Nucleoside ester prodrug substrate specificity of liver carboxylesterase

Journal of Pharmacology and Experimental Therapeutics

Volumn 316, Issue 2, 2006, Pages 572-580

  Landowski, Christopher P ^a   Lorenzi, Philip L ^a   Song, Xueqin ^a   Amidon, Gordon L ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 BROMO 5,6 DICHLORO 1 (BETA DEXTRO RIBOFURANOSYL)BENZIMIDAZOLE; AMINO ACID DERIVATIVE; BENZIMIDAZOLE DERIVATIVE; CARBOXYLESTERASE; ESTERASE; FLOXURIDINE; GEMCITABINE; ISOLEUCINE; LIVER ENZYME; NUCLEOSIDE ANALOG; PHENYLALANINE; PRODRUG; UNCLASSIFIED DRUG; VALACICLOVIR; VALACYCLOVIRASE; VALINE;

ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG DESIGN; DRUG DISPOSITION; DRUG HYDROLYSIS; DRUG RECEPTOR BINDING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SPECIFICITY; ESTERIFICATION; HUMAN; HUMAN CELL; MEDICAL ASSESSMENT; PRIORITY JOURNAL; PROTEIN HYDROLYSIS; RECEPTOR AFFINITY;

ANIMALS; BENZIMIDAZOLES; CACO-2 CELLS; CARBOXYLESTERASE; CYTOSOL; DEOXYCYTIDINE; ESTERS; FLOXURIDINE; HUMANS; HYDROLYSIS; LIVER; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEOSIDES; PRODRUGS; RIBONUCLEOSIDES; SUBSTRATE SPECIFICITY; SWINE;

EID: 31144463532     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.092726     Document Type: Article

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