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Volumn 8, Issue 12, 2013, Pages

Maintenance of basal levels of autophagy in Huntington's disease mouse models displaying metabolic dysfunction

Author keywords

[No Author keywords available]

Indexed keywords

HUNTINGTIN; MESSENGER RNA;

EID: 84893427651     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0083050     Document Type: Article
Times cited : (18)

References (115)
  • 1
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
    • The Huntington's Disease Collaborative Research Group
    • The Huntington's Disease Collaborative Research Group (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72: 971-983.
    • (1993) Cell , vol.72 , pp. 971-983
  • 2
    • 78650031174 scopus 로고    scopus 로고
    • Huntington's disease: From molecular pathogenesis to clinical treatment
    • Ross CA, Tabrizi SJ (2011) Huntington's disease: from molecular pathogenesis to clinical treatment. Lancet Neurol 10: 83-98.
    • (2011) Lancet Neurol , vol.10 , pp. 83-98
    • Ross, C.A.1    Tabrizi, S.J.2
  • 3
    • 80052544727 scopus 로고    scopus 로고
    • Huntington's disease: Clinical presentation and treatment
    • Novak MJ, Tabrizi SJ (2011) Huntington's disease: clinical presentation and treatment. Int Rev Neurobiol 98: 297-323.
    • (2011) Int Rev Neurobiol , vol.98 , pp. 297-323
    • Novak, M.J.1    Tabrizi, S.J.2
  • 5
    • 36549036813 scopus 로고    scopus 로고
    • Psychiatric Symptoms in Huntington's Disease before Diagnosis: The Predict-HD Study
    • DOI 10.1016/j.biopsych.2006.11.034, PII S0006322306015617
    • Duff K, Paulsen JS, Beglinger LJ, Langbehn DR, Stout JC (2007) Psychiatric symptoms in Huntington's disease before diagnosis: the predict-HD study. Biol Psychiatry 62: 1341-1346. (Pubitemid 350180721)
    • (2007) Biological Psychiatry , vol.62 , Issue.12 , pp. 1341-1346
    • Duff, K.1    Paulsen, J.S.2    Beglinger, L.J.3    Langbehn, D.R.4    Stout, J.C.5
  • 6
    • 81055156193 scopus 로고    scopus 로고
    • Cognitive impairment in Huntington disease: Diagnosis and treatment
    • Paulsen JS (2011) Cognitive impairment in Huntington disease: diagnosis and treatment. Curr Neurol Neurosci Rep 11: 474-483.
    • (2011) Curr Neurol Neurosci Rep , vol.11 , pp. 474-483
    • Paulsen, J.S.1
  • 8
    • 34447579898 scopus 로고    scopus 로고
    • Neuropsychiatry of Huntington's disease
    • Rosenblatt A (2007) Neuropsychiatry of Huntington's disease. Dialogues Clin Neurosci 9: 191-197.
    • (2007) Dialogues Clin Neurosci , vol.9 , pp. 191-197
    • Rosenblatt, A.1
  • 13
    • 41349100027 scopus 로고    scopus 로고
    • The metabolic profile of early Huntington's disease-a combined human and transgenic mouse study
    • Goodman AO, Murgatroyd PR, Medina-Gomez G, Wood NI, Finer N, et al. (2008) The metabolic profile of early Huntington's disease-a combined human and transgenic mouse study. Experimental neurology 210: 691-698.
    • (2008) Experimental Neurology , vol.210 , pp. 691-698
    • Goodman, A.O.1    Murgatroyd, P.R.2    Medina-Gomez, G.3    Wood, N.I.4    Finer, N.5
  • 17
    • 77957790499 scopus 로고    scopus 로고
    • Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis
    • Soneson C, Fontes M, Zhou Y, Denisov V, Paulsen JS, et al. (2010) Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis. Neurobiology of disease 40: 531-543.
    • (2010) Neurobiology of Disease , vol.40 , pp. 531-543
    • Soneson, C.1    Fontes, M.2    Zhou, Y.3    Denisov, V.4    Paulsen, J.S.5
  • 18
    • 77957977395 scopus 로고    scopus 로고
    • Hypothalamic and neuroendocrine changes in Huntington's disease
    • Hult S, Schultz K, Soylu R, Petersen A (2010) Hypothalamic and neuroendocrine changes in Huntington's disease. Curr Drug Targets 11: 1237-1249.
