메뉴 건너뛰기




Volumn 69, Issue , 2014, Pages 553-580

New directions in nicotine vaccine design and use

Author keywords

Addiction; Immunogen; Immunotherapy; Nicotine; Vaccine

Indexed keywords

ANTIGEN; CARRIER PROTEIN; HAPTEN; IMMUNOLOGICAL ADJUVANT; LIPOSOME; NANOPARTICLE; NICOTINE; NICOTINE VACCINE; PHOSPHORYL LIPID A;

EID: 84893176616     PISSN: 10543589     EISSN: 15578925     Source Type: Book Series    
DOI: 10.1016/B978-0-12-420118-7.00014-7     Document Type: Chapter
Times cited : (79)

References (85)
  • 1
    • 0003448477 scopus 로고
    • Anon, U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Office on Smoking and Health, Atlanta, GA
    • Anon The health consequences of smoking: Nicotine addiction, a report of the Surgeon General 1988, U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Office on Smoking and Health, Atlanta, GA.
    • (1988) The health consequences of smoking: Nicotine addiction, a report of the Surgeon General
  • 2
    • 19444372381 scopus 로고    scopus 로고
    • Trial watch: Xenova's TA-NIC vaccine shows promise
    • Anon
    • Anon Trial watch: Xenova's TA-NIC vaccine shows promise. Expert Review of Vaccines 2004, 3:386.
    • (2004) Expert Review of Vaccines , vol.3 , pp. 386
  • 5
    • 84871031431 scopus 로고    scopus 로고
    • Investigating the effects of a hydrolytically stable hapten and a Th1 adjuvant on heroin vaccine performance
    • Bremer P.T., Janda K.D. Investigating the effects of a hydrolytically stable hapten and a Th1 adjuvant on heroin vaccine performance. Journal of Medicinal Chemistry 2012, 55:10776-10780.
    • (2012) Journal of Medicinal Chemistry , vol.55 , pp. 10776-10780
    • Bremer, P.T.1    Janda, K.D.2
  • 6
    • 84875130963 scopus 로고    scopus 로고
    • Prospects, promise and problems on the road to effective vaccines and related therapies for substance abuse
    • Brimijoin S., Shen X., Orson F., Kosten T. Prospects, promise and problems on the road to effective vaccines and related therapies for substance abuse. Expert Review of Vaccines 2013, 12:323-332.
    • (2013) Expert Review of Vaccines , vol.12 , pp. 323-332
    • Brimijoin, S.1    Shen, X.2    Orson, F.3    Kosten, T.4
  • 9
    • 34547916473 scopus 로고    scopus 로고
    • Acetaldehyde, a major constituent of tobacco smoke, enhances behavioral, endocrine, and neuronal responses to nicotine in adolescent and adult rats
    • Cao J., Belluzzi J.D., Loughlin S.E., Keyler D.E., Pentel P.R., Leslie F.M. Acetaldehyde, a major constituent of tobacco smoke, enhances behavioral, endocrine, and neuronal responses to nicotine in adolescent and adult rats. Neuropsychopharmacology 2007, 32:2025-2035.
    • (2007) Neuropsychopharmacology , vol.32 , pp. 2025-2035
    • Cao, J.1    Belluzzi, J.D.2    Loughlin, S.E.3    Keyler, D.E.4    Pentel, P.R.5    Leslie, F.M.6
  • 12
    • 84870506539 scopus 로고    scopus 로고
    • High immunogenicity of nicotine vaccines obtained by intradermal delivery with safe adjuvants
    • Chen X., Pravetoni M., Bhayana B., Pentel P.R., Wu M.X. High immunogenicity of nicotine vaccines obtained by intradermal delivery with safe adjuvants. Vaccine 2012, 31:159-164.
    • (2012) Vaccine , vol.31 , pp. 159-164
    • Chen, X.1    Pravetoni, M.2    Bhayana, B.3    Pentel, P.R.4    Wu, M.X.5
  • 13
    • 77954049160 scopus 로고    scopus 로고
    • The addition of five minor tobacco alkaloids increases nicotine-induced hyperactivity, sensitization and intravenous self-administration in rats
    • Clemens K.J., Caille S., Stinus L., Cador M. The addition of five minor tobacco alkaloids increases nicotine-induced hyperactivity, sensitization and intravenous self-administration in rats. The International Journal of Neuropsychopharmacology 2009, 12:1355-1366.
