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National Institute on Drug Abuse Research Report Series
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3
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Preclinical development of a vaccine Against Smoking
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LeSage MG, Keyler DE, Pentel PR. Current status of immunologic approaches to treating tobacco dependence: vaccines and nicotine-specific antibodies. AAPS J 2006;8:E65-75 •• This well-written paper provides a recent and comprehensive review of the research related to nicotine vaccines, as well as important considerations for their use in humans.
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LeSage MG, Keyler DE, Pentel PR. Current status of immunologic approaches to treating tobacco dependence: vaccines and nicotine-specific antibodies. AAPS J 2006;8:E65-75 •• This well-written paper provides a recent and comprehensive review of the research related to nicotine vaccines, as well as important considerations for their use in humans.
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5
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This article provides a highly accessible, yet detailed and thought-provoking review of a vaccine approach to treating drug addiction more broadly, ••
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Kosten T, Owens SM. Immunotherapy for the treatment of drug abuse. Pharmacol Ther 2005;108:76-85 •• This article provides a highly accessible, yet detailed and thought-provoking review of a vaccine approach to treating drug addiction more broadly.
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Effects of a nicotine conjugate vaccine on the acquisition and maintenance of nicotine self-administration in rats
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This paper reports an early treatment study indicating that Nabi Pharmaceutical's vaccine NicVAX produced nicotine-specific antibodies and was well tolerated in human participants, •
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Hatsukami DK, Rennard S, Jorenby D, et al. Safety and immunogenicity of a nicotine conjugate vaccine in current smokers. Clin Pharmacol Ther 2005;78:456-67 • This paper reports an early treatment study indicating that Nabi Pharmaceutical's vaccine NicVAX produced nicotine-specific antibodies and was well tolerated in human participants.
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A therapeutic vaccine for nicotine dependence: Preclinical efficacy, and phase I safety and immunogenicity
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This paper reports an early treatment study indicating that Cytos Biotechnology's vaccine NicQb induced produced nicotine-specific antibodies and was well tolerated in human participants, •
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Maurer P, Jennings GT, Willers J, et al. A therapeutic vaccine for nicotine dependence: preclinical efficacy, and phase I safety and immunogenicity. Eur J Immunol 2005;35:2031-40 • This paper reports an early treatment study indicating that Cytos Biotechnology's vaccine NicQb induced produced nicotine-specific antibodies and was well tolerated in human participants.
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Along with providing preclinical evidence in support of a vaccine for the major metabolite of nicotine cotinine, this paper prompts broader consideration of immunotherapy approaches to smoking that target more than the primary addictive constituents of tobacco, •
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Oliver JL, Pashmi G, Barnett P, et al. Development of an anti-cotinine vaccine to potentiate nicotine-based smoking cessation strategies. Vaccine 2007;25:7354-62 • Along with providing preclinical evidence in support of a vaccine for the major metabolite of nicotine (cotinine), this paper prompts broader consideration of immunotherapy approaches to smoking that target more than the primary addictive constituents of tobacco.
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