-
4
-
-
54949156003
-
Substance abuse vaccines
-
Orson FM, Kinsey BM, Singh RA, Wu Y, Gardner T, Kosten TR. Substance abuse vaccines. Ann. N. Y. Acad. Sci. 1141, 257-269 (2008).
-
(2008)
Ann. N. Y. Acad. Sci.
, vol.1141
, pp. 257-269
-
-
Orson, F.M.1
Kinsey, B.M.2
Singh, R.A.3
Wu, Y.4
Gardner, T.5
Kosten, T.R.6
-
6
-
-
33644801063
-
Current status of immunologic approaches to treating tobacco dependence: Vaccines and nicotine-specific antibodies
-
LeSage MG, Keyler DE, Pentel PR. Current status of immunologic approaches to treating tobacco dependence: vaccines and nicotine-specific antibodies. AAPS J. 8(1), E65-E75 (2006).
-
(2006)
AAPS J.
, vol.8
, Issue.1
-
-
Lesage, M.G.1
Keyler, D.E.2
Pentel, P.R.3
-
7
-
-
67650449269
-
Development of active and passive human vaccines to treat methamphetamine addiction
-
Gentry WB, Rüedi-Bettschen D, Owens SM. Development of active and passive human vaccines to treat methamphetamine addiction. Hum. Vaccin. 5(4), 206-213 (2009).
-
(2009)
Hum. Vaccin.
, vol.5
, Issue.4
, pp. 206-213
-
-
Gentry, W.B.1
Rüedi-Bettschen, D.2
Owens, S.M.3
-
8
-
-
22444437907
-
Vaccine pharmacotherapy for the treatment of cocaine dependence
-
Martell BA, Mitchell E, Poling J, Gonsai K, Kosten TR. Vaccine pharmacotherapy for the treatment of cocaine dependence. Biol. Psychiatry 58(2), 158-164 (2005).
-
(2005)
Biol. Psychiatry
, vol.58
, Issue.2
, pp. 158-164
-
-
Martell, B.A.1
Mitchell, E.2
Poling, J.3
Gonsai, K.4
Kosten, T.R.5
-
9
-
-
0015598721
-
Antibody production in mice. V. The suppressive effect of anti-carrier antibodies on cellular cooperation in the induction of secondary anti-hapten antibody responses
-
Hamaoka T, Takatsu K, Kitagawa M. Antibody production in mice. V. The suppressive effect of anti-carrier antibodies on cellular cooperation in the induction of secondary anti-hapten antibody responses. Immunology 24(3), 409-424 (1973).
-
(1973)
Immunology
, vol.24
, Issue.3
, pp. 409-424
-
-
Hamaoka, T.1
Takatsu, K.2
Kitagawa, M.3
-
10
-
-
79952195569
-
Cocaine analog coupled to disrupted adenovirus: A vaccine strategy to evoke high-titer immunity against addictive drugs
-
Hicks MJ, De BP, Rosenberg JB et al. Cocaine analog coupled to disrupted adenovirus: a vaccine strategy to evoke high-titer immunity against addictive drugs. Mol. Ther. 19(3), 612-619 (2011).
-
(2011)
Mol. Ther.
, vol.19
, Issue.3
, pp. 612-619
-
-
Hicks, M.J.1
De Bp Rosenberg, J.B.2
-
11
-
-
16044371587
-
Efficacy of a therapeutic cocaine vaccine in rodent models
-
Fox BS, Kantak KM, Edwards MA et al. Efficacy of a therapeutic cocaine vaccine in rodent models. Nat. Med. 2(10), 1129-1132 (1996).
-
(1996)
Nat. Med.
, vol.2
, Issue.10
, pp. 1129-1132
-
-
Fox, B.S.1
Kantak, K.M.2
Edwards, M.A.3
-
12
-
-
0016338395
-
Changes in heroin self-administration by a rhesus monkey after morphine immunisation
-
Bonese KF, Wainer BH, Fitch FW, Rothberg RM, Schuster CR. Changes in heroin self-administration by a rhesus monkey after morphine immunisation. Nature 252(5485), 708-710 (1974).
-
(1974)
Nature
, vol.252
, Issue.5485
, pp. 708-710
-
-
Bonese, K.F.1
Wainer, B.H.2
Fitch, F.W.3
Rothberg, R.M.4
Schuster, C.R.5
-
13
-
-
34250788109
-
Using hapten design to discover therapeutic monoclonal antibodies for treating methamphetamine abuse
-
Peterson EC, Gunnell M, Che Y et al. Using hapten design to discover therapeutic monoclonal antibodies for treating methamphetamine abuse. J. Pharmacol. Exp. Ther. 322(1), 30-39 (2007).
-
(2007)
J. Pharmacol. Exp. Ther.
, vol.322
, Issue.1
, pp. 30-39
-
-
Peterson, E.C.1
Gunnell, M.2
Che, Y.3
-
14
-
-
2442661486
-
Effects of murine-derived anti-methamphetamine monoclonal antibodies on (+)-methamphetamine self-administration in the rat
-
McMillan DE, Hardwick WC, Li M et al. Effects of murine-derived anti-methamphetamine monoclonal antibodies on (+)-methamphetamine self-administration in the rat. J. Pharmacol. Exp. Ther. 309(3), 1248-1255 (2004).
-
(2004)
J. Pharmacol. Exp. Ther.
, vol.309
, Issue.3
, pp. 1248-1255
-
-
McMillan, D.E.1
Hardwick, W.C.2
Li, M.3
-
15
-
-
67649271523
-
Passive immunization with a nicotine-specific monoclonal antibody decreases brain nicotine levels but does not precipitate withdrawal in nicotine-dependent rats
-
Roiko SA, Harris AC, LeSage MG, Keyler DE, Pentel PR. Passive immunization with a nicotine-specific monoclonal antibody decreases brain nicotine levels but does not precipitate withdrawal in nicotine-dependent rats. Pharmacol. Biochem. Behav. 93(2), 105-111 (2009).