    • (2009) The International Journal of Neuropsychopharmacology , vol.12 , pp. 1355-1366
    • Clemens, K.J.1    Caille, S.2    Stinus, L.3    Cador, M.4
  • 15
    • 80054979538 scopus 로고    scopus 로고
    • Combined active and passive immunization against nicotine: Minimizing monoclonal antibody requirements using a target antibody concentration strategy
    • Cornish K.E., Harris A.C., LeSage M.G., Keyler D.E., Burroughs D., Earley C., et al. Combined active and passive immunization against nicotine: Minimizing monoclonal antibody requirements using a target antibody concentration strategy. International Immunopharmacology 2011, 11:1809-1815.
    • (2011) International Immunopharmacology , vol.11 , pp. 1809-1815
    • Cornish, K.E.1    Harris, A.C.2    LeSage, M.G.3    Keyler, D.E.4    Burroughs, D.5    Earley, C.6
  • 17
    • 79952559384 scopus 로고    scopus 로고
    • Decreased serum antibody responses to recombinant pneumocystis antigens in HIV-infected and uninfected current smokers
    • Crothers K., Daly K.R., Rimland D., Goetz M.B., Gibert C.L., Butt A.A., et al. Decreased serum antibody responses to recombinant pneumocystis antigens in HIV-infected and uninfected current smokers. Clinical and Vaccine Immunology 2011, 18:380-386.
    • (2011) Clinical and Vaccine Immunology , vol.18 , pp. 380-386
    • Crothers, K.1    Daly, K.R.2    Rimland, D.3    Goetz, M.B.4    Gibert, C.L.5    Butt, A.A.6
  • 19
    • 84872773039 scopus 로고    scopus 로고
    • Disrupted adenovirus-based vaccines against small addictive molecules circumvent anti-adenovirus immunity
    • De B.P., Pagovich O.E., Hicks M.J., Rosenberg J.B., Moreno A.Y., Janda K.D., et al. Disrupted adenovirus-based vaccines against small addictive molecules circumvent anti-adenovirus immunity. Human Gene Therapy 2013, 24:58-66.
    • (2013) Human Gene Therapy , vol.24 , pp. 58-66
    • De, B.P.1    Pagovich, O.E.2    Hicks, M.J.3    Rosenberg, J.B.4    Moreno, A.Y.5    Janda, K.D.6
  • 20
    • 84888433718 scopus 로고    scopus 로고
    • Increased efficacy of a trivalent nicotine vaccine compared to a dose-matched monovalent vaccine when formulated with alum
    • de Villiers S.H., Cornish K.E., Troska A.J., Pravetoni M., Pentel P.R. Increased efficacy of a trivalent nicotine vaccine compared to a dose-matched monovalent vaccine when formulated with alum. Vaccine 2013, 31:6185-6193.
    • (2013) Vaccine , vol.31 , pp. 6185-6193
    • de Villiers, S.H.1    Cornish, K.E.2    Troska, A.J.3    Pravetoni, M.4    Pentel, P.R.5
  • 21
    • 77049121986 scopus 로고    scopus 로고
    • Nicotine hapten structure, antibody selectivity and effect relationships: Results from a nicotine vaccine screening procedure
    • de Villiers S.H., Lindblom N., Kalayanov G., Gordon S., Baraznenok I., Malmerfelt A., et al. Nicotine hapten structure, antibody selectivity and effect relationships: Results from a nicotine vaccine screening procedure. Vaccine 2010, 28:2161-2168.
    • (2010) Vaccine , vol.28 , pp. 2161-2168
    • de Villiers, S.H.1    Lindblom, N.2    Kalayanov, G.3    Gordon, S.4    Baraznenok, I.5    Malmerfelt, A.6
  • 22
    • 84878230641 scopus 로고    scopus 로고
    • Effect of a nicotine vaccine on nicotine binding to beta2*-nicotinic acetylcholine receptors in vivo in human tobacco smokers
    • Esterlis I., Hannestad J.O., Perkins E., Bois F., D'Souza D.C., Tyndale R.F., et al. Effect of a nicotine vaccine on nicotine binding to beta2*-nicotinic acetylcholine receptors in vivo in human tobacco smokers. The American Journal of Psychiatry 2013, 170:399-407.
