Effect of menthol on the pharmacokinetics and pharmacodynamics of felodipine in healthy subjects

European Journal of Clinical Pharmacology

Volumn 60, Issue 11, 2005, Pages 785-790

  Gelal, Ayse ^a   Balkan, Dilara ^a   Ozzeybek, Deniz ^a   Kaplan, Yusuf C ^a   Gurler, Selma ^a   Guven, Hulya ^a   Benowitz, Neal L ^b  

^a DOKUZ EYLUL UNIVERSITY   (Turkey)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Essential oils; Felodipine; Menthol; Monoterpenes

Indexed keywords

4 (2,3 DICHLOROPHENYL) 2,6 DIMETHYL 3,5 PYRIDINEDICARBOXYLIC ACID ETHYL METHYL ESTER; CALCIUM CHANNEL BLOCKING AGENT; FELODIPINE; MENTHOL;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG CAPSULE; DRUG EFFECT; FEMALE; GAS CHROMATOGRAPHY; HEMODYNAMIC MONITORING; HUMAN; MALE; MASS SPECTROMETRY; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TABLET;

ADULT; AREA UNDER CURVE; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DRUG INTERACTIONS; FELODIPINE; FEMALE; HALF-LIFE; HEART RATE; HUMANS; MALE; MENTHOL; METABOLIC CLEARANCE RATE;

EID: 15444378525     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-004-0847-8     Document Type: Article

References (20)

1. Thomson MICROMEDEX (1974-2004) MICROMEDEX(R) Healthcare Series vol 119 expires 3/2004
2. Eccles R (1994) Menthol and related cooling compounds. J Pharm Pharmacol 46:618-630
3. Baytop T (1999) Therapy with medicinal plants in Turkey (past and present). Nobel, Istanbul, pp 302-303
4. Wacher V, Wong S, Wong HT (2002) Peppermint oil enhances cyclosporine oral bioavailability in rats: comparison with D-α-tocopheryl poly(ethylene glycol 1000) succinate (TPGS) and ketoconazole. J Pharm Sci 91:77-90
5. Dresser GK, Wacher V, Wong S, Wong HT, Bailey DG (2002) Evaluation of peppermint oil and ascorbyl palmitate as inhibitors of cytochrome P4503A4 activity in vitro and in vivo. Clin Pharmacol Ther 72:247-255
6. Dunselman PH, Edgar B (1991) Felodipine clinical pharmacokinetics. Clin Pharmacokinet 21:418-430
7. Saltiel E, Ellrodt AG, Monk JP, Langley MS (1988) Felodipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension. Drugs 36:387-428
8. Bailey DG, Bend JR, Arnold JM, Tran LT, Spence JD (1996) Erythromycin-felodipine interaction: magnitude, mechanism, and comparison with grapefruit juice. Clin Pharmacol Ther 60(1):25-33
9. Edgar B, Lundborg P, Regardh CG (1987) Clinical Pharmacokinetics of felodipine, a summary. Drugs 34:16-27
10. Hawthorn M, Ferrante J, Luchoswki E, Rutledge A, Wei XY, Triggle DJ (1988) The actions of peppermint oil and menthol on calcium channel dependent processes in intestinal, neuronal and cardiac preparations. Aliment Pharmacol Ther 2:101-118
11. Edgar B, Regardh CG, Johnsson G, Johansson L, Lundborg P, Löfberg I, Rönn O (1985) Felodipine kinetics in healthy men. Clin Pharmacol Ther 38:205-211
12. Ahnoff M (1984) Determination of felodipine in plasma by capillary gas chromatography with electron capture detection. J Pharm Biomed Anal 2:519-526
13. Steinijans VW, Hartmann M, Huber R, Radtke HW (1991) Lack of pharmacokinetic interaction as an equivalence problem. Int J Clin Pharmacol Ther Toxicol 29(8):323-328
14. Gelal A, Jacob P, Yu L, Benowitz NL (1999) Disposition kinetics and effects of menthol. Clin Pharmacol Ther 66:128-135
15. Madyastha KM, Srivastan V (1988) Studies on the metabolism of 1-menthol in rats. Drug Metab Dispos 16:765-772
16. Austin CA, Shephard EA, Pike SF, Rabin BR, Phillips IR (1988) The effect of terpenoid compounds on cytochrome P-450 levels in rat liver. Biochem Pharmacol 37:2223-2229
17. De-Olivera ACAX, Fidalgo-Neto AA, Paumgartten FJR (1999) In vitro inhibition of liver monooxygenases by β-ionone, 1,8-cineole, (-)-menthol and terpinol. Toxicol 135:33-41
18. Gelal A, Guven H, Balkan D, Artok L, Benowitz NL (2003) Influence of menthol on caffeine disposition and pharmacodynamics in healthy female volunteers. Eur J Clin Pharmacol 59:417-422
19. 3 H] 1-menthol in the rat. Drug Metab Dispos 22:616-624
20. Bell GD, Dutka DP, Henry DA, Langman MJS (1981) Glucuronidation of 1-menthol in man: the effects of prior treatment with cimetidine and phenobarbitone (abstract). Br J Clin Pharmacol 12:274P