메뉴 건너뛰기




Volumn 12, Issue 3, 2013, Pages 323-332

Prospects, promise and problems on the road to effective vaccines and related therapies for substance abuse

Author keywords

adenovirus gene transfer vector; antidrug immunoglobulin; butyrylcholinesterase; clinical trial; cocaine abuse; cocaine hydrolase; metabolism based therapies; monoclonal antibody; vaccine

Indexed keywords

ADENOVIRUS VECTOR; CHOLINESTERASE; DEXAMETHASONE; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; INTERLEUKIN 6; MONOCLONAL ANTIBODY; NIC 9D9; NICOTINE VACCINE; UNCLASSIFIED DRUG;

EID: 84875130963     PISSN: 14760584     EISSN: 17448395     Source Type: Journal    
DOI: 10.1586/erv.13.1     Document Type: Review
Times cited : (26)

References (94)
  • 6
    • 33644801063 scopus 로고    scopus 로고
    • Current status of immunologic approaches to treating tobacco dependence: Vaccines and nicotine-specific antibodies
    • LeSage MG, Keyler DE, Pentel PR. Current status of immunologic approaches to treating tobacco dependence: vaccines and nicotine-specific antibodies. AAPS J. 8(1), E65-E75 (2006).
    • (2006) AAPS J. , vol.8 , Issue.1
    • Lesage, M.G.1    Keyler, D.E.2    Pentel, P.R.3
  • 7
    • 67650449269 scopus 로고    scopus 로고
    • Development of active and passive human vaccines to treat methamphetamine addiction
    • Gentry WB, Rüedi-Bettschen D, Owens SM. Development of active and passive human vaccines to treat methamphetamine addiction. Hum. Vaccin. 5(4), 206-213 (2009).
    • (2009) Hum. Vaccin. , vol.5 , Issue.4 , pp. 206-213
    • Gentry, W.B.1    Rüedi-Bettschen, D.2    Owens, S.M.3
  • 9
    • 0015598721 scopus 로고
    • Antibody production in mice. V. The suppressive effect of anti-carrier antibodies on cellular cooperation in the induction of secondary anti-hapten antibody responses
    • Hamaoka T, Takatsu K, Kitagawa M. Antibody production in mice. V. The suppressive effect of anti-carrier antibodies on cellular cooperation in the induction of secondary anti-hapten antibody responses. Immunology 24(3), 409-424 (1973).
    • (1973) Immunology , vol.24 , Issue.3 , pp. 409-424
    • Hamaoka, T.1    Takatsu, K.2    Kitagawa, M.3
  • 10
    • 79952195569 scopus 로고    scopus 로고
    • Cocaine analog coupled to disrupted adenovirus: A vaccine strategy to evoke high-titer immunity against addictive drugs
    • Hicks MJ, De BP, Rosenberg JB et al. Cocaine analog coupled to disrupted adenovirus: a vaccine strategy to evoke high-titer immunity against addictive drugs. Mol. Ther. 19(3), 612-619 (2011).
    • (2011) Mol. Ther. , vol.19 , Issue.3 , pp. 612-619
    • Hicks, M.J.1    De Bp Rosenberg, J.B.2
  • 11
    • 16044371587 scopus 로고    scopus 로고
    • Efficacy of a therapeutic cocaine vaccine in rodent models
    • Fox BS, Kantak KM, Edwards MA et al. Efficacy of a therapeutic cocaine vaccine in rodent models. Nat. Med. 2(10), 1129-1132 (1996).
    • (1996) Nat. Med. , vol.2 , Issue.10 , pp. 1129-1132
    • Fox, B.S.1    Kantak, K.M.2    Edwards, M.A.3
  • 12
    • 0016338395 scopus 로고
    • Changes in heroin self-administration by a rhesus monkey after morphine immunisation
    • Bonese KF, Wainer BH, Fitch FW, Rothberg RM, Schuster CR. Changes in heroin self-administration by a rhesus monkey after morphine immunisation. Nature 252(5485), 708-710 (1974).
    • (1974) Nature , vol.252 , Issue.5485 , pp. 708-710
    • Bonese, K.F.1    Wainer, B.H.2    Fitch, F.W.3    Rothberg, R.M.4    Schuster, C.R.5
  • 13
    • 34250788109 scopus 로고    scopus 로고
    • Using hapten design to discover therapeutic monoclonal antibodies for treating methamphetamine abuse
    • Peterson EC, Gunnell M, Che Y et al. Using hapten design to discover therapeutic monoclonal antibodies for treating methamphetamine abuse. J. Pharmacol. Exp. Ther. 322(1), 30-39 (2007).
    • (2007) J. Pharmacol. Exp. Ther. , vol.322 , Issue.1 , pp. 30-39
    • Peterson, E.C.1    Gunnell, M.2    Che, Y.3
  • 14
    • 2442661486 scopus 로고    scopus 로고
    • Effects of murine-derived anti-methamphetamine monoclonal antibodies on (+)-methamphetamine self-administration in the rat
    • McMillan DE, Hardwick WC, Li M et al. Effects of murine-derived anti-methamphetamine monoclonal antibodies on (+)-methamphetamine self-administration in the rat. J. Pharmacol. Exp. Ther. 309(3), 1248-1255 (2004).
    • (2004) J. Pharmacol. Exp. Ther. , vol.309 , Issue.3 , pp. 1248-1255
    • McMillan, D.E.1    Hardwick, W.C.2    Li, M.3
  • 15
    • 67649271523 scopus 로고    scopus 로고
    • Passive immunization with a nicotine-specific monoclonal antibody decreases brain nicotine levels but does not precipitate withdrawal in nicotine-dependent rats
    • Roiko SA, Harris AC, LeSage MG, Keyler DE, Pentel PR. Passive immunization with a nicotine-specific monoclonal antibody decreases brain nicotine levels but does not precipitate withdrawal in nicotine-dependent rats. Pharmacol. Biochem. Behav. 93(2), 105-111 (2009).