-
(2009)
Pharmacol. Biochem. Behav.
, vol.93
, Issue.2
, pp. 105-111
-
-
Roiko, S.A.1
Harris, A.C.2
Lesage, M.G.3
Keyler, D.E.4
Pentel, P.R.5
-
16
-
-
0344861819
-
Effects of nicotine infusion on the metabolism of the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone (NNK) in rats
-
Keyler D, Pentel PR, Kuehl G, Collins G, Murphy SE. Effects of nicotine infusion on the metabolism of the tobacco carcinogen 4-(methylnitrosamino)-1-(3- pyridyl)-1- butanone (NNK) in rats. Cancer Lett. 202(1), 1-9 (2003).
-
(2003)
Cancer Lett.
, vol.202
, Issue.1
, pp. 1-9
-
-
Keyler, D.1
Pentel, P.R.2
Kuehl, G.3
Collins, G.4
Murphy, S.E.5
-
17
-
-
33845889554
-
A chimeric human/murine anticocaine monoclonal antibody inhibits the distribution of cocaine to the brain in mice
-
Norman AB, Tabet MR, Norman MK, Buesing WR, Pesce AJ, Ball WJ. A chimeric human/murine anticocaine monoclonal antibody inhibits the distribution of cocaine to the brain in mice. J. Pharmacol. Exp. Ther. 320(1), 145-153 (2007).
-
(2007)
J. Pharmacol. Exp. Ther.
, vol.320
, Issue.1
, pp. 145-153
-
-
Norman, A.B.1
Tabet, M.R.2
Norman, M.K.3
Buesing, W.R.4
Pesce, A.J.5
Ball, W.J.6
-
18
-
-
0031470566
-
Active immunization alters the plasma nicotine concentration in rats
-
Hieda Y, Keyler DE, Vandevoort JT et al. Active immunization alters the plasma nicotine concentration in rats. J. Pharmacol. Exp. Ther. 283(3), 1076-1081 (1997).
-
(1997)
J. Pharmacol. Exp. Ther.
, vol.283
, Issue.3
, pp. 1076-1081
-
-
Hieda, Y.1
Keyler, D.E.2
Vandevoort, J.T.3
-
19
-
-
0037436021
-
Pharmacodynamic mechanisms of monoclonal antibody-based antagonism of (+)-methamphetamine in rats
-
Byrnes-Blake KA, Laurenzana EM, Carroll FI et al. Pharmacodynamic mechanisms of monoclonal antibody-based antagonism of (+)-methamphetamine in rats. Eur. J. Pharmacol. 461(2-3), 119-128 (2003).
-
(2003)
Eur. J. Pharmacol.
, vol.461
, Issue.2-3
, pp. 119-128
-
-
Byrnes-Blake, K.A.1
Laurenzana, E.M.2
Carroll, F.I.3
-
20
-
-
26444588706
-
Monoclonal IgG affinity and treatment time alters antagonism of (+)-methamphetamine effects in rats
-
Byrnes-Blake KA, Laurenzana EM, Landes RD, Gentry WB, Owens SM. Monoclonal IgG affinity and treatment time alters antagonism of (+)-methamphetamine effects in rats. Eur. J. Pharmacol. 521(1-3), 86-94 (2005).
-
(2005)
Eur. J. Pharmacol.
, vol.521
, Issue.1-3
, pp. 86-94
-
-
Byrnes-Blake, K.A.1
Laurenzana, E.M.2
Landes, R.D.3
Gentry, W.B.4
Owens, S.M.5
-
21
-
-
0037092439
-
The rate of intravenous cocaine administration determines susceptibility to sensitization
-
Samaha AN, Li Y, Robinson TE. The rate of intravenous cocaine administration determines susceptibility to sensitization. J. Neurosci. 22(8), 3244-3250 (2002).
-
(2002)
J. Neurosci.
, vol.22
, Issue.8
, pp. 3244-3250
-
-
Samaha, A.N.1
Li, Y.2
Robinson, T.E.3
-
22
-
-
0026463456
-
Severity of dependence and route of administration of heroin, cocaine and amphetamines
-
Gossop M, Griffiths P, Powis B, Strang J. Severity of dependence and route of administration of heroin, cocaine and amphetamines. Br. J. Addict. 87(11), 1527-1536 (1992).
-
(1992)
Br. J. Addict.
, vol.87
, Issue.11
, pp. 1527-1536
-
-
Gossop, M.1
Griffiths, P.2
Powis, B.3
Strang, J.4
-
23
-
-
0037081517
-
Human therapeutic cocaine vaccine: Safety and immunogenicity
-
Kosten TR, Rosen M, Bond J et al. Human therapeutic cocaine vaccine: safety and immunogenicity. Vaccine 20(7-8), 1196-1204 (2002).
-
(2002)
Vaccine
, vol.20
, Issue.7-8
, pp. 1196-1204
-
-
Kosten, T.R.1
Rosen, M.2
Bond, J.3
-
24
-
-
49649104752
-
A vaccine against nicotine for smoking cessation: A randomized controlled trial
-
Cornuz J, Zwahlen S, Jungi WF et al. A vaccine against nicotine for smoking cessation: a randomized controlled trial. PLoS ONE 3(6), e2547 (2008).
-
(2008)
PLoS ONE
, vol.3
, Issue.6
-
-
Cornuz, J.1
Zwahlen, S.2
Jungi, W.F.3
-
25
-
-
28144465243
-
Safety and immunogenicity of a nicotine conjugate vaccine in current smokers
-
Hatsukami DK, Rennard S, Jorenby D et al. Safety and immunogenicity of a nicotine conjugate vaccine in current smokers. Clin. Pharmacol. Ther. 78(5), 456-467 (2005).
-
(2005)
Clin. Pharmacol. Ther.