    • (2013) The American Journal of Psychiatry , vol.170 , pp. 399-407
    • Esterlis, I.1    Hannestad, J.O.2    Perkins, E.3    Bois, F.4    D'Souza, D.C.5    Tyndale, R.F.6
  • 27
    • 33646097912 scopus 로고    scopus 로고
    • Safety and efficiency of an anti-(+)-methamphetamine monoclonal antibody in the protection against cardiovascular and central nervous system effects of (+)-methamphetamine in rats
    • Gentry W.B., Laurenzana E.M., Williams D.K., West J.R., Berg R.J., Terlea T., et al. Safety and efficiency of an anti-(+)-methamphetamine monoclonal antibody in the protection against cardiovascular and central nervous system effects of (+)-methamphetamine in rats. International Immunopharmacology 2006, 6:968-977.
    • (2006) International Immunopharmacology , vol.6 , pp. 968-977
    • Gentry, W.B.1    Laurenzana, E.M.2    Williams, D.K.3    West, J.R.4    Berg, R.J.5    Terlea, T.6
  • 29
    • 79954620578 scopus 로고    scopus 로고
    • DNA origami with complex curvatures in three-dimensional space
    • Han D., Pal S., Nangreave J., Deng Z., Liu Y., Yan H. DNA origami with complex curvatures in three-dimensional space. Science 2011, 332:342-346.
    • (2011) Science , vol.332 , pp. 342-346
    • Han, D.1    Pal, S.2    Nangreave, J.3    Deng, Z.4    Liu, Y.5    Yan, H.6
  • 35
    • 0033859862 scopus 로고    scopus 로고
    • Vaccination against nicotine during continued nicotine administration in rats: Immunogenicity of the vaccine and effects on nicotine distribution to brain
    • Hieda Y., Keyler D.E., Ennifar S., Fattom A., Pentel P.R. Vaccination against nicotine during continued nicotine administration in rats: Immunogenicity of the vaccine and effects on nicotine distribution to brain. International Journal of Immunopharmacology 2000, 22:809-819.
    • (2000) International Journal of Immunopharmacology , vol.22 , pp. 809-819
    • Hieda, Y.1    Keyler, D.E.2    Ennifar, S.3    Fattom, A.4    Pentel, P.R.5
  • 36
    • 84870462302 scopus 로고    scopus 로고
    • The efficacy and safety of a nicotine conjugate vaccine (NicVAX(R)) or placebo co-administered with varenicline (Champix(R)) for smoking cessation: Study protocol of a phase IIb, double blind, randomized, placebo controlled trial
    • Hoogsteder P.H., Kotz D., van Spiegel P.I., Viechtbauer W., Brauer R., Kessler P.D., et al. The efficacy and safety of a nicotine conjugate vaccine (NicVAX(R)) or placebo co-administered with varenicline (Champix(R)) for smoking cessation: Study protocol of a phase IIb, double blind, randomized, placebo controlled trial. BMC Public Health 2012, 12:1052.
    • (2012) BMC Public Health , vol.12 , pp. 1052
    • Hoogsteder, P.H.1    Kotz, D.2    van Spiegel, P.I.3    Viechtbauer, W.4    Brauer, R.5    Kessler, P.D.6
  • 37
    • 0035874752 scopus 로고    scopus 로고
    • An immunotherapeutic program for the treatment of nicotine addiction: Hapten design and synthesis
    • Isomura S., Wirsching P., Janda K.D. An immunotherapeutic program for the treatment of nicotine addiction: Hapten design and synthesis. Journal of Organic Chemistry 2001, 66:4115-4121.
    • (2001) Journal of Organic Chemistry , vol.66 , pp. 4115-4121
    • Isomura, S.1    Wirsching, P.2    Janda, K.D.3
  • 38
    • 79952173864 scopus 로고    scopus 로고
    • Programming the magnitude and persistence of antibody responses with innate immunity
    • Kasturi S.P., Skountzou I., Albrecht R.A., Koutsonanos D., Hua T., Nakaya H.I., et al. Programming the magnitude and persistence of antibody responses with innate immunity. Nature 2011, 470:543-547.