    • (2009) Pharmacol. Biochem. Behav. , vol.93 , Issue.2 , pp. 105-111
    • Roiko, S.A.1    Harris, A.C.2    Lesage, M.G.3    Keyler, D.E.4    Pentel, P.R.5
  • 16
    • 0344861819 scopus 로고    scopus 로고
    • Effects of nicotine infusion on the metabolism of the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone (NNK) in rats
    • Keyler D, Pentel PR, Kuehl G, Collins G, Murphy SE. Effects of nicotine infusion on the metabolism of the tobacco carcinogen 4-(methylnitrosamino)-1-(3- pyridyl)-1- butanone (NNK) in rats. Cancer Lett. 202(1), 1-9 (2003).
    • (2003) Cancer Lett. , vol.202 , Issue.1 , pp. 1-9
    • Keyler, D.1    Pentel, P.R.2    Kuehl, G.3    Collins, G.4    Murphy, S.E.5
  • 17
    • 33845889554 scopus 로고    scopus 로고
    • A chimeric human/murine anticocaine monoclonal antibody inhibits the distribution of cocaine to the brain in mice
    • Norman AB, Tabet MR, Norman MK, Buesing WR, Pesce AJ, Ball WJ. A chimeric human/murine anticocaine monoclonal antibody inhibits the distribution of cocaine to the brain in mice. J. Pharmacol. Exp. Ther. 320(1), 145-153 (2007).
    • (2007) J. Pharmacol. Exp. Ther. , vol.320 , Issue.1 , pp. 145-153
    • Norman, A.B.1    Tabet, M.R.2    Norman, M.K.3    Buesing, W.R.4    Pesce, A.J.5    Ball, W.J.6
  • 18
    • 0031470566 scopus 로고    scopus 로고
    • Active immunization alters the plasma nicotine concentration in rats
    • Hieda Y, Keyler DE, Vandevoort JT et al. Active immunization alters the plasma nicotine concentration in rats. J. Pharmacol. Exp. Ther. 283(3), 1076-1081 (1997).
    • (1997) J. Pharmacol. Exp. Ther. , vol.283 , Issue.3 , pp. 1076-1081
    • Hieda, Y.1    Keyler, D.E.2    Vandevoort, J.T.3
  • 19
    • 0037436021 scopus 로고    scopus 로고
    • Pharmacodynamic mechanisms of monoclonal antibody-based antagonism of (+)-methamphetamine in rats
    • Byrnes-Blake KA, Laurenzana EM, Carroll FI et al. Pharmacodynamic mechanisms of monoclonal antibody-based antagonism of (+)-methamphetamine in rats. Eur. J. Pharmacol. 461(2-3), 119-128 (2003).
    • (2003) Eur. J. Pharmacol. , vol.461 , Issue.2-3 , pp. 119-128
    • Byrnes-Blake, K.A.1    Laurenzana, E.M.2    Carroll, F.I.3
  • 20
    • 26444588706 scopus 로고    scopus 로고
    • Monoclonal IgG affinity and treatment time alters antagonism of (+)-methamphetamine effects in rats
    • Byrnes-Blake KA, Laurenzana EM, Landes RD, Gentry WB, Owens SM. Monoclonal IgG affinity and treatment time alters antagonism of (+)-methamphetamine effects in rats. Eur. J. Pharmacol. 521(1-3), 86-94 (2005).
    • (2005) Eur. J. Pharmacol. , vol.521 , Issue.1-3 , pp. 86-94
    • Byrnes-Blake, K.A.1    Laurenzana, E.M.2    Landes, R.D.3    Gentry, W.B.4    Owens, S.M.5
  • 21
    • 0037092439 scopus 로고    scopus 로고
    • The rate of intravenous cocaine administration determines susceptibility to sensitization
    • Samaha AN, Li Y, Robinson TE. The rate of intravenous cocaine administration determines susceptibility to sensitization. J. Neurosci. 22(8), 3244-3250 (2002).
    • (2002) J. Neurosci. , vol.22 , Issue.8 , pp. 3244-3250
    • Samaha, A.N.1    Li, Y.2    Robinson, T.E.3
  • 22
    • 0026463456 scopus 로고
    • Severity of dependence and route of administration of heroin, cocaine and amphetamines
    • Gossop M, Griffiths P, Powis B, Strang J. Severity of dependence and route of administration of heroin, cocaine and amphetamines. Br. J. Addict. 87(11), 1527-1536 (1992).
    • (1992) Br. J. Addict. , vol.87 , Issue.11 , pp. 1527-1536
    • Gossop, M.1    Griffiths, P.2    Powis, B.3    Strang, J.4
  • 23
    • 0037081517 scopus 로고    scopus 로고
    • Human therapeutic cocaine vaccine: Safety and immunogenicity
    • Kosten TR, Rosen M, Bond J et al. Human therapeutic cocaine vaccine: safety and immunogenicity. Vaccine 20(7-8), 1196-1204 (2002).
    • (2002) Vaccine , vol.20 , Issue.7-8 , pp. 1196-1204
    • Kosten, T.R.1    Rosen, M.2    Bond, J.3
  • 24
    • 49649104752 scopus 로고    scopus 로고
    • A vaccine against nicotine for smoking cessation: A randomized controlled trial
    • Cornuz J, Zwahlen S, Jungi WF et al. A vaccine against nicotine for smoking cessation: a randomized controlled trial. PLoS ONE 3(6), e2547 (2008).
    • (2008) PLoS ONE , vol.3 , Issue.6
    • Cornuz, J.1    Zwahlen, S.2    Jungi, W.F.3
  • 25
    • 28144465243 scopus 로고    scopus 로고
    • Safety and immunogenicity of a nicotine conjugate vaccine in current smokers
    • Hatsukami DK, Rennard S, Jorenby D et al. Safety and immunogenicity of a nicotine conjugate vaccine in current smokers. Clin. Pharmacol. Ther. 78(5), 456-467 (2005).