    • (2010) Curr Drug Targets , vol.11 , pp. 1237-1249
    • Hult, S.1    Schultz, K.2    Soylu, R.3    Petersen, A.4
  • 19
    • 84885920163 scopus 로고    scopus 로고
    • Hypothalamic and Limbic System Changes in Huntington's Disease
    • Petersen A, Gabery S (2012) Hypothalamic and Limbic System Changes in Huntington's Disease. Journal of Huntington's Disease: 5-16.
    • (2012) Journal of Huntington's Disease , pp. 5-16
    • Petersen, A.1    Gabery, S.2
  • 20
    • 0030605896 scopus 로고    scopus 로고
    • Somatostatin 1-12 immunoreactivity is decreased in the hypothalamic lateral tuberal nucleus of Hungington's disease patients
    • DOI 10.1016/0006-8993(96)00080-7
    • Timmers HJ, Swaab DF, van de Nes JA, Kremer HP (1996) Somatostatin 1-12 immunoreactivity is decreased in the hypothalamic lateral tuberal nucleus of Huntington's disease patients. Brain Res 728: 141-148. (Pubitemid 26252805)
    • (1996) Brain Research , vol.728 , Issue.2 , pp. 141-148
    • Timmers, H.J.L.M.1    Swaab, D.F.2    Van De, N.J.A.P.3    Kremer, H.P.H.4
  • 22
    • 51249102726 scopus 로고    scopus 로고
    • Hypocretin and melanin-concentrating hormone in patients with Huntington disease
    • Aziz A, Fronczek R, Maat-Schieman M, Unmehopa U, Roelandse F, et al. (2008) Hypocretin and melanin-concentrating hormone in patients with Huntington disease. Brain pathology 18: 474-483.
    • (2008) Brain Pathology , vol.18 , pp. 474-483
    • Aziz, A.1    Fronczek, R.2    Maat-Schieman, M.3    Unmehopa, U.4    Roelandse, F.5
  • 23
    • 78651085932 scopus 로고    scopus 로고
    • Changes in key hypothalamic neuropeptide populations in Huntington disease revealed by neuropathological analyses
    • Gabery S, Murphy K, Schultz K, Loy CT, McCusker E, et al. (2010) Changes in key hypothalamic neuropeptide populations in Huntington disease revealed by neuropathological analyses. Acta neuropathologica 120: 777-788.
    • (2010) Acta Neuropathologica , vol.120 , pp. 777-788
    • Gabery, S.1    Murphy, K.2    Schultz, K.3    Loy, C.T.4    McCusker, E.5
  • 24
    • 79953756679 scopus 로고    scopus 로고
    • Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits
    • Hult S, Soylu R, Bjorklund T, Belgardt BF, Mauer J, et al. (2011) Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits. Cell Metab 13: 428-439.
    • (2011) Cell Metab , vol.13 , pp. 428-439
    • Hult, S.1    Soylu, R.2    Bjorklund, T.3    Belgardt, B.F.4    Mauer, J.5
  • 25
    • 84881580793 scopus 로고    scopus 로고
    • Hypothalamic expression of mutant huntingtin contributes to the development of depressive-like behavior in the BAC transgenic mouse model of Huntington's disease
    • Hult Lundh S, Nilsson N, Soylu R, Kirik D, Petersen A (2013) Hypothalamic expression of mutant huntingtin contributes to the development of depressive-like behavior in the BAC transgenic mouse model of Huntington's disease. Human molecular genetics.
    • (2013) Human Molecular Genetics
    • Hult Lundh, S.1    Nilsson, N.2    Soylu, R.3    Kirik, D.4    Petersen, A.5
  • 26
    • 46749157501 scopus 로고    scopus 로고
    • Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice
    • Gray M, Shirasaki DI, Cepeda C, Andre VM, Wilburn B, et al. (2008) Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice. J Neurosci 28: 6182-6195.
    • (2008) J Neurosci , vol.28 , pp. 6182-6195
    • Gray, M.1    Shirasaki, D.I.2    Cepeda, C.3    Andre, V.M.4    Wilburn, B.5
  • 29
    • 72549095406 scopus 로고    scopus 로고
    • Regulation mechanisms and signaling pathways of autophagy
    • He C, Klionsky DJ (2009) Regulation mechanisms and signaling pathways of autophagy. Annual review of genetics 43: 67-93.
