메뉴 건너뛰기




Volumn 125, Issue 10, 2012, Pages 2509-2522

RECQL4 is essential for the transport of p53 to mitochondria in normal human cells in the absence of exogenous stress

Author keywords

53BP1; Bloom helicase; Mitochondrial localization signal; Nuclear localization signal; Tom20 receptor

Indexed keywords

CAMPTOTHECIN; HYDROXYUREA; MITOMYCIN C; NUCLEAR PROTEIN; PROTEIN P53; PROTEIN RECQL4; UNCLASSIFIED DRUG; ZINOSTATIN;

EID: 84864804909     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.101501     Document Type: Article
Times cited : (90)

References (55)
  • 1
    • 27144488229 scopus 로고    scopus 로고
    • Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol gamma
    • Achanta, G., Sasaki, R., Feng, L., Carew, J. S., Lu, W., Pelicano, H., Keating, M. J. and Huang, P. (2005). Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol gamma. EMBO J. 24, 3482-3492.
    • (2005) EMBO J , vol.24 , pp. 3482-3492
    • Achanta, G.1    Sasaki, R.2    Feng, L.3    Carew, J.S.4    Lu, W.5    Pelicano, H.6    Keating, M.J.7    Huang, P.8
  • 2
    • 43049162175 scopus 로고    scopus 로고
    • RecQ helicases: guardian angels of the DNA replication fork
    • Bachrati, C. Z. and Hickson, I. D. (2008). RecQ helicases: guardian angels of the DNA replication fork. Chromosoma 117, 219-233.
    • (2008) Chromosoma , vol.117 , pp. 219-233
    • Bachrati, C.Z.1    Hickson, I.D.2
  • 4
    • 0036187913 scopus 로고    scopus 로고
    • Extensive feature detection of N-terminal protein sorting signals
    • Bannai, H., Tamada, Y., Maruyama, O., Nakai, K. and Miyano, S. (2002). Extensive feature detection of N-terminal protein sorting signals. Bioinformatics 18, 298-305.
    • (2002) Bioinformatics , vol.18 , pp. 298-305
    • Bannai, H.1    Tamada, Y.2    Maruyama, O.3    Nakai, K.4    Miyano, S.5
  • 5
    • 0032832195 scopus 로고    scopus 로고
    • Physical and functional interaction between p53 and the Werner's syndrome protein
    • Blander, G., Kipnis, J., Leal, J. F., Yu, C. E., Schellenberg, G. D. and Oren, M. (1999). Physical and functional interaction between p53 and the Werner's syndrome protein. J. Biol. Chem. 274, 29463-29469.
    • (1999) J. Biol. Chem. , vol.274 , pp. 29463-29469
    • Blander, G.1    Kipnis, J.2    Leal, J.F.3    Yu, C.E.4    Schellenberg, G.D.5    Oren, M.6
  • 6
    • 0033728483 scopus 로고    scopus 로고
    • The Werner syndrome protein contributes to induction of p53 by DNA damage
    • Blander, G., Zalle, N., Leal, J. F., Bar-Or, R. L., Yu, C. E. and Oren, M. (2000). The Werner syndrome protein contributes to induction of p53 by DNA damage. FASEB J. 14, 2138-2140.
    • (2000) FASEB J , vol.14 , pp. 2138-2140
    • Blander, G.1    Zalle, N.2    Leal, J.F.3    Bar-Or, R.L.4    Yu, C.E.5    Oren, M.6
  • 7
    • 33847641404 scopus 로고    scopus 로고
    • Nuclear import and retention domains in the amino terminus of RECQL4
    • Burks, L. M., Yin, J. and Plon, S. E. (2007). Nuclear import and retention domains in the amino terminus of RECQL4. Gene 391, 26-38.
    • (2007) Gene , vol.391 , pp. 26-38
    • Burks, L.M.1    Yin, J.2    Plon, S.E.3
  • 8
    • 68749112707 scopus 로고    scopus 로고
    • Importing mitochondrial proteins: machineries and mechanisms
    • Chacinska, A., Koehler, C. M., Milenkovic, D., Lithgow, T. and Pfanner, N. (2009). Importing mitochondrial proteins: machineries and mechanisms. Cell 138, 628-644.