, vol.78
, Issue.5
, pp. 456-467
-
-
Hatsukami, D.K.1
Rennard, S.2
Jorenby, D.3
-
26
-
-
84874042611
-
Spontaneous development of IgM anti-cocaine antibodies in habitual cocaine users: Effect on IgG antibody responses to a cocaine cholera toxin B conjugate vaccine
-
Orson F, Rossen RD, Shen X, Lopez AY, Wu Y, Kosten T. Spontaneous development of IgM anti-cocaine antibodies in habitual cocaine users: effect on IgG antibody responses to a cocaine cholera toxin B conjugate vaccine. Am. J. Addict. 22(2), 169-174 (2012).
-
(2012)
Am. J. Addict.
, vol.22
, Issue.2
, pp. 169-174
-
-
Orson, F.1
Rossen, R.D.2
Shen, X.3
Lopez, A.Y.4
Wu, Y.5
Kosten, T.6
-
27
-
-
62449333563
-
The effect of a chimeric human/murine anti-cocaine monoclonal antibody on cocaine self-administration in rats
-
Norman AB, Norman MK, Buesing WR, Tabet MR, Tsibulsky VL, Ball WJ. The effect of a chimeric human/murine anti-cocaine monoclonal antibody on cocaine self-administration in rats. J. Pharmacol. Exp. Ther. 328(3), 873-881 (2009).
-
(2009)
J. Pharmacol. Exp. Ther.
, vol.328
, Issue.3
, pp. 873-881
-
-
Norman, A.B.1
Norman, M.K.2
Buesing, W.R.3
Tabet, M.R.4
Tsibulsky, V.L.5
Ball, W.J.6
-
28
-
-
0142212156
-
Use of anti-(+)-methamphetamine monoclonal antibody to significantly alter (+)-methamphetamine and (+)-amphetamine disposition in rats
-
Laurenzana EM, Byrnes-Blake KA, Milesi-Hallé A, Gentry WB, Williams DK, Owens SM. Use of anti-(+)-methamphetamine monoclonal antibody to significantly alter (+)-methamphetamine and (+)-amphetamine disposition in rats. Drug Metab. Dispos. 31(11), 1320-1326 (2003).
-
(2003)
Drug Metab. Dispos.
, vol.31
, Issue.11
, pp. 1320-1326
-
-
Laurenzana, E.M.1
Byrnes-Blake, K.A.2
Milesi-Hallé, A.3
Gentry, W.B.4
Williams, D.K.5
Owens, S.M.6
-
29
-
-
0142089747
-
Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer
-
Raper SE, Chirmule N, Lee FS et al. Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer. Mol. Genet. Metab. 80(1-2), 148-158 (2003).
-
(2003)
Mol. Genet. Metab.
, vol.80
, Issue.1-2
, pp. 148-158
-
-
Raper, S.E.1
Chirmule, N.2
Lee, F.S.3
-
30
-
-
0036147236
-
Toxicity of a first-generation adenoviral vector in rhesus macaques
-
Lozier JN, Csako G, Mondoro TH et al. Toxicity of a first-generation adenoviral vector in rhesus macaques. Hum. Gene Ther. 13(1), 113-124 (2002).
-
(2002)
Hum. Gene Ther.
, vol.13
, Issue.1
, pp. 113-124
-
-
Lozier, J.N.1
Csako, G.2
Mondoro, T.H.3
-
31
-
-
84864358304
-
Gene therapy for primary immunodeficiencies
-
Rivat C, Santilli G, Gaspar HB, Thrasher AJ. Gene therapy for primary immunodeficiencies. Hum. Gene Ther. 23(7), 668-675 (2012).
-
(2012)
Hum. Gene Ther.
, vol.23
, Issue.7
, pp. 668-675
-
-
Rivat, C.1
Santilli, G.2
Gaspar, H.B.3
Thrasher, A.J.4
-
32
-
-
79952464971
-
Gene therapy for vision loss - Recent developments
-
Stieger K, Lorenz B. Gene therapy for vision loss - recent developments. Discov. Med. 10(54), 425-433 (2010).
-
(2010)
Discov. Med.
, vol.10
, Issue.54
, pp. 425-433
-
-
Stieger, K.1
Lorenz, B.2
-
33
-
-
84867461170
-
Immunotherapeutic strategies for cancer treatment: A novel protein transfer approach for cancer vaccine development
-
Shashidharamurthy R, Bozeman EN, Patel J, Kaur R, Meganathan J, Selvaraj P. Immunotherapeutic strategies for cancer treatment: a novel protein transfer approach for cancer vaccine development. Med. Res. Rev. 32(6), 1197-1219 (2012).
-
(2012)
Med. Res. Rev.
, vol.32
, Issue.6
, pp. 1197-1219
-
-
Shashidharamurthy, R.1
Bozeman, E.N.2
Patel, J.3
Kaur, R.4
Meganathan, J.5
Selvaraj, P.6
-
34
-
-
22744444388
-
Stable antibody expression at therapeutic levels using the 2A peptide
-
Fang J, Qian JJ, Yi S et al. Stable antibody expression at therapeutic levels using the 2A peptide. Nat. Biotechnol. 23(5), 584-590 (2005).
-
(2005)
Nat. Biotechnol.
, vol.23
, Issue.5
, pp. 584-590
-
-
Fang, J.1
Qian, J.J.2
Yi, S.3
-
35
-
-
0034518447
-
Gene transfer of anti-gp41 antibody and CD4 immunoadhesin strongly reduces the HIV-1 load in humanized severe combined immunodeficient mice
-
Sanhadji K, Grave L, Touraine JL et al. Gene transfer of anti-gp41 antibody and CD4 immunoadhesin strongly reduces the HIV-1 load in humanized severe combined immunodeficient mice. AIDS 14(18), 2813-2822 (2000).
-
(2000)
AIDS
, vol.14
, Issue.18
, pp. 2813-2822
-
-
Sanhadji, K.1
Grave, L.2
Touraine, J.L.3
-
36
-
-
84863186975
-
AAV-directed persistent expression of a gene encoding anti-nicotine antibody for smoking cessation
-
Hicks MJ, Rosenberg JB, De BP et al. AAV-directed persistent expression of a gene encoding anti-nicotine antibody for smoking cessation. Sci. Transl. Med. 4(140), 140ra87 (2012).