    • (2009) Annual Review of Genetics , vol.43 , pp. 67-93
    • He, C.1    Klionsky, D.J.2
  • 30
    • 77951214016 scopus 로고    scopus 로고
    • Mammalian autophagy: Core molecular machinery and signaling regulation
    • Yang Z, Klionsky DJ (2010) Mammalian autophagy: core molecular machinery and signaling regulation. Current opinion in cell biology 22: 124-131.
    • (2010) Current Opinion in Cell Biology , vol.22 , pp. 124-131
    • Yang, Z.1    Klionsky, D.J.2
  • 31
    • 0035364748 scopus 로고    scopus 로고
    • Expanded CAG repeats in exon 1 of the Huntington's disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration
    • Petersen A, Larsen KE, Behr GG, Romero N, Przedborski S, et al. (2001) Expanded CAG repeats in exon 1 of the Huntington's disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration. Hum Mol Genet 10: 1243-1254. (Pubitemid 32600478)
    • (2001) Human Molecular Genetics , vol.10 , Issue.12 , pp. 1243-1254
    • Petersen, A.1    Larsen, K.E.2    Behr, G.G.3    Romero, N.4    Przedborski, S.5    Brundin, P.6    Sulzer, D.7
  • 32
    • 33745192802 scopus 로고    scopus 로고
    • Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
    • Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, et al. (2006) Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441: 885-889.
    • (2006) Nature , vol.441 , pp. 885-889
    • Hara, T.1    Nakamura, K.2    Matsui, M.3    Yamamoto, A.4    Nakahara, Y.5
  • 33
    • 77951665859 scopus 로고    scopus 로고
    • Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease
    • Martinez-Vicente M, Talloczy Z, Wong E, Tang G, Koga H, et al. (2010) Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease. Nature neuroscience 13: 567-576.
    • (2010) Nature Neuroscience , vol.13 , pp. 567-576
    • Martinez-Vicente, M.1    Talloczy, Z.2    Wong, E.3    Tang, G.4    Koga, H.5
  • 34
    • 63049132756 scopus 로고    scopus 로고
    • Acetylation targets mutant huntingtin to autophagosomes for degradation
    • Jeong H, Then F, Melia TJ, Jr., Mazzulli JR, Cui L, et al. (2009) Acetylation targets mutant huntingtin to autophagosomes for degradation. Cell 137: 60-72.
    • (2009) Cell , vol.137 , pp. 60-72
    • Jeong, H.1    Then, F.2    Melia Jr., T.J.3    Mazzulli, J.R.4    Cui, L.5
  • 37
    • 84867427022 scopus 로고    scopus 로고
    • The role of chaperone-mediated autophagy in huntingtin degradation
    • Qi L, Zhang XD, Wu JC, Lin F, Wang J, et al. (2012) The role of chaperone-mediated autophagy in huntingtin degradation. PloS one 7: e46834.
    • (2012) PloS One , vol.7
    • Qi, L.1    Zhang, X.D.2    Wu, J.C.3    Lin, F.4    Wang, J.5
  • 38
    • 77649219699 scopus 로고    scopus 로고
    • Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice
    • Zheng S, Clabough EB, Sarkar S, Futter M, Rubinsztein DC, et al. (2010) Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice. PLoS Genet 6: e1000838.
    • (2010) PLoS Genet , vol.6
    • Zheng, S.1    Clabough, E.B.2    Sarkar, S.3    Futter, M.4    Rubinsztein, D.C.5
  • 39
    • 80053563760 scopus 로고    scopus 로고
    • Induction of autophagy with catalytic mTOR inhibitors reduces huntingtin aggregates in a neuronal cell model
    • Roscic A, Baldo B, Crochemore C, Marcellin D, Paganetti P (2011) Induction of autophagy with catalytic mTOR inhibitors reduces huntingtin aggregates in a neuronal cell model. J Neurochem 119: 398-407.
    • (2011) J Neurochem , vol.119 , pp. 398-407
    • Roscic, A.1    Baldo, B.2    Crochemore, C.3    Marcellin, D.4    Paganetti, P.5
  • 40
    • 49349090155 scopus 로고    scopus 로고
    • Huntington's disease: Degradation of mutant huntingtin by autophagy
    • Sarkar S, Rubinsztein DC (2008) Huntington's disease: degradation of mutant huntingtin by autophagy. The FEBS journal 275: 4263-4270.