    • (2009) Cell , vol.138 , pp. 628-644
    • Chacinska, A.1    Koehler, C.M.2    Milenkovic, D.3    Lithgow, T.4    Pfanner, N.5
  • 9
    • 0029915525 scopus 로고    scopus 로고
    • Computational method to predict mitochondrially imported proteins and their targeting sequences
    • Claros, M. G. and Vincens, P. (1996). Computational method to predict mitochondrially imported proteins and their targeting sequences. Eur. J. Biochem. 241, 779-786.
    • (1996) Eur. J. Biochem. , vol.241 , pp. 779-786
    • Claros, M.G.1    Vincens, P.2
  • 10
    • 4444323263 scopus 로고    scopus 로고
    • p53 functions in the incorporation step in DNA base excision repair in mouse liver mitochondria
    • de Souza-Pinto, N. C., Harris, C. C. and Bohr, V. A. (2004). p53 functions in the incorporation step in DNA base excision repair in mouse liver mitochondria. Oncogene 23, 6559-6568.
    • (2004) Oncogene , vol.23 , pp. 6559-6568
    • de Souza-Pinto, N.C.1    Harris, C.C.2    Bohr, V.A.3
  • 11
    • 0024298711 scopus 로고
    • A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides
    • Deshaies, R. J., Koch, B. D., Werner-Washburne, M., Craig, E. A. and Schekman, R. (1988). A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides. Nature 332, 800-805.
    • (1988) Nature , vol.332 , pp. 800-805
    • Deshaies, R.J.1    Koch, B.D.2    Werner-Washburne, M.3    Craig, E.A.4    Schekman, R.5
  • 12
  • 13
    • 34248531753 scopus 로고    scopus 로고
    • Locating proteins in the cell using TargetP SignalP and related tools
    • Emanuelsson, O., Brunak, S., von Heijne, G. and Nielsen, H. (2007). Locating proteins in the cell using TargetP, SignalP and related tools. Nat. Protoc. 2, 953-971.
    • (2007) Nat. Protoc. , vol.2 , pp. 953-971
    • Emanuelsson, O.1    Brunak, S.2    von Heijne, G.3    Nielsen, H.4
  • 15
    • 0035857043 scopus 로고    scopus 로고
    • The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control
    • Garkavtsev, I. V., Kley, N., Grigorian, I. A. and Gudkov, A. V. (2001). The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control. Oncogene 20, 8276-8280.
    • (2001) Oncogene , vol.20 , pp. 8276-8280
    • Garkavtsev, I.V.1    Kley, N.2    Grigorian, I.A.3    Gudkov, A.V.4
  • 16
    • 65949083750 scopus 로고    scopus 로고
    • Cytoplasmic functions of the tumour suppressor p53
    • Green, D. R. and Kroemer, G. (2009). Cytoplasmic functions of the tumour suppressor p53. Nature 458, 1127-1130.
    • (2009) Nature , vol.458 , pp. 1127-1130
    • Green, D.R.1    Kroemer, G.2
  • 17
    • 33646201325 scopus 로고    scopus 로고
    • Formation of a nuclear complex containing the p53 tumor suppressor, YB-1, and the Werner syndrome gene product in cells treated with UV light
    • Guay, D., Gaudreault, I., Massip, L. and Lebel, M. (2006). Formation of a nuclear complex containing the p53 tumor suppressor, YB-1, and the Werner syndrome gene product in cells treated with UV light. Int. J. Biochem. Cell Biol. 38, 1300-1313.
    • (2006) Int. J. Biochem. Cell Biol. , vol.38 , pp. 1300-1313
    • Guay, D.1    Gaudreault, I.2    Massip, L.3    Lebel, M.4
  • 18
    • 45049086666 scopus 로고    scopus 로고
    • Sensitivity of RECQL4-deficient fibroblasts from Rothmund-Thomson syndrome patients to genotoxic agents
    • Jin, W., Liu, H., Zhang, Y., Otta, S. K., Plon, S. E. and Wang, L. L. (2008). Sensitivity of RECQL4-deficient fibroblasts from Rothmund-Thomson syndrome patients to genotoxic agents. Hum. Genet. 123, 643-653.
