Early glial activation, synaptic changes and axonal pathology in the thalamocortical system of Niemann-Pick type C1 mice

Neurobiology of Disease

Volumn 45, Issue 3, 2012, Pages 1086-1100

  Pressey, Sarah N R ^a,c   Smith, David A ^b   Wong, Andrew M S ^a   Platt, Frances M ^b   Cooper, Jonathan D ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Astrocytes; Axonal spheroids; Cortex; Microglia; Neurodegeneration; Neuropathology; Niemann Pick type C; Synapse; Thalamus

Indexed keywords

CD68 ANTIGEN; CHOLESTEROL; GLIAL FIBRILLARY ACIDIC PROTEIN; GLYCOSPHINGOLIPID; SYNAPTOBREVIN 2; SYNAPTOSOMAL ASSOCIATED PROTEIN 25;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; BRAIN REGION; CONTROLLED STUDY; DISEASE COURSE; GLIOSIS; IMMUNOREACTIVITY; MARKER GENE; MICROGLIAL ACTIVATION; MOUSE; NERVE CELL PLASTICITY; NERVE DEGENERATION; NERVE FIBER; NERVE STIMULATION; NEUROPATHOLOGY; NIEMANN PICK DISEASE; NONHUMAN; NPC1 GENE; PRIORITY JOURNAL; PROTEIN AGGREGATION; SYNAPTIC TRANSMISSION; THALAMOCORTICAL TRACT; THALAMUS; WHITE MATTER;

AGE FACTORS; ANALYSIS OF VARIANCE; ANIMALS; ANTIGENS, CD; AXONS; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; GENE EXPRESSION REGULATION; GLUTAMATE DECARBOXYLASE; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; NEURAL PATHWAYS; NEUROGLIA; NEURONS; NIEMANN-PICK DISEASES; PROTEINS; R-SNARE PROTEINS; SYNAPSES; THALAMUS;

EID: 84856583715     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2011.12.027     Document Type: Article

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