    • (2011) Nature , vol.470 , pp. 543-547
    • Kasturi, S.P.1    Skountzou, I.2    Albrecht, R.A.3    Koutsonanos, D.4    Hua, T.5    Nakaya, H.I.6
  • 39
    • 22344435723 scopus 로고    scopus 로고
    • Monoclonal nicotine-specific antibodies reduce nicotine distribution to brain in rats: Dose- and affinity-response relationships
    • Keyler D.E., Roiko S.A., Benlhabib E., LeSage M.G., St Peter J.V., Stewart S., et al. Monoclonal nicotine-specific antibodies reduce nicotine distribution to brain in rats: Dose- and affinity-response relationships. Drug Metabolism and Disposition 2005, 33:1056-1061.
    • (2005) Drug Metabolism and Disposition , vol.33 , pp. 1056-1061
    • Keyler, D.E.1    Roiko, S.A.2    Benlhabib, E.3    LeSage, M.G.4    St Peter, J.V.5    Stewart, S.6
  • 42
    • 61749101130 scopus 로고    scopus 로고
    • CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases
    • Klinman D.M., Klaschik S., Sato T., Tross D. CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases. Advanced Drug Delivery Reviews 2009, 61:248-255.
    • (2009) Advanced Drug Delivery Reviews , vol.61 , pp. 248-255
    • Klinman, D.M.1    Klaschik, S.2    Sato, T.3    Tross, D.4
  • 46
    • 0344944249 scopus 로고    scopus 로고
    • Effects of continuous nicotine infusion on nicotine self-administration in rats: Relationship between continuously infused and self-administered nicotine doses and serum concentrations
    • LeSage M.G., Keyler D.E., Collins G., Pentel P.R. Effects of continuous nicotine infusion on nicotine self-administration in rats: Relationship between continuously infused and self-administered nicotine doses and serum concentrations. Psychopharmacology 2003, 170:278-286.
    • (2003) Psychopharmacology , vol.170 , pp. 278-286
    • LeSage, M.G.1    Keyler, D.E.2    Collins, G.3    Pentel, P.R.4
  • 47
    • 32844473670 scopus 로고    scopus 로고
    • Effects of a nicotine conjugate vaccine on the acquisition and maintenance of nicotine self-administration in rats
    • LeSage M.G., Keyler D.E., Hieda Y., Collins G., Burroughs D., Le C., et al. Effects of a nicotine conjugate vaccine on the acquisition and maintenance of nicotine self-administration in rats. Psychopharmacology 2006, 184:409-416.
    • (2006) Psychopharmacology , vol.184 , pp. 409-416
    • LeSage, M.G.1    Keyler, D.E.2    Hieda, Y.3    Collins, G.4    Burroughs, D.5    Le, C.6
  • 48
    • 33644801063 scopus 로고    scopus 로고
    • Current status of immunologic approaches to treating tobacco dependence: Vaccines and nicotine-specific antibodies
    • LeSage M.G., Keyler D.E., Pentel P.R. Current status of immunologic approaches to treating tobacco dependence: Vaccines and nicotine-specific antibodies. The AAPS Journal 2006, 8:E65-E75.
    • (2006) The AAPS Journal , vol.8
    • LeSage, M.G.1    Keyler, D.E.2    Pentel, P.R.3
  • 49
    • 84860335932 scopus 로고    scopus 로고
    • Enhanced attenuation of nicotine discrimination in rats by combining nicotine-specific antibodies with a nicotinic receptor antagonist
    • LeSage M.G., Shelley D., Pravetoni M., Pentel P.R. Enhanced attenuation of nicotine discrimination in rats by combining nicotine-specific antibodies with a nicotinic receptor antagonist. Pharmacology, Biochemistry, and Behavior 2012, 102:157-162.