-
(2012)
Sci. Transl. Med.
, vol.4
, Issue.140
-
-
Hicks, M.J.1
Rosenberg, J.B.2
De, B.P.3
-
37
-
-
0016860852
-
Plasma nicotine levels after smoking cigarettes with high, medium, and low nicotine yields
-
Russell MA, Wilson C, Patel UA, Feyerabend C, Cole PV. Plasma nicotine levels after smoking cigarettes with high, medium, and low nicotine yields. Br. Med. J. 2(5968), 414-416 (1975).
-
(1975)
Br. Med. J.
, vol.2
, Issue.5968
, pp. 414-416
-
-
Russell, M.A.1
Wilson, C.2
Patel, U.A.3
Feyerabend, C.4
Cole, P.V.5
-
38
-
-
84861664392
-
AAVrh.10-mediated expression of an anti-cocaine antibody mediates persistent passive immunization that suppresses cocaine-induced behavior
-
Rosenberg JB, Hicks MJ, De BP et al. AAVrh.10-mediated expression of an anti-cocaine antibody mediates persistent passive immunization that suppresses cocaine-induced behavior. Hum. Gene Ther. 23(5), 451-459 (2012).
-
(2012)
Hum. Gene Ther.
, vol.23
, Issue.5
, pp. 451-459
-
-
Rosenberg, J.B.1
Hicks, M.J.2
De, B.P.3
-
39
-
-
0031743608
-
Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery
-
Zufferey R, Dull T, Mandel RJ et al. Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery. J. Virol. 72(12), 9873-9880 (1998).
-
(1998)
J. Virol.
, vol.72
, Issue.12
, pp. 9873-9880
-
-
Zufferey, R.1
Dull, T.2
Mandel, R.J.3
-
40
-
-
0142084745
-
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
-
Hacein-Bey-Abina S, Von Kalle C, Schmidt M et al. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 302(5644), 415-419 (2003).
-
(2003)
Science
, vol.302
, Issue.5644
, pp. 415-419
-
-
Hacein-Bey-Abina, S.1
Von Kalle, C.2
Schmidt, M.3
-
41
-
-
0028875936
-
Transfer of genes to humans: Early lessons and obstacles to success
-
Crystal RG. Transfer of genes to humans: early lessons and obstacles to success. Science 270(5235), 404-410 (1995).
-
(1995)
Science
, vol.270
, Issue.5235
, pp. 404-410
-
-
Crystal, R.G.1
-
42
-
-
0030462599
-
A helperdependent adenovirus vector system: Removal of helper virus by Cre-mediated excision of the viral packaging signal
-
Parks RJ, Chen L, Anton M, Sankar U, Rudnicki MA, Graham FL. A helperdependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc. Natl Acad. Sci. USA 93(24), 13565-13570 (1996).
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, Issue.24
, pp. 13565-13570
-
-
Parks, R.J.1
Chen, L.2
Anton, M.3
Sankar, U.4
Russell, M.A.5
Graham, F.L.6
-
43
-
-
0028169741
-
Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain
-
Kaplitt MG, Leone P, Samulski RJ et al. Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain. Nat. Genet. 8(2), 148-154 (1994).
-
(1994)
Nat. Genet.
, vol.8
, Issue.2
, pp. 148-154
-
-
Kaplitt, M.G.1
Leone, P.2
Samulski, R.J.3
-
44
-
-
77955924785
-
Oligoarray comparative genomic hybridization of renal cell tumors that developed in patients with acquired cystic renal disease
-
Kuntz E, Yusenko MV, Nagy A, Kovacs G. Oligoarray comparative genomic hybridization of renal cell tumors that developed in patients with acquired cystic renal disease. Hum. Pathol. 41(9), 1345-1349 (2010).
-
(2010)
Hum. Pathol.
, vol.41
, Issue.9
, pp. 1345-1349
-
-
Kuntz, E.1
Yusenko, M.V.2
Nagy, A.3
Kovacs, G.4
-
45
-
-
22144497124
-
Retrospective birth dating of cells in humans
-
Spalding KL, Bhardwaj RD, Buchholz BA, Druid H, Frisén J. Retrospective birth dating of cells in humans. Cell 122(1), 133-143 (2005).
-
(2005)
Cell
, vol.122
, Issue.1
, pp. 133-143
-
-
Spalding, K.L.1
Bhardwaj, R.D.2
Buchholz, B.A.3
Druid, H.4
Frisén, J.5
-
46
-
-
11144248909
-
The innate immune response to adenovirus vectors
-
Muruve DA. The innate immune response to adenovirus vectors. Hum. Gene Ther. 15(12), 1157-1166 (2004).
-
(2004)
Hum. Gene Ther.
, vol.15
, Issue.12
, pp. 1157-1166
-
-
Muruve, D.A.1
-
47
-
-
43049178300
-
Progress and prospects: Gene therapy for genetic diseases with helper-dependent adenoviral vectors
-
Brunetti-Pierri N, Ng P. Progress and prospects: gene therapy for genetic diseases with helper-dependent adenoviral vectors. Gene Ther. 15(8), 553-560 (2008).
-
(2008)
Gene Ther.
, vol.15
, Issue.8
, pp. 553-560
-
-
Brunetti-Pierri, N.1
Ng, P.2
-
48
-
-
79956014843
-
Helper-dependent adenoviral vectors for liver-directed gene therapy
-
Brunetti-Pierri N, Ng P. Helper-dependent adenoviral vectors for liver-directed gene therapy. Hum. Mol. Genet. 20(R1), R7-13 (2011).
-
(2011)
Hum. Mol. Genet.
