Synthesis of 2-substituted-N-[4-(1-methyl-4,5-diphenyl-1H-imidazole-2-yl) phenyl] acetamide derivatives and evaluation of theiranticancer activity

European Journal of Medicinal Chemistry

Volumn 45, Issue 8, 2010, Pages 3320-3328

  Özkay, Yusuf ^a   Işikdaǧ, Ilhan ^a   Incesu, Zerrin ^a   Akalin, Gülşen ^a  

^a ANADOLU UNIVERSITY   (Turkey)

Author keywords

Azole,benzazole; Cancer; HT 29; Imidazole; MCF 7; Piperazine

Indexed keywords

1 METHYL 2 (4 AMINOPHENYL) 4,5 DIPHENYL 1H IMIDAZOLE; 2 (1 METHYL 1H IMIDAZOLE 2 YL) SULFANYL N [4 (1 METHYL 4,5 DIPHENYL 1H IMIDAZOLE 2 YL)PHENYL]ACETAMIDE; 2 (4 BENZYLPIPERAZINE 1 YL) N [4 (1 METHYL 4,5 DIPHENYL 1H IMIDAZOLE 2 YL)PHENYL]ACETAMIDE; 2 (4 DIMETHYLAMINOETHYLPIPERAZINE 1 YL) N [4 (1 METHYL 4,5 DIPHENYL 1H IMIDAZOLE 2 YL)PHENYL]ACETAMIDE; 2 (4 ETHYLPIPERAZINE 1 YL) N [4 (1 METHYL 4,5 DIPHENYL 1H IMIDAZOLE 2 YL)PHENYL]ACETAMIDE; 2 (4 METHYL 4H 1,2,4 TRIAZOLE 3 YL) SULFANYL N [4 (1 METHYL 4,5 DIPHENYL 1H IMIDAZOLE 2 YL)PHENYL]ACETAMIDE; 2 (4 METHYLPIPERAZINE 1 YL) N [4 (1 METHYL 4,5 DIPHENYL 1H IMIDAZOLE 2 YL)PHENYL]ACETAMIDE; 2 (4 PHENYLPIPERAZINE 1 YL) N [4 (1 METHYL 4,5 DIPHENYL 1H IMIDAZOLE 2 YL)PHENYL]ACETAMIDE; 2 (5 CHLORO BENZOXAZOLE 2 YL) SULFANYL N [4 (1 METHYL 4,5 DIPHENYL 1H IMIDAZOLE 2 YL)PHENYL]ACETAMIDE; 2 (5 METHYL 1H 1,2,4 THIADIAZOLE 3 YL) SULFANYL N [4 (1 METHYL 4,5 DIPHENYL 1H IMIDAZOLE 2 YL)PHENYL]ACETAMIDE; 2 (5 METHYL BENZOXAZOLE 2 YL) SULFANYL N [4 (1 METHYL 4,5 DIPHENYL 1H IMIDAZOLE 2 YL)PHENYL]ACETAMIDE; 2 (METHYL 1H 1,2,3,4 TETRAZOLE 5 YL) SULFANYL N [4 (1 METHYL 4,5 DIPHENYL 1H IMIDAZOLE 2 YL)PHENYL]ACETAMIDE; 2 BENZOTHIAZOLE 2 YL SULFANYL N [4 (1 METHYL 4,5 DIPHENYL 1H IMIDAZOLE 2 YL)PHENYL]ACETAMIDE; 2 BENZOXAZOLE 2 YL SULFANYL N [4 (1 METHYL 4,5 DIPHENYL 1H IMIDAZOLE 2 YL)PHENYL]ACETAMIDE; 2 CHLORO N [4 (4,5 DIPHENYL 1H IMIDAZOLE 2 YL)PHENYL]ACETAMIDE; 2 N [4 (1 METHYL 4,5 DIPHENYL 1H IMIDAZOLE 2 YL)PHENYL]ACETAMIDE DERIVATIVE; 2 THIAZOLINE 2 YL SULFANYL N [4 (1 METHYL 4,5 DIPHENYL 1H IMIDAZOLE 2 YL)PHENYL]ACETAMIDE; 2 [4 (4 CHLOROBENZYL)PIPERAZINE 1 YL] N [4 (1 METHYL 4,5 DIPHENYL 1H IMIDAZOLE 2 YL)PHENYL]ACETAMIDE; 2 [4 (4 METHOXYBENZYL)PIPERAZINE 1 YL] N [4 (1 METHYL 4,5 DIPHENYL 1H IMIDAZOLE 2 YL)PHENYL]ACETAMIDE; 2 [4 (4 METHYLBENZYL)PIPERAZINE 1 YL] N [4 (1 METHYL 4,5 DIPHENYL 1H IMIDAZOLE 2 YL)PHENYL]ACETAMIDE; IMIDAZOLE DERIVATIVE; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; COLON CANCER; CYTOTOXICITY; DNA FRAGMENTATION; DNA SYNTHESIS; DRUG STRUCTURE; DRUG SYNTHESIS;

EID: 77954309331     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.04.015     Document Type: Article

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