    • (2012) Pharmacology, Biochemistry, and Behavior , vol.102 , pp. 157-162
    • LeSage, M.G.1    Shelley, D.2    Pravetoni, M.3    Pentel, P.R.4
  • 51
    • 27944446969 scopus 로고    scopus 로고
    • Active immunisation against nicotine blocks the reward facilitating effects of nicotine and partially prevents nicotine withdrawal in the rat as measured by dopamine output in the nucleus accumbens, brain reward thresholds and somatic signs
    • Lindblom N., de Villiers S.H., Semenova S., Kalayanov G., Gordon S., Schilstrom B., et al. Active immunisation against nicotine blocks the reward facilitating effects of nicotine and partially prevents nicotine withdrawal in the rat as measured by dopamine output in the nucleus accumbens, brain reward thresholds and somatic signs. Archives of Pharmacology 2005, 372:182-194.
    • (2005) Archives of Pharmacology , vol.372 , pp. 182-194
    • Lindblom, N.1    de Villiers, S.H.2    Semenova, S.3    Kalayanov, G.4    Gordon, S.5    Schilstrom, B.6
  • 52
    • 84864702099 scopus 로고    scopus 로고
    • A DNA nanostructure platform for directed assembly of synthetic vaccines
    • Liu X., Xu Y., Yu T., Clifford C., Liu Y., Yan H., et al. A DNA nanostructure platform for directed assembly of synthetic vaccines. Nano Letters 2012, 12:4254-4259.
    • (2012) Nano Letters , vol.12 , pp. 4254-4259
    • Liu, X.1    Xu, Y.2    Yu, T.3    Clifford, C.4    Liu, Y.5    Yan, H.6
  • 54
    • 84878417756 scopus 로고    scopus 로고
    • Liposomes containing monophosphoryl lipid A: A potent adjuvant system for inducing antibodies to heroin hapten analogs
    • Matyas G.R., Mayorov A.V., Rice K.C., Jacobson A.E., Cheng K., Iyer M.R., et al. Liposomes containing monophosphoryl lipid A: A potent adjuvant system for inducing antibodies to heroin hapten analogs. Vaccine 2013, 31:2804-2810.
    • (2013) Vaccine , vol.31 , pp. 2804-2810
    • Matyas, G.R.1    Mayorov, A.V.2    Rice, K.C.3    Jacobson, A.E.4    Cheng, K.5    Iyer, M.R.6
  • 55
    • 22544431937 scopus 로고    scopus 로고
    • A therapeutic vaccine for nicotine dependence: Preclinical efficacy, and Phase I safety and immunogenicity
    • Maurer P., Jennings G.T., Willers J., Rohner F., Lindman Y., Roubicek K., et al. A therapeutic vaccine for nicotine dependence: Preclinical efficacy, and Phase I safety and immunogenicity. European Journal of Immunology 2005, 35:2031-2040.
    • (2005) European Journal of Immunology , vol.35 , pp. 2031-2040
    • Maurer, P.1    Jennings, G.T.2    Willers, J.3    Rohner, F.4    Lindman, Y.5    Roubicek, K.6
  • 56
    • 84875968123 scopus 로고    scopus 로고
    • Enhancing immunogenicity of a 3'aminomethylnicotine-DT-conjugate anti-nicotine vaccine with CpG adjuvant in mice and non-human primates
    • McCluskie M.J., Pryde D.C., Gervais D.P., Stead D.R., Zhang N., Benoit M., et al. Enhancing immunogenicity of a 3'aminomethylnicotine-DT-conjugate anti-nicotine vaccine with CpG adjuvant in mice and non-human primates. International Immunopharmacology 2013, 16:50-56.
    • (2013) International Immunopharmacology , vol.16 , pp. 50-56
    • McCluskie, M.J.1    Pryde, D.C.2    Gervais, D.P.3    Stead, D.R.4    Zhang, N.5    Benoit, M.6
  • 59
    • 79954622209 scopus 로고    scopus 로고
    • Therapeutic in vivo gene transfer for genetic disease using AAV: Progress and challenges
    • Mingozzi F., High K.A. Therapeutic in vivo gene transfer for genetic disease using AAV: Progress and challenges. Nature Reviews. Genetics 2011, 12:341-355.
    • (2011) Nature Reviews. Genetics , vol.12 , pp. 341-355
    • Mingozzi, F.1    High, K.A.2
  • 60
    • 84867469601 scopus 로고    scopus 로고
    • Probing the protective effects of a conformationally constrained nicotine vaccine
    • Moreno A.Y., Azar M.R., Koob G.F., Janda K.D. Probing the protective effects of a conformationally constrained nicotine vaccine. Vaccine 2012, 30:6665-6670.