, vol.20
, Issue.R1
-
-
Brunetti-Pierri, N.1
Ng, P.2
-
49
-
-
13044304200
-
Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons
-
Morral N, O'Neal W, Rice K et al. Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons. Proc. Natl Acad. Sci. USA 96(22), 12816-12821 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, Issue.22
, pp. 12816-12821
-
-
Morral, N.1
O'Neal, W.2
Rice, K.3
-
50
-
-
70349481529
-
Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy
-
Brantly ML, Chulay JD, Wang L et al. Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy. Proc. Natl Acad. Sci. USA 106(38), 16363-16368 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, Issue.38
, pp. 16363-16368
-
-
Brantly, M.L.1
Chulay, J.D.2
Wang, L.3
-
51
-
-
33644820684
-
Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response
-
Manno CS, Pierce GF, Arruda VR et al. Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response. Nat. Med. 12(3), 342-347 (2006).
-
(2006)
Nat. Med.
, vol.12
, Issue.3
, pp. 342-347
-
-
Manno, C.S.1
Pierce, G.F.2
Arruda, V.R.3
-
52
-
-
80053547854
-
Liver-directed gene therapy with helper-dependent adenoviral vectors: Current state of the art and future challenges
-
Vetrini F, Ng P. Liver-directed gene therapy with helper-dependent adenoviral vectors: current state of the art and future challenges. Curr. Pharm. Des. 17(24), 2488-2499 (2011).
-
(2011)
Curr. Pharm. Des.
, vol.17
, Issue.24
, pp. 2488-2499
-
-
Vetrini, F.1
Ng, P.2
-
53
-
-
63949084441
-
Transient pretreatment with glucocorticoid ablates innate toxicity of systemically delivered adenoviral vectors without reducing efficacy
-
Seregin SS, Appledorn DM, McBride AJ et al. Transient pretreatment with glucocorticoid ablates innate toxicity of systemically delivered adenoviral vectors without reducing efficacy. Mol. Ther. 17(4), 685-696 (2009).
-
(2009)
Mol. Ther.
, vol.17
, Issue.4
, pp. 685-696
-
-
Seregin, S.S.1
Appledorn, D.M.2
McBride, A.J.3
-
54
-
-
28444469819
-
Suppression of inflammation by dexamethasone prolongs adenoviral vector-mediated transgene expression in murine nasal mucosa
-
Kumahara K, Nagata H, Watanabe K et al. Suppression of inflammation by dexamethasone prolongs adenoviral vector-mediated transgene expression in murine nasal mucosa. Acta Otolaryngol. 125(12), 1301-1306 (2005).
-
(2005)
Acta Otolaryngol.
, vol.125
, Issue.12
, pp. 1301-1306
-
-
Kumahara, K.1
Nagata, H.2
Watanabe, K.3
-
55
-
-
0742307422
-
Acute toxicity after high-dose systemic injection of helper-dependent adenoviral vectors into nonhuman primates
-
Brunetti-Pierri N, Palmer DJ, Beaudet AL, Carey KD, Finegold M, Ng P. Acute toxicity after high-dose systemic injection of helper-dependent adenoviral vectors into nonhuman primates. Hum. Gene Ther. 15(1), 35-46 (2004).
-
(2004)
Hum. Gene Ther.
, vol.15
, Issue.1
, pp. 35-46
-
-
Brunetti-Pierri, N.1
Palmer, D.J.2
Beaudet, A.L.3
Carey, K.D.4
Finegold, M.5
Ng, P.6
-
56
-
-
0017664631
-
Hydrolysis of cocaine in human plasma by cholinesterase
-
Stewart DJ, Inaba T, Tang BK, Kalow W. Hydrolysis of cocaine in human plasma by cholinesterase. Life Sci. 20(9), 1557-1563 (1977).
-
(1977)
Life Sci.
, vol.20
, Issue.9
, pp. 1557-1563
-
-
Stewart, D.J.1
Inaba, T.2
Tang, B.K.3
Kalow, W.4
-
57
-
-
0036119167
-
The role of pharmacogenetically-variable cytochrome P450 enzymes in drug abuse and dependence
-
Howard LA, Sellers EM, Tyndale RF. The role of pharmacogenetically- variable cytochrome P450 enzymes in drug abuse and dependence. Pharmacogenomics 3(2), 185-199 (2002).
-
(2002)
Pharmacogenomics
, vol.3
, Issue.2
, pp. 185-199
-
-
Howard, L.A.1
Sellers, E.M.2
Tyndale, R.F.3
-
58
-
-
0033866924
-
Inhibition of cytochrome P450 2A6 increases nicotine's oral bioavailability and decreases smoking
-
Sellers EM, Kaplan HL, Tyndale RF. Inhibition of cytochrome P450 2A6 increases nicotine's oral bioavailability and decreases smoking. Clin. Pharmacol. Ther. 68(1), 35-43 (2000).
-
(2000)
Clin. Pharmacol. Ther.
, vol.68
, Issue.1
, pp. 35-43
-
-
Sellers, E.M.1
Kaplan, H.L.2
Tyndale, R.F.3
-
59
-
-
0030735986
-
Enhancing cocaine metabolism with butyrylcholinesterase as a treatment strategy
-
Gorelick DA. Enhancing cocaine metabolism with butyrylcholinesterase as a treatment strategy. Drug Alcohol Depend. 48(3), 159-165 (1997).
-
(1997)
Drug Alcohol Depend.
, vol.48
, Issue.3
, pp. 159-165
-
-
Gorelick, D.A.1
-
60
-
-
0032944436
-
An improved cocaine hydrolase: The A328Y mutant of human butyrylcholinesterase is 4-fold more efficient
-
Xie W, Altamirano CV, Bartels CF, Speirs RJ, Cashman JR, Lockridge O. An improved cocaine hydrolase: the A328Y mutant of human butyrylcholinesterase is 4-fold more efficient. Mol. Pharmacol. 55(1), 83-91 (1999).
-
(1999)
Mol. Pharmacol.
