A nicotine conjugate vaccine reduces nicotine distribution to brain and attenuates its behavioral and cardiovascular effects in rats

Pharmacology Biochemistry and Behavior

Volumn 65, Issue 1, 2000, Pages 191-198

  Pentel, Paul R ^a,d   Malin, David H ^b   Ennifar, Sofiane ^c   Hieda, Yoko ^a   Keyler, Dan E ^a,d   Lake, J Ronald ^b   Milstein, Judit R ^c   Basham, Lisa E ^c   Coy, R Todd ^b   Moon, J William D ^b   Naso, Robert ^c   Fattom, Ali ^c  

^a MINNEAPOLIS MEDICAL RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF HOUSTON CLEAR LAKE   (United States)

^c Nabi Biopharmaceuticals   (United States)

^d HENNEPIN COUNTY MEDICAL CENTER   (United States)

Author keywords

Antibody; Blood pressure; Immunization; Locomotor activity; Nicotine; Pharmacokinetics; Vaccine

Indexed keywords

IMMUNOGLOBULIN G ANTIBODY; NICOTINE;

ACTIVE IMMUNIZATION; ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE REGULATION; BRAIN LEVEL; DEPENDENT PERSONALITY DISORDER; DRUG PROTEIN BINDING; LOCOMOTION; NONHUMAN; PRIORITY JOURNAL; RAT; SYSTOLIC BLOOD PRESSURE; TREATMENT OUTCOME;

ANIMALS; BLOOD PRESSURE; BRAIN; IMMUNIZATION, PASSIVE; IMMUNOGLOBULIN G; MOTOR ACTIVITY; NICOTINE; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; VACCINATION; VACCINES, CONJUGATE;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0033957739     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(99)00206-3     Document Type: Article

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