNER SYNDROME;

AGING, PREMATURE; ANIMALS; CARCINOGENESIS; CELL AGING; DISEASE MODELS, ANIMAL; DNA HELICASES; GENES, P53; GENOMIC INSTABILITY; HUMANS; MITOCHONDRIA; NEOPLASMS; OXIDATIVE STRESS; PHENOTYPE; REACTIVE OXYGEN SPECIES; TELOMERE; TOR SERINE-THREONINE KINASES; WERNER SYNDROME;

EID: 84893725392     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2013.1592     Document Type: Article

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