    • (2008) Hum. Genet. , vol.123 , pp. 643-653
    • Jin, W.1    Liu, H.2    Zhang, Y.3    Otta, S.K.4    Plon, S.E.5    Wang, L.L.6
  • 20
    • 0032736140 scopus 로고    scopus 로고
    • Rothmund-thomson syndrome responsible gene RECQL4: genomic structure and products
    • Kitao, S., Lindor, N. M., Shiratori, M., Furuichi, Y. and Shimamoto, A. (1999a). Rothmund-thomson syndrome responsible gene, RECQL4: genomic structure and products. Genomics 61, 268-276.
    • (1999) Genomics , vol.61 , pp. 268-276
    • Kitao, S.1    Lindor, N.M.2    Shiratori, M.3    Furuichi, Y.4    Shimamoto, A.5
  • 22
    • 0041661881 scopus 로고    scopus 로고
    • Replication of mitochondrial DNA occurs throughout the mitochondria of cultured human cells
    • Magnusson, J., Orth, M., Lestienne, P. and Taanman, J. W. (2003). Replication of mitochondrial DNA occurs throughout the mitochondria of cultured human cells. Exp. Cell Res. 289, 133-142.
    • (2003) Exp. Cell Res. , vol.289 , pp. 133-142
    • Magnusson, J.1    Orth, M.2    Lestienne, P.3    Taanman, J.W.4
  • 23
    • 4344566202 scopus 로고    scopus 로고
    • Mitochondrial p53 levels parallel total p53 levels independent of stress response in human colorectal carcinoma and glioblastoma cells
    • Mahyar-Roemer, M., Fritzsche, C., Wagner, S., Laue, M. and Roemer, K. (2004). Mitochondrial p53 levels parallel total p53 levels independent of stress response in human colorectal carcinoma and glioblastoma cells. Oncogene 23, 6226-6236.
    • (2004) Oncogene , vol.23 , pp. 6226-6236
    • Mahyar-Roemer, M.1    Fritzsche, C.2    Wagner, S.3    Laue, M.4    Roemer, K.5
  • 24
    • 0034717014 scopus 로고    scopus 로고
    • Death signal-induced localization of p53 protein to mitochondria A potential role in apoptotic signaling
    • Marchenko, N. D., Zaika, A. and Moll, U. M. (2000). Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling. J. Biol. Chem. 275, 16202-16212.
    • (2000) J. Biol. Chem. , vol.275 , pp. 16202-16212
    • Marchenko, N.D.1    Zaika, A.2    Moll, U.M.3
  • 25
    • 33745471225 scopus 로고    scopus 로고
    • The N-terminal noncatalytic region of Xenopus RecQ4 is required for chromatin binding of DNA polymerase alpha in the initiation of DNA replication
    • Matsuno, K., Kumano, M., Kubota, Y., Hashimoto, Y. and Takisawa, H. (2006). The N-terminal noncatalytic region of Xenopus RecQ4 is required for chromatin binding of DNA polymerase alpha in the initiation of DNA replication. Mol. Cell. Biol. 26, 4843-4852.
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 4843-4852
    • Matsuno, K.1    Kumano, M.2    Kubota, Y.3    Hashimoto, Y.4    Takisawa, H.5
  • 27
    • 0032972509 scopus 로고    scopus 로고
    • PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localization
    • Nakai, K. and Horton, P. (1999). PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localization. Trends Biochem. Sci. 24, 34-35.
    • (1999) Trends Biochem. Sci. , vol.24 , pp. 34-35
    • Nakai, K.1    Horton, P.2
  • 28
    • 0037466277 scopus 로고    scopus 로고
    • Peptide library approach with a disulfide tether to refine the Tom20 recognition motif in mitochondrial presequences
    • Obita, T., Muto, T., Endo, T. and Kohda, D. (2003). Peptide library approach with a disulfide tether to refine the Tom20 recognition motif in mitochondrial presequences. J. Mol. Biol. 328, 495-504.