    • (2005) Clin. Pharmacol. Ther. , vol.78 , Issue.5 , pp. 456-467
    • Hatsukami, D.K.1    Rennard, S.2    Jorenby, D.3
  • 26
    • 84874042611 scopus 로고    scopus 로고
    • Spontaneous development of IgM anti-cocaine antibodies in habitual cocaine users: Effect on IgG antibody responses to a cocaine cholera toxin B conjugate vaccine
    • Orson F, Rossen RD, Shen X, Lopez AY, Wu Y, Kosten T. Spontaneous development of IgM anti-cocaine antibodies in habitual cocaine users: effect on IgG antibody responses to a cocaine cholera toxin B conjugate vaccine. Am. J. Addict. 22(2), 169-174 (2012).
    • (2012) Am. J. Addict. , vol.22 , Issue.2 , pp. 169-174
    • Orson, F.1    Rossen, R.D.2    Shen, X.3    Lopez, A.Y.4    Wu, Y.5    Kosten, T.6
  • 27
    • 62449333563 scopus 로고    scopus 로고
    • The effect of a chimeric human/murine anti-cocaine monoclonal antibody on cocaine self-administration in rats
    • Norman AB, Norman MK, Buesing WR, Tabet MR, Tsibulsky VL, Ball WJ. The effect of a chimeric human/murine anti-cocaine monoclonal antibody on cocaine self-administration in rats. J. Pharmacol. Exp. Ther. 328(3), 873-881 (2009).
    • (2009) J. Pharmacol. Exp. Ther. , vol.328 , Issue.3 , pp. 873-881
    • Norman, A.B.1    Norman, M.K.2    Buesing, W.R.3    Tabet, M.R.4    Tsibulsky, V.L.5    Ball, W.J.6
  • 28
    • 0142212156 scopus 로고    scopus 로고
    • Use of anti-(+)-methamphetamine monoclonal antibody to significantly alter (+)-methamphetamine and (+)-amphetamine disposition in rats
    • Laurenzana EM, Byrnes-Blake KA, Milesi-Hallé A, Gentry WB, Williams DK, Owens SM. Use of anti-(+)-methamphetamine monoclonal antibody to significantly alter (+)-methamphetamine and (+)-amphetamine disposition in rats. Drug Metab. Dispos. 31(11), 1320-1326 (2003).
    • (2003) Drug Metab. Dispos. , vol.31 , Issue.11 , pp. 1320-1326
    • Laurenzana, E.M.1    Byrnes-Blake, K.A.2    Milesi-Hallé, A.3    Gentry, W.B.4    Williams, D.K.5    Owens, S.M.6
  • 29
    • 0142089747 scopus 로고    scopus 로고
    • Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer
    • Raper SE, Chirmule N, Lee FS et al. Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer. Mol. Genet. Metab. 80(1-2), 148-158 (2003).
    • (2003) Mol. Genet. Metab. , vol.80 , Issue.1-2 , pp. 148-158
    • Raper, S.E.1    Chirmule, N.2    Lee, F.S.3
  • 30
    • 0036147236 scopus 로고    scopus 로고
    • Toxicity of a first-generation adenoviral vector in rhesus macaques
    • Lozier JN, Csako G, Mondoro TH et al. Toxicity of a first-generation adenoviral vector in rhesus macaques. Hum. Gene Ther. 13(1), 113-124 (2002).
    • (2002) Hum. Gene Ther. , vol.13 , Issue.1 , pp. 113-124
    • Lozier, J.N.1    Csako, G.2    Mondoro, T.H.3
  • 32
    • 79952464971 scopus 로고    scopus 로고
    • Gene therapy for vision loss - Recent developments
    • Stieger K, Lorenz B. Gene therapy for vision loss - recent developments. Discov. Med. 10(54), 425-433 (2010).
    • (2010) Discov. Med. , vol.10 , Issue.54 , pp. 425-433
    • Stieger, K.1    Lorenz, B.2
  • 33
    • 84867461170 scopus 로고    scopus 로고
    • Immunotherapeutic strategies for cancer treatment: A novel protein transfer approach for cancer vaccine development
    • Shashidharamurthy R, Bozeman EN, Patel J, Kaur R, Meganathan J, Selvaraj P. Immunotherapeutic strategies for cancer treatment: a novel protein transfer approach for cancer vaccine development. Med. Res. Rev. 32(6), 1197-1219 (2012).
    • (2012) Med. Res. Rev. , vol.32 , Issue.6 , pp. 1197-1219
    • Shashidharamurthy, R.1    Bozeman, E.N.2    Patel, J.3    Kaur, R.4    Meganathan, J.5    Selvaraj, P.6
  • 34
    • 22744444388 scopus 로고    scopus 로고
    • Stable antibody expression at therapeutic levels using the 2A peptide
    • Fang J, Qian JJ, Yi S et al. Stable antibody expression at therapeutic levels using the 2A peptide. Nat. Biotechnol. 23(5), 584-590 (2005).
    • (2005) Nat. Biotechnol. , vol.23 , Issue.5 , pp. 584-590
    • Fang, J.1    Qian, J.J.2    Yi, S.3
  • 35
    • 0034518447 scopus 로고    scopus 로고
    • Gene transfer of anti-gp41 antibody and CD4 immunoadhesin strongly reduces the HIV-1 load in humanized severe combined immunodeficient mice
    • Sanhadji K, Grave L, Touraine JL et al. Gene transfer of anti-gp41 antibody and CD4 immunoadhesin strongly reduces the HIV-1 load in humanized severe combined immunodeficient mice. AIDS 14(18), 2813-2822 (2000).