    • (2012) Vaccine , vol.30 , pp. 6665-6670
    • Moreno, A.Y.1    Azar, M.R.2    Koob, G.F.3    Janda, K.D.4
  • 63
    • 84874042611 scopus 로고    scopus 로고
    • Spontaneous development of IgM anti-cocaine antibodies in habitual cocaine users: Effect on IgG antibody responses to a cocaine cholera toxin B conjugate vaccine
    • Orson F.M., Rossen R.D., Shen X., Lopez A.Y., Wu Y., Kosten T.R. Spontaneous development of IgM anti-cocaine antibodies in habitual cocaine users: Effect on IgG antibody responses to a cocaine cholera toxin B conjugate vaccine. The American Journal on Addictions 2013, 22:169-174.
    • (2013) The American Journal on Addictions , vol.22 , pp. 169-174
    • Orson, F.M.1    Rossen, R.D.2    Shen, X.3    Lopez, A.Y.4    Wu, Y.5    Kosten, T.R.6
  • 64
    • 79952282195 scopus 로고    scopus 로고
    • Different B cell populations mediate early and late memory during an endogenous immune response
    • Pape K.A., Taylor J.J., Maul R.W., Gearhart P.J., Jenkins M.K. Different B cell populations mediate early and late memory during an endogenous immune response. Science 2011, 331:1203-1207.
    • (2011) Science , vol.331 , pp. 1203-1207
    • Pape, K.A.1    Taylor, J.J.2    Maul, R.W.3    Gearhart, P.J.4    Jenkins, M.K.5
  • 66
    • 33645890288 scopus 로고    scopus 로고
    • Differential effects of passive immunization with nicotine-specific antibodies on the acute and chronic distribution of nicotine to brain in rats
    • Pentel P.R., Dufek M.B., Roiko S.A., Lesage M.G., Keyler D.E. Differential effects of passive immunization with nicotine-specific antibodies on the acute and chronic distribution of nicotine to brain in rats. The Journal of Pharmacology and Experimental Therapeutics 2006, 317:660-666.
    • (2006) The Journal of Pharmacology and Experimental Therapeutics , vol.317 , pp. 660-666
    • Pentel, P.R.1    Dufek, M.B.2    Roiko, S.A.3    Lesage, M.G.4    Keyler, D.E.5
  • 67
    • 0033957739 scopus 로고    scopus 로고
    • A nicotine conjugate vaccine reduces nicotine distribution to brain and attenuates its behavioral and cardiovascular effects in rats
    • Pentel P.R., Malin D.H., Ennifar S., Hieda Y., Keyler D.E., Lake J.R., et al. A nicotine conjugate vaccine reduces nicotine distribution to brain and attenuates its behavioral and cardiovascular effects in rats. Pharmacology, Biochemistry, and Behavior 2000, 65:191-198.
    • (2000) Pharmacology, Biochemistry, and Behavior , vol.65 , pp. 191-198
    • Pentel, P.R.1    Malin, D.H.2    Ennifar, S.3    Hieda, Y.4    Keyler, D.E.5    Lake, J.R.6
  • 69
    • 79953687362 scopus 로고    scopus 로고
    • Vaccination against nicotine alters the distribution of nicotine delivered via cigarette smoke inhalation to rats
    • Pravetoni M., Keyler D.E., Raleigh M.D., Harris A.C., Lesage M.G., Mattson C.K., et al. Vaccination against nicotine alters the distribution of nicotine delivered via cigarette smoke inhalation to rats. Biochemical Pharmacology 2011, 81:1164-1170.
    • (2011) Biochemical Pharmacology , vol.81 , pp. 1164-1170
    • Pravetoni, M.1    Keyler, D.E.2    Raleigh, M.D.3    Harris, A.C.4    Lesage, M.G.5    Mattson, C.K.6
  • 70
    • 33747616656 scopus 로고    scopus 로고
    • Engineering of therapeutic antibodies to minimize immunogenicity and optimize function
    • Presta L.G. Engineering of therapeutic antibodies to minimize immunogenicity and optimize function. Advanced Drug Delivery Reviews 2006, 58:640-656.