    • (2008) The FEBS Journal , vol.275 , pp. 4263-4270
    • Sarkar, S.1    Rubinsztein, D.C.2
  • 42
    • 33644540193 scopus 로고    scopus 로고
    • Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway
    • Yamamoto A, Cremona ML, Rothman JE (2006) Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway. J Cell Biol 172: 719-731.
    • (2006) J Cell Biol , vol.172 , pp. 719-731
    • Yamamoto, A.1    Cremona, M.L.2    Rothman, J.E.3
  • 43
    • 78649704325 scopus 로고    scopus 로고
    • Autophagy and metabolism
    • Rabinowitz JD, White E (2010) Autophagy and metabolism. Science 330: 1344-1348.
    • (2010) Science , vol.330 , pp. 1344-1348
    • Rabinowitz, J.D.1    White, E.2
  • 44
    • 84856953003 scopus 로고    scopus 로고
    • Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation
    • Coupe B, Ishii Y, Dietrich MO, Komatsu M, Horvath TL, et al. (2012) Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation. Cell metabolism 15: 247-255.
    • (2012) Cell Metabolism , vol.15 , pp. 247-255
    • Coupe, B.1    Ishii, Y.2    Dietrich, M.O.3    Komatsu, M.4    Horvath, T.L.5
  • 45
    • 79960951346 scopus 로고    scopus 로고
    • Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance
    • Kaushik S, Rodriguez-Navarro JA, Arias E, Kiffin R, Sahu S, et al. (2011) Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance. Cell Metab 14: 173-183.
    • (2011) Cell Metab , vol.14 , pp. 173-183
    • Kaushik, S.1    Rodriguez-Navarro, J.A.2    Arias, E.3    Kiffin, R.4    Sahu, S.5
  • 46
    • 80052712323 scopus 로고    scopus 로고
    • Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway
    • Meng Q, Cai D (2011) Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway. The Journal of biological chemistry 286: 32324-32332.
    • (2011) The Journal of Biological Chemistry , vol.286 , pp. 32324-32332
    • Meng, Q.1    Cai, D.2
  • 47
    • 84859416906 scopus 로고    scopus 로고
    • Role of hypothalamic proopiomelanocortin neuron autophagy in the control of appetite and leptin response
    • Quan W, Kim HK, Moon EY, Kim SS, Choi CS, et al. (2012) Role of hypothalamic proopiomelanocortin neuron autophagy in the control of appetite and leptin response. Endocrinology 153: 1817-1826.
    • (2012) Endocrinology , vol.153 , pp. 1817-1826
    • Quan, W.1    Kim, H.K.2    Moon, E.Y.3    Kim, S.S.4    Choi, C.S.5
  • 49
    • 0035710746 scopus 로고    scopus 로고
    • -DeltaDeltaCT method
    • DOI 10.1006/meth.2001.1262
    • Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408. (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 50
    • 44949231424 scopus 로고    scopus 로고
    • T method
    • DOI 10.1038/nprot.2008.73, PII NPROT.2008.73
    • Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative C(T) method. Nature protocols 3: 1101-1108. (Pubitemid 351818697)
    • (2008) Nature Protocols , vol.3 , Issue.6 , pp. 1101-1108
    • Schmittgen, T.D.1    Livak, K.J.2
  • 52
    • 33749042331 scopus 로고    scopus 로고
    • Transcriptional Repression of PGC-1alpha by Mutant Huntingtin Leads to Mitochondrial Dysfunction and Neurodegeneration
    • DOI 10.1016/j.cell.2006.09.015, PII S0092867406012050
    • Cui L, Jeong H, Borovecki F, Parkhurst CN, Tanese N, et al. (2006) Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration. Cell 127: 59-69. (Pubitemid 44466642)
    • (2006) Cell , vol.127 , Issue.1 , pp. 59-69
    • Cui, L.1    Jeong, H.2    Borovecki, F.3    Parkhurst, C.N.4    Tanese, N.5    Krainc, D.6
  • 54
    • 12744279625 scopus 로고    scopus 로고
    • Transcriptional dysregulation in striatal projection- and interneurons in a mouse model of Huntington's disease: Neuronal selectivity and potential neuroprotective role of HAP1
    • Zucker B, Luthi-Carter R, Kama JA, Dunah AW, Stern EA, et al. (2005) Transcriptional dysregulation in striatal projection- and interneurons in a mouse model of Huntington's disease: neuronal selectivity and potential neuroprotective role of HAP1. Human molecular genetics 14: 179-189.