    • (2000) AIDS , vol.14 , Issue.18 , pp. 2813-2822
    • Sanhadji, K.1    Grave, L.2    Touraine, J.L.3
  • 36
    • 84863186975 scopus 로고    scopus 로고
    • AAV-directed persistent expression of a gene encoding anti-nicotine antibody for smoking cessation
    • Hicks MJ, Rosenberg JB, De BP et al. AAV-directed persistent expression of a gene encoding anti-nicotine antibody for smoking cessation. Sci. Transl. Med. 4(140), 140ra87 (2012).
    • (2012) Sci. Transl. Med. , vol.4 , Issue.140
    • Hicks, M.J.1    Rosenberg, J.B.2    De, B.P.3
  • 37
    • 0016860852 scopus 로고
    • Plasma nicotine levels after smoking cigarettes with high, medium, and low nicotine yields
    • Russell MA, Wilson C, Patel UA, Feyerabend C, Cole PV. Plasma nicotine levels after smoking cigarettes with high, medium, and low nicotine yields. Br. Med. J. 2(5968), 414-416 (1975).
    • (1975) Br. Med. J. , vol.2 , Issue.5968 , pp. 414-416
    • Russell, M.A.1    Wilson, C.2    Patel, U.A.3    Feyerabend, C.4    Cole, P.V.5
  • 38
    • 84861664392 scopus 로고    scopus 로고
    • AAVrh.10-mediated expression of an anti-cocaine antibody mediates persistent passive immunization that suppresses cocaine-induced behavior
    • Rosenberg JB, Hicks MJ, De BP et al. AAVrh.10-mediated expression of an anti-cocaine antibody mediates persistent passive immunization that suppresses cocaine-induced behavior. Hum. Gene Ther. 23(5), 451-459 (2012).
    • (2012) Hum. Gene Ther. , vol.23 , Issue.5 , pp. 451-459
    • Rosenberg, J.B.1    Hicks, M.J.2    De, B.P.3
  • 39
    • 0031743608 scopus 로고    scopus 로고
    • Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery
    • Zufferey R, Dull T, Mandel RJ et al. Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery. J. Virol. 72(12), 9873-9880 (1998).
    • (1998) J. Virol. , vol.72 , Issue.12 , pp. 9873-9880
    • Zufferey, R.1    Dull, T.2    Mandel, R.J.3
  • 40
    • 0142084745 scopus 로고    scopus 로고
    • LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
    • Hacein-Bey-Abina S, Von Kalle C, Schmidt M et al. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 302(5644), 415-419 (2003).
    • (2003) Science , vol.302 , Issue.5644 , pp. 415-419
    • Hacein-Bey-Abina, S.1    Von Kalle, C.2    Schmidt, M.3
  • 41
    • 0028875936 scopus 로고
    • Transfer of genes to humans: Early lessons and obstacles to success
    • Crystal RG. Transfer of genes to humans: early lessons and obstacles to success. Science 270(5235), 404-410 (1995).
    • (1995) Science , vol.270 , Issue.5235 , pp. 404-410
    • Crystal, R.G.1
  • 42
    • 0030462599 scopus 로고    scopus 로고
    • A helperdependent adenovirus vector system: Removal of helper virus by Cre-mediated excision of the viral packaging signal
    • Parks RJ, Chen L, Anton M, Sankar U, Rudnicki MA, Graham FL. A helperdependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc. Natl Acad. Sci. USA 93(24), 13565-13570 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , Issue.24 , pp. 13565-13570
    • Parks, R.J.1    Chen, L.2    Anton, M.3    Sankar, U.4    Russell, M.A.5    Graham, F.L.6
  • 43
    • 0028169741 scopus 로고
    • Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain
    • Kaplitt MG, Leone P, Samulski RJ et al. Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain. Nat. Genet. 8(2), 148-154 (1994).
    • (1994) Nat. Genet. , vol.8 , Issue.2 , pp. 148-154
    • Kaplitt, M.G.1    Leone, P.2    Samulski, R.J.3
  • 44
    • 77955924785 scopus 로고    scopus 로고
    • Oligoarray comparative genomic hybridization of renal cell tumors that developed in patients with acquired cystic renal disease
    • Kuntz E, Yusenko MV, Nagy A, Kovacs G. Oligoarray comparative genomic hybridization of renal cell tumors that developed in patients with acquired cystic renal disease. Hum. Pathol. 41(9), 1345-1349 (2010).
    • (2010) Hum. Pathol. , vol.41 , Issue.9 , pp. 1345-1349
    • Kuntz, E.1    Yusenko, M.V.2    Nagy, A.3    Kovacs, G.4
  • 46
    • 11144248909 scopus 로고    scopus 로고
    • The innate immune response to adenovirus vectors
    • Muruve DA. The innate immune response to adenovirus vectors. Hum. Gene Ther. 15(12), 1157-1166 (2004).
    • (2004) Hum. Gene Ther. , vol.15 , Issue.12 , pp. 1157-1166
    • Muruve, D.A.1
  • 47
    • 43049178300 scopus 로고    scopus 로고
    • Progress and prospects: Gene therapy for genetic diseases with helper-dependent adenoviral vectors
    • Brunetti-Pierri N, Ng P. Progress and prospects: gene therapy for genetic diseases with helper-dependent adenoviral vectors. Gene Ther. 15(8), 553-560 (2008).
    • (2008) Gene Ther. , vol.15 , Issue.8 , pp. 553-560
    • Brunetti-Pierri, N.1    Ng, P.2
  • 48
    • 79956014843 scopus 로고    scopus 로고
    • Helper-dependent adenoviral vectors for liver-directed gene therapy
    • Brunetti-Pierri N, Ng P. Helper-dependent adenoviral vectors for liver-directed gene therapy. Hum. Mol. Genet. 20(R1), R7-13 (2011).
