Modulation of 11β-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 11, 2010, Pages 3265-3271

  Webster, Scott P ^a   Binnie, Margaret ^a   McConnell, Kirsty M M ^a   Sooy, Karen ^a   Ward, Peter ^a   Greaney, Michael F ^b   Vinter, Andy ^c   Pallin, T David ^d   Dyke, Hazel J ^d   Gill, Matthew I A ^d   Warner, Ines ^d   Seckl, Jonathan R ^a   Walker, Brian R ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c Cresset BioMolecular Discovery Ltd   (United Kingdom)

^d Argenta Discovery Ltd   (United Kingdom)

Author keywords

11 HSD1; 11 Hydroxysteroid dehydrogenase type 1; Drug discovery; Metabolic syndrome

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; 11BETA HYDROXYSTEROID DEHYDROGENASE 2; BVT 116429; PF 915275; UNCLASSIFIED DRUG; ENZYME INHIBITOR; TETRAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG STABILITY; HUMAN; IN VITRO STUDY; LIVER MICROSOME; MOUSE; NONHUMAN; ANIMAL; CHEMICAL STRUCTURE; DRUG ANTAGONISM;

MURINAE;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANIMALS; ENZYME INHIBITORS; HUMANS; MICE; MODELS, MOLECULAR; TETRAZOLES;

EID: 77953284860     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.04.055     Document Type: Article

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