Synthesis and antiproliferative activity of new 1,5-disubstituted tetrazoles bearing hydrazone moiety

Medicinal Chemistry Research

Volumn 23, Issue 2, 2014, Pages 1067-1075

  Kaplancikli, Zafer Asim ^a   Yurttaş, Leyla ^a   Özdemir, Ahmet ^a   Turan Zitouni, Gülhan ^a   Çiftçi, Gülşen Akalin ^a   Yildirim, Şafak Ulusoylar ^a   Mohsen, Usama Abu ^b  

^a ANADOLU UNIVERSITY   (Turkey)

^b AL AZHAR UNIVERSITY   (Palestine)

Author keywords

Antiproliferative activity; Caspase 3; Hydrazone; MTT assay; Tetrazole

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; HYDRAZONE DERIVATIVE; MITOXANTRONE; N' (2 CHLOROBENZYLIDENE) 4 [(1 PHENYL 1H TETRAZOLE 5 YL)THIO]BUTANOHYDRAZIDE; N' (2 HYDROXY 3,5 DICHLOROBENZYLIDENE) 4 [(1 PHENYL 1H TETRAZOLE 5 YL)THIO]BUTANOHYDRAZIDE; N' (2,3 DICHLOROBENZYLIDENE) 4 [(1 PHENYL 1H TETRAZOLE 5 YL)THIO]BUTANOHYDRAZIDE; N' (3 CHLORO 4 METHYLAMIONOBENZYLIDENE) 4 [(1 PHENYL 1H TETRAZOLE 5 YL)THIO]BUTANOHYDRAZIDE; N' (3 CHLOROBENZYLIDENE) 4 [(1 PHENYL 1H TETRAZOLE 5 YL)THIO]BUTANOHYDRAZIDE; N' (3,4 DICHLOROBENZYLIDENE) 4 [(1 PHENYL 1H TETRAZOLE 5 YL)THIO]BUTANOHYDRAZIDE; N' (3,5 DICHLOROBENZYLIDENE) 4 [(1 PHENYL 1H TETRAZOLE 5 YL)THIO]BUTANOHYDRAZIDE; N' (4 CHLOROBENZYLIDENE) 4 [(1 PHENYL 1H TETRAZOLE 5 YL)THIO]BUTANOHYDRAZIDE; TETRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL CYCLE M PHASE; CELL VIABILITY; CONTROLLED STUDY; DNA SYNTHESIS; DNA SYNTHESIS INHIBITION; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVATION; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC 50; MASS SPECTROMETRY; MTT ASSAY; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 84893725211     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-013-0717-y     Document Type: Article

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