    • (2011) Hum. Mol. Genet. , vol.20 , Issue.R1
    • Brunetti-Pierri, N.1    Ng, P.2
  • 49
    • 13044304200 scopus 로고    scopus 로고
    • Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons
    • Morral N, O'Neal W, Rice K et al. Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons. Proc. Natl Acad. Sci. USA 96(22), 12816-12821 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , Issue.22 , pp. 12816-12821
    • Morral, N.1    O'Neal, W.2    Rice, K.3
  • 50
    • 70349481529 scopus 로고    scopus 로고
    • Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy
    • Brantly ML, Chulay JD, Wang L et al. Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy. Proc. Natl Acad. Sci. USA 106(38), 16363-16368 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , Issue.38 , pp. 16363-16368
    • Brantly, M.L.1    Chulay, J.D.2    Wang, L.3
  • 51
    • 33644820684 scopus 로고    scopus 로고
    • Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response
    • Manno CS, Pierce GF, Arruda VR et al. Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response. Nat. Med. 12(3), 342-347 (2006).
    • (2006) Nat. Med. , vol.12 , Issue.3 , pp. 342-347
    • Manno, C.S.1    Pierce, G.F.2    Arruda, V.R.3
  • 52
    • 80053547854 scopus 로고    scopus 로고
    • Liver-directed gene therapy with helper-dependent adenoviral vectors: Current state of the art and future challenges
    • Vetrini F, Ng P. Liver-directed gene therapy with helper-dependent adenoviral vectors: current state of the art and future challenges. Curr. Pharm. Des. 17(24), 2488-2499 (2011).
    • (2011) Curr. Pharm. Des. , vol.17 , Issue.24 , pp. 2488-2499
    • Vetrini, F.1    Ng, P.2
  • 53
    • 63949084441 scopus 로고    scopus 로고
    • Transient pretreatment with glucocorticoid ablates innate toxicity of systemically delivered adenoviral vectors without reducing efficacy
    • Seregin SS, Appledorn DM, McBride AJ et al. Transient pretreatment with glucocorticoid ablates innate toxicity of systemically delivered adenoviral vectors without reducing efficacy. Mol. Ther. 17(4), 685-696 (2009).
    • (2009) Mol. Ther. , vol.17 , Issue.4 , pp. 685-696
    • Seregin, S.S.1    Appledorn, D.M.2    McBride, A.J.3
  • 54
    • 28444469819 scopus 로고    scopus 로고
    • Suppression of inflammation by dexamethasone prolongs adenoviral vector-mediated transgene expression in murine nasal mucosa
    • Kumahara K, Nagata H, Watanabe K et al. Suppression of inflammation by dexamethasone prolongs adenoviral vector-mediated transgene expression in murine nasal mucosa. Acta Otolaryngol. 125(12), 1301-1306 (2005).
    • (2005) Acta Otolaryngol. , vol.125 , Issue.12 , pp. 1301-1306
    • Kumahara, K.1    Nagata, H.2    Watanabe, K.3
  • 55
    • 0742307422 scopus 로고    scopus 로고
    • Acute toxicity after high-dose systemic injection of helper-dependent adenoviral vectors into nonhuman primates
    • Brunetti-Pierri N, Palmer DJ, Beaudet AL, Carey KD, Finegold M, Ng P. Acute toxicity after high-dose systemic injection of helper-dependent adenoviral vectors into nonhuman primates. Hum. Gene Ther. 15(1), 35-46 (2004).
    • (2004) Hum. Gene Ther. , vol.15 , Issue.1 , pp. 35-46
    • Brunetti-Pierri, N.1    Palmer, D.J.2    Beaudet, A.L.3    Carey, K.D.4    Finegold, M.5    Ng, P.6
  • 56
    • 0017664631 scopus 로고
    • Hydrolysis of cocaine in human plasma by cholinesterase
    • Stewart DJ, Inaba T, Tang BK, Kalow W. Hydrolysis of cocaine in human plasma by cholinesterase. Life Sci. 20(9), 1557-1563 (1977).
    • (1977) Life Sci. , vol.20 , Issue.9 , pp. 1557-1563
    • Stewart, D.J.1    Inaba, T.2    Tang, B.K.3    Kalow, W.4
  • 57
    • 0036119167 scopus 로고    scopus 로고
    • The role of pharmacogenetically-variable cytochrome P450 enzymes in drug abuse and dependence
    • Howard LA, Sellers EM, Tyndale RF. The role of pharmacogenetically- variable cytochrome P450 enzymes in drug abuse and dependence. Pharmacogenomics 3(2), 185-199 (2002).
    • (2002) Pharmacogenomics , vol.3 , Issue.2 , pp. 185-199
    • Howard, L.A.1    Sellers, E.M.2    Tyndale, R.F.3
  • 58
    • 0033866924 scopus 로고    scopus 로고
    • Inhibition of cytochrome P450 2A6 increases nicotine's oral bioavailability and decreases smoking
    • Sellers EM, Kaplan HL, Tyndale RF. Inhibition of cytochrome P450 2A6 increases nicotine's oral bioavailability and decreases smoking. Clin. Pharmacol. Ther. 68(1), 35-43 (2000).
    • (2000) Clin. Pharmacol. Ther. , vol.68 , Issue.1 , pp. 35-43
    • Sellers, E.M.1    Kaplan, H.L.2    Tyndale, R.F.3
  • 59
    • 0030735986 scopus 로고    scopus 로고
    • Enhancing cocaine metabolism with butyrylcholinesterase as a treatment strategy
    • Gorelick DA. Enhancing cocaine metabolism with butyrylcholinesterase as a treatment strategy. Drug Alcohol Depend. 48(3), 159-165 (1997).
    • (1997) Drug Alcohol Depend. , vol.48 , Issue.3 , pp. 159-165
    • Gorelick, D.A.1
  • 60
    • 0032944436 scopus 로고    scopus 로고
    • An improved cocaine hydrolase: The A328Y mutant of human butyrylcholinesterase is 4-fold more efficient
    • Xie W, Altamirano CV, Bartels CF, Speirs RJ, Cashman JR, Lockridge O. An improved cocaine hydrolase: the A328Y mutant of human butyrylcholinesterase is 4-fold more efficient. Mol. Pharmacol. 55(1), 83-91 (1999).