, vol.55
, Issue.1
, pp. 83-91
-
-
Xie, W.1
Altamirano, C.V.2
Bartels, C.F.3
Speirs, R.J.4
Cashman, J.R.5
Lockridge, O.6
-
61
-
-
0036077314
-
Re-engineering butyrylcholinesterase as a cocaine hydrolase
-
Sun H, Pang YP, Lockridge O, Brimijoin S. Re-engineering butyrylcholinesterase as a cocaine hydrolase. Mol. Pharmacol. 62(2), 220-224 (2002).
-
(2002)
Mol. Pharmacol.
, vol.62
, Issue.2
, pp. 220-224
-
-
Sun, H.1
Pang, Y.P.2
Lockridge, O.3
Brimijoin, S.4
-
62
-
-
0034871717
-
Simultaneous pharmacokinetic modeling of cocaine and its metabolites, norcocaine and benzyoylecgonine, after intravenous and oral administration in rats
-
Sun L, Lau CE. Simultaneous pharmacokinetic modeling of cocaine and its metabolites, norcocaine and benzyoylecgonine, after intravenous and oral administration in rats. Drug Metab. Disp. 29, 1183-1189 (2001).
-
(2001)
Drug Metab. Disp.
, vol.29
, pp. 1183-1189
-
-
Sun, L.1
Lau, C.E.2
-
63
-
-
28044458963
-
Computational redesign of human butyrylcholinesterase for anticocaine medication
-
Pan Y, Gao D, Yang W et al. Computational redesign of human butyrylcholinesterase for anticocaine medication. Proc. Natl Acad. Sci. USA 102(46), 16656-16661 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, Issue.46
, pp. 16656-16661
-
-
Pan, Y.1
Gao, D.2
Yang, W.3
-
64
-
-
77955517250
-
Characterization of a high-activity mutant of human butyrylcholinesterase against (-)-cocaine
-
Yang W, Xue L, Fang L, Chen X, Zhan CG. Characterization of a high-activity mutant of human butyrylcholinesterase against (-)-cocaine. Chem. Biol. Interact. 187(1-3), 148-152 (2010).
-
(2010)
Chem. Biol. Interact.
, vol.187
, Issue.1-3
, pp. 148-152
-
-
Yang, W.1
Xue, L.2
Fang, L.3
Chen, X.4
Zhan, C.G.5
-
65
-
-
51749096409
-
Most efficient cocaine hydrolase designed by virtual screening of transition states
-
Zheng F, Yang W, Ko MC et al. Most efficient cocaine hydrolase designed by virtual screening of transition states. J. Am. Chem. Soc. 130(36), 12148-12155 (2008).
-
(2008)
J. Am. Chem. Soc.
, vol.130
, Issue.36
, pp. 12148-12155
-
-
Zheng, F.1
Yang, W.2
Ko, M.C.3
-
66
-
-
48749118846
-
A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats
-
Brimijoin S, Gao Y, Anker JJ et al. A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats. Neuropsychopharmacology 33(11), 2715-2725 (2008).
-
(2008)
Neuropsychopharmacology
, vol.33
, Issue.11
, pp. 2715-2725
-
-
Brimijoin, S.1
Gao, Y.2
Anker, J.J.3
-
67
-
-
84856813588
-
Cocaine hydrolase encoded in viral vector blocks the reinstatement of cocaine seeking in rats for months
-
Anker JJ, Brimijoin S, Gao Y et al. Cocaine hydrolase encoded in viral vector blocks the reinstatement of cocaine seeking in rats for months. Biol. Psychiatry 71(8), 700-705 (2012).
-
(2012)
Biol. Psychiatry
, vol.71
, Issue.8
, pp. 700-705
-
-
Anker, J.J.1
Brimijoin, S.2
Gao, Y.3
-
68
-
-
78549267772
-
Prophylaxis with human serum butyrylcholinesterase protects guinea pigs exposed to multiple lethal doses of soman or VX
-
Saxena A, Sun W, Fedorko JM, Koplovitz I, Doctor BP. Prophylaxis with human serum butyrylcholinesterase protects guinea pigs exposed to multiple lethal doses of soman or VX. Biochem. Pharmacol. 81(1), 164-169 (2011).
-
(2011)
Biochem. Pharmacol.
, vol.81
, Issue.1
, pp. 164-169
-
-
Saxena, A.1
Sun, W.2
Fedorko, J.M.3
Koplovitz, I.4
Doctor, B.P.5
-
69
-
-
28744450575
-
Human serum butyrylcholinesterase: In vitro and in vivo stability, pharmacokinetics, and safety in mice
-
Saxena A, Sun W, Luo C, Doctor BP. Human serum butyrylcholinesterase: in vitro and in vivo stability, pharmacokinetics, and safety in mice. Chem. Biol. Interact. 199-203 (2005).
-
(2005)
Chem. Biol. Interact.
, pp. 199-203
-
-
Saxena, A.1
Sun, W.2
Luo, C.3
Doctor, B.P.4
-
70
-
-
79952515951
-
Biochemical, molecular and preclinical characterization of a double-virus-reduced human butyrylcholinesterase preparation designed for clinical use
-
Weber A, Butterweck H, Mais-Paul U et al. Biochemical, molecular and preclinical characterization of a double-virus-reduced human butyrylcholinesterase preparation designed for clinical use. Vox Sang. 100(3), 285-297 (2011).
-
(2011)
Vox Sang.
, vol.100
, Issue.3
, pp. 285-297
-
-
Weber, A.1
Butterweck, H.2
Mais-Paul, U.3
-
71
-
-
11244266133
-
Gene transfer of cocaine hydrolase suppresses cardiovascular responses to cocaine in rats
-
Gao Y, Atanasova E, Sui N, Pancook JD, Watkins JD, Brimijoin S. Gene transfer of cocaine hydrolase suppresses cardiovascular responses to cocaine in rats. Mol. Pharmacol. 67(1), 204-211 (2005).
-
(2005)
Mol. Pharmacol.
