Propylene glycol-linked amino acid/dipeptide diester prodrugs of oleanolic acid for PepT1-mediated transport: Synthesis, intestinal permeability, and pharmacokinetics

Molecular Pharmaceutics

Volumn 10, Issue 4, 2013, Pages 1378-1387

  Cao, Feng ^a   Gao, Yahan ^a   Wang, Meng ^a   Fang, Lei ^a,b   Ping, Qineng ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b SOUTHEAST UNIVERSITY   (China)

Author keywords

bioavailability; Caco 2; ester prodrug; in situ single pass intestinal perfusion; oleanolic acid; peptide transporter 1; pharmacokinetics; propylene glycol linker

Indexed keywords

4 (2 HYDROXYETHYL) 1 PIPERAZINEETHANESULFONIC ACID; AMINO ACID; ANTIINFLAMMATORY AGENT; OLEANOLIC ACID; PEPTIDE TRANSPORTER 1; PRODRUG; PROPYLENE GLYCOL;

ARTICLE; DRUG BIOAVAILABILITY; DRUG PENETRATION; DRUG STABILITY; HUMAN; HUMAN CELL; IN VIVO STUDY; INTESTINE PERFUSION; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RAT;

AMINO ACIDS; ANIMALS; BIOLOGICAL AVAILABILITY; CACO-2 CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIPEPTIDES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINES; MALE; MEMBRANE TRANSPORT PROTEINS; OLEANOLIC ACID; PERFUSION; PERMEABILITY; PRODRUGS; PROPYLENE GLYCOL; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; WATER;

EID: 84875784206     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300647m     Document Type: Article

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