    • (1999) Mol. Pharmacol. , vol.55 , Issue.1 , pp. 83-91
    • Xie, W.1    Altamirano, C.V.2    Bartels, C.F.3    Speirs, R.J.4    Cashman, J.R.5    Lockridge, O.6
  • 61
    • 0036077314 scopus 로고    scopus 로고
    • Re-engineering butyrylcholinesterase as a cocaine hydrolase
    • Sun H, Pang YP, Lockridge O, Brimijoin S. Re-engineering butyrylcholinesterase as a cocaine hydrolase. Mol. Pharmacol. 62(2), 220-224 (2002).
    • (2002) Mol. Pharmacol. , vol.62 , Issue.2 , pp. 220-224
    • Sun, H.1    Pang, Y.P.2    Lockridge, O.3    Brimijoin, S.4
  • 62
    • 0034871717 scopus 로고    scopus 로고
    • Simultaneous pharmacokinetic modeling of cocaine and its metabolites, norcocaine and benzyoylecgonine, after intravenous and oral administration in rats
    • Sun L, Lau CE. Simultaneous pharmacokinetic modeling of cocaine and its metabolites, norcocaine and benzyoylecgonine, after intravenous and oral administration in rats. Drug Metab. Disp. 29, 1183-1189 (2001).
    • (2001) Drug Metab. Disp. , vol.29 , pp. 1183-1189
    • Sun, L.1    Lau, C.E.2
  • 63
    • 28044458963 scopus 로고    scopus 로고
    • Computational redesign of human butyrylcholinesterase for anticocaine medication
    • Pan Y, Gao D, Yang W et al. Computational redesign of human butyrylcholinesterase for anticocaine medication. Proc. Natl Acad. Sci. USA 102(46), 16656-16661 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , Issue.46 , pp. 16656-16661
    • Pan, Y.1    Gao, D.2    Yang, W.3
  • 64
    • 77955517250 scopus 로고    scopus 로고
    • Characterization of a high-activity mutant of human butyrylcholinesterase against (-)-cocaine
    • Yang W, Xue L, Fang L, Chen X, Zhan CG. Characterization of a high-activity mutant of human butyrylcholinesterase against (-)-cocaine. Chem. Biol. Interact. 187(1-3), 148-152 (2010).
    • (2010) Chem. Biol. Interact. , vol.187 , Issue.1-3 , pp. 148-152
    • Yang, W.1    Xue, L.2    Fang, L.3    Chen, X.4    Zhan, C.G.5
  • 65
    • 51749096409 scopus 로고    scopus 로고
    • Most efficient cocaine hydrolase designed by virtual screening of transition states
    • Zheng F, Yang W, Ko MC et al. Most efficient cocaine hydrolase designed by virtual screening of transition states. J. Am. Chem. Soc. 130(36), 12148-12155 (2008).
    • (2008) J. Am. Chem. Soc. , vol.130 , Issue.36 , pp. 12148-12155
    • Zheng, F.1    Yang, W.2    Ko, M.C.3
  • 66
    • 48749118846 scopus 로고    scopus 로고
    • A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats
    • Brimijoin S, Gao Y, Anker JJ et al. A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats. Neuropsychopharmacology 33(11), 2715-2725 (2008).
    • (2008) Neuropsychopharmacology , vol.33 , Issue.11 , pp. 2715-2725
    • Brimijoin, S.1    Gao, Y.2    Anker, J.J.3
  • 67
    • 84856813588 scopus 로고    scopus 로고
    • Cocaine hydrolase encoded in viral vector blocks the reinstatement of cocaine seeking in rats for months
    • Anker JJ, Brimijoin S, Gao Y et al. Cocaine hydrolase encoded in viral vector blocks the reinstatement of cocaine seeking in rats for months. Biol. Psychiatry 71(8), 700-705 (2012).
    • (2012) Biol. Psychiatry , vol.71 , Issue.8 , pp. 700-705
    • Anker, J.J.1    Brimijoin, S.2    Gao, Y.3
  • 68
    • 78549267772 scopus 로고    scopus 로고
    • Prophylaxis with human serum butyrylcholinesterase protects guinea pigs exposed to multiple lethal doses of soman or VX
    • Saxena A, Sun W, Fedorko JM, Koplovitz I, Doctor BP. Prophylaxis with human serum butyrylcholinesterase protects guinea pigs exposed to multiple lethal doses of soman or VX. Biochem. Pharmacol. 81(1), 164-169 (2011).
    • (2011) Biochem. Pharmacol. , vol.81 , Issue.1 , pp. 164-169
    • Saxena, A.1    Sun, W.2    Fedorko, J.M.3    Koplovitz, I.4    Doctor, B.P.5
  • 69
    • 28744450575 scopus 로고    scopus 로고
    • Human serum butyrylcholinesterase: In vitro and in vivo stability, pharmacokinetics, and safety in mice
    • Saxena A, Sun W, Luo C, Doctor BP. Human serum butyrylcholinesterase: in vitro and in vivo stability, pharmacokinetics, and safety in mice. Chem. Biol. Interact. 199-203 (2005).
    • (2005) Chem. Biol. Interact. , pp. 199-203
    • Saxena, A.1    Sun, W.2    Luo, C.3    Doctor, B.P.4
  • 70
    • 79952515951 scopus 로고    scopus 로고
    • Biochemical, molecular and preclinical characterization of a double-virus-reduced human butyrylcholinesterase preparation designed for clinical use
    • Weber A, Butterweck H, Mais-Paul U et al. Biochemical, molecular and preclinical characterization of a double-virus-reduced human butyrylcholinesterase preparation designed for clinical use. Vox Sang. 100(3), 285-297 (2011).