, vol.67
, Issue.1
, pp. 204-211
-
-
Gao, Y.1
Atanasova, E.2
Sui, N.3
Pancook, J.D.4
Watkins, J.D.5
Brimijoin, S.6
-
72
-
-
0029054932
-
Rescue, propagation, and partial purification of a helper virus-dependent adenovirus vector
-
Mitani K, Graham FL, Caskey CT, Kochanek S. Rescue, propagation, and partial purification of a helper virus-dependent adenovirus vector. Proc. Natl Acad. Sci. USA 92(9), 3854-3858 (1995).
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, Issue.9
, pp. 3854-3858
-
-
Mitani, K.1
Graham, F.L.2
Caskey, C.T.3
Kochanek, S.4
-
73
-
-
0029943155
-
A new adenoviral vector: Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and -galactosidase
-
Kochanek S, Clemens PR, Mitani K, Chen HH, Chan S, Caskey CT. A new adenoviral vector: Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and ?-galactosidase. Proc. Natl Acad. Sci. USA 93(12), 5731-5736 (1996).
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, Issue.12
, pp. 5731-5736
-
-
Kochanek, S.1
Clemens, P.R.2
Mitani, K.3
Chen, H.H.4
Chan, S.5
Caskey, C.T.6
-
74
-
-
42649145845
-
Efficient and durable gene transfer to transplanted heart using adeno-associated virus 9 vector
-
Miyagi N, Rao VP, Ricci D et al. Efficient and durable gene transfer to transplanted heart using adeno-associated virus 9 vector. J. Heart Lung Transplant. 27(5), 554-560 (2008).
-
(2008)
J. Heart Lung Transplant.
, vol.27
, Issue.5
, pp. 554-560
-
-
Miyagi, N.1
Rao, V.P.2
Ricci, D.3
-
75
-
-
34247871536
-
Recombinant adeno-associated virus vector for gene transfer to the transplanted rat heart
-
Schirmer JM, Miyagi N, Rao VP et al. Recombinant adeno-associated virus vector for gene transfer to the transplanted rat heart. Transpl. Int. 20(6), 550-557 (2007).
-
(2007)
Transpl. Int.
, vol.20
, Issue.6
, pp. 550-557
-
-
Schirmer, J.M.1
Miyagi, N.2
Rao, V.P.3
-
76
-
-
0035818555
-
Lifetime correction of genetic deficiency in mice with a single injection of helper-dependent adenoviral vector
-
Kim IH, Józkowicz A, Piedra PA, Oka K, Chan L. Lifetime correction of genetic deficiency in mice with a single injection of helper-dependent adenoviral vector. Proc. Natl Acad. Sci. USA 98(23), 13282-13287 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, Issue.23
, pp. 13282-13287
-
-
Kim, I.H.1
Józkowicz, A.2
Piedra, P.A.3
Oka, K.4
Chan, L.5
-
77
-
-
84875803205
-
Effects of anti-cocaine vaccine and viral gene transfer of cocaine hydrolase in mice on cocaine toxicity including motor strength and liver damage
-
doi:10.1016/j.cbi.2012.08.006 Epub ahead of print
-
Gao Y, Geng L, Orson F et al. Effects of anti-cocaine vaccine and viral gene transfer of cocaine hydrolase in mice on cocaine toxicity including motor strength and liver damage. Chem Biol. Interact. doi:10.1016/j. cbi.2012.08.006 (2012) (Epub ahead of print).
-
(2012)
Chem Biol. Interact.
-
-
Gao, Y.1
Geng, L.2
Orson, F.3
-
78
-
-
79960630209
-
Differentiating the rapid actions of cocaine
-
Wise RA, Kiyatkin EA. Differentiating the rapid actions of cocaine. Nat. Rev. Neurosci. 12(8), 479-484 (2011).
-
(2011)
Nat. Rev. Neurosci.
, vol.12
, Issue.8
, pp. 479-484
-
-
Wise, R.A.1
Kiyatkin, E.A.2
-
79
-
-
84863668596
-
Probing cocaine-antibody interactions in buffer and human serum
-
Ramakrishnan M, Alves De Melo F, Kinsey BM, Ladbury JE, Kosten TR, Orson FM. Probing cocaine-antibody interactions in buffer and human serum. PLoS ONE 7(7), e40518 (2012).
-
(2012)
PLoS ONE
, vol.7
, Issue.7
-
-
Ramakrishnan, M.1
Alves De Melo, F.2
Kinsey, B.M.3
Ladbury, J.E.4
Kosten, T.R.5
Orson, F.M.6
-
80
-
-
77954566230
-
The concept of pharmacologic cocaine interception as a treatment for drug abuse
-
Gao Y, Orson FM, Kinsey B, Kosten T, Brimijoin S. The concept of pharmacologic cocaine interception as a treatment for drug abuse. Chem. Biol. Interact. 187(1-3), 421-424 (2010).
-
(2010)
Chem. Biol. Interact.
, vol.187
, Issue.1-3
, pp. 421-424
-
-
Gao, Y.1
Orson, F.M.2
Kinsey, B.3
Kosten, T.4
Brimijoin, S.5
-
81
-
-
84865063361
-
Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion
-
Carroll ME, Zlebnik NE, Anker JJ et al. Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion. PLoS ONE 7(8), e43536 (2012).
-
(2012)
PLoS ONE
, vol.7
, Issue.8
-
-
Carroll, M.E.1
Zlebnik, N.E.2
Anker, J.J.3
-
82
-
-
0029983685
-
'Sero-switch' Adenovirus-mediated in vivo gene transfer: Circumvention of anti-adenovirus humoral immune defenses against repeat adenovirus vector administration by changing the adenovirus serotype
-
Mastrangeli A, Harvey BG, Yao J et al. 'Sero-switch' adenovirus-mediated in vivo gene transfer: circumvention of anti-adenovirus humoral immune defenses against repeat adenovirus vector administration by changing the adenovirus serotype. Hum. Gene Ther. 7(1), 79-87 (1996).
-
(1996)
Hum. Gene Ther.