    • (2005) Human Molecular Genetics , vol.14 , pp. 179-189
    • Zucker, B.1    Luthi-Carter, R.2    Kama, J.A.3    Dunah, A.W.4    Stern, E.A.5
  • 55
    • 0037101835 scopus 로고    scopus 로고
    • Dysregulation of gene expression in the R6/2 model of polyglutamine disease: Parallel changes in muscle and brain
    • Luthi-Carter R, Hanson SA, Strand AD, Bergstrom DA, Chun W, et al. (2002) Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain. Human molecular genetics 11: 1911-1926.
    • (2002) Human Molecular Genetics , vol.11 , pp. 1911-1926
    • Luthi-Carter, R.1    Hanson, S.A.2    Strand, A.D.3    Bergstrom, D.A.4    Chun, W.5
  • 58
    • 79952033383 scopus 로고    scopus 로고
    • In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons
    • Thomas EA, Coppola G, Tang B, Kuhn A, Kim S, et al. (2011) In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons. Human molecular genetics 20: 1049-1060.
    • (2011) Human Molecular Genetics , vol.20 , pp. 1049-1060
    • Thomas, E.A.1    Coppola, G.2    Tang, B.3    Kuhn, A.4    Kim, S.5
  • 61
    • 35348886043 scopus 로고    scopus 로고
    • Physiological functions of Atg6/Beclin 1: A unique autophagy-related protein
    • DOI 10.1038/cr.2007.78, PII CR200778
    • Cao Y, Klionsky DJ (2007) Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein. Cell research 17: 839-849. (Pubitemid 47585112)
    • (2007) Cell Research , vol.17 , Issue.10 , pp. 839-849
    • Cao, Y.1    Klionsky, D.J.2
  • 62
    • 79952355107 scopus 로고    scopus 로고
    • Selective autophagy mediated by autophagic adapter proteins
    • Johansen T, Lamark T (2011) Selective autophagy mediated by autophagic adapter proteins. Autophagy 7: 279-296.
    • (2011) Autophagy , vol.7 , pp. 279-296
    • Johansen, T.1    Lamark, T.2
  • 66
    • 79957916551 scopus 로고    scopus 로고
    • p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects
    • Bartlett BJ, Isakson P, Lewerenz J, Sanchez H, Kotzebue RW, et al. (2011) p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects. Autophagy 7: 572-583.
    • (2011) Autophagy , vol.7 , pp. 572-583
    • Bartlett, B.J.1    Isakson, P.2    Lewerenz, J.3    Sanchez, H.4    Kotzebue, R.W.5
  • 67
    • 84873569630 scopus 로고    scopus 로고
    • Brain region- and age-dependent dysregulation of p62 and NBR1 in a mouse model of Huntington's disease
    • Rue L, Lopez-Soop G, Gelpi E, Martinez-Vicente M, Alberch J, et al. (2013) Brain region- and age-dependent dysregulation of p62 and NBR1 in a mouse model of Huntington's disease. Neurobiol Dis 52: 219-228.
    • (2013) Neurobiol Dis , vol.52 , pp. 219-228
    • Rue, L.1    Lopez-Soop, G.2    Gelpi, E.3    Martinez-Vicente, M.4    Alberch, J.5
  • 68
    • 77953499072 scopus 로고    scopus 로고
    • Mutant huntingtin fragment selectively suppresses Brn-2 POU domain transcription factor to mediate hypothalamic cell dysfunction
    • Yamanaka T, Tosaki A, Miyazaki H, Kurosawa M, Furukawa Y, et al. (2010) Mutant huntingtin fragment selectively suppresses Brn-2 POU domain transcription factor to mediate hypothalamic cell dysfunction. Human molecular genetics 19: 2099-2112.
    • (2010) Human Molecular Genetics , vol.19 , pp. 2099-2112
    • Yamanaka, T.1    Tosaki, A.2    Miyazaki, H.3    Kurosawa, M.4    Furukawa, Y.5
  • 69
    • 0025885733 scopus 로고
    • Neuronal loss in layers V and VI of cerebral cortex in Huntington's disease
    • Hedreen JC, Peyser CE, Folstein SE, Ross CA (1991) Neuronal loss in layers V and VI of cerebral cortex in Huntington's disease. Neuroscience letters 133: 257-261.