    • (2006) Advanced Drug Delivery Reviews , vol.58 , pp. 640-656
    • Presta, L.G.1
  • 71
    • 84857269063 scopus 로고    scopus 로고
    • Nicotine vaccines to assist with smoking cessation: Current status of research
    • Raupach T., Hoogsteder P.H., Onno van Schayck C.P. Nicotine vaccines to assist with smoking cessation: Current status of research. Drugs 2012, 72:e1-e16.
    • (2012) Drugs , vol.72
    • Raupach, T.1    Hoogsteder, P.H.2    Onno van Schayck, C.P.3
  • 73
    • 67649271523 scopus 로고    scopus 로고
    • Passive immunization with a nicotine-specific monoclonal antibody decreases brain nicotine levels but does not precipitate withdrawal in nicotine-dependent rats
    • Roiko S.A., Harris A.C., LeSage M.G., Keyler D.E., Pentel P.R. Passive immunization with a nicotine-specific monoclonal antibody decreases brain nicotine levels but does not precipitate withdrawal in nicotine-dependent rats. Pharmacology, Biochemistry, and Behavior 2009, 93:105-111.
    • (2009) Pharmacology, Biochemistry, and Behavior , vol.93 , pp. 105-111
    • Roiko, S.A.1    Harris, A.C.2    LeSage, M.G.3    Keyler, D.E.4    Pentel, P.R.5
  • 74
    • 84864912959 scopus 로고    scopus 로고
    • The effect of smoking and alcohol consumption on markers of systemic inflammation, immunoglobulin levels and immune response following pneumococcal vaccination in patients with arthritis
    • Roseman C., Truedsson L., Kapetanovic M.C. The effect of smoking and alcohol consumption on markers of systemic inflammation, immunoglobulin levels and immune response following pneumococcal vaccination in patients with arthritis. Arthritis Research and Therapy 2012, 14:R170.
    • (2012) Arthritis Research and Therapy , vol.14
    • Roseman, C.1    Truedsson, L.2    Kapetanovic, M.C.3
  • 79
    • 77749245832 scopus 로고    scopus 로고
    • The controversial relationship between NLRP3, alum, danger signals and the next-generation adjuvants
    • Spreafico R., Ricciardi-Castagnoli P., Mortellaro A. The controversial relationship between NLRP3, alum, danger signals and the next-generation adjuvants. European Journal of Immunology 2010, 40:638-642.
    • (2010) European Journal of Immunology , vol.40 , pp. 638-642
    • Spreafico, R.1    Ricciardi-Castagnoli, P.2    Mortellaro, A.3
  • 80
    • 84869878749 scopus 로고    scopus 로고
    • Heterogeneity in the differentiation and function of memory B cells
    • Taylor J.J., Jenkins M.K., Pape K.A. Heterogeneity in the differentiation and function of memory B cells. Trends in Immunology 2012, 33:590-597.
    • (2012) Trends in Immunology , vol.33 , pp. 590-597
    • Taylor, J.J.1    Jenkins, M.K.2    Pape, K.A.3
  • 81
    • 84882693921 scopus 로고    scopus 로고
    • Niccine(R), a nicotine vaccine, for relapse prevention: A Phase II, randomized, placebo-controlled, multicenter clinical trial
    • Tonstad S., Heggen E., Giljam H., Lagerback P.A., Tonnesen P., Wikingsson L.D., et al. Niccine(R), a nicotine vaccine, for relapse prevention: A Phase II, randomized, placebo-controlled, multicenter clinical trial. Nicotine & Tobacco Research 2013, 15(9):1492-1501.
    • (2013) Nicotine & Tobacco Research , vol.15 , Issue.9 , pp. 1492-1501
    • Tonstad, S.1    Heggen, E.2    Giljam, H.3    Lagerback, P.A.4    Tonnesen, P.5    Wikingsson, L.D.6
  • 84
  • 85
    • 84878821247 scopus 로고    scopus 로고
    • Nanovaccines and their mode of action
    • Zaman M., Good M.F., Toth I. Nanovaccines and their mode of action. Methods 2013, 60:226-231.
    • (2013) Methods , vol.60 , pp. 226-231
    • Zaman, M.1    Good, M.F.2    Toth, I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.