The dipeptide monoester prodrugs of floxuridine and gemcitabine-feasibility of orally administrable nucleoside analogs

Pharmaceuticals

Volumn 7, Issue 2, 2014, Pages 169-191

  Tsume, Yasuhiro ^a   Borras Bermejo, Blanca ^b   Amidon, Gordon L ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF LLEIDA   (Spain)

Author keywords

Dipeptide; Floxuridine prodrug; Gemcitabine prodrug; Mouse in situ perfusion; Pancreatic tumor cells

Indexed keywords

5' LEVO PHENYLALANYL LEVO TYROSYL FLOXURIDINE; 5' LEVO PHENYLALANYL LEVO TYROSYL GEMCITABINE; DIPEPTIDE; FLOXURIDINE; GEMCITABINE; PRODRUG; UNCLASSIFIED DRUG;

ACIDITY; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL; CELL PROLIFERATION; CONCENTRATION RESPONSE; DRUG MECHANISM; DRUG METABOLISM; DRUG PENETRATION; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME STABILITY; HUMAN; HUMAN CELL; INTESTINE PERFUSION; MEMBRANE PERMEABILITY; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PH;

EID: 84893446371     PISSN: None     EISSN: 14248247     Source Type: Journal    
DOI: 10.3390/ph7020169     Document Type: Article

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