    • (1991) Neuroscience Letters , vol.133 , pp. 257-261
    • Hedreen, J.C.1    Peyser, C.E.2    Folstein, S.E.3    Ross, C.A.4
  • 71
    • 84860483495 scopus 로고    scopus 로고
    • Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice
    • Pouladi MA, Stanek LM, Xie Y, Franciosi S, Southwell AL, et al. (2012) Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice. Hum Mol Genet 21: 2219-2232.
    • (2012) Hum Mol Genet , vol.21 , pp. 2219-2232
    • Pouladi, M.A.1    Stanek, L.M.2    Xie, Y.3    Franciosi, S.4    Southwell, A.L.5
  • 73
    • 2942625910 scopus 로고    scopus 로고
    • Differential loss of striatal projection systems in Huntington's disease: A quantitative immunohistochemical study
    • DOI 10.1016/j.jchemneu.2004.02.005, PII S0891061804000286
    • Deng YP, Albin RL, Penney JB, Young AB, Anderson KD, et al. (2004) Differential loss of striatal projection systems in Huntington's disease: a quantitative immunohistochemical study. Journal of chemical neuroanatomy 27: 143-164. (Pubitemid 38739355)
    • (2004) Journal of Chemical Neuroanatomy , vol.27 , Issue.3 , pp. 143-164
    • Deng, Y.P.1    Albin, R.L.2    Penney, J.B.3    Young, A.B.4    Anderson, K.D.5    Reiner, A.6
  • 74
    • 27744599679 scopus 로고    scopus 로고
    • A proposed hypothalamic-thalamic-striatal axis for the integration of energy balance, arousal, and food reward
    • DOI 10.1002/cne.20769
    • Kelley AE, Baldo BA, Pratt WE (2005) A proposed hypothalamic- thalamicstriatal axis for the integration of energy balance, arousal, and food reward. The Journal of comparative neurology 493: 72-85. (Pubitemid 41636189)
    • (2005) Journal of Comparative Neurology , vol.493 , Issue.1 , pp. 72-85
    • Kelley, A.E.1    Baldo, B.A.2    Pratt, W.E.3
  • 75
    • 28444442694 scopus 로고    scopus 로고
    • Corticostriatal-hypothalamic circuitry and food motivation: Integration of energy, action and reward
    • DOI 10.1016/j.physbeh.2005.08.066, PII S0031938405004051
    • Kelley AE, Baldo BA, Pratt WE, Will MJ (2005) Corticostriatal- hypothalamic circuitry and food motivation: integration of energy, action and reward. Physiology & behavior 86: 773-795. (Pubitemid 41728993)
    • (2005) Physiology and Behavior , vol.86 , Issue.5 , pp. 773-795
    • Kelley, A.E.1    Baldo, B.A.2    Pratt, W.E.3    Will, M.J.4
  • 76
    • 84879950983 scopus 로고    scopus 로고
    • Monitoring autophagy in the treatment of protein aggregate diseases: Steps toward identifying autophagic biomarkers
    • Weihl CC (2013) Monitoring autophagy in the treatment of protein aggregate diseases: steps toward identifying autophagic biomarkers. Neurotherapeutics 10: 383-390.
    • (2013) Neurotherapeutics , vol.10 , pp. 383-390
    • Weihl, C.C.1
  • 77
    • 84855544817 scopus 로고    scopus 로고
    • Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets
    • Jiang M, Wang J, Fu J, Du L, Jeong H, et al. (2012) Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets. Nature medicine 18: 153-158.
    • (2012) Nature Medicine , vol.18 , pp. 153-158
    • Jiang, M.1    Wang, J.2    Fu, J.3    Du, L.4    Jeong, H.5
  • 78
    • 84873323723 scopus 로고    scopus 로고
    • Vesicular glycolysis provides on-board energy for fast axonal transport
    • Zala D, Hinckelmann MV, Yu H, Lyra da Cunha MM, Liot G, et al. (2013) Vesicular glycolysis provides on-board energy for fast axonal transport. Cell 152: 479-491.
    • (2013) Cell , vol.152 , pp. 479-491
    • Zala, D.1    Hinckelmann, M.V.2    Yu, H.3    Lyra Da Cunha, M.M.4    Liot, G.5
  • 80
    • 1242338792 scopus 로고    scopus 로고
    • Assessment of the Nutrition Status of Patients With Huntington's Disease
    • DOI 10.1016/j.nut.2003.10.007
    • Trejo A, Tarrats RM, Alonso ME, Boll MC, Ochoa A, et al. (2004) Assessment of the nutrition status of patients with Huntington's disease. Nutrition 20: 192-196. (Pubitemid 38220981)
    • (2004) Nutrition , vol.20 , Issue.2 , pp. 192-196
    • Trejo, A.1    Tarrats, R.M.2    Alonso, M..E.3    Boll, M.-C.4    Ochoa, A.5    Velasquez, L.6
  • 81
    • 0021927818 scopus 로고
    • Diabetes mellitus in Huntington disease
    • Farrer LA (1985) Diabetes mellitus in Huntington disease. Clinical genetics 27: 62-67.