, vol.7
, Issue.1
, pp. 79-87
-
-
Mastrangeli, A.1
Harvey, B.G.2
Yao, J.3
-
83
-
-
67651055389
-
Lasting reduction of cocaine action in neostriatum-A hydrolase gene therapy approach
-
Gao Y, Brimijoin S. Lasting reduction of cocaine action in neostriatum-a hydrolase gene therapy approach. J. Pharmacol. Exp. Ther. 330(2), 449-457 (2009).
-
(2009)
J. Pharmacol. Exp. Ther.
, vol.330
, Issue.2
, pp. 449-457
-
-
Gao, Y.1
Brimijoin, S.2
-
84
-
-
0015734707
-
Inheritance of two types of deficiency of human serum cholinesterase
-
Scott EM. Inheritance of two types of deficiency of human serum cholinesterase. Ann. Hum. Genet. 37(2), 139-143 (1973).
-
(1973)
Ann. Hum. Genet.
, vol.37
, Issue.2
, pp. 139-143
-
-
Scott, E.M.1
-
85
-
-
0009549759
-
Complete pseudocholinesterase deficiency: Genetic and immunologic characterization
-
Hodgkin W, Giblett ER, Levine H, Bauer W, Motulsky AG. Complete pseudocholinesterase deficiency: genetic and immunologic characterization. J. Clin. Invest. 44, 486-493 (1965).
-
(1965)
J. Clin. Invest.
, vol.44
, pp. 486-493
-
-
Hodgkin, W.1
Giblett, E.R.2
Levine, H.3
Bauer, W.4
Motulsky, A.G.5
-
86
-
-
78650634444
-
Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine
-
Xue L, Ko MC, Tong M et al. Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine. Mol. Pharmacol. 79(2), 290-297 (2011).
-
(2011)
Mol. Pharmacol.
, vol.79
, Issue.2
, pp. 290-297
-
-
Xue, L.1
Ko, M.C.2
Tong, M.3
-
87
-
-
84859340427
-
Characterization of human serum butyrylcholinesterase in rhesus monkeys: Behavioral and physiological effects
-
Myers TM, Sun W, Naik RS, Clark MG, Doctor BP, Saxena A. Characterization of human serum butyrylcholinesterase in rhesus monkeys: behavioral and physiological effects. Neurotoxicol. Teratol. 34(3), 323-330 (2012).
-
(2012)
Neurotoxicol. Teratol.
, vol.34
, Issue.3
, pp. 323-330
-
-
Myers, T.M.1
Sun, W.2
Naik, R.S.3
Clark, M.G.4
Doctor, B.P.5
Saxena, A.6
-
88
-
-
77955511979
-
Demonstration of in vivo stability and lack of immunogenicity of a polyethyleneglycolconjugated recombinant CHO-derived butyrylcholinesterase bioscavenger using a homologous macaque model
-
Rosenberg YJ, Saxena A, Sun W et al. Demonstration of in vivo stability and lack of immunogenicity of a polyethyleneglycolconjugated recombinant CHO-derived butyrylcholinesterase bioscavenger using a homologous macaque model. Chem. Biol. Interact. 187(1-3), 279-286 (2010).
-
(2010)
Chem. Biol. Interact.
, vol.187
, Issue.1-3
, pp. 279-286
-
-
Rosenberg, Y.J.1
Saxena, A.2
Sun, W.3
-
89
-
-
77951030229
-
Safety of administration of human butyrylcholinesterase and its conjugates with soman or VX in rats
-
Genovese RF, Sun W, Johnson CC, Ditargiani RC, Doctor BP, Saxena A. Safety of administration of human butyrylcholinesterase and its conjugates with soman or VX in rats. Basic Clin. Pharmacol. Toxicol. 106(5), 428-434 (2010).
-
(2010)
Basic Clin. Pharmacol. Toxicol.
, vol.106
, Issue.5
, pp. 428-434
-
-
Genovese, R.F.1
Sun, W.2
Johnson, C.C.3
Ditargiani, R.C.4
Doctor, B.P.5
Saxena, A.6
-
90
-
-
0033836376
-
Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse
-
Li B, Stribley JA, Ticu A et al. Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse. J. Neurochem. 75(3), 1320-1331 (2000).
-
(2000)
J. Neurochem.
, vol.75
, Issue.3
, pp. 1320-1331
-
-
Li, B.1
Stribley, J.A.2
Ticu, A.3
-
91
-
-
0004251292
-
-
North Holland Publishing Co., Amsterdam, The Netherlands
-
Silver A. Biology of Cholinesterases. North Holland Publishing Co., Amsterdam, The Netherlands (1974).
-
(1974)
Biology of Cholinesterases.
-
-
Silver, A.1
-
92
-
-
0032081223
-
125I-labeled fasciculin 2: A new tool for quantitation of acetylcholinesterase densities at synaptic sites by EM-autoradiography
-
Anglister L, Eichler J, Szabo M, Haesaert B, Salpeter MM. 125I-labeled fasciculin 2: a new tool for quantitation of acetylcholinesterase densities at synaptic sites by EM-autoradiography. J. Neurosci. Methods 81(1-2), 63-71 (1998).
-
(1998)
J. Neurosci. Methods
, vol.81
, Issue.1-2
, pp. 63-71
-
-
Anglister, L.1
Eichler, J.2
Szabo, M.3
Haesaert, B.4
Salpeter, M.M.5
-
93
-
-
50649106421
-
Whole body and tissue imaging of the butyrylcholinesterase knockout mouse injected with near infrared dye labeled butyrylcholinesterase
-
Duysen EG, Lockridge O. Whole body and tissue imaging of the butyrylcholinesterase knockout mouse injected with near infrared dye labeled butyrylcholinesterase. Chem. Biol. Interact. 175(1-3), 119-124 (2008).
-
(2008)
Chem. Biol. Interact.
, vol.175
, Issue.1-3
, pp. 119-124
-
-
Duysen, E.G.1
Lockridge, O.2
|