    • (2011) Vox Sang. , vol.100 , Issue.3 , pp. 285-297
    • Weber, A.1    Butterweck, H.2    Mais-Paul, U.3
  • 71
    • 11244266133 scopus 로고    scopus 로고
    • Gene transfer of cocaine hydrolase suppresses cardiovascular responses to cocaine in rats
    • Gao Y, Atanasova E, Sui N, Pancook JD, Watkins JD, Brimijoin S. Gene transfer of cocaine hydrolase suppresses cardiovascular responses to cocaine in rats. Mol. Pharmacol. 67(1), 204-211 (2005).
    • (2005) Mol. Pharmacol. , vol.67 , Issue.1 , pp. 204-211
    • Gao, Y.1    Atanasova, E.2    Sui, N.3    Pancook, J.D.4    Watkins, J.D.5    Brimijoin, S.6
  • 72
    • 0029054932 scopus 로고
    • Rescue, propagation, and partial purification of a helper virus-dependent adenovirus vector
    • Mitani K, Graham FL, Caskey CT, Kochanek S. Rescue, propagation, and partial purification of a helper virus-dependent adenovirus vector. Proc. Natl Acad. Sci. USA 92(9), 3854-3858 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , Issue.9 , pp. 3854-3858
    • Mitani, K.1    Graham, F.L.2    Caskey, C.T.3    Kochanek, S.4
  • 73
    • 0029943155 scopus 로고    scopus 로고
    • A new adenoviral vector: Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and -galactosidase
    • Kochanek S, Clemens PR, Mitani K, Chen HH, Chan S, Caskey CT. A new adenoviral vector: Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and ?-galactosidase. Proc. Natl Acad. Sci. USA 93(12), 5731-5736 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , Issue.12 , pp. 5731-5736
    • Kochanek, S.1    Clemens, P.R.2    Mitani, K.3    Chen, H.H.4    Chan, S.5    Caskey, C.T.6
  • 74
    • 42649145845 scopus 로고    scopus 로고
    • Efficient and durable gene transfer to transplanted heart using adeno-associated virus 9 vector
    • Miyagi N, Rao VP, Ricci D et al. Efficient and durable gene transfer to transplanted heart using adeno-associated virus 9 vector. J. Heart Lung Transplant. 27(5), 554-560 (2008).
    • (2008) J. Heart Lung Transplant. , vol.27 , Issue.5 , pp. 554-560
    • Miyagi, N.1    Rao, V.P.2    Ricci, D.3
  • 75
    • 34247871536 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus vector for gene transfer to the transplanted rat heart
    • Schirmer JM, Miyagi N, Rao VP et al. Recombinant adeno-associated virus vector for gene transfer to the transplanted rat heart. Transpl. Int. 20(6), 550-557 (2007).
    • (2007) Transpl. Int. , vol.20 , Issue.6 , pp. 550-557
    • Schirmer, J.M.1    Miyagi, N.2    Rao, V.P.3
  • 76
    • 0035818555 scopus 로고    scopus 로고
    • Lifetime correction of genetic deficiency in mice with a single injection of helper-dependent adenoviral vector
    • Kim IH, Józkowicz A, Piedra PA, Oka K, Chan L. Lifetime correction of genetic deficiency in mice with a single injection of helper-dependent adenoviral vector. Proc. Natl Acad. Sci. USA 98(23), 13282-13287 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , Issue.23 , pp. 13282-13287
    • Kim, I.H.1    Józkowicz, A.2    Piedra, P.A.3    Oka, K.4    Chan, L.5
  • 77
    • 84875803205 scopus 로고    scopus 로고
    • Effects of anti-cocaine vaccine and viral gene transfer of cocaine hydrolase in mice on cocaine toxicity including motor strength and liver damage
    • doi:10.1016/j.cbi.2012.08.006 Epub ahead of print
    • Gao Y, Geng L, Orson F et al. Effects of anti-cocaine vaccine and viral gene transfer of cocaine hydrolase in mice on cocaine toxicity including motor strength and liver damage. Chem Biol. Interact. doi:10.1016/j. cbi.2012.08.006 (2012) (Epub ahead of print).
    • (2012) Chem Biol. Interact.
    • Gao, Y.1    Geng, L.2    Orson, F.3
  • 78
    • 79960630209 scopus 로고    scopus 로고
    • Differentiating the rapid actions of cocaine
    • Wise RA, Kiyatkin EA. Differentiating the rapid actions of cocaine. Nat. Rev. Neurosci. 12(8), 479-484 (2011).
    • (2011) Nat. Rev. Neurosci. , vol.12 , Issue.8 , pp. 479-484
    • Wise, R.A.1    Kiyatkin, E.A.2
  • 80
    • 77954566230 scopus 로고    scopus 로고
    • The concept of pharmacologic cocaine interception as a treatment for drug abuse
    • Gao Y, Orson FM, Kinsey B, Kosten T, Brimijoin S. The concept of pharmacologic cocaine interception as a treatment for drug abuse. Chem. Biol. Interact. 187(1-3), 421-424 (2010).
    • (2010) Chem. Biol. Interact. , vol.187 , Issue.1-3 , pp. 421-424
    • Gao, Y.1    Orson, F.M.2    Kinsey, B.3    Kosten, T.4    Brimijoin, S.5
  • 81
    • 84865063361 scopus 로고    scopus 로고
    • Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion
    • Carroll ME, Zlebnik NE, Anker JJ et al. Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion. PLoS ONE 7(8), e43536 (2012).