    • (1985) Clinical Genetics , vol.27 , pp. 62-67
    • Farrer, L.A.1
  • 84
    • 84893413950 scopus 로고    scopus 로고
    • Autophagy in the control of food intake
    • Singh R (2012) Autophagy in the control of food intake. Adipocyte 1: 75-79.
    • (2012) Adipocyte , vol.1 , pp. 75-79
    • Singh, R.1
  • 85
    • 33646800306 scopus 로고    scopus 로고
    • Loss of autophagy in the central nervous system causes neurodegeneration in mice
    • Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, et al. (2006) Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441: 880-884.
    • (2006) Nature , vol.441 , pp. 880-884
    • Komatsu, M.1    Waguri, S.2    Chiba, T.3    Murata, S.4    Iwata, J.5
  • 86
    • 33847652900 scopus 로고    scopus 로고
    • Autophagy and neurodegeneration: When the cleaning crew goes on strike
    • DOI 10.1016/S1474-4422(07)70076-5, PII S1474442207700765
    • Martinez-Vicente M, Cuervo AM (2007) Autophagy and neurodegeneration: when the cleaning crew goes on strike. Lancet Neurol 6: 352-361. (Pubitemid 46367949)
    • (2007) Lancet Neurology , vol.6 , Issue.4 , pp. 352-361
    • Martinez-Vicente, M.1    Cuervo, A.M.2
  • 87
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • DOI 10.1038/nature06639, PII NATURE06639
    • Mizushima N, Levine B, Cuervo AM, Klionsky DJ (2008) Autophagy fights disease through cellular self-digestion. Nature 451: 1069-1075. (Pubitemid 351317450)
    • (2008) Nature , vol.451 , Issue.7182 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 89
    • 84879942257 scopus 로고    scopus 로고
    • Atg4b-Dependent Autophagic Flux Alleviates Huntington's Disease Progression
    • Proenca CC, Stoehr N, Bernhard M, Seger S, Genoud C, et al. (2013) Atg4b-Dependent Autophagic Flux Alleviates Huntington's Disease Progression. PloS one 8: e68357.
    • (2013) PloS One , vol.8
    • Proenca, C.C.1    Stoehr, N.2    Bernhard, M.3    Seger, S.4    Genoud, C.5
  • 90
    • 37849042536 scopus 로고    scopus 로고
    • A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin
    • Sarkar S, Krishna G, Imarisio S, Saiki S, O'Kane CJ, et al. (2008) A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin. Human molecular genetics 17: 170-178.
    • (2008) Human Molecular Genetics , vol.17 , pp. 170-178
    • Sarkar, S.1    Krishna, G.2    Imarisio, S.3    Saiki, S.4    O'Kane, C.J.5
  • 92
    • 57649227693 scopus 로고    scopus 로고
    • Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies
    • Sarkar S, Ravikumar B, Floto RA, Rubinsztein DC (2009) Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine- expanded huntingtin and related proteinopathies. Cell Death Differ 16: 46-56.
    • (2009) Cell Death Differ , vol.16 , pp. 46-56
    • Sarkar, S.1    Ravikumar, B.2    Floto, R.A.3    Rubinsztein, D.C.4
  • 93
    • 34250864795 scopus 로고    scopus 로고
    • Protein turnover via autophagy: Implications for metabolism
    • DOI 10.1146/annurev.nutr.27.061406.093749
    • Mizushima N, Klionsky DJ (2007) Protein turnover via autophagy: implications for metabolism. Annual review of nutrition 27: 19-40. (Pubitemid 351373346)
    • (2007) Annual Review of Nutrition , vol.27 , pp. 19-40
    • Mizushima, N.1    Klionsky, D.J.2
  • 97
    • 77957565855 scopus 로고    scopus 로고
    • Age at onset in Huntington's disease is modified by the autophagy pathway: Implication of the V471A polymorphism in Atg7
    • Metzger S, Saukko M, Van Che H, Tong L, Puder Y, et al. (2010) Age at onset in Huntington's disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7. Hum Genet 128: 453-459.
