Effect of a nicotine vaccine on nicotine binding to β 2*-nicotinic acetylcholine receptors in vivo in human tobacco smokers

American Journal of Psychiatry

Volumn 170, Issue 4, 2013, Pages 399-407

  Esterlis, Irina ^a   Hannestad, Jonas O ^a   Perkins, Evgenia ^a   Bois, Frederic ^a   D'Souza, D Cyril ^a   Tyndale, Rachel F ^a   Seibyl, John P ^a   Hatsukami, Dorothy M ^a   Cosgrove, Kelly P ^a   O'Malley, Stephanie S ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3' AMINOMETHYLNICOTINE EXOPROTEIN A CONJUGATE; NICOTINE; NICOTINE VACCINE; NICOTINIC RECEPTOR BETA2; UNCLASSIFIED DRUG; 5 IODO 3 (2 AZETIDINYLMETHOXY)PYRIDINE; 5-IODO-3-(2-AZETIDINYLMETHOXY)PYRIDINE; AZETIDINE DERIVATIVE; DIAGNOSTIC AGENT; NICOTINIC RECEPTOR; PYRIDINE DERIVATIVE; RADIOACTIVE IODINE; VACCINE;

ADULT; BRAIN REGION; CLINICAL ARTICLE; CONFERENCE PAPER; DRUG EFFICACY; FEMALE; HUMAN; IMMUNIZATION; IN VIVO STUDY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SMOKING; SMOKING HABIT; TOBACCO DEPENDENCE; ARTICLE; BRAIN; CLINICAL TRIAL; DRUG ANTAGONISM; DRUG EFFECT; FUNCTIONAL NEUROIMAGING; IMMUNOLOGY; METABOLISM; METHODOLOGY; PSYCHOLOGICAL ASPECT; SCINTISCANNING; SMOKING CESSATION; STATISTICS; VACCINATION;

ADULT; AZETIDINES; BRAIN; FEMALE; FUNCTIONAL NEUROIMAGING; HUMANS; IODINE RADIOISOTOPES; MALE; NICOTINE; PYRIDINES; RECEPTORS, NICOTINIC; SMOKING; SMOKING CESSATION; TOBACCO USE DISORDER; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; VACCINATION; VACCINES;

MLCS; MLOWN;

EID: 84878230641     PISSN: 0002953X     EISSN: 15357228     Source Type: Journal    
DOI: 10.1176/appi.ajp.2012.12060793     Document Type: Conference Paper

References (31)