    • (2003) J. Mol. Biol. , vol.328 , pp. 495-504
    • Obita, T.1    Muto, T.2    Endo, T.3    Kohda, D.4
  • 29
    • 45449110194 scopus 로고    scopus 로고
    • Homologous recombination and maintenance of genome integrity: cancer and aging through the prism of human RecQ helicases
    • Ouyang, K. J., Woo, L. L. and Ellis, N. A. (2008). Homologous recombination and maintenance of genome integrity: cancer and aging through the prism of human RecQ helicases. Mech. Ageing Dev. 129, 425-440.
    • (2008) Mech. Ageing Dev. , vol.129 , pp. 425-440
    • Ouyang, K.J.1    Woo, L.L.2    Ellis, N.A.3
  • 30
    • 27144460601 scopus 로고    scopus 로고
    • The human Rothmund-Thomson syndrome gene product, RECQL4, localizes to distinct nuclear foci that coincide with proteins involved in the maintenance of genome stability
    • Petkovic, M., Dietschy, T., Freire, R., Jiao, R. and Stagljar, I. (2005). The human Rothmund-Thomson syndrome gene product, RECQL4, localizes to distinct nuclear foci that coincide with proteins involved in the maintenance of genome stability. J. Cell Sci. 118, 4261-4269.
    • (2005) J. Cell Sci. , vol.118 , pp. 4261-4269
    • Petkovic, M.1    Dietschy, T.2    Freire, R.3    Jiao, R.4    Stagljar, I.5
  • 31
    • 0034214123 scopus 로고    scopus 로고
    • Protein sorting: recognizing mitochondrial presequences
    • Pfanner, N. (2000). Protein sorting: recognizing mitochondrial presequences. Curr. Biol. 10, R412-R415.
    • (2000) Curr. Biol. , vol.10
    • Pfanner, N.1
  • 32
    • 21744432851 scopus 로고    scopus 로고
    • Differences in the association of p53 phosphorylated on serine 15 and key enzymes of homologous recombination
    • Restle, A., Janz, C. and Wiesmüller, L. (2005). Differences in the association of p53 phosphorylated on serine 15 and key enzymes of homologous recombination. Oncogene 24, 4380-4387.
    • (2005) Oncogene , vol.24 , pp. 4380-4387
    • Restle, A.1    Janz, C.2    Wiesmüller, L.3
  • 34
    • 20444380748 scopus 로고    scopus 로고
    • Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome
    • Sangrithi, M. N., Bernal, J. A., Madine, M., Philpott, A., Lee, J., Dunphy, W. G. and Venkitaraman, A. R. (2005). Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome. Cell 121, 887-898.
    • (2005) Cell , vol.121 , pp. 887-898
    • Sangrithi, M.N.1    Bernal, J.A.2    Madine, M.3    Philpott, A.4    Lee, J.5    Dunphy, W.G.6    Venkitaraman, A.R.7
  • 35
    • 0034739853 scopus 로고    scopus 로고
    • p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks
    • Schultz, L. B., Chehab, N. H., Malikzay, A. and Halazonetis, T. D. (2000). p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J. Cell Biol. 151, 1381-1390.
    • (2000) J. Cell Biol. , vol.151 , pp. 1381-1390
    • Schultz, L.B.1    Chehab, N.H.2    Malikzay, A.3    Halazonetis, T.D.4
  • 36
    • 11244344381 scopus 로고    scopus 로고
    • p53: traffic cop at the crossroads of DNA repair and recombination
    • Sengupta, S. and Harris, C. C. (2005). p53: traffic cop at the crossroads of DNA repair and recombination. Nat. Rev. Mol. Cell Biol. 6, 44-55.
    • (2005) Nat. Rev. Mol. Cell Biol. , vol.6 , pp. 44-55
    • Sengupta, S.1    Harris, C.C.2
  • 37
    • 0035883863 scopus 로고    scopus 로고
    • Ligand-dependent interaction of the glucocorticoid receptor with p53 enhances their degradation by Hdm2
    • Sengupta, S. and Wasylyk, B. (2001). Ligand-dependent interaction of the glucocorticoid receptor with p53 enhances their degradation by Hdm2. Genes Dev. 15, 2367-2380.