    • (2010) Hum Genet , vol.128 , pp. 453-459
    • Metzger, S.1    Saukko, M.2    Van Che, H.3    Tong, L.4    Puder, Y.5
  • 99
    • 84862547657 scopus 로고    scopus 로고
    • The regulation of Nterminal Huntingtin (Htt552) accumulation by Beclin1
    • Wu JC, Qi L, Wang Y, Kegel KB, Yoder J, et al. (2012) The regulation of Nterminal Huntingtin (Htt552) accumulation by Beclin1. Acta pharmacologica Sinica 33: 743-751.
    • (2012) Acta Pharmacologica Sinica , vol.33 , pp. 743-751
    • Wu, J.C.1    Qi, L.2    Wang, Y.3    Kegel, K.B.4    Yoder, J.5
  • 100
    • 79951578639 scopus 로고    scopus 로고
    • Chaperone-mediated autophagy dysfunction in the pathogenesis of neurodegeneration
    • Koga H, Cuervo AM (2011) Chaperone-mediated autophagy dysfunction in the pathogenesis of neurodegeneration. Neurobiology of disease 43: 29-37.
    • (2011) Neurobiology of Disease , vol.43 , pp. 29-37
    • Koga, H.1    Cuervo, A.M.2
  • 103
    • 84870890695 scopus 로고    scopus 로고
    • Expression of Mutant Huntingtin in Leptin Receptor-Expressing Neurons Does Not Control the Metabolic and Psychiatric Phenotype of the BACHD Mouse
    • Lundh SH, Soylu R, Petersen A (2012) Expression of Mutant Huntingtin in Leptin Receptor-Expressing Neurons Does Not Control the Metabolic and Psychiatric Phenotype of the BACHD Mouse. PLoS One 7: e51168.
    • (2012) PLoS One , vol.7
    • Lundh, S.H.1    Soylu, R.2    Petersen, A.3
  • 106
    • 84869210001 scopus 로고    scopus 로고
    • Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation
    • Romanov J, Walczak M, Ibiricu I, Schuchner S, Ogris E, et al. (2012) Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation. The EMBO journal 31: 4304-4317.
    • (2012) The EMBO Journal , vol.31 , pp. 4304-4317
    • Romanov, J.1    Walczak, M.2    Ibiricu, I.3    Schuchner, S.4    Ogris, E.5
  • 108
    • 67650517556 scopus 로고    scopus 로고
    • NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets
    • Lamark T, Kirkin V, Dikic I, Johansen T (2009) NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets. Cell cycle 8: 1986-1990.
    • (2009) Cell Cycle , vol.8 , pp. 1986-1990
    • Lamark, T.1    Kirkin, V.2    Dikic, I.3    Johansen, T.4
  • 109
    • 67650234499 scopus 로고    scopus 로고
    • NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets
    • Kirkin V, Lamark T, Johansen T, Dikic I (2009) NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets. Autophagy 5: 732-733.
    • (2009) Autophagy , vol.5 , pp. 732-733
    • Kirkin, V.1    Lamark, T.2    Johansen, T.3    Dikic, I.4
  • 110
    • 79954422997 scopus 로고    scopus 로고
    • Chaperone-mediated autophagy in protein quality control
    • Arias E, Cuervo AM (2011) Chaperone-mediated autophagy in protein quality control. Current opinion in cell biology 23: 184-189.
    • (2011) Current Opinion in Cell Biology , vol.23 , pp. 184-189
    • Arias, E.1    Cuervo, A.M.2
  • 112
    • 77952007543 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR): Conducting the cellular signaling symphony
    • Foster KG, Fingar DC (2010) Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony. The Journal of biological chemistry 285: 14071-14077.
    • (2010) The Journal of Biological Chemistry , vol.285 , pp. 14071-14077
    • Foster, K.G.1    Fingar, D.C.2
  • 114
    • 62749096589 scopus 로고    scopus 로고
    • Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms
    • Dunlop EA, Tee AR (2009) Mammalian target of rapamycin complex 1: signalling inputs, substrates and feedback mechanisms. Cellular signalling 21: 827-835.
    • (2009) Cellular Signalling , vol.21 , pp. 827-835
    • Dunlop, E.A.1    Tee, A.R.2


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