1. Hasman A, Holm S: Nicotine conjugate vaccine: is there a right to a smoking future? J Med Ethics 2004; 30: 344-345
2. Keyler DE, Roiko SA, Earley CA, Murtaugh MP, Pentel PR: Enhanced immunogenicity of a bivalent nicotine vaccine. Int Immunopharmacol 2008; 8: 1589-1594
3. Keyler DE, Hieda Y, St Peter J, Pentel PR: Altered disposition of repeated nicotine doses in rats immunized against nicotine. Nicotine Tob Res 1999; 1: 241-249
4. Keyler DE, Roiko SA, Benlhabib E, LeSage MG, St Peter JV, Stewart S, Fuller S, Le CT, Pentel PR: Monoclonal nicotinespecific antibodies reduce nicotine distribution to brain in rats: dose- and affinity-response relationships. Drug Metab Dispos 2005; 33: 1056-1061
5. Hatsukami DK, Jorenby DE, Gonzales D, Rigotti NA, Glover ED, Oncken CA, Tashkin DP, Reus VI, Akhavain RC, Fahim RE, Kessler PD, Niknian M, Kalnik MW, Rennard SI: Immunogenicity and smoking-cessation outcomes for a novel nicotine immunotherapeutic. Clin Pharmacol Ther 2011; 89: 392-399
6. Hatsukami DK, Rennard S, Jorenby D, Fiore M, Koopmeiners J, de Vos A, Horwith G, Pentel PR: Safety and immunogenicity of a nicotine conjugate vaccine in current smokers. Clin Pharmacol Ther 2005; 78: 456-467
7. Pentel PR, Malin DH, Ennifar S, Hieda Y, Keyler DE, Lake JR, Milstein JR, Basham LE, Coy RT, Moon JW, Naso R, Fattom A: A nicotine conjugate vaccine reduces nicotine distribution to brain and attenuates its behavioral and cardiovascular effects in rats. Pharmacol Biochem Behav 2000; 65: 191-198
8. Carrera MR, Ashley JA, Hoffman TZ, Isomura S, Wirsching P, Koob GF, Janda KD: Investigations using immunization to attenuate the psychoactive effects of nicotine. Bioorg Med Chem 2004; 12: 563-570
9. Cerny EH, Lévy R, Mauel J, Mpandi M, Mutter M, Henzelin- Nkubana C, Patiny L, Tuchscherer G, Cerny T: Preclinical development of a vaccine 'against smoking'. Onkologie 2002; 25: 406-411
10. de Villiers SH, Lindblom N, Kalayanov G, Gordon S, Johansson AM, Svensson TH: Active immunization against nicotine alters the distribution of nicotine but not the metabolism to cotinine in the rat. Naunyn Schmiedebergs Arch Pharmacol 2004; 370: 299-304
11. Malin DH, Alvarado CL, Woodhouse KS, Karp H, Urdiales E, Lay D, Appleby P, Moon WD, Ennifar S, Basham L, Fattom A: Passive immunization against nicotine attenuates nicotine discrimination. Life Sci 2002; 70: 2793-2798
12. LeSage MG, Keyler DE, Hieda Y, Collins G, Burroughs D, Le C, Pentel PR: Effects of a nicotine conjugate vaccine on the acquisition and maintenance of nicotine self-administration in rats. Psychopharmacology (Berl) 2006; 184: 409-416
13. Staley JK, Krishnan-Sarin S, Cosgrove KP, Krantzler E, Frohlich E, Perry E, Dubin JA, Estok K, Brenner E, Baldwin RM, Tamagnan GD, Seibyl JP, Jatlow P, Picciotto MR, London ED, O'Malley S, van Dyck CH: Human tobacco smokers in early abstinence have higher levels of beta2 nicotinic acetylcholine receptors than nonsmokers. J Neurosci 2006; 26: 8707-8714
14. 2*-nicotinic acetylcholine receptor occupancy after use of a nicotine inhaler. Int J Neuropsychopharmacol 2011; 14: 389-398
15. Esterlis I, Cosgrove KP, Batis JC, Bois F, Stiklus SM, Perkins E, Seibyl JP, Carson RE, Staley JK: Quantification of smokinginduced occupancy of b2-nicotinic acetylcholine receptors: estimation of nondisplaceable binding. J Nucl Med 2010; 51: 1226-1233
16. Brody AL, Mandelkern MA, London ED, Olmstead RE, Farahi J, Scheibal D, Jou J, Allen V, Tiongson E, Chefer SI, Koren AO, Mukhin AG: Cigarette smoking saturates brain alpha 4 beta 2 nicotinic acetylcholine receptors. Arch Gen Psychiatry 2006; 63: 907-915
17. Cosgrove KP, Batis J, Bois F, Maciejewski PK, Esterlis I, Kloczynski T, Stiklus S, Krishnan-Sarin S, O'Malley S, Perry E, Tamagnan G, Seibyl JP, Staley JK: Beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking. Arch Gen Psychiatry 2009; 66: 666-676
18. Heatherton TF, Kozlowski LT, Frecker RC, Fagerström KO: The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. Br J Addict 1991; 86: 1119-1127
19. Hatsukami DK, Hughes JR, Pickens RW, Svikis D: Tobacco withdrawal symptoms: an experimental analysis. Psychopharmacology (Berl) 1984; 84: 231-236
20. Tiffany ST, Drobes DJ: The development and initial validation of a questionnaire on smoking urges. Br J Addict 1991; 86: 1467-1476
21. Toll BA, Katulak NA, McKee SA: Investigating the factor structure of the Questionnaire on Smoking Urges1-Brief (QSU-Brief). Addict Behav 2006; 31: 1231-1239
22. Radloff L: The CES-D scale: a self-report depression scale for research in the general population. Appl Psychol Meas 1977; 1: 385-401
23. Spielberger C, Corsuch R: Manual for State-Trait Anxiety Inventory. Palo Alto, Calif, Consulting Psychologists Press, 1983
24. Dempsey D, Tutka P, Jacob P 3rd, Allen F, Schoedel K, Tyndale RF, Benowitz NL: Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity. Clin Pharmacol Ther 2004; 76: 64-72
25. Staley JK, van Dyck CH, Weinzimmer D, Brenner E, Baldwin RM, Tamagnan GD, Riccardi P, Mitsis E, Seibyl JP: 123I-5-IA-85380 SPECT measurement of nicotinic acetylcholine receptors in human brain by the constant infusion paradigm: feasibility and reproducibility. J Nucl Med 2005; 46: 1466-1472
26. Cunningham VJ, Rabiner EA, Slifstein M, Laruelle M, Gunn RN: Measuring drug occupancy in the absence of a reference region: the Lassen plot re-visited. J Cereb Blood Flow Metab 2010; 30: 46-50
27. Pravetoni M, Keyler DE, Raleigh MD, Harris AC, Lesage MG, Mattson CK, Pettersson S, Pentel PR: Vaccination against nicotine alters the distribution of nicotine delivered via cigarette smoke inhalation to rats. Biochem Pharmacol 2011; 81: 1164-1170
28. Satoskar SD, Keyler DE, LeSage MG, Raphael DE, Ross CA, Pentel PR: Tissue-dependent effects of immunization with a nicotine conjugate vaccine on the distribution of nicotine in rats. Int Immunopharmacol 2003; 3: 957-970
29. Mukhin AG, Gündisch D, Horti AG, Koren AO, Tamagnan G, Kimes AS, Chambers J, Vaupel DB, King SL, Picciotto MR, Innis RB, London ED: 5-Iodo-A-85380, an alpha4beta2 subtypeselective ligand for nicotinic acetylcholine receptors. Mol Pharmacol 2000; 57: 642-649
30. Vaupel DB, Mukhin AG, Kimes AS, Horti AG, Koren AO, London ED: In vivo studies with [125I]5-I-A-85380, a nicotinic acetylcholine receptor radioligand. Neuroreport 1998; 9: 2311-2317
31. Endres CJ, Carson RE: Assessment of dynamic neurotransmitter changes with bolus or infusion delivery of neuroreceptor ligands. J Cereb Blood Flow Metab 1998; 18: 1196-1210