The achievement of mass balance by simultaneous quantification of floxuridine prodrug, floxuridine, 5-fluorouracil, 5-dihydrouracil, α-fluoro-β-ureidopropionate, α-fluoro-β-alanine using LC-MS

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 13-14, 2011, Pages 915-920

  Tsume, Yasuhiro ^a   Provoda, Chester J ^a   Amidon, Gordon L ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Fluoro alanine (FBAL); Fluoro ureidopropionate (FUPA); 5 Fluorodihydrouracil (FUH2); 5 Fluorouracil (5 FU); Floxuridine (5 FdUrd); Floxuridine prodrug; LC MS; Mass balance; Metabolite

Indexed keywords

5-FLUORODIHYDROURACIL; 5-FLUOROURACIL (5-FU); FLOXURIDINE (5-FDURD); LC-MS; MASS BALANCE; PRODRUGS;

AMINO ACIDS; BIOMOLECULES; ESTERS; MASS SPECTROMETRY; METABOLITES;

METABOLISM;

5 DIHYDROURACIL; ALPHA FLUORO BETA ALANINE; ALPHA FLUORO BETA UREIDOPROPIONATE; DRUG METABOLITE; FLOXURIDINE; FLOXURIDINE DERIVATIVE; FLUOROURACIL; PRODRUG; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; DRUG HYDROLYSIS; DRUG STRUCTURE; HUMAN; HUMAN CELL; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL;

ANALYSIS OF VARIANCE; ANTIMETABOLITES, ANTINEOPLASTIC; BETA-ALANINE; CELL EXTRACTS; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLOXURIDINE; FLUOROURACIL; HUMANS; LINEAR MODELS; MASS SPECTROMETRY; REPRODUCIBILITY OF RESULTS; URACIL; UREA;

EID: 79953303672     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.02.045     Document Type: Article

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