    • (2001) Genes Dev , vol.15 , pp. 2367-2380
    • Sengupta, S.1    Wasylyk, B.2
  • 44
    • 0030462463 scopus 로고    scopus 로고
    • BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway
    • Strobel, T., Swanson, L., Korsmeyer, S. and Cannistra, S. A. (1996). BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway. Proc. Natl. Acad. Sci. USA 93, 14094-14099.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 14094-14099
    • Strobel, T.1    Swanson, L.2    Korsmeyer, S.3    Cannistra, S.A.4
  • 48
    • 33646399211 scopus 로고    scopus 로고
    • RECQL4-deficient cells are hypersensitive to oxidative stress/damage: Insights for osteosarcoma prevalence and heterogeneity in Rothmund-Thomson syndrome
    • Werner, S. R., Prahalad, A. K., Yang, J. and Hock, J. M. (2006). RECQL4-deficient cells are hypersensitive to oxidative stress/damage: Insights for osteosarcoma prevalence and heterogeneity in Rothmund-Thomson syndrome. Biochem. Biophys. Res. Commun. 345, 403-409.
    • (2006) Biochem. Biophys. Res. Commun. , vol.345 , pp. 403-409
    • Werner, S.R.1    Prahalad, A.K.2    Yang, J.3    Hock, J.M.4
  • 49
    • 59749094729 scopus 로고    scopus 로고
    • Physical and functional interactions between human mitochondrial single-stranded DNA-binding protein and tumour suppressor p53
    • Wong, T. S., Rajagopalan, S., Townsley, F. M., Freund, S. M., Petrovich, M., Loakes, D. and Fersht, A. R. (2009). Physical and functional interactions between human mitochondrial single-stranded DNA-binding protein and tumour suppressor p53. Nucleic Acids Res. 37, 568-581.
    • (2009) Nucleic Acids Res , vol.37 , pp. 568-581
    • Wong, T.S.1    Rajagopalan, S.2    Townsley, F.M.3    Freund, S.M.4    Petrovich, M.5    Loakes, D.6    Fersht, A.R.7
  • 50
    • 62049085034 scopus 로고    scopus 로고
    • Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein
    • Xu, X. and Liu, Y. (2009). Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4. EMBO J. 28, 568-577.
    • (2009) RECQ4. EMBO J. , vol.28 , pp. 568-577
    • Xu, X.1    Liu, Y.2
  • 51
    • 70350573964 scopus 로고    scopus 로고
    • MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication
    • Xu, X., Rochette, P. J., Feyissa, E. A., Su, T. V. and Liu, Y. (2009). MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication. EMBO J. 28, 3005-3014.
    • (2009) EMBO J , vol.28 , pp. 3005-3014
    • Xu, X.1    Rochette, P.J.2    Feyissa, E.A.3    Su, T.V.4    Liu, Y.5
  • 52
    • 0037737758 scopus 로고    scopus 로고
    • Regulation of p53 responses by post-translational modifications
    • Xu, Y. (2003). Regulation of p53 responses by post-translational modifications. Cell Death Differ. 10, 400-403.
    • (2003) Cell Death Differ , vol.10 , pp. 400-403
    • Xu, Y.1
  • 54
    • 19544366597 scopus 로고    scopus 로고
    • RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway
    • Yin, J., Kwon, Y. T., Varshavsky, A. and Wang, W. (2004). RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway. Hum. Mol. Genet. 13, 2421-2430.
    • (2004) Hum. Mol. Genet. , vol.13 , pp. 2421-2430
    • Yin, J.1    Kwon, Y.T.2    Varshavsky, A.3    Wang, W.4
  • 55
    • 0037428164 scopus 로고    scopus 로고
    • Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70
    • Young, J. C., Hoogenraad, N. J. and Hartl, F. U. (2003). Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70. Cell 112, 41-50.
    • (2003) Cell , vol.112 , pp. 41-50
    • Young, J.C.1    Hoogenraad, N.J.2    Hartl, F.U.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.