    • (2012) PLoS ONE , vol.7 , Issue.8
    • Carroll, M.E.1    Zlebnik, N.E.2    Anker, J.J.3
  • 82
    • 0029983685 scopus 로고    scopus 로고
    • 'Sero-switch' Adenovirus-mediated in vivo gene transfer: Circumvention of anti-adenovirus humoral immune defenses against repeat adenovirus vector administration by changing the adenovirus serotype
    • Mastrangeli A, Harvey BG, Yao J et al. 'Sero-switch' adenovirus-mediated in vivo gene transfer: circumvention of anti-adenovirus humoral immune defenses against repeat adenovirus vector administration by changing the adenovirus serotype. Hum. Gene Ther. 7(1), 79-87 (1996).
    • (1996) Hum. Gene Ther. , vol.7 , Issue.1 , pp. 79-87
    • Mastrangeli, A.1    Harvey, B.G.2    Yao, J.3
  • 83
    • 67651055389 scopus 로고    scopus 로고
    • Lasting reduction of cocaine action in neostriatum-A hydrolase gene therapy approach
    • Gao Y, Brimijoin S. Lasting reduction of cocaine action in neostriatum-a hydrolase gene therapy approach. J. Pharmacol. Exp. Ther. 330(2), 449-457 (2009).
    • (2009) J. Pharmacol. Exp. Ther. , vol.330 , Issue.2 , pp. 449-457
    • Gao, Y.1    Brimijoin, S.2
  • 84
    • 0015734707 scopus 로고
    • Inheritance of two types of deficiency of human serum cholinesterase
    • Scott EM. Inheritance of two types of deficiency of human serum cholinesterase. Ann. Hum. Genet. 37(2), 139-143 (1973).
    • (1973) Ann. Hum. Genet. , vol.37 , Issue.2 , pp. 139-143
    • Scott, E.M.1
  • 85
    • 0009549759 scopus 로고
    • Complete pseudocholinesterase deficiency: Genetic and immunologic characterization
    • Hodgkin W, Giblett ER, Levine H, Bauer W, Motulsky AG. Complete pseudocholinesterase deficiency: genetic and immunologic characterization. J. Clin. Invest. 44, 486-493 (1965).
    • (1965) J. Clin. Invest. , vol.44 , pp. 486-493
    • Hodgkin, W.1    Giblett, E.R.2    Levine, H.3    Bauer, W.4    Motulsky, A.G.5
  • 86
    • 78650634444 scopus 로고    scopus 로고
    • Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine
    • Xue L, Ko MC, Tong M et al. Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine. Mol. Pharmacol. 79(2), 290-297 (2011).
    • (2011) Mol. Pharmacol. , vol.79 , Issue.2 , pp. 290-297
    • Xue, L.1    Ko, M.C.2    Tong, M.3
  • 87
    • 84859340427 scopus 로고    scopus 로고
    • Characterization of human serum butyrylcholinesterase in rhesus monkeys: Behavioral and physiological effects
    • Myers TM, Sun W, Naik RS, Clark MG, Doctor BP, Saxena A. Characterization of human serum butyrylcholinesterase in rhesus monkeys: behavioral and physiological effects. Neurotoxicol. Teratol. 34(3), 323-330 (2012).
    • (2012) Neurotoxicol. Teratol. , vol.34 , Issue.3 , pp. 323-330
    • Myers, T.M.1    Sun, W.2    Naik, R.S.3    Clark, M.G.4    Doctor, B.P.5    Saxena, A.6
  • 88
    • 77955511979 scopus 로고    scopus 로고
    • Demonstration of in vivo stability and lack of immunogenicity of a polyethyleneglycolconjugated recombinant CHO-derived butyrylcholinesterase bioscavenger using a homologous macaque model
    • Rosenberg YJ, Saxena A, Sun W et al. Demonstration of in vivo stability and lack of immunogenicity of a polyethyleneglycolconjugated recombinant CHO-derived butyrylcholinesterase bioscavenger using a homologous macaque model. Chem. Biol. Interact. 187(1-3), 279-286 (2010).
    • (2010) Chem. Biol. Interact. , vol.187 , Issue.1-3 , pp. 279-286
    • Rosenberg, Y.J.1    Saxena, A.2    Sun, W.3
  • 90
    • 0033836376 scopus 로고    scopus 로고
    • Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse
    • Li B, Stribley JA, Ticu A et al. Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse. J. Neurochem. 75(3), 1320-1331 (2000).
    • (2000) J. Neurochem. , vol.75 , Issue.3 , pp. 1320-1331
    • Li, B.1    Stribley, J.A.2    Ticu, A.3
  • 91
    • 0004251292 scopus 로고
    • North Holland Publishing Co., Amsterdam, The Netherlands
    • Silver A. Biology of Cholinesterases. North Holland Publishing Co., Amsterdam, The Netherlands (1974).
    • (1974) Biology of Cholinesterases.
    • Silver, A.1
  • 92
    • 0032081223 scopus 로고    scopus 로고
    • 125I-labeled fasciculin 2: A new tool for quantitation of acetylcholinesterase densities at synaptic sites by EM-autoradiography
    • Anglister L, Eichler J, Szabo M, Haesaert B, Salpeter MM. 125I-labeled fasciculin 2: a new tool for quantitation of acetylcholinesterase densities at synaptic sites by EM-autoradiography. J. Neurosci. Methods 81(1-2), 63-71 (1998).
    • (1998) J. Neurosci. Methods , vol.81 , Issue.1-2 , pp. 63-71
    • Anglister, L.1    Eichler, J.2    Szabo, M.3    Haesaert, B.4    Salpeter, M.M.5
  • 93
    • 50649106421 scopus 로고    scopus 로고
    • Whole body and tissue imaging of the butyrylcholinesterase knockout mouse injected with near infrared dye labeled butyrylcholinesterase
    • Duysen EG, Lockridge O. Whole body and tissue imaging of the butyrylcholinesterase knockout mouse injected with near infrared dye labeled butyrylcholinesterase. Chem. Biol. Interact. 175(1-3), 119-124 (2008).
    • (2008) Chem. Biol. Interact. , vol.175 , Issue.1-3 , pp. 119-124
    • Duysen, E.G.1    